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Protein creates paths for growing nerve cells
Date:12/19/2012

Working with mice, Johns Hopkins scientists have discovered that a particular protein helps nerve cells extend themselves along the spinal cord during mammalian development. Their results shed light on the subset of muscular dystrophies that result from mutations in the gene that holds the code for the protein, called dystroglycan, and also show how the nerve and muscle failings of the degenerative diseases are related.

As mammals like mice and humans develop, nerve cells in the brain and spinal cord must form connections with themselves and with muscles to assure proper control of movement. Nerve cells sometimes extend the whole length of the spinal cord to connect sensory nerves bearing information, for example, from the legs to the brain. To do so, nerve cells anchor their "headquarters," or cell bodies, in one location, and then extend a long, thin projection all the way to their target locations. These projections, or axons, can be 10,000 times longer than the cell body.

In a report published in the journal Neuron on Dec. 6, the authors suggest that, during fetal development, axons extend themselves along specific pathways created by dystroglycan.

"Dystroglycan creates a path and then binds other molecules that act as traffic signs, providing directional cues for axons en route to their targets," says David Ginty, Ph.D., a Howard Hughes investigator and professor of neuroscience in the Institute for Basic Biomedical Sciences at the Johns Hopkins University School of Medicine."

To find new genes associated with axon migration, Kevin Wright, Ph.D., a postdoctoral fellow in Ginty's laboratory, chemically provoked random genetic changes throughout the genomes of mice and then examined their axons for defective organization. What stood out were mutations in two genes that resulted in axon growth patterns similar to those in mice lacking the protein Slit, which is known to provide directional cues for nerve axon
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Contact: Catherine Kolf
ckolf@jhmi.edu
443-287-2251
Johns Hopkins Medicine
Source:Eurekalert  

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