Navigation Links
Protein could offer target to reduce lung damage from smoking-caused emphysema
Date:5/16/2011

Members of the research team, led by first author Matthias Clauss, Ph.D., IU associate research professor of cellular and integrative physiology, created an antibody designed to specifically target EMAPII and block its activity. The mice received an inhaled version of the antibody during their third month of smoking. They then were exposed to a fourth month of smoking without the treatment.

The mice receiving the treatment had significantly less cell death and inflammation and improved lung function compared to the smoking mice who did not receive the treatment. Moreover the benefits to the treated mice continued even after the treatment stopped.

Next steps include optimizing the duration of the antibody treatments to determine whether they continue to have an effect after the animals have stopped smoking, she said. Plans also call for work to measure levels of the cytokine in large numbers of human emphysema and COPD patients to determine whether it can be used as a biomarker to measure the presence, severity or type of lung disease.

Considerable research work remains before an EMAPII antibody might be ready for testing in humans, Dr. Petrache said.


'/>"/>

Contact: Eric Schoch
eschoch@iupui.edu
317-274-7722
Indiana University School of Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. UT Southwestern researchers find protein that might be key to cutting cancer cells blood supply
2. Researchers show heparan sulfate adjusts functions of growth factor proteins
3. Weizmann Institute scientists discover: A protein that contributes to obesity
4. Illinois professor chairs committee that recommends immediate calories, protein for TBI
5. Several baffling puzzles in protein molecular structure solved with new method
6. Discovery identifies elaborate G-protein network in plants
7. Researchers combine active proteins with material derived from fruit fly
8. Researchers get a first look at the mechanics of membrane proteins
9. Polarized microscopy technique shows new details of how proteins are arranged
10. Secrets of a precision protein machine
11. Starch-controlling gene fuels more protein in soybean plants
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... in eastern New South Wales, Australia when NASA,s Aqua ... UTC on July 11 (12:35 p.m. local time/11:35 p.m. ... New South Wales (NSW), the Moderate Resolution Imaging Spectroradiometer ... region and spotted smoke (light brown) from various fires. ... outlined in red. , The New South Wales, Australia ...
(Date:7/11/2014)... "mouse TRAP" to capture the early signs of kidney ... the Journal of Clinical Investigation . Their new ... extract cellular and genetic information from a variety of ... Institute for Medical Research in 2008, TRAP involves attaching ... of the cell type of interest. Scientists can then ...
(Date:7/11/2014)... scientists from the Max Planck Institute for Medical Research ... in understanding photosynthesis, the process by which the Earth ... atmosphere and which is therefore crucial for all higher ... report the first direct visualization of a crucial event ... a specific protein complex, photosystem II, splits water into ...
Breaking Biology News(10 mins):A first direct glimpse of photosynthesis in action 2
... three Canadians suffer from stress and the number is on ... the physiological state wasn,t properly named until the 1930s, new ... plagued humans for hundreds, and perhaps thousands of years. ... Journal of Archaeological Science , detected the stress hormone cortisol ...
... , WALL, N.J., Dec. 9 BIO-key ... in finger-based biometric identification solutions, today announced that ... security publications, named BIO-key International the 2009 Innovator ... Biometrics. , (Logo: http://www.newscom.com/cgi-bin/prnh/20050509/BIOKEYLOGO ) , ...
... While supplements can help some people meet their ... is the best way for most people to obtain ... their risk of chronic disease, according to a newly ... Dietetic Association. This paper is an update of ADA,s ...
Cached Biology News:Studying hair of ancient Peruvians answers questions about stress 2BIO-key(R) Selected as 2009 Industry Innovator in Biometrics by SC Magazine 2BIO-key(R) Selected as 2009 Industry Innovator in Biometrics by SC Magazine 3ADA releases updated position paper on nutrient supplementation 2
(Date:7/10/2014)... of psychiatric disorders has been extremely challenging because there ... are insufficient to cause disease. Now investigators reporting in ... Cell Stem Cell describe a strategy that ... with other risk factors or environmental exposures to affect ... a genetic variant that may predispose individuals to schizophrenia. ...
(Date:7/10/2014)... forever. Nanophysics makes sure of that. Mechanics researchers at Linkping ... Physical Review E . Knowledge that can be of ... be able to sit still forever, and walk around upside ... soon be able to buy smart new fasteners that hold ... is, sooner or later the grip is lost, no matter ...
(Date:7/10/2014)... will see the two universities and NPL collaborate to ... and industry and their complementary academic strengths., Working with ... shape the scientific priorities of the UK. The establishment ... 300 high-calibre PhD students, will provide a pipeline of ... potential of the Laboratory will be grown through the ...
(Date:1/15/2014)... , Jan. 15, 2014  Bill Jacobs Automotive, a group ... is teaming up with the Heartland Blood Center and offering ... drive. The drive takes place Saturday, Jan. 18 at the ... 2 p.m. (Photo: http://photos.prnewswire.com/prnh/20140115/MN46637 )  ...
Breaking Biology Technology:New strategy could uncover genes at the root of psychiatric illnesses 2Even geckos can lose their grip 2Universities of Surrey and Strathclyde selected as strategic partners in the future operation of the National Physical Laboratory 2Universities of Surrey and Strathclyde selected as strategic partners in the future operation of the National Physical Laboratory 3Join the Bill Jacobs Auto blood drive and receive a free oil change 2
... ... new indoor composting kit from SCD Probiotics. Designed to fit under most ... using SCD,s probiotic technology, helps accelerate the process and reduces foul odors normally associated ... ...
... Dragon Pharmaceutical Inc. ("Dragon Pharma" or the "Company" TSX: DDD; OTCBB: DRUG), an international ... March 31, 2010 . , , , ... Ended March 31, 2010 , , ... recorded $49.06 million of revenues for the quarter ended March 31, ...
... ... Chips , ... California (PRWEB) May 17, 2010 -- Forza Silicon Corporation announced today that the Company’s ... PJR. Forza is a leading designer and fabless turnkey supplier of CMOS imaging chips, ...
Cached Biology Technology:All Seasons Indoor Composter™ and All Seasons Bokashi™ Provide Easy Way to Recycle Food Waste Right in Your Kitchen 2All Seasons Indoor Composter™ and All Seasons Bokashi™ Provide Easy Way to Recycle Food Waste Right in Your Kitchen 3Dragon Pharma reports 2010 first quarter financial results 2Dragon Pharma reports 2010 first quarter financial results 3Dragon Pharma reports 2010 first quarter financial results 4Dragon Pharma reports 2010 first quarter financial results 5Forza Silicon Achieves ISO 9001 Certification 2
Kit includes your choice of reagents for labeling 3 x 10 9 cells and EasySep magnet....
Plasmid expressing PLAP reporter gene....
Puromycin resistance gene (pac), provided in a pORF plasmid. pORF is an expression plasmid selectable with Ampicillin....
...
Biology Products: