Navigation Links
Protein identified as critical to insulating the body's wiring could also become treatment target
Date:5/19/2009

AUGUSTA, Ga. - A new protein identified as critical to insulating the wiring that connects the brain and body could one day be a treatment target for divergent diseases, from rare ones that lower the pain threshold to cancer, Medical College of Georgia researchers say.

They report this week in Proceedings of the National Academy of Sciences Online Early Edition that in the peripheral nervous system that controls arms and legs, the protein erbin regulates the protein neuregulin 1, stabilizing and interacting with the ErbB2 receptor on Schwann cells so they can make myelin, which insulates the wiring.

Their studies in mice have shown that when erbin is missing or mutated, the insulation is inadequate, slowing communication.

"Erbin is like a tuner to make signaling stronger or weaker," says Dr. Lin Mei, the study's corresponding author and director of MCG's Institute of Molecular Medicine and Genetics.

Without erbin, the myelin production system falls apart. Eventually raw, over-exposed nerves can die.

"Receptors for neuregulin 1 just get degraded and lost," says Dr. Mei, Georgia Research Alliance Eminent Scholar in Neuroscience. "Schwann cells can see neuregulin 1 sitting there but they can't do anything without the receptor."

Impaired myelin formation and maintenance is implicated in a variety of neurological and psychiatric diseases including schizophrenia, multiple sclerosis and Charcot-Marie-Tooth neuropathy, a genetic, progressive disease that weakens muscles.

Cancer is an issue because the ErbB2 receptor also is an oncogene highly expressed in tumors. ErbB2 helps cancer cells grow and spread so finding its role in the receptor's stability and function provides a potential new site for targeted cancer therapy, says Dr. Yanmei Tao says, postdoctoral fellow in neurobiology and the study's first author. In fact, antibodies to ErbB2 already are available to patients with breast and prostate cancers.

For nerves to communicate with each other or another cell type, such as a muscle cell, they reach out with an arm or extension called an axon. Much like the telephone lines that line roadways, these arms require proper insulation, called myelin, composed mostly of lipids and some proteins.

Axons that transmit quick messages such as telling legs to walk need a lot of insulation. Sensory nerves such as those on the fingertips that prompt retraction from a hot stovetop need less.

"In any given nerve, some axons are wrapped heavily by myelin," Dr. Mei says. "It's based on nerve function. For example, if the nerve needs more speed in conducting a signal or information, like motor nerves, they would be wrapped more."

In fact, erbin is enriched in regions with a lot of myelinated axons, such as the sciatic nerve, which runs down the lower back into the legs, the researchers found.

Dr. Mei also is exploring the role of neuregulin 1 in cell talk in the brain. He and collaborators have identified a sort of a sort of check and balance for brain cell activity managed by neuregulin-1 in the area of the brain where complex reasoning and decisions about appropriate social behavior occur. They showed that neuregulin-1 and another receptor, ErbB4, help keep a healthy balance between excitation and inhibition of brain cells.

Their studies published in Neuron in 2007 showed neuregulin-1 and ErbB4, promote inhibition at the site of inhibitory synapses in the brain by increasing release of GABA, a major inhibitory neurotransmitter.

In 2000, the researchers showed the pair also are at excitatory synapses, communication points between neurons where the neurotransmitter glutamate excites cells to action. Here, neuregulin-1 and ErbB4 suppress excitation.

These findings have implications for conditions such as schizophrenia and seizures, where cell talk is out of control.


'/>"/>

Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
Source:Eurekalert  

Related biology news :

1. Key protein regulating inflammation may prove relevant to controlling sepsis
2. Pliable proteins keep photosynthesis on the light path
3. Heart protein regulates blood vessel maintenance
4. EMBL scientists develop first fully automated pipeline for multiprotein complex production
5. Protein analysis methods, viral vectors featured in Cold Spring Harbor Protocols
6. Small molecules might block mutant protein production in Huntingtons disease
7. ISU researcher identifies key function in protein, cell transcription
8. Brain protein central to both Parkinsons, drug addiction identified
9. SUMO protein guides chromatin remodeler to suppress genes
10. New study reveals the protein that makes phosphate chains in yeast
11. Autopilot guides proteins in brain
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Protein identified as critical to insulating the body's wiring could also become treatment target
(Date:5/16/2017)... 2017   Bridge Patient Portal , an ... MD EMR Systems , an electronic medical record ... have established a partnership to build an interface ... GE Centricity™ products, including Centricity Practice Solution (CPS), ... These new integrations will allow healthcare delivery networks ...
(Date:4/18/2017)... a global expert in SoC-based imaging and computing solutions, has developed ... the company,s hybrid codec technology. A demonstration utilizing TeraFaces ® , ... showcased during the upcoming Medtec Japan at Tokyo Big Sight April ... Vegas Convention Center April 24-27. ... Click here for an image of the M820 ...
(Date:4/11/2017)... GARDENS, Fla. , April 11, 2017 /PRNewswire/ ... management and secure authentication solutions, today announced that ... by Intelligence Advanced Research Projects Activity (IARPA) to ... IARPA,s Thor program. "Innovation has been ... and IARPA,s Thor program will allow us to ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... , ... October 12, 2017 ... ... announces publication of a United States multicenter, prospective clinical study that demonstrates ... point-of-care diagnostic test capable of identifying clinically significant acute bacterial and viral ...
(Date:10/11/2017)... ... October 11, 2017 , ... ... President Andi Purple announced Dr. Suneel I. Sheikh, the co-founder, CEO and chief ... ), Inc. has been selected for membership in ARCS Alumni Hall of ...
(Date:10/11/2017)... Md. (PRWEB) , ... October 11, 2017 , ... ... digital pathology, announced today it will be hosting a Webinar titled, “Pathology is ... Advanced Pathology Associates , on digital pathology adoption best practices and how Proscia ...
(Date:10/11/2017)... , ... October 11, 2017 , ... ... the implantation and pregnancy rates in frozen and fresh in vitro fertilization ... progesterone and maternal age to IVF success. , After comparing the results from ...
Breaking Biology Technology: