Navigation Links
Protein handlers should be effective treatment target for cancer and Alzheimer's
Date:8/6/2009

AUGUSTA, Ga. Cancer and Alzheimer's have excess protein in common and scientists say learning more about how proteins are made and eliminated will lead to better treatment for both.

Medical College of Georgia researchers Drs. Nahid F. Mivechi and Dimitrios Moskofidis have received two National Cancer Institute grants totaling nearly $3 million and a $982,800, four-year grant from the U.S. Department of Veterans Affairs in the last 12 months to support studies of proteins and the molecular chaperones that manage them from cradle to grave.

Understanding the exact role molecular chaperones play in cancer and Alzheimer's should lead to better ways to intervene in both, says Dr. Mivechi, director of the MCG Center for Molecular Chaperone Biology/Radiobiology and Cancer Virology.

Everyone needs molecular chaperones which prompt genes to make proteins, move proteins around the body, fold them up into the proper shape to function properly and even haul them off when they no longer work. Cancer needs them even more for the endless cell replication required for tumor growth, Dr. Mivechi says. Essentially the opposite happens in Alzheimer's in which excess protein is a major component of the destructive brain plaque that is the disease's hallmark. Dr. Mivechi believes molecular chaperones, which typically slow in activity with age, are failing at their job so that proteins aggregate in the brain, contributing to Alzheimer's and other neurodegenerative diseases in which brain cell communication is interrupted.

The MCG center has evidence that disabling molecular chaperones or the heat shock factors that control some of them, disables tumor formation in the liver and probably the breast. Researchers are also now examining brain tumors as well as pancreatic and prostate cancer.

They also want to know whether ramping up the activity of molecular chaperone can essentially make them act young again and halt development of Alzh
'/>"/>

Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Pitt researchers find promising candidate protein for cancer prevention vaccines
2. Structure of protective protein in the eye lens revealed
3. Little-known protein found to be key player
4. New computer simulation helps explain folding in important cellular protein
5. Protein that promotes cancer cell growth identified
6. Sticky protein helps reinforce fragile muscle membranes
7. Plant protein doorkeepers block invading microbes, study finds
8. Protein can help cells or cause cancer, Purdue researcher finds
9. Plant protein doorkeepers block invading microbes, study finds
10. Structural biology scores with protein snapshot
11. Proteins in gel
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Protein handlers should be effective treatment target for cancer and Alzheimer's
(Date:9/16/2014)... September 16, 2014 Schizophrenia is associated with increased ... body of research suggests that the relationship between schizophrenia ... patients to use nicotine to self-medicate symptoms and cognitive ... published in the current issue of Biological Psychiatry ... that the level of nicotine receptors in the brain ...
(Date:9/16/2014)... practically all vital functions in an organism. For ... particular substances and control immune system responses. Researchers ... function independently of each other, but instead form ... networks, you find many similarities with online social ... of Plant Systems Biology. "Some proteins are good ...
(Date:9/15/2014)... Human skin and gut microbes influence processes from digestion ... are the most biodiverse terrestrial ecosystems on the planet, ... trees in the tropics. Smithsonian scientists and colleagues working ... samples from a single tree were home to more ... from 57 tree species contained more than 7,000 different ...
Breaking Biology News(10 mins):Smoking and schizophrenia linked by alterations in brain nicotine signals 2Good networkers make prime targets 2Smithsonian scientists discover tropical tree microbiome in Panama 2
... model in mice because their symptoms are complex and ... transferred to a mouse. The lack of animal models ... strategically altering a protein-making molecule, a mouse was made ... and cause paralysis of the arms and legs in ...
... for making some of our immune proteins into the inflammatory ... that will appear in the June 8 issue of the ... study, conducted by a team of researchers in Italy, also ... those genes into risk factors for intestinal disorders. ...
... in <A HREF=",http://chinese.eurekalert.org/zh/pub_releases/2009-05/bc-pmp051909.php,">Chinese . A protein ... to take on a similar role in bacterial cells, ... journal BMC Microbiology . The Arabidopsis thaliana ... cells, polar regions keeping cell division at its ...
Cached Biology News:A new mouse model provides insight into genetic neurological disorders 2Immune genes adapt to parasites 2Plant Min protein sits tight and rescues E. coli 2
(Date:9/16/2014)... Pharma Packaging Solutions announced ... for their 89th year in business. Adding ... Packaging Solutions is preparing packaging operations changes ... new procedures. Establishing training and system validation ... Pharma Packaging Solutions will be ready to ...
(Date:9/16/2014)... NEW ORLEANS , Sept. 16, 2014 ... Austin, Texas -based cybersecurity company focused on ... 2FA ONE, will support the ability to generate a ... As a pioneer of user-based RFID authentication, ... used for physical access, for many years. RFID authentication ...
(Date:9/15/2014)... , Sept. 15, 2014   Global ... innovator of scientific products and services for satellite ... Acquisition Solution for Integrated Services (OASIS) from the ... GST was selected to provide the government best-value ... Small Business (SB) category in Pool 4. The ...
(Date:9/15/2014)... go downhill fast when a patient has sepsis, a ... a patient,s blood -- often too fast for antibiotics ... spleen and developed by a team at Harvard,s Wyss ... way doctors treat sepsis. , "Even with the ... care units at least 30 percent of the time," ...
Breaking Biology Technology:Adding Serialization Capabilities and Expanded Capacity, Pharma Packaging Solutions Is Preparing for 89th Year of Business 22FA, Inc. Announces RFID-based One-Time Password (OTP) Authentication 2Global Science & Technology, Inc. Awarded GSA OASIS Small Business Contract 2Global Science & Technology, Inc. Awarded GSA OASIS Small Business Contract 3Blood-cleansing biospleen device developed for sepsis therapy 2Blood-cleansing biospleen device developed for sepsis therapy 3Blood-cleansing biospleen device developed for sepsis therapy 4
... 16 Today, Grifols S.A. (Grifols), a global healthcare ... new national testing laboratory in San Marcos, Texas at ... Construction of the laboratory represents the first phase ... production facilities. When completed, the new facilities will ...
... interactions of millions of proteins. These are the building blocks ... problem is that proteins are extremely difficult to study, particularly ... in all sizes and weights. Now, Kris Gevaert from VIB/Ghent ... have achieved a breakthrough in protein research. Using yeast, they ...
... 21, Inc. (Nasdaq: NXXI ), the developer and ... and Diabetes Essentials® brands that help consumers manage blood ... chronic joint pain, today announced financial results for the ... 30, 2009. , For the quarter ended June ...
Cached Biology Technology:Grifols Breaks Ground on New National Testing Laboratory 2Powerhouses in the cell dismantled 2Nutrition 21 Announces Financial Results for Q4 of Fiscal 2009 and Full Year Fiscal 2009 2Nutrition 21 Announces Financial Results for Q4 of Fiscal 2009 and Full Year Fiscal 2009 3Nutrition 21 Announces Financial Results for Q4 of Fiscal 2009 and Full Year Fiscal 2009 4Nutrition 21 Announces Financial Results for Q4 of Fiscal 2009 and Full Year Fiscal 2009 5Nutrition 21 Announces Financial Results for Q4 of Fiscal 2009 and Full Year Fiscal 2009 6
... optically clear polystyrene with frosted labeling ... for cell counting. 100% integrity tested. ... new product number, created to easily ... no availability yet, please order under ...
Packaging: package with 500 l Patent/trademark/license (electronic): (r) Registered trademark of Molecular Probes...
... VersaDoc MP 4000 System is a ... system capable of supporting a wide ... chemiluminescence, densitometry, and chemiflourescence. Red, ... imaging of multiplexed fluorescent samples, reducing ...
... hydrophobic barrier pen for immunohistochemistry and in ... frozen or paraffin-embedded tissue sections mounted on ... heat-stable, water-repellent barrier that keeps staining reagents ... of reagents when differentially staining two sections ...
Biology Products: