Navigation Links
Protein could offer target to reduce lung damage from smoking-caused emphysema
Date:5/16/2011

An international research team has identified a lung protein that appears to play a key role in smoking-related emphysema and have crafted an antibody to block its activity, Indiana University scientists reported.

The research, conducted in mice, suggests that the protein, a cytokine named EMAPII, could provide a target for drugs to treat emphysema, said Irina Petrache, M.D., associate professor of medicine at the Indiana University School of Medicine. The research was posted online May 16 for the June edition of The Journal of Clinical Investigation.

Emphysema, a form of chronic obstructive pulmonary disease (COPD) that affects nearly 5 million people in the U.S alone, is caused by the destruction of cells that transfer oxygen from the lungs to the blood, along with inflammation in the lungs. Cigarette smoking is the most common cause of emphysema.

The cytokine EMAPII a type of cell-signaling molecule is normally part of the process of early lung development. Research had previously found that EMAPII could cause the death of cells that line blood vessels endothelial cells and inflammation, but it had not been identified as the molecular culprit at work when cigarette smoking inflicted its damage on the lungs.

"The fact that we could have a single target affecting two major processes made us excited about looking for it in response to smoking," said Dr. Petrache, the Floyd and Reba Smith Investigator in Respiratory Disease at IU.

When the researchers induced emphysema in mice exposed to cigarette smoke, tests showed the mice had elevated levels of the EMAPII cytokine. In other tests, the scientists also found elevated levels of the cytokine in the lungs of patients with COPD.

The researchers also found that the cell death caused by the EMAPII resulted in the release of enzymes that cause more production of EMAPII, causing a vicious cycle of elevated cytokine levels and more cell death.


'/>"/>

Contact: Eric Schoch
eschoch@iupui.edu
317-274-7722
Indiana University School of Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. UT Southwestern researchers find protein that might be key to cutting cancer cells blood supply
2. Researchers show heparan sulfate adjusts functions of growth factor proteins
3. Weizmann Institute scientists discover: A protein that contributes to obesity
4. Illinois professor chairs committee that recommends immediate calories, protein for TBI
5. Several baffling puzzles in protein molecular structure solved with new method
6. Discovery identifies elaborate G-protein network in plants
7. Researchers combine active proteins with material derived from fruit fly
8. Researchers get a first look at the mechanics of membrane proteins
9. Polarized microscopy technique shows new details of how proteins are arranged
10. Secrets of a precision protein machine
11. Starch-controlling gene fuels more protein in soybean plants
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... Since Alexandre Edmond Becquerel first discovered the photovoltaic effect ... harness the power of sunlight for its own purposes. ... 2014 issue of the FASEB Journal ... exploiting the power of sunlight by focusing on a ... conserved throughout evolution. This conservationor persistence over time and ...
(Date:7/31/2014)... Professor of Clinical Surgery at LSU Health Sciences Center ... team of plastic and reconstructive surgeons who report a ... select patients for a specific surgical migraine treatment technique. ... surgery to decompress the nerves that trigger migraines experienced ... The study, which confirms the benefit of surgical treatment ...
(Date:7/31/2014)... 31, 2014 Biometrics industry sees ... smart technologies; companies turn towards digital currency: NXT-ID, Inc. ... Amazon.com Inc. (NASDAQ: AMZN ), Facebook Inc. ... GOOG ) and Microsoft Corporation (NASDAQ: MSFT) ... the growing m-commerce market, announces a video featuring its ...
Breaking Biology News(10 mins):Scientists shine bright new light on how living things capture energy from the sun 2Surgeons report significant migraine relief from cosmetic eyelid surgery technique 2Smart Technology Consumer's Interest in Mobile Payment Products Grows - Company Secures Deal with Major Airline to Display Advertisements in Flight for its Next Generation Smart Wallet 2Smart Technology Consumer's Interest in Mobile Payment Products Grows - Company Secures Deal with Major Airline to Display Advertisements in Flight for its Next Generation Smart Wallet 3Smart Technology Consumer's Interest in Mobile Payment Products Grows - Company Secures Deal with Major Airline to Display Advertisements in Flight for its Next Generation Smart Wallet 4Smart Technology Consumer's Interest in Mobile Payment Products Grows - Company Secures Deal with Major Airline to Display Advertisements in Flight for its Next Generation Smart Wallet 5Smart Technology Consumer's Interest in Mobile Payment Products Grows - Company Secures Deal with Major Airline to Display Advertisements in Flight for its Next Generation Smart Wallet 6
... for overcoming sleep deprivation. Sam Ridgway from the US Navy ... half of their brains to sleep while the other half ... able to remain continually vigilant for sounds for days on ... San Diego and Tel Aviv wonder whether the dolphins, unrelenting ...
... the first time, experts have compiled a comprehensive overview ... for the treatment of several cancers. , Personalizing Cancer ... of results of therapeutic regimens across a broad range ... Journal of Nuclear Medicine is a unique reference tool ...
... 2009 As people become more educated, studies have demonstrated ... calories but higher in nutrients. They also pay more. In ... Journal of the American Dietetic Association , researchers from ... costs of a sample of 164 adults in the Seattle, ...
Cached Biology News:Dolphins maintain round-the-clock visual vigilance 2Publication sets guidelines across cancer therapies: Ensuring the best in patient management 2People of higher socioeconomic status choose better diets -- but pay more per calorie 2
(Date:7/31/2014)... Boston’s Adult Stem Cell Technology Center, LLC ... stem cell biotechnologies. Currently the company holds seven ... patent applications currently under examination by the U.S. Patent ... of the most vexing problems in adult stem cell ... are difficult to identify; and they have been difficult ...
(Date:7/30/2014)... 2014 Regulus Therapeutics Inc . (NASDAQ: ... discovery and development of innovative medicines targeting microRNAs, today ... for the quarter ended June 30, 2014 on Wednesday, ... Regulus will host a conference call ... pm Eastern Daylight Time to discuss its second quarter ...
(Date:7/30/2014)... 30, 2014 W. R. Grace ... of the REVELERIS® Prep purification system , ... chromatographers, and other researchers to perform both flash ... unit. , With the REVELERIS® Prep purification system, ... chromatography modes with a simple touch of the ...
(Date:7/30/2014)... 30, 2014 A study presented at ... and efficacy of CSL Behring,s C1 Inhibitor (C1-INH) ... in highly sensitized patients. C1-INH is a human ... system. The study shows that post-transplant ... the levels of complement components 3 and 4, ...
Breaking Biology Technology:The Adult Stem Cell Technology Center, LLC Launches A Marketing Campaign To License Adult Stem Cell Biotechnologies 2The Adult Stem Cell Technology Center, LLC Launches A Marketing Campaign To License Adult Stem Cell Biotechnologies 3Regulus Announces Timing for Second Quarter 2014 Financial Results Webcast and Conference Call 2Regulus Announces Timing for Second Quarter 2014 Financial Results Webcast and Conference Call 3Grace Launches New REVELERIS® Prep Purification System 2Study Suggests C1-INH May Aid in Prevention of Antibody-Mediated Rejection Following Kidney Transplant 2Study Suggests C1-INH May Aid in Prevention of Antibody-Mediated Rejection Following Kidney Transplant 3
... 3 BioMarin,Pharmaceutical Inc. (Nasdaq and SWX: BMRN) ... a program to develop an IgA protease for,treating ... cleave IgA,complexes, the deposition of which causes IgA ... BioMarin has executed a research,and option agreement with ...
... Vicus Therapeutics, LLC, an,oncology-focused, clinical-stage biopharmaceutical company, ... present at the BMO Capital,Markets Focus on Healthcare ... 2007 at 1:30 p.m. ET at the Millennium ... Therapeutics, Vicus Therapeutics is a privately-held, biopharmaceutical ...
... Dec. 3 Signalife, Inc.,(Amex: SGN ) ... Congress on,Cardiac Pacing and Electrophysiology to be held ... Dr. Muricio Arruda, who has been testing,Signalife,s wireless ... the Cleveland Clinic Heart Center, will,present a prototoype ...
Cached Biology Technology:BioMarin and IGAN Biosciences to Collaborate on Development of an Enzyme Therapy to Treat IgA Nephropathy, a Rare and Life-Threatening Kidney Disease 2BioMarin and IGAN Biosciences to Collaborate on Development of an Enzyme Therapy to Treat IgA Nephropathy, a Rare and Life-Threatening Kidney Disease 3BioMarin and IGAN Biosciences to Collaborate on Development of an Enzyme Therapy to Treat IgA Nephropathy, a Rare and Life-Threatening Kidney Disease 4Signalife Presence at XIII World Congress on Cardiac Pacing and Electrophysiology 2Signalife Presence at XIII World Congress on Cardiac Pacing and Electrophysiology 3
The Wellwash 4 Mk 2 microplate washer combines flexibility, simplicity and ease of use. This reliable microplate washer meets the exacting standards of today's ELISA assay requirements....
... MLF1 Interacting Protein/PBIP1 (phospho T78) ( ... Antigen: Synthetic ... 73-83 of Human MLF1 Interacting Protein ... 359815 Swiss ...
... Nuclease is a genetically engineered endonuclease. This ... and RNA while having no proteolytic activity. ... of conditions and possesses an exceptionally high ... acids from recombinant proteins, its use enables ...
... save space and organize gloves, safety ... They are the perfect benchtop storage ... labs, processing and manufacturing. Clear static-dissipative ... particles they attract. Many other sizes ...
Biology Products: