Navigation Links
Protein handlers should be effective treatment target for cancer and Alzheimer's
Date:8/6/2009

eimer's, Parkinson's and other neurodegenerative diseases.

"We have to find the balance," Dr. Mivechi says of the center's concurrent work to find drugs that adjust the activity of molecular chaperones and heat shock factors. She theorizes these drugs would be used for limited periods to avoid trading cancer for an increased risk of neurodegenerative disease or vice versa.

"A lot of drugs, such as chemotherapeutic agents, can kill cancer but they also kill normal tissue. That is a limiting factor. We are looking for better drugs," she says.

The MCG center is among the first to study molecular chaperones and heat shock factors in animals to better understand their role in these diseases. Drs. Mivechi and Moskofidis, a viral immunologist, have developed 20 mouse models missing different molecular chaperones or heat shock factors in the last decade to help explore the large family of molecular chaperones. For contrast, they also have a mouse that over expresses heat shock factor 1, or Hsf1, a major activator of molecular chaperones.

They are now focusing on developing mice that lack molecular chaperones or heat shock factors in targeted areas, such as liver or breast tissue, as well as mice in which these can be removed during cancer to determine what impact their loss has on active disease. They also are cross breeding the mice, to create one, for example, that also over expresses the molecule, Her2/Neu, which is over active in some of the most aggressive breast cancers. By comparing the resulting mouse to one that just over expresses Her2/Neu, they can examine the impact of Hsf1, Dr. Mivechi says.

"That is how these findings will translate to patients," Dr. Mivechi says. "We need to know, not only how deleting or augmenting molecular chaperones and heat shock factors affects disease development, but also how it impacts disease progression."

Their studies also will help researchers pinpoint which molecular chape
'/>"/>

Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
Source:Eurekalert  

1

GOOD

Page: 1 2 3

Related biology news :

1. Pitt researchers find promising candidate protein for cancer prevention vaccines
2. Structure of protective protein in the eye lens revealed
3. Little-known protein found to be key player
4. New computer simulation helps explain folding in important cellular protein
5. Protein that promotes cancer cell growth identified
6. Sticky protein helps reinforce fragile muscle membranes
7. Plant protein doorkeepers block invading microbes, study finds
8. Protein can help cells or cause cancer, Purdue researcher finds
9. Plant protein doorkeepers block invading microbes, study finds
10. Structural biology scores with protein snapshot
11. Proteins in gel
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Protein handlers should be effective treatment target for cancer and Alzheimer's
Protein handlers should be effective treatment target for cancer and Alzheimer's
(Date:12/16/2009)... TORONTO, Dec. 7 IgeaCare Solutions Inc. ... assets of the healthcare communications company previously operating ... Solutions will now move forward under new leadership ... Mr. Michael Rochon to the position of Chief ... will focus on providing a superior servicing and ...
(Date:12/15/2009)... The 2009 Frost & Sullivan European Border ... Sagem Securite (Safran Group) for its innovative ... the company,s expertise in advanced biometric technology ... value-added products to end users. ,, ... Securite has been involved in delivering identification ...
(Date:12/15/2009)... GenWay Biotech, Inc. GenWay Clinical Laboratory, San Diego, ... College of American Pathologists (CAP), based on results ... The laboratory,s director was advised of this national ... services being provided." GenWay Biotech Inc. GenWay Clinical ... nationwide. , The CAP Laboratory Accreditation Program, begun ...
Breaking Biology News(10 mins):IgeaCare Solutions Inc. Emerges Under New Leadership and Funding 2Frost & Sullivan Recognises Sagem Securite for its Innovative Automated Border Control Systems 2Frost & Sullivan Recognises Sagem Securite for its Innovative Automated Border Control Systems 3Frost & Sullivan Recognises Sagem Securite for its Innovative Automated Border Control Systems 4Last Day of Special Olympics Minnesotas 2009 Summer Games 49537 1Last Day of Special Olympics Minnesotas 2009 Summer Games 49537 2Last Day of Special Olympics Minnesotas 2009 Summer Games 49537 3Cell Therapeutics Announces Final Results of its Fixed Price Exchange Offers for Any and All of its 24118 9 Million Convertible Notes Outstanding 49533 1Cell Therapeutics Announces Final Results of its Fixed Price Exchange Offers for Any and All of its 24118 9 Million Convertible Notes Outstanding 49533 2Cell Therapeutics Announces Final Results of its Fixed Price Exchange Offers for Any and All of its 24118 9 Million Convertible Notes Outstanding 49533 3UGA researchers achieve breakthrough in effort to develop tiny biological fuel cells 49530 1UGA researchers achieve breakthrough in effort to develop tiny biological fuel cells 49530 2
... CITY A single organ may contain more than one ... prospects for using the versatile cells to replace damaged tissue ... from the laboratory of geneticist Mario Capecchi, the University of ... of the journal Nature Genetics, Capecchi and geneticist Eugenio Sangiorgi ...
... understand the design principles and origins of the human ... origins of the brain and how it evolved into ... research suggests that it is not size alone that ... sophisticated molecular processing of nerve impulses allowed development of ...
... June 6 Communication,Intelligence Corporation (the "Company") (OTC ... solutions for business process,automation in the financial industry ... today that it has closed a financing, on,June ... (the "Investor")., As part of the financing, ...
Other Biology News:Caution on stem cell therapy 2Caution on stem cell therapy 3Caution on stem cell therapy 4Origins of the brain 2Origins of the brain 3Communication Intelligence Corporation Closes $3.6 Million Financing 2Communication Intelligence Corporation Closes $3.6 Million Financing 3Communication Intelligence Corporation Closes $3.6 Million Financing 4
(Date:12/15/2009)... The International Society for Medical Publication ... is continuing to accept abstracts for its 6th ... VA, April 19-21, 2010. This marks the first ... join the organization to submit an abstract to ... 12 AM EST, January 15, 2010. For submission ...
(Date:12/15/2009)... 15 Thomson ... has become the first drug pipeline database to ... information. This highly anticipated new content is being ... ,, Thomson Pharma will ... publications, press releases, conferences, and other sources across ...
(Date:12/14/2009)... Dec. 14 Array BioPharma Inc. (Nasdaq: ... ) today announced that they entered into an ... small-molecule glucokinase activator program, including ARRY-403, currently being ... patients with Type 2 diabetes. ,, ... receive an upfront payment of $60 million and ...
(Date:12/14/2009)... with State Biotech Leaders to Develop Blueprint ... Development while Boosting Rhode Island,s Growing Biotech ... R.I., Dec. 14 Several of ... medicine and biotechnology gathered today at Brown ... importance of medical innovation in Rhode Island ...
Breaking Biology Technology:The International Society for Medical Publication Professionals Announces Call for Abstracts for Its 6th Annual Meeting 2The International Society for Medical Publication Professionals Announces Call for Abstracts for Its 6th Annual Meeting 3Thomson Reuters is First to Offer Fully Integrated Pipeline and Clinical Trials 2Array BioPharma and Amgen Partner in Type 2 Diabetes 2Array BioPharma and Amgen Partner in Type 2 Diabetes 3Array BioPharma and Amgen Partner in Type 2 Diabetes 4Array BioPharma and Amgen Partner in Type 2 Diabetes 5Array BioPharma and Amgen Partner in Type 2 Diabetes 6Array BioPharma and Amgen Partner in Type 2 Diabetes 7Former Congressman Dick Gephardt Brings National Spotlight to Rhode Island with 'Best and Brightest Forum on Medical Innovation' 2Former Congressman Dick Gephardt Brings National Spotlight to Rhode Island with 'Best and Brightest Forum on Medical Innovation' 3Former Congressman Dick Gephardt Brings National Spotlight to Rhode Island with 'Best and Brightest Forum on Medical Innovation' 4
... June 3 Ingenuity Systems, the,leading provider of ... of a four year agreement with Boehringer Ingelheim,for ... throughout the,Boehringer Ingelheim research and development organization to ... general tool for biological search,and exploration., The ...
... LLC Pursues the Elimination of Medical Mistakes ... National TIME OUT Day - June 18, ... risks,of any surgical procedure, the devastating news of a medical ... patients,trust Surgical Teams to successfully handle their lives with the ...
... Ill., June 2 Medline Industries, Inc., the,nation,s ... announced today that it has signed a three-year ... manufacturer of liquid products,for personal care, infection control ... shortages of mouth rinse in the healthcare market, ...
Other Biology Technology:Ingenuity Systems Announces Multi-Year Agreement With Boehringer Ingelheim 2Before Every Surgery - 'Take a TIME OUT(R)' 2Medline Signs 3-Year Purchasing Agreement for Mouth Rinse From Chester Labs 2
RORgamma (S-14)...
... Custom DNA microarrays designed for your specific ... powerful Paraflo microfluidic synthesis platform. Thousands of ... and LC Sciences can provide assistance with ... as part of our comprehensive Custom DNA ...
... Microarrays designed for RNA aptamer screening and ... and powerful Paraflo microfluidic on-chip synthesis platform. ... our comprehensive DNA/RNA Aptamer Microarray Service. ... RNA Aptamer Microarray contains greater than 1500 ...
... differentiation of mouse embryonic stem cells to ... the midbrain, where they are mainly located ... area, and the retrorubral field. These dopaminergic ... dopamine innervation ( e.g.projections to the caudate ...
Biology Products: