Navigation Links
Protein handlers should be effective treatment target for cancer and Alzheimer's
Date:8/6/2009

AUGUSTA, Ga. Cancer and Alzheimer's have excess protein in common and scientists say learning more about how proteins are made and eliminated will lead to better treatment for both.

Medical College of Georgia researchers Drs. Nahid F. Mivechi and Dimitrios Moskofidis have received two National Cancer Institute grants totaling nearly $3 million and a $982,800, four-year grant from the U.S. Department of Veterans Affairs in the last 12 months to support studies of proteins and the molecular chaperones that manage them from cradle to grave.

Understanding the exact role molecular chaperones play in cancer and Alzheimer's should lead to better ways to intervene in both, says Dr. Mivechi, director of the MCG Center for Molecular Chaperone Biology/Radiobiology and Cancer Virology.

Everyone needs molecular chaperones which prompt genes to make proteins, move proteins around the body, fold them up into the proper shape to function properly and even haul them off when they no longer work. Cancer needs them even more for the endless cell replication required for tumor growth, Dr. Mivechi says. Essentially the opposite happens in Alzheimer's in which excess protein is a major component of the destructive brain plaque that is the disease's hallmark. Dr. Mivechi believes molecular chaperones, which typically slow in activity with age, are failing at their job so that proteins aggregate in the brain, contributing to Alzheimer's and other neurodegenerative diseases in which brain cell communication is interrupted.

The MCG center has evidence that disabling molecular chaperones or the heat shock factors that control some of them, disables tumor formation in the liver and probably the breast. Researchers are also now examining brain tumors as well as pancreatic and prostate cancer.

They also want to know whether ramping up the activity of molecular chaperone can essentially make them act young again and halt development of Alzh
'/>"/>

Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Pitt researchers find promising candidate protein for cancer prevention vaccines
2. Structure of protective protein in the eye lens revealed
3. Little-known protein found to be key player
4. New computer simulation helps explain folding in important cellular protein
5. Protein that promotes cancer cell growth identified
6. Sticky protein helps reinforce fragile muscle membranes
7. Plant protein doorkeepers block invading microbes, study finds
8. Protein can help cells or cause cancer, Purdue researcher finds
9. Plant protein doorkeepers block invading microbes, study finds
10. Structural biology scores with protein snapshot
11. Proteins in gel
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Protein handlers should be effective treatment target for cancer and Alzheimer's
(Date:10/15/2014)... Fred Alt will be awarded the 44th Rosenstiel Award ... for his pioneering research exploring the mechanisms of genomic ... cancer cells. Alt is the second alumnus to win ... Nobel Prize in 2003. , Alt is the Charles ... at Harvard Medical School and an investigator at the ...
(Date:10/14/2014)... 14, 2014)—It,s been millions of years since T. ... led by Ohio University scientists is breathing life back ... through dinosaur snouts. The research has important implications for ... but to enhance the sense of smell and cool ... said Ohio University doctoral student Jason Bourke, lead author ...
(Date:10/14/2014)... oil supplements, rich in omega-3 fatty acids, do not reduce ... the heart can beat as fast as 150 beats a ... Montreal Heart Institute were published in the Journal of ... For the trial, 337 patients with atrial fibrillation not receiving ... fish oil a day or to placebo for up to ...
Breaking Biology News(10 mins):Brandeis awards 44th Rosenstiel Award to pioneering geneticist Fred Alt 2Dinosaur breathing study shows that noses enhanced smelling and cooled brain 2Dinosaur breathing study shows that noses enhanced smelling and cooled brain 3
... Symposium on Multimodality Cardiovascular Molecular Imaging ... cell therapy, leading-edge research in imaging technology and ... of cardiovascular receptors, vascular biology, myocardial metabolism and ... Partnership for Critical Markers of Disease will host ...
... million year old fossils reveal much earlier origins of modern ... The chances of an octopus corpse surviving long enough to ... only a single fossil species was known, and from fewer ... octopus is. Even if you have never encountered one in ...
... - NASA scientists analyzing the dust of meteorites have discovered ... on its most basic, molecular level. "We found more ... created in space and brought to Earth by meteorite impacts ... of NASA,s Goddard Space Flight Center in Greenbelt, Md. "By ...
Cached Biology News:SNM Symposium on Multimodality Cardiovascular Molecular Imaging 2Cretaceous octopus with ink and suckers -- the world's least likely fossils? 2NASA researchers find clues to a secret of life 2NASA researchers find clues to a secret of life 3
(Date:10/22/2014)... KONG , Oct. 22, 2014  aTyr Pharma ... that rare disease expert John C. McKew , ... McKew brings more than two decades of expertise in ... Institutes of Health, Wyeth Research and Genetics Institute, Inc. ... aTyr,s efforts to expand and translate its novel Physiocrine ...
(Date:10/20/2014)... Inc. (TSXV: BRM) ("Biorem" or "the Company") today announced four new ... and provides a good start to Q4.  The orders are for ... and one in the Middle East . ... Peter Bruijns , President & CEO. "Total bidding activity and ... have been for any complete year since the company has tracked ...
(Date:10/20/2014)... Earle Martin , Chief ... that Ellen Teplitzky, an experienced attorney specializing in ... industry, has joined the firm as Director of ... practice. NDA Partners provides legal services, including ... to top law firms and their clients in ...
(Date:10/19/2014)... The Asia-Pacific Bromine Market report defines and segments ... forecast of revenue. , Browse through the TOC ... get an idea of the in-depth analysis provided. ... in the Asia-Pacific bromine market, and is supported ... http://www.micromarketmonitor.com/market/asia-pacific-bromine-6741503144.html , Bromine is a volatile and ...
Breaking Biology Technology:aTyr Pharma Appoints John C. McKew, Ph.D., as Vice President, Research 2aTyr Pharma Appoints John C. McKew, Ph.D., as Vice President, Research 3NDA Partners Appoints Ellen Teplitzky, JD as Director of its Legal Services Practice 2The Asia-Pacific Bromine Market is estimated to grow to $4,080.1 million by 2018 - New Report by MicroMarket Monitor 2The Asia-Pacific Bromine Market is estimated to grow to $4,080.1 million by 2018 - New Report by MicroMarket Monitor 3
... Reportlinker.com announces that a new market research ... Enzymes: Sustainable Alternatives with Remarkable ... Enzymes are among the most ... host of different roles in a wide ...
... Oppenheimer & Co. Inc., a unit of Oppenheimer Holdings, ... the firm as Managing Director in the Healthcare group of ... its life science business. He will report to Brian McCarthy, ... Since 2003, Matthias had worked at JMP Securities, where ...
... 2011 Children at Paterson Public School No. 5 ... of more than 200 volunteers from Roche, New Jersey ... organizers from non-profit KaBOOM!. The new playground provides the ... as well as children living in the neighborhood with ...
Cached Biology Technology:Reportlinker Adds Enzymes: Sustainable Alternatives with Remarkable Scope 2Reportlinker Adds Enzymes: Sustainable Alternatives with Remarkable Scope 3Designed by Kids, Built by Volunteers: Roche, New Jersey Community Development Corporation, and KaBOOM! Build New Playground in Just One Day for Paterson Public School Children 2Designed by Kids, Built by Volunteers: Roche, New Jersey Community Development Corporation, and KaBOOM! Build New Playground in Just One Day for Paterson Public School Children 3Designed by Kids, Built by Volunteers: Roche, New Jersey Community Development Corporation, and KaBOOM! Build New Playground in Just One Day for Paterson Public School Children 4
...
Request Info...
Human RUNX2/CBFA1 MAb (Clone 232902)...
... Peroxidase Conjugate, 2 ml. ... enzyme molecules for use ... situ hybridization applications.High specificity ... Labeling & Detection, Protein ...
Biology Products: