Navigation Links
Protein could offer target to reduce lung damage from smoking-caused emphysema
Date:5/16/2011

An international research team has identified a lung protein that appears to play a key role in smoking-related emphysema and have crafted an antibody to block its activity, Indiana University scientists reported.

The research, conducted in mice, suggests that the protein, a cytokine named EMAPII, could provide a target for drugs to treat emphysema, said Irina Petrache, M.D., associate professor of medicine at the Indiana University School of Medicine. The research was posted online May 16 for the June edition of The Journal of Clinical Investigation.

Emphysema, a form of chronic obstructive pulmonary disease (COPD) that affects nearly 5 million people in the U.S alone, is caused by the destruction of cells that transfer oxygen from the lungs to the blood, along with inflammation in the lungs. Cigarette smoking is the most common cause of emphysema.

The cytokine EMAPII a type of cell-signaling molecule is normally part of the process of early lung development. Research had previously found that EMAPII could cause the death of cells that line blood vessels endothelial cells and inflammation, but it had not been identified as the molecular culprit at work when cigarette smoking inflicted its damage on the lungs.

"The fact that we could have a single target affecting two major processes made us excited about looking for it in response to smoking," said Dr. Petrache, the Floyd and Reba Smith Investigator in Respiratory Disease at IU.

When the researchers induced emphysema in mice exposed to cigarette smoke, tests showed the mice had elevated levels of the EMAPII cytokine. In other tests, the scientists also found elevated levels of the cytokine in the lungs of patients with COPD.

The researchers also found that the cell death caused by the EMAPII resulted in the release of enzymes that cause more production of EMAPII, causing a vicious cycle of elevated cytokine levels and more cell death.


'/>"/>

Contact: Eric Schoch
eschoch@iupui.edu
317-274-7722
Indiana University School of Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. UT Southwestern researchers find protein that might be key to cutting cancer cells blood supply
2. Researchers show heparan sulfate adjusts functions of growth factor proteins
3. Weizmann Institute scientists discover: A protein that contributes to obesity
4. Illinois professor chairs committee that recommends immediate calories, protein for TBI
5. Several baffling puzzles in protein molecular structure solved with new method
6. Discovery identifies elaborate G-protein network in plants
7. Researchers combine active proteins with material derived from fruit fly
8. Researchers get a first look at the mechanics of membrane proteins
9. Polarized microscopy technique shows new details of how proteins are arranged
10. Secrets of a precision protein machine
11. Starch-controlling gene fuels more protein in soybean plants
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... - Today, FindBiometrics, the leading source of biometrics industry news, interviews ... design. "When we launched FindBiometrics 12 years ago ... , founder and CEO of FindBiometrics. "Now it,s maturing very ... key players on a very broad scale.  We are known ...
(Date:1/22/2015)... Hall E -   EyeLock Inc. , a market leader ... its EyeLock ID technology integrated in a 3D printed automobile ... Ridge National Laboratory (ORNL) at the 2015 North ... is being used to validate the driver and authorize the ...
(Date:1/22/2015)...  A man-made form of insulin delivered by nasal spray ... adults with mild cognitive impairment and Alzheimer,s disease dementia, ... Wake Forest Baptist Medical Center. The study,s ... impairment (MCI) or mild to moderate Alzheimer,s dementia (AD). ...
Breaking Biology News(10 mins):Identity Industry Leading Publication Debuts New Look As Biometrics Hit Mainstream 2EyeLock Debuts First Iris Authentication Technology Embedded in 3D Printed Automobile 2EyeLock Debuts First Iris Authentication Technology Embedded in 3D Printed Automobile 3Nasal Spray with Insulin Equivalent Shows Promise as Treatment for Adults with Mild Cognitive Impairment, Alzheimer's Dementia 2Nasal Spray with Insulin Equivalent Shows Promise as Treatment for Adults with Mild Cognitive Impairment, Alzheimer's Dementia 3
... BETHESDA, MD, USA, DECEMBER 1, 2011 The collaboration ... a more extensive and advanced facility for archiving, sharing, ... American Society for Cell Biology (ASCB) and the National ... University of California, San Diego (UCSD), have joined forces ...
... COLUMBIA, Mo. When a muscle is damaged, ... to "wake up" and contribute to repairing the muscle. ... satellite cells could help with the repair, and are ... tissue. This knowledge could ultimately help doctors more effectively ...
... A Michigan State University researcher is using a ... a portable wastewater treatment system that could improve ... is being spearheaded by Wei Liao, an MSU ... will generate energy and produce drinking water, thus ...
Cached Biology News:2 top biological imaging centers offer powerful free online tool to researchers and public 2Adult stem cells use special pathways to repair damaged muscle, MU researchers find 2Wastewater system generates energy, produces drinking water 2
(Date:1/22/2015)... Rootstown, OH (PRWEB) January 22, 2015 Crystal ... announced today that it has received AOAC-PTM Certifications for the ... O111, O121, and O145; collectively referred to as STEC or ... at 1 colony forming unit (cfu) per 325 g of ...
(Date:1/22/2015)... Dr. Greg Leyer of UAS Labs recently ... Supplements Pre-Conference seminar on probiotics in San Diego, CA. ... education conference for health care professionals. This year’s pre-conference seminar ... probiotics in health. Dr. Leyer spoke about the emerging topics ...
(Date:1/22/2015)... Diagenode, Inc., a leading global provider ... complete solutions for epigenetics research, recently launched a ... need for manual processing. The new ChIPettor System ... histones or transcription factors and a semi-automated pipette ...
(Date:1/22/2015)... Calif. , Jan. 22. 2015  Varian Medical Systems (NYSE: ... software, has been honored for its commitment to sustainability with ... companies. Varian is the highest ranked healthcare equipment company among ... today during the World Economic Forum at Davos, ...
Breaking Biology Technology:Crystal Diagnostics Awarded AOAC-PTM Accreditation for the Rapid Detection of “Big 6” E.coli Food Pathogens 2Diagenode Launches Unique Semi-Automated Solution for Chromatin Immunoprecipitation 2Varian Honored Among World's 100 Most Sustainable Corporations 2
... Scale Study Results Presented in Prostate, Lung and Brain Tumor ... ... (Nasdaq: ARAY ), a global leader in the field of radiosurgery,today ... was held January 23-27, 2008 in,Scottsdale, Ariz., At this year,s CyberKnife ...
... Keck Graduate Institute,(KGI) today announced that James Greenwood, ... will discuss "The American,Health Care System & the ... the 7th Annual Simon Ramo Distinguished Lecture Series ... "We are thoroughly delighted that Jim Greenwood will ...
... CITY, Feb. 12 /PRNewswire-FirstCall/ - AEterna Zentaris Inc.,(NASDAQ: ... company focused on,endocrine therapy and oncology, today reported ... agonist linked to doxorubicin,has commenced in its Phase ... had begun in December 2007. This open-label,non-comparative multi-center ...
Cached Biology Technology:CyberKnife Users' Meeting Highlights Major Clinical Data Milestones and Emerging Trends 2CyberKnife Users' Meeting Highlights Major Clinical Data Milestones and Emerging Trends 3CyberKnife Users' Meeting Highlights Major Clinical Data Milestones and Emerging Trends 4KGI Announces BIO President Greenwood to Address Health Care Reform and the Presidential Race at Simon Ramo Lecture 2KGI Announces BIO President Greenwood to Address Health Care Reform and the Presidential Race at Simon Ramo Lecture 3AEterna Zentaris Reports First Patients Treated with Anti-Cancer Compound AEZS-108 in Phase 2 Trial in Ovarian and Endometrial Cancers 2AEterna Zentaris Reports First Patients Treated with Anti-Cancer Compound AEZS-108 in Phase 2 Trial in Ovarian and Endometrial Cancers 3AEterna Zentaris Reports First Patients Treated with Anti-Cancer Compound AEZS-108 in Phase 2 Trial in Ovarian and Endometrial Cancers 4
Experion StdSens chips are the microfluidic chips used to perform standard-sensitivity RNA analysis (nanogram levels) with the Experion automated electrophoresis system. Each chip has the capacity to...
... The Experion system, 100-120 and 220-240 V, ... the steps of gel-based electrophoresis, including some ... configuration is used for protein analysis (it ... for RNA analysis). The system includes the ...
... are preactivated with carbonyl diimidazole chemistry that ... The PS10 array contains the same binding ... with an updated hydrophobic barrier coating. These ... mm diameter spots spatially compatible with one ...
... Second Mitochondria Derived Activator of ... 20 mM HEPES, pH 7.5 AVOID FREEZE/THAW CYCLES. ... Smac/DIABLO with a carboxy terminal His•Tag ® ... E. coli . Smac/DIABLO is released along with ...
Biology Products: