Navigation Links
Protein identified as critical to insulating the body's wiring could also become treatment target
Date:5/19/2009

AUGUSTA, Ga. - A new protein identified as critical to insulating the wiring that connects the brain and body could one day be a treatment target for divergent diseases, from rare ones that lower the pain threshold to cancer, Medical College of Georgia researchers say.

They report this week in Proceedings of the National Academy of Sciences Online Early Edition that in the peripheral nervous system that controls arms and legs, the protein erbin regulates the protein neuregulin 1, stabilizing and interacting with the ErbB2 receptor on Schwann cells so they can make myelin, which insulates the wiring.

Their studies in mice have shown that when erbin is missing or mutated, the insulation is inadequate, slowing communication.

"Erbin is like a tuner to make signaling stronger or weaker," says Dr. Lin Mei, the study's corresponding author and director of MCG's Institute of Molecular Medicine and Genetics.

Without erbin, the myelin production system falls apart. Eventually raw, over-exposed nerves can die.

"Receptors for neuregulin 1 just get degraded and lost," says Dr. Mei, Georgia Research Alliance Eminent Scholar in Neuroscience. "Schwann cells can see neuregulin 1 sitting there but they can't do anything without the receptor."

Impaired myelin formation and maintenance is implicated in a variety of neurological and psychiatric diseases including schizophrenia, multiple sclerosis and Charcot-Marie-Tooth neuropathy, a genetic, progressive disease that weakens muscles.

Cancer is an issue because the ErbB2 receptor also is an oncogene highly expressed in tumors. ErbB2 helps cancer cells grow and spread so finding its role in the receptor's stability and function provides a potential new site for targeted cancer therapy, says Dr. Yanmei Tao says, postdoctoral fellow in neurobiology and the study's first author. In fact, antibodies to ErbB2 already are available to patients with breast and prostate
'/>"/>

Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Key protein regulating inflammation may prove relevant to controlling sepsis
2. Pliable proteins keep photosynthesis on the light path
3. Heart protein regulates blood vessel maintenance
4. EMBL scientists develop first fully automated pipeline for multiprotein complex production
5. Protein analysis methods, viral vectors featured in Cold Spring Harbor Protocols
6. Small molecules might block mutant protein production in Huntingtons disease
7. ISU researcher identifies key function in protein, cell transcription
8. Brain protein central to both Parkinsons, drug addiction identified
9. SUMO protein guides chromatin remodeler to suppress genes
10. New study reveals the protein that makes phosphate chains in yeast
11. Autopilot guides proteins in brain
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Protein identified as critical to insulating the body's wiring could also become treatment target
(Date:7/24/2014)... which life arose have been maintained in our cells today ... Research published today in the Journal of Biological Chemistry ... also in animals still perform ancient reactions thought to have ... billion years ago. , The primordial soup theory suggests that ... of the combination of metals, gases from the atmosphere and ...
(Date:7/24/2014)... . , Electric cars ... common sight on the roads of the Scandinavian country ... new vehicle registrations for the second time. This poses a ... claim only a small portion of the market. Of the ... mere 8000 are electric powered. The main factors discouraging motorists ...
(Date:7/23/2014)... SAN DIEGO , July 24, 2014 Pfenex ... initial public offering of 8,333,333 shares of its common stock ... In addition, Pfenex has granted the underwriters a 30-day option ... at the initial public offering price. The shares are expected ... 2014, under the symbol "PFNX". William Blair ...
Breaking Biology News(10 mins):Nano-supercapacitors for electric cars 2Nano-supercapacitors for electric cars 3Pfenex Inc. Announces Pricing Of Initial Public Offering 2
... cell biology and showing off the powers of new ... Golgi apparatus, which sorts newly synthesized proteins for transport ... during cell division, according to research to be presented ... Cell Biology (ASCB) annual meeting in New Orleans. ...
... the year,s end-of-life refrigerators, TVs, mobile phones, computers, monitors, ... cord worldwide could fill a line of 40-ton trucks ... Equator. That forecast, based on data compiled by ... of UN organizations, industry, governments, non-government and science organizations ...
... that present-day organisms evolved from earlier life forms. ... enzymes that help complete chemical processessuch as converting food ... Now a University of Iowa researcher and his colleagues ... "dihydrofolate reductase" as it occurred from bacteria to humans. ...
Cached Biology News:High-resolution 3-D imaging draws new picture of Golgi's whereabouts during cell division 2World e-waste map reveals national volumes, international flows 2World e-waste map reveals national volumes, international flows 3World e-waste map reveals national volumes, international flows 4World e-waste map reveals national volumes, international flows 5UI researcher studies evolution on the molecular level 2
(Date:7/24/2014)... 24, 2014  Neogen Corporation (Nasdaq: NEOG ... its potential revenue from new rodenticide research are premature. ... analysts on July 22, 2014, Neogen,s CEO commented about ... research. "It was my intent Tuesday at ... of a new type of rodenticide, but certainly not ...
(Date:7/24/2014)... The first part of the session ... in Human Studies” will cover comprehensive clinical support in ... With increasing R&D costs and declining industry success in ... the knowledge collected in early Phase I/IIa study data ... late stage development. , Next, the presenters will examine ...
(Date:7/24/2014)... , July 24, 2014   Cypher Genomics, ... the appointment of Adam Simpson as ... provides rapid and comprehensive annotation and interpretation of ... reporting. "Cypher,s technology has the potential ... by enhancing diagnostic accuracy, optimizing therapeutic approaches and ...
(Date:7/23/2014)... 24, 2014 Lyfebulb, the International Pemphigus ... and NASDAQ OMX First North Premier, ... announced a collaboration to increase awareness of unmet ... an event attended by more than sixty patients, ... a health and wellness company dedicated to serving ...
Breaking Biology Technology:Neogen comments on SenesTech 2Best Practices for Optimizing Dose Escalation in First in Human Studies, New Webinar August 6th Hosted by Xtalks 2Cypher Genomics Announces the Appointment of Adam Simpson as President and COO to Advance Transformative Genome Interpretation Technology 2Cypher Genomics Announces the Appointment of Adam Simpson as President and COO to Advance Transformative Genome Interpretation Technology 3Innovative Collaboration To Increase Awareness Of Bullous Pemphigoid, A Rare Autoimmune Disease Of The Skin 2Innovative Collaboration To Increase Awareness Of Bullous Pemphigoid, A Rare Autoimmune Disease Of The Skin 3Innovative Collaboration To Increase Awareness Of Bullous Pemphigoid, A Rare Autoimmune Disease Of The Skin 4Innovative Collaboration To Increase Awareness Of Bullous Pemphigoid, A Rare Autoimmune Disease Of The Skin 5
... 22, 2012 /PRNewswire-iReach/ -- FirstMark, the diagnostic ... that the company will be exhibiting at the 61st ... of Cardiology (ACC) in Chicago, March 24-27, Booth #15084. ... is the first and only multiple biomarker blood test ...
... The new Dynaflow Resolve System was developed in close ... demand for a simpler technology capable of complex perfusion ... perfusion system that enables novel experimental protocols by allowing ... type, and any compound. The new and improved system ...
... March 21, 2012 AtheroNova Inc. (OTCBB: AHRO), a ... compounds to regress atherosclerotic plaque, today announced that it ... development stage company, no revenues were recognized in the ... were $2,560,235 for 2011 compared to $2,679,435 in 2010. ...
Cached Biology Technology:FirstMark Exhibiting at the American College of Cardiology 61st Annual Scientific Sessions & Expo 2Cellectricon Launches Dynaflow® Resolve System Enabling Novel Ion Channel Assays 2AtheroNova Releases 2011 Financial Results 2AtheroNova Releases 2011 Financial Results 3
... DNA Engine Dyad instrument is the most ... Featuring MJ's world-class thermal performance, the Dyad ... as well as point-and-click navigation via touch ... can be easily and economically expanded to ...
...
Practical tool for easy, effective sealing of 0.2ml PCR tubes and plates using cap strips....
... RT Telomerase Detection Kit is ... assay for the fluorometric detection ... telomerase activity. It incorporates refinements ... and adds the ability to ...
Biology Products: