Navigation Links
Protein identified as critical to insulating the body's wiring could also become treatment target
Date:5/19/2009

AUGUSTA, Ga. - A new protein identified as critical to insulating the wiring that connects the brain and body could one day be a treatment target for divergent diseases, from rare ones that lower the pain threshold to cancer, Medical College of Georgia researchers say.

They report this week in Proceedings of the National Academy of Sciences Online Early Edition that in the peripheral nervous system that controls arms and legs, the protein erbin regulates the protein neuregulin 1, stabilizing and interacting with the ErbB2 receptor on Schwann cells so they can make myelin, which insulates the wiring.

Their studies in mice have shown that when erbin is missing or mutated, the insulation is inadequate, slowing communication.

"Erbin is like a tuner to make signaling stronger or weaker," says Dr. Lin Mei, the study's corresponding author and director of MCG's Institute of Molecular Medicine and Genetics.

Without erbin, the myelin production system falls apart. Eventually raw, over-exposed nerves can die.

"Receptors for neuregulin 1 just get degraded and lost," says Dr. Mei, Georgia Research Alliance Eminent Scholar in Neuroscience. "Schwann cells can see neuregulin 1 sitting there but they can't do anything without the receptor."

Impaired myelin formation and maintenance is implicated in a variety of neurological and psychiatric diseases including schizophrenia, multiple sclerosis and Charcot-Marie-Tooth neuropathy, a genetic, progressive disease that weakens muscles.

Cancer is an issue because the ErbB2 receptor also is an oncogene highly expressed in tumors. ErbB2 helps cancer cells grow and spread so finding its role in the receptor's stability and function provides a potential new site for targeted cancer therapy, says Dr. Yanmei Tao says, postdoctoral fellow in neurobiology and the study's first author. In fact, antibodies to ErbB2 already are available to patients with breast and prostate cancers.

For nerves to communicate with each other or another cell type, such as a muscle cell, they reach out with an arm or extension called an axon. Much like the telephone lines that line roadways, these arms require proper insulation, called myelin, composed mostly of lipids and some proteins.

Axons that transmit quick messages such as telling legs to walk need a lot of insulation. Sensory nerves such as those on the fingertips that prompt retraction from a hot stovetop need less.

"In any given nerve, some axons are wrapped heavily by myelin," Dr. Mei says. "It's based on nerve function. For example, if the nerve needs more speed in conducting a signal or information, like motor nerves, they would be wrapped more."

In fact, erbin is enriched in regions with a lot of myelinated axons, such as the sciatic nerve, which runs down the lower back into the legs, the researchers found.

Dr. Mei also is exploring the role of neuregulin 1 in cell talk in the brain. He and collaborators have identified a sort of a sort of check and balance for brain cell activity managed by neuregulin-1 in the area of the brain where complex reasoning and decisions about appropriate social behavior occur. They showed that neuregulin-1 and another receptor, ErbB4, help keep a healthy balance between excitation and inhibition of brain cells.

Their studies published in Neuron in 2007 showed neuregulin-1 and ErbB4, promote inhibition at the site of inhibitory synapses in the brain by increasing release of GABA, a major inhibitory neurotransmitter.

In 2000, the researchers showed the pair also are at excitatory synapses, communication points between neurons where the neurotransmitter glutamate excites cells to action. Here, neuregulin-1 and ErbB4 suppress excitation.

These findings have implications for conditions such as schizophrenia and seizures, where cell talk is out of control.


'/>"/>

Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
Source:Eurekalert  

Related biology news :

1. Key protein regulating inflammation may prove relevant to controlling sepsis
2. Pliable proteins keep photosynthesis on the light path
3. Heart protein regulates blood vessel maintenance
4. EMBL scientists develop first fully automated pipeline for multiprotein complex production
5. Protein analysis methods, viral vectors featured in Cold Spring Harbor Protocols
6. Small molecules might block mutant protein production in Huntingtons disease
7. ISU researcher identifies key function in protein, cell transcription
8. Brain protein central to both Parkinsons, drug addiction identified
9. SUMO protein guides chromatin remodeler to suppress genes
10. New study reveals the protein that makes phosphate chains in yeast
11. Autopilot guides proteins in brain
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Protein identified as critical to insulating the body's wiring could also become treatment target
(Date:12/16/2016)... global wearable medical device market, in terms of value, is projected ... in 2016, at a CAGR of 18.0% during the forecast period. ... Growth in ... launch of a growing number of smartphone-based healthcare apps compatible with ... increasing focus on physical fitness. Furthermore, growing trend ...
(Date:12/15/2016)... ... Markets has announced the addition of the "Global Military Biometrics Market ... the global military biometrics market to grow at a CAGR of 7.5% ... based on an in-depth market analysis with inputs from industry experts. The ... years. The report also includes a discussion of the key vendors operating ...
(Date:12/15/2016)... "Increase in mobile transactions is driving the growth of ... expected to grow from USD 4.03 billion in 2015 ... of 29.3% between 2016 and 2022. The market is ... smart devices, government initiatives, and increasing penetration of e-commerce ... to grow at a high rate during the forecast ...
Breaking Biology News(10 mins):
(Date:1/12/2017)... ... January 12, 2017 , ... After her brain cancer ... gave her only a few months to live. Now a paper publishing January ... Rosendahl’s disease and increased both the quantity and quality of her life: Adding ...
(Date:1/12/2017)... Pune, India , January 12, 2017 A new ... Type and End Users - Global Opportunity Analysis and Industry Forecast, 2014-2022," projects that ... $2,921 million in 2015, growing at a CAGR of 15.07% during the forecast period. ... ... Market Research Logo ...
(Date:1/11/2017)... AURORA, Colo. (PRWEB) , ... January 11, 2017 ... ... in the journal Clinical Cancer Research show early promise of the investigational anti-cancer ... progressed despite a median 5 previous treatment regimens. Twenty-seven percent of these heavily ...
(Date:1/11/2017)... , ... January 11, 2017 , ... ... society for optics and photonics , are commending the U.S. Congress and President ... signing Friday by the President of the American Innovation and Competitiveness Act (AICA). ...
Breaking Biology Technology: