Navigation Links
Protein handlers should be effective treatment target for cancer and Alzheimer's
Date:8/6/2009

AUGUSTA, Ga. Cancer and Alzheimer's have excess protein in common and scientists say learning more about how proteins are made and eliminated will lead to better treatment for both.

Medical College of Georgia researchers Drs. Nahid F. Mivechi and Dimitrios Moskofidis have received two National Cancer Institute grants totaling nearly $3 million and a $982,800, four-year grant from the U.S. Department of Veterans Affairs in the last 12 months to support studies of proteins and the molecular chaperones that manage them from cradle to grave.

Understanding the exact role molecular chaperones play in cancer and Alzheimer's should lead to better ways to intervene in both, says Dr. Mivechi, director of the MCG Center for Molecular Chaperone Biology/Radiobiology and Cancer Virology.

Everyone needs molecular chaperones which prompt genes to make proteins, move proteins around the body, fold them up into the proper shape to function properly and even haul them off when they no longer work. Cancer needs them even more for the endless cell replication required for tumor growth, Dr. Mivechi says. Essentially the opposite happens in Alzheimer's in which excess protein is a major component of the destructive brain plaque that is the disease's hallmark. Dr. Mivechi believes molecular chaperones, which typically slow in activity with age, are failing at their job so that proteins aggregate in the brain, contributing to Alzheimer's and other neurodegenerative diseases in which brain cell communication is interrupted.

The MCG center has evidence that disabling molecular chaperones or the heat shock factors that control some of them, disables tumor formation in the liver and probably the breast. Researchers are also now examining brain tumors as well as pancreatic and prostate cancer.

They also want to know whether ramping up the activity of molecular chaperone can essentially make them act young again and halt development of Alzh
'/>"/>

Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Pitt researchers find promising candidate protein for cancer prevention vaccines
2. Structure of protective protein in the eye lens revealed
3. Little-known protein found to be key player
4. New computer simulation helps explain folding in important cellular protein
5. Protein that promotes cancer cell growth identified
6. Sticky protein helps reinforce fragile muscle membranes
7. Plant protein doorkeepers block invading microbes, study finds
8. Protein can help cells or cause cancer, Purdue researcher finds
9. Plant protein doorkeepers block invading microbes, study finds
10. Structural biology scores with protein snapshot
11. Proteins in gel
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Protein handlers should be effective treatment target for cancer and Alzheimer's
(Date:8/21/2014)... Ever heard of the water window? It consists of ... are not absorbed by the water in biological tissues. ... develop coherent radiations within the water window. These could ... a high-contrast image of the biological samples or to ... study identifies the physical mechanism needed to efficiently generate ...
(Date:8/21/2014)... designed by an international standards process, will be available ... an invited review published in the OnlineFirst version of ... the official journal of the American Society for Parenteral ... reduce the occurrence of misconnection that can be harmful ... are used to join medical devices, components, and accessories ...
(Date:8/21/2014)... a novel and versatile modeling strategy to simulate polyelectrolyte ... as well as for studying polyelectrolytes, including DNA and ... much larger and more complex polyelectrolyte systems, and to ... author of a paper on the work and a ... and Engineering. "This is a big step forward for ...
Breaking Biology News(10 mins):Water window imaging opportunity 2New feeding tube connectors will improve patient safety 2Researchers develop models to study polyelectrolytes, including DNA and RNA 2
... European College of Neuropsychopharmacology (ECNP) is pleased to announce ... 2010 ECNP Lifetime Achievement Award in recognition of his ... diseases and neuropsychiatric drug development. The ECNP Lifetime Achievement ... impact on the field of neuropsychopharmacology. The award is ...
... firms and other life science organizations are ... environments and developing more sustainable operations, reports ... (GEN). This promising trend was made clear ... discussions that took place at GEN,s ( ...
... A new study from the Center for Interdisciplinary ... an additional link between Light At Night (LAN) and ... carried out at the University of Haifa that also ... to ,environmental light pollution, which the study has shown ...
Cached Biology News:Moussa B.H. Youdim wins the 2010 ECNP Lifetime Achievement Award 2GEN reports on the greening of the life sciences 2Connection between light at night (LAN) and cancer revealed in additional study 2
(Date:8/22/2014)... Ophthalmic drug delivery technologies or ... endeavors as the anatomy, physiology and biochemistry of ... foreign substances. Ocular drug delivery technologies provide several ... minimal use of needles; also it enables high ... specific targeting within the ocular globe. On the ...
(Date:8/22/2014)... Research and Markets has announced the addition ... Reagents (Cloning, Epigenetics, PCR, Restriction Digestion, Sequencing) Market - ... The global molecular biology enzymes market was ... to grow at a CAGR of 13.74% to reach ... reagents find applications in a large number of fields ...
(Date:8/22/2014)... 22, 2014 The identification of ... can be accelerated by exome sequencing. Built on ... the custom SeqCap EZ Developer system has been ... Watson will additionally present how he achieved coverage ... human and mouse exome kits. With over 236,000 ...
(Date:8/21/2014)... & Rockville, MD (PRWEB) August 21, 2014 ... (ITI) is making progress in its development of JRC-LAMP-vax, ... Japanese red cedar pollen. Phase IC studies began this ... real solution to hay fever. , The Japanese red ... 35 million people in Japan. Mountain Cedar pollen wreaks ...
Breaking Biology Technology:Ocular Drug Delivery Technologies Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 2Ocular Drug Delivery Technologies Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 3Ocular Drug Delivery Technologies Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 4Global Molecular Biology Enzymes, Kits, & Reagents (Cloning, Epigenetics, PCR, Restriction Digestion, Sequencing) Market - Forecast to 2018 2Global Molecular Biology Enzymes, Kits, & Reagents (Cloning, Epigenetics, PCR, Restriction Digestion, Sequencing) Market - Forecast to 2018 3Efficient Identification of Protein-Coding Variants in a Model Organism Through Exome Sequencing, New Webinar Hosted by Xtalks 2Relief for Allergy Sufferers Finally in Sight: Immunomic Therapeutics Closes in on Treatment for Hay Fever in Japan, U.S. 2Relief for Allergy Sufferers Finally in Sight: Immunomic Therapeutics Closes in on Treatment for Hay Fever in Japan, U.S. 3Relief for Allergy Sufferers Finally in Sight: Immunomic Therapeutics Closes in on Treatment for Hay Fever in Japan, U.S. 4
... Ind., Jan. 23 Zimmer Holdings, Inc.,(NYSE: ZMH ... announced,today it will be participating in the Wachovia Securities ... 10:15 a.m. Eastern Time., A live webcast of ... at http://investor.zimmer.com . The webcast will,be archived for ...
... QED International Associates, Inc.,administrator for the HealthShares(TM) ... HealthShares(TM) Exchange-Traded Funds, today announced,that effective at the ... Pharmaceuticals Inc. (Nasdaq: REGN ) will replace ... HealthShares(TM) Composite Index. MGI Pharma is being,acquired by ...
... 23 /PRNewswire/ - Dalton Medicinal Chemistry Partners,the ... announces that it,has achieved another targeted milestone ... (Canada) Ltd., Dalton Medicinal Chemistry Partners ... and synthesize novel compounds against an,antiviral target ...
Cached Biology Technology:QED International Associates Announces Changes to the HealthShares(TM) Composite, HealthShares(TM) Cancer and HealthShares(TM) Neuroscience Indexes 2
... FastPlax Antibody is used to detect the ... surface of infected cells as early as ... of the FastPlax Titer Kit, which allows ... hours. The FastPlax Antibody can ...
Alexa Fluor 647 anti-mouse IL-12 (Interleukin-12) / IL-23 (Interleukin-23) p40 25 ug...
PKC (pSer345), phospho-specific...
PE Rat anti-Hu CD267 Storage Temperature: Refrigerate(2 to 8C)...
Biology Products: