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Protein data bank archives 50,000th molecule structure
Date:4/8/2008

tructures by 2014, said Philip E. Bourne, associate director of the RCSB PDB and professor of pharmacology at the UCSD Skaggs School of Pharmacy and Pharmaceutical Sciences.

The RCSB PDB, based at Rutgers University and the UCSD, is responsible for releasing PDB entries into the archive after they have been reviewed and annotated. At Rutgers, RCSB PDB members annotate structures and develop the sophisticated infrastructure needed to handle these complex data. The primary FTP site is based at SDSC, which serves as the distribution point for users.

The RCSB PDB presents a comprehensive website and database that lets users search, analyze and visualize the structures of biological macromolecules and their relationships to sequence, function and disease. In addition, it features a Molecule of the Month series, which recently published its 100th installment (see accompanying illustrations).

Proteins, one of the main building blocks for living organisms, come in a variety of shapes, with the form of a protein corresponding to its function. The structures housed in the PDB demonstrate great diversity in size, complexity and function, including:

  • Insulin, the protein deficient in diabetic patients
  • p53 tumor suppressor, a protein often implicated in cancer
  • Anthrax toxin, the disease-causing protein made by anthrax
  • Amyloid peptide, a protein implicated in Alzheimers disease.


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Contact: Joseph Blumberg
blumberg@ur.rutgers.edu
732-932-7084 x652
Rutgers University
Source:Eurekalert  

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