Navigation Links
Protein controls blood vessel formation, offers new drug target
Date:12/4/2007

CHAPEL HILL After an injury, the body grows new blood vessels to repair damaged tissue. But sometimes too much growth causes problems, as when new blood vessels in the eyes leak, causing diabetic retinopathy and blindness if not treated.

A protein called CIB1 discovered by researchers at the University of North Carolina at Chapel Hill School of Medicine appears to play a major role in controlling new blood vessel growth, offering a target for drug treatments to help the body repair itself after injury and control unwanted blood vessel growth.

In the future, this knowledge may help our ability to control blood vessel growth in disease situations such as wound healing, retinal diseases and diabetes, said Leslie Parise, Ph.D., senior study author and professor and chair of biochemistry and biophysics in the UNC School of Medicine.

The results will appear in an upcoming print issue of the journal Circulation Research and were published online Nov. 1, 2007. The research was funded by the National Institutes of Health.

Parises lab first discovered the protein, called CIB1 in 1997. It was originally found in blood platelets. CIB1 keeps blood platelets from sticking together, acting as a natural anti-coagulant to prevent clots that might lead to heart attacks or strokes. But further research showed CIB1 appears in almost every cell type in the body, Parise said. For example, male mice bred without both copies of the CIB1 gene are infertile.

In the current study, Parise and her colleagues found CIB1 in the endothelial cells that line all blood vessels. These cells jump-start new blood vessel growth via a process called angiogenesis. During angiogenesis, biological signals prompt endothelial cells to release enzymes and other chemicals that allow them to move away from existing blood vessels and form new ones.

While angiogenesis plays a critical role in embryo growth, CIB1 appears to only affect blood vessel gr
'/>"/>

Contact: Les Lang
llang@med.unc.edu
919-843-9687
University of North Carolina at Chapel Hill
Source:Eurekalert

Page: 1 2

Related biology news :

1. Protein chatter linked to cancer activation
2. Scientists link fragile X tremor/ataxia syndrome to binding protein in RNA
3. Researchers identify proteins involved in new neurodegenerative syndrome
4. Low levels of key protein may indicate pancreatic cancer risk
5. Structure of 450 million year old protein reveals evolutions steps
6. Scientists retrace evolution with first atomic structure of an ancient protein
7. Specific brain protein required for nerve cell connections to form and function
8. NIH awards researcher $1.5 million new innovator grant for fruit-fly studies of prion proteins
9. Interacting protein theory awaits test from new neutron analysis tools
10. Depression, aging, and proteins made by a virus may all play role in heart disease
11. Census of protein architectures offers new view of history of life
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/18/2015)... June 18, 2015 NXT-ID, Inc. (NASDAQ: NXTD ... on the growing mobile commerce market announces that its Wocket® ... on "Money on the Mark", scheduled to air on WABC ... June 20 th . The broadcast air- ... 7:00 to 8:00pm EST. NXT-ID, Inc.,s CEO Gino Pereira ...
(Date:6/17/2015)... JOSE, Calif. , June 17, 2015 /PRNewswire/ ... in human interface solutions, today announced that Xiaomi, ... adopted the Synaptics ® ClearPad ® ... of display driver integrated circuits (DDICs) for its ... Pro. By leveraging ClearPad for full in-cell display ...
(Date:6/16/2015)... NEW YORK , June 16, 2015  With ... the world, security remains a top concern. The recent ... confirms the need for strong authentication within government ... HYPR Token, a biometric one-time password (OTP) authenticator, has ... Processing Standards (FIPS) 140-2 Level 3 validation for tamper ...
Breaking Biology News(10 mins):NXT-ID, Inc.'s CEO Gino Pereira Talks About the Wocket Smart Wallet on WABC Radio, New York City, June 20th 2NXT-ID, Inc.'s CEO Gino Pereira Talks About the Wocket Smart Wallet on WABC Radio, New York City, June 20th 3Synaptics Touchscreen and Display Driver IC Solutions Power Xiaomi's Latest Flagship Smartphones 2Synaptics Touchscreen and Display Driver IC Solutions Power Xiaomi's Latest Flagship Smartphones 3Government Ready Biometric Security Approaching as HYPR Corp. Files FIPS 140-2 Level 3 Validation for Its Proprietary Biometric Token 2Government Ready Biometric Security Approaching as HYPR Corp. Files FIPS 140-2 Level 3 Validation for Its Proprietary Biometric Token 3
... , SANTA ANA, Calif. and ... Microsystems, Inc., d.b.a. Identive Group (Nasdaq: INVE ; Frankfurt ... for the security, identification and RFID industries, today announced that ... three new executives in line with the announced reorganization of ...
... 2010 The Translational Genomics Research Institute (TGen) today ... agreement with the Van Andel Research Institute (VARI) that ... TGen expects the agreement to create a ... and treatments for patient benefit. ...
... Medicine believe they may have discovered how the hormone ... findings will be presented at the Annual Scientific Meeting ... by Errol Norwitz, M.D., professor in the Department of ... Preterm birthdelivery prior to 37 weeks gestationhas become increasingly ...
Cached Biology News:Identive Group Expands Executive Management Team 2Identive Group Expands Executive Management Team 3TGen finalizes alliance with Van Andel Research Institute 2TGen finalizes alliance with Van Andel Research Institute 3
(Date:6/26/2015)... Research and Markets( ... "Global Cancer Biosimilars Market Opportunity Outlook" ... of cancer biosimilar is required because they have ... have dominated the cancer segment for several decade ... past few years. They are biologic in origin ...
(Date:6/26/2015)... The report "Biolubricants Market by ... fluids, Chainsaw oils, Mold Release Agents), End Use (Industrial, ... trends and Forecasts to 2020" published by MarketsandMarkets, The ... 2020 at a CAGR of 6.27% between 2015 and ... and   66 Figures spread through 170 Pages and ...
(Date:6/25/2015)... YORK , June 25, 2015 Last June, ... project to track the virus using large-scale genome sequencing. Their ... published June 18 in the journal Cell ... traveled and mutated over seven months of the recent Ebola ... the working draft, data, workflows, and full edit history ...
(Date:6/25/2015)... June 25, 2015 Current asthma medications, ... cells or by dilating the airways, can stop ... Hospital, Brigham and Women,s Hospital and Harvard Medical ... asthma: targeting certain sensory nerve endings in the ... Reporting online in the journal Neuron ...
Breaking Biology Technology:Global Cancer Biosimilars Market Opportunity Outlook 2Global Cancer Biosimilars Market Opportunity Outlook 3Biolubricants Market Worth $2,972.13 Million by 2020 2Biolubricants Market Worth $2,972.13 Million by 2020 3Open Science Takes Major Leap Forward 2Targeting Nerve Endings To Curb Allergic Asthma 2Targeting Nerve Endings To Curb Allergic Asthma 3Targeting Nerve Endings To Curb Allergic Asthma 4Targeting Nerve Endings To Curb Allergic Asthma 5
... TNGN ), a leader in regenerative medicine, today ... on Wednesday, October 27, 2010 in New York, New York. ... product development portfolio and upcoming corporate milestones, and will expand ... The live webcast of the event will be available ...
... Calif., Oct. 12 With more than 200 ... Workshop, Microsoft Research showcases two technologies that facilitate ... a MODISAzure-based environmental service. (Logo: ... Programmers and developers in bioscience now ...
... The Ontario Institute for Cancer Research (OICR) today announced ... Inc., an Ontario company that is developing a software ... detailed disease and treatment data without compromising individual privacy. ... Assessment Tool (PARAT), is currently being used by hospitals ...
Cached Biology Technology:Tengion Announces Webcast of Analyst and Investor Meeting on October 27, 2010 2Microsoft Research Makes Microsoft Biology Foundation and MODISAzure-Based Environmental Service Available to Scientists and Researchers 2Microsoft Research Makes Microsoft Biology Foundation and MODISAzure-Based Environmental Service Available to Scientists and Researchers 3Microsoft Research Makes Microsoft Biology Foundation and MODISAzure-Based Environmental Service Available to Scientists and Researchers 4OICR Makes Equity Investment in Medical Information Company 2
...
... Antigen peptide transporter ... TAP2) (Peptide transporter PSF2) ... (PSF-2) (Peptide transporter involved ... [Source:Uniprot/SWISSPROT;Acc:Q03519] ...
... Recognizes Nabeta2. The epitope specific ... in any other known proteins.,SPECIES ... to work on human because ... conserved (17/19 residues). Reactivity with ...
This monoclonal antibody recognizes the light chain of human Factor XII and at 100 nM inhibits 50% of Factor XII activity. It may be used in ELISA to detect human Factor XII and in coagulation assay...
Biology Products: