Navigation Links
Protein fibrils as alternative plastics?
Date:5/28/2008

This release is available in German.

Amyloid deposits in tissues and organs are linked to a number of diseases, including Alzheimers, Parkinsons, type II diabetes, and prion diseases such as BSE. However, amyloids are not just pathological substances; they have potential as a nanomaterials. The potential applications of these supramolecular assemblies exceed those of synthetic polymers, state Ehud Gazit and co-author Izhack Cherny in the journal Angewandte Chemie, since the building blocks may introduce biological function in addition to mechanical properties.

Even in nature, amyloids are not merely abnormal, incorrectly folded proteins; they are physiological components of organisms. For example, they are an important protective material in the egg envelopes of insects and fish. They are also involved in the formation of the biofilms of many bacteria, a coating on the surface of the bacterial cells that protects them from antimicrobial substances and facilitates their attachment to surfaces.

Amyloid fibrils are bundles of highly ordered protein filaments made of ladder-like strands and can be several micrometers long. In cross-section, amyloids appear as hollow cylinders or ribbons. Although amyloid fibrils are proteins, they more closely resemble synthetic polymers (plastics) than the usual globular proteins. Amyloids can display amazing mechanical properties similar to spider silk. Spider silk is, by weight, significantly stronger than steel and can be stretched to many times its original length without tearing properties that have not been reproducible with synthetic fibers.

The self-assembly properties of amyloids, together with their observed plasticity, makes them attractive natural building blocks for the design of new nanostructures and nanomaterials, according to the authors from the University of Tel Aviv (Israel). These building blocks can be broadly varied by means of simple molecular biological techniques. Surfaces could be given tailored and biocompatible coatings, for example, in analytical flow devices for medical technology or bioanalysis. Other ideas include amyloid hydrogels for the encapsulation and controlled release of drugs and for scaffolds for three-dimensional cell cultures and tissue engineering. Functional proteins such as enzymes could be bound to amyloid-forming sequences to mimic biological processes.

Amyloid fibrils are also suitable as matrices for nanostructures. For example, it has been possible to produce a conducting nanoscale coaxial cable by filling amyloid nanotubes with sliver and externally coating them with gold.


'/>"/>

Contact: Ehud Gazit
ehudg@post.tau.ac.il
972-364-09030
Wiley-Blackwell
Source:Eurekalert  

Related biology news :

1. Montana State University researchers map iron transport protein
2. Plant biologists discover unexpected proteins affecting small RNAs
3. New clues to how proteins dissolve and crystallize
4. Ancient protein offers clues to killer condition
5. New discovery on role of vital protein that fights meningitis
6. Researchers report the cloning of a key group of human genes, the protein kinases
7. Genetic sequencing of protein from T. rex bone confirms dinosaurs link to birds
8. Proteins that stop a major signaling pathway can also generate new proteins
9. Researchers reveal structure of protein that repairs damage to cancer cells
10. Pathogen virulence proteins suppress plant immunity
11. Protein data bank archives 50,000th molecule structure
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Protein fibrils as alternative plastics?
(Date:4/11/2017)... April 11, 2017 Crossmatch®, a globally-recognized ... solutions, today announced that it has been awarded ... Projects Activity (IARPA) to develop next-generation Presentation Attack ... "Innovation has been a driving force within ... will allow us to innovate and develop new ...
(Date:4/6/2017)... , April 6, 2017 Forecasts ... ANPR, Document Readers, by End-Use (Transportation & Logistics, Government ... Oil, Gas & Fossil Generation Facility, Nuclear Power), Industrial, ... Other) Are you looking for a definitive ... ...
(Date:4/4/2017)... , April 4, 2017   EyeLock LLC , ... that the United States Patent and Trademark Office (USPTO) ... covers the linking of an iris image with a ... and represents the company,s 45 th issued patent. ... is very timely given the multi-modal biometric capabilities that ...
Breaking Biology News(10 mins):
(Date:4/27/2017)... MN (PRWEB) , ... April 27, 2017 , ... ... Pain and Migraine Therapeutics Summit ( http://www.paintherapeuticsummit.com ) is coming to San Diego, ... communities attend this conference to learn about the latest advances in the treatment ...
(Date:4/27/2017)... ... April 27, 2017 , ... ... mass flow controllers based on capillary thermal mass flow technology provide exponentially more ... control applications. Over 80% of all industrial processes—such as those involving chemical ...
(Date:4/27/2017)... USA (PRWEB) , ... April 27, 2017 , ... ... optics and photonics , joined other scientists, researchers, engineers, and industry professionals in ... to strengthen America's ability to compete in the world photonics industry. , This ...
(Date:4/27/2017)... NASHVILLE, Tenn. , April 27, 2017  Pendant ... company developing innovative surface modification and drug delivery technologies, ... & Johnson Innovation, JLABS @ Toronto ... Chief Executive Officer of Pendant Biosciences, noted, "We are ... Toronto community, and are honored to ...
Breaking Biology Technology: