Navigation Links
Protein found in heart may be target for colon cancer therapies
Date:9/13/2011

A protein critical in heart development may also play a part in colon cancer progression.

Research led by investigators from Vanderbilt-Ingram Cancer Center and the Vanderbilt Eye Institute suggests that the protein BVES (blood vessel endocardial substance) which also is key in regulating corneal cells may be a therapeutic target for halting colon cancer metastasis.

The study, appearing in the October issue of the Journal of Clinical Investigation, further suggests that BVES may be important more broadly in many, or most, epithelial cancers.

About 85 percent of cancers originate in epithelial cells that form the body's external and internal linings (such as the skin and the lining of the gastrointestinal tract).

However, the main clinical concern is not the primary tumor, but the potential for that tumor to leave its tissue of origin and spread throughout the body (a process called "metastasis").

A critical step in metastatic progression of epithelial cancers happens when epithelial cells "revert" to a less differentiated state a process called "epithelial-mesenchymal transition" or EMT.

Ophthalmologist Min Chang, M.D., studies the healing process in the cornea, perhaps the most highly regulated epithelium in the body. From collaborative studies with David Bader, Ph.D., who discovered BVES and showed its importance in heart development, Chang found that BVES was highly expressed and regulated in corneal cells.

When BVES is disrupted in corneal cells, they become disorganized, almost "cancer-like," noted Chang, an assistant professor of Ophthalmology and Visual Sciences and co-author on the study.

Chang then brought these findings to the attention of colleague Christopher Williams, M.D., Ph.D., assistant professor of Medicine and Cancer Biology and co-author on the study.

"When he described these cells, it sounded a lot like the way cancer cells looked when they were unde
'/>"/>

Contact: Melissa Marino
melissa.marino@vanderbilt.edu
615-322-4747
Vanderbilt University Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. USC scientists identify key protein linked to acute liver failure
2. Scripps Research scientists pinpoint shape-shifting mechanism critical to protein signaling
3. Scientists find new drug candidates for set of protein-folding diseases
4. Foods rich in protein, dairy products help dieters preserve muscle and lose belly fat: study
5. Research offers new way to target shape-shifting proteins
6. Molecular chaperones traffic signaling proteins between cells in plant stem-cell maintenance pathway
7. Degrading proteins to divide cells
8. Protein in the urine spells kidney failure for African-Americans
9. Single protein, key to ebola virus infection, could aid in drug design
10. Three-part handoff delivers proteins to membrane surface
11. Newfound hijacked proteins linked to salmonella virulence
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... 22, 2014  NXT-ID, Inc. (NASDAQ: NXTD and ... on the growing mobile commerce market, announces it has retained ... for the 2015 International CES debut of the Wocket™ biometric ... be at the NXT-ID booth January 6th and 7 th ...
(Date:12/19/2014)... and Markets ( http://www.researchandmarkets.com/research/86ncd6/micro_market ) has announced the ... Security Systems Market" report to their offering. ... perimeter security market is estimated to grow at a CAGR ... holds a larger share in this market, Canada ...
(Date:12/17/2014)... , Dec. 15, 2014 The Defense Logistics Agency ... detect and prevent counterfeit microcircuits from entering into its ... an in-house microcircuit anti-counterfeit initiative dubbed DNA marking. The ... increasing their reliability throughout the supply chain. The new ...
Breaking Biology News(10 mins):NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 3NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 4Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 3Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 2Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 3
... people with asthma, a couple of puffs from an inhaler ... become resistant to the calming effect of that medicine, they ... them to the hospital or worse. Now, ... help explain what,s going on in the lungs of these ...
... European Alps suggests that population declines to be observed ... effects of recent climate warming on mountain plants. A ... Department of Conservation Biology, Vegetation and Landscape Ecology of ... to predict migration of mountain plants which explicitly takes ...
... principle have produced enough of the greenhouse gas methane to ... time when the Earth was warm and wet. That,s according ... Current Biology, a Cell Press publication. The hulking ... were widespread about 150 million years ago. As in cows, ...
Cached Biology News:Scientists discover new type of cell with a key role in treatment-resistant asthma 2Scientists discover new type of cell with a key role in treatment-resistant asthma 3European mountain plant population shows delayed response to climate change 2Gaseous emissions from dinosaurs may have warmed prehistoric earth 2
(Date:1/23/2015)... (PRWEB) January 23, 2015 Portal Solutions ... digital workplaces on Microsoft Office 365 and SharePoint platforms ... 50 Award program for being one of the region’s fastest-growing ... and employee growth. , “To be recognized a second ...
(Date:1/22/2015)... 2015 Shimadzu Scientific Instruments today ... UV-visible spectrophotometer. Offering wavelength scanning from 190 to ... for applications in a variety of industries, including ... user-friendly UV-1280 enables intuitive operation, while the enhanced ...
(Date:1/22/2015)... Bedford, NH (PRWEB) January 22, 2015 ... offers a table top laboratory homogenizer, the PandaPLUS 2000, ... nanoparticles, nanodispersions, nanoemulsions , and cell disruption . ... processing dairy products, fruit juices, liquid food, food additives ...
(Date:1/22/2015)... Cambridge Semantics, the leading provider of smart data solutions driven ... record-breaking year across the board for the company. , ... and our Smart Data solutions, our customers were able to ... to record growth for the company in 2014,” said Alok ...
Breaking Biology Technology:Washington SmartCEO Announces Portal Solutions as 2015 Future 50 Award Winner Second Year in a Row 2Washington SmartCEO Announces Portal Solutions as 2015 Future 50 Award Winner Second Year in a Row 3Shimadzu’s New Monitored Single-Beam UV-Vis Spectrophotometer Offers Comprehensive Measurement Options in a Compact Body 2GEA Niro Soavi Announces the PandaPLUS 2000 Homogenizer for Processing New Applications for Nanoemulsions and Cell Disruption 2Cambridge Semantics Announces Record Results for 2014 2
... March 19, 2012   Organovo Holdings, Inc. (OTCQB: ... oversubscribed $15.2 million private placement. At the final closing, ... the sale of 6.9 million Units, at a price ... has approximately 43.7 million shares of common stock issued ...
... Toby Odenheim, director of IT services at Synteract, ... to present on Selecting the Optimum EDC Platform to ... Clinical Trials, East Coast conference , to be held in ... EDT, Wed., March 28, discussing a variety of drivers to ...
... a note telling you that the product contains L(+)-lactic acid, ... of their atoms. The two"isomers", L(+) and D(-), have different ... right or left respectively. Of course the capacity to alter ... to solutions of yoghurt. Light interacts in one way or ...
Cached Biology Technology:Organovo Announces Close of $15.2 Million Private Placement to Advance 3D Bioprinting for Medical Applications 2Organovo Announces Close of $15.2 Million Private Placement to Advance 3D Bioprinting for Medical Applications 3Synteract Director of IT Services Toby Odenheim Speaking at March 2012 Outsourcing in Clinical Trials East Coast Conference 2Synteract Director of IT Services Toby Odenheim Speaking at March 2012 Outsourcing in Clinical Trials East Coast Conference 3Designer lights from the physics lab 2
... are cytopathic effect inhibition assays, also known as ... tissue culture supernatents; serum from PK studies and ... is defined as the quantity of interferon required ... viral infection by 50%. All standards ...
... Topoisomerase I from vaccinia virus is a ... positive and negative superhelical turns (also called ... DNA. The product of the reaction is ... positive or negative superhelical turns. DNA Topoisomerase ...
... Topoisomerase I from vaccinia virus is ... both positive and negative superhelical turns (also ... closed DNA. The product of the reaction ... fewer positive or negative superhelical turns. DNA ...
... CpGenome Fast DNA Modification Kit contains reagents ... a DNA sample. In the bisulfite reaction, ... converting them to uracils, while 5-methylcytosines remain ... DNA will differ depending on whether the ...
Biology Products: