Navigation Links
Protein controls blood vessel formation, offers new drug target
Date:12/4/2007

CHAPEL HILL After an injury, the body grows new blood vessels to repair damaged tissue. But sometimes too much growth causes problems, as when new blood vessels in the eyes leak, causing diabetic retinopathy and blindness if not treated.

A protein called CIB1 discovered by researchers at the University of North Carolina at Chapel Hill School of Medicine appears to play a major role in controlling new blood vessel growth, offering a target for drug treatments to help the body repair itself after injury and control unwanted blood vessel growth.

In the future, this knowledge may help our ability to control blood vessel growth in disease situations such as wound healing, retinal diseases and diabetes, said Leslie Parise, Ph.D., senior study author and professor and chair of biochemistry and biophysics in the UNC School of Medicine.

The results will appear in an upcoming print issue of the journal Circulation Research and were published online Nov. 1, 2007. The research was funded by the National Institutes of Health.

Parises lab first discovered the protein, called CIB1 in 1997. It was originally found in blood platelets. CIB1 keeps blood platelets from sticking together, acting as a natural anti-coagulant to prevent clots that might lead to heart attacks or strokes. But further research showed CIB1 appears in almost every cell type in the body, Parise said. For example, male mice bred without both copies of the CIB1 gene are infertile.

In the current study, Parise and her colleagues found CIB1 in the endothelial cells that line all blood vessels. These cells jump-start new blood vessel growth via a process called angiogenesis. During angiogenesis, biological signals prompt endothelial cells to release enzymes and other chemicals that allow them to move away from existing blood vessels and form new ones.

While angiogenesis plays a critical role in embryo growth, CIB1 appears to only affect blood vessel gr
'/>"/>

Contact: Les Lang
llang@med.unc.edu
919-843-9687
University of North Carolina at Chapel Hill
Source:Eurekalert

Page: 1 2

Related biology news :

1. Protein chatter linked to cancer activation
2. Scientists link fragile X tremor/ataxia syndrome to binding protein in RNA
3. Researchers identify proteins involved in new neurodegenerative syndrome
4. Low levels of key protein may indicate pancreatic cancer risk
5. Structure of 450 million year old protein reveals evolutions steps
6. Scientists retrace evolution with first atomic structure of an ancient protein
7. Specific brain protein required for nerve cell connections to form and function
8. NIH awards researcher $1.5 million new innovator grant for fruit-fly studies of prion proteins
9. Interacting protein theory awaits test from new neutron analysis tools
10. Depression, aging, and proteins made by a virus may all play role in heart disease
11. Census of protein architectures offers new view of history of life
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/15/2014)... are many viral diseases in the world for which ... fever, which is spread by mosquitoes in the tropics, ... more familiar in Finland and is easily spread by ... children and the elderly. , Researchers at Aalto University ... in preliminary tests to prevent the spread of one ...
(Date:4/15/2014)... parasites of cuttlefish, squid and octopus has uncovered ... shown how they may help in investigating populations ... has described 10 new parasite species− dicyemid mesozoans ... (cuttlefish, squid and octopus). They are the ... Australian waters. , "Although dicyemid parasites have ...
(Date:4/15/2014)... 15, 2014) New research published in the ... American College of Nutrition shows whey protein, either ... part of a weight-loss or weight-maintenance diet, may provide ... , The meta-analysis included 14 randomized controlled trials with ... those weight loss studies that used whey protein to ...
Breaking Biology News(10 mins):Nanocrystalline cellulose modified into an efficient viral inhibitor 2Bizarre parasite may provide cuttlefish clues 2New meta-analysis builds on the power of whey protein for improved body composition 2New meta-analysis builds on the power of whey protein for improved body composition 3
... pave the way for individually tailored therapiesContinuing its ... responses to medications, the National Institutes of Health ... years to renew its Pharmacogenetics Research Network (PGRN). ... will eventually help doctors tailor drug prescriptions to ...
... Research carried out with the participation of the ... molecule helps an important pathogen, Brucella abortus, escape ... agents (macrophages). This research has been published in ... model of an intracellular parasite, a category that ...
... Institution of Oceanography at the University of California, San ... Venezia Nuova and Thetis SPA, has launched a multifaceted ... effects of sediment translocation in Venice lagoon, a vital ... The new effort, a two-year, $1.5 million project for ...
Cached Biology News:NIH renews network focused on how genes influence drug responses 2NIH renews network focused on how genes influence drug responses 3NIH renews network focused on how genes influence drug responses 4New Scripps Oceanography project to study sediments and ecosystem restoration in Venice lagoon 2New Scripps Oceanography project to study sediments and ecosystem restoration in Venice lagoon 3
(Date:1/15/2014)... January 15, 2014 This webinar ... on nonclinical and clinical safety assessment in biosimilars. ... guide a path for biosimilar drug development, however ... of biosimilarity with regards to quality, safety and ... of biosimilar drug development and registration, development strategies ...
(Date:1/15/2014)... NC (PRWEB) January 15, 2014 ... an enhancement to its Online Web Portal for Life ... now have the ability to specify the subject matter ... nearly 50 life science sub-domains. This will help reduce ... and scientific fields, and decrease the likelihood of error. ...
(Date:1/14/2014)... Doylestown, PA (PRWEB) January 14, 2014 ... – 11 p.m. , Location: Warrington Country Club, 1360 ... Hepatitis B Foundation, the only national nonprofit organization solely ... improving the quality of life for those affected worldwide, ... 11 at Warrington Country Club in Warrington, Pa. ...
(Date:1/14/2014)... York, NY (PRWEB) January 14, 2014 ... initiated coverage of Alliqua, Inc. (OTCQB: ALQA). Alliqua ... and marketing proprietary products to serve the wound ... , In late 2012, Alliqua was restructured ... launched the company’s new strategy to become a ...
Breaking Biology Technology:Xtalks Life Sciences Webinar Examines Safety Assessment of Biosimilars 2DTS Improves Efficiency for Life Science Document Translations 2Hepatitis B Foundation to Host Annual Crystal Ball Gala 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3
... The American ... 22nd in San Antonio, Texas, USA. AFS is holding its 23rd Annual Conference, March 22-25, ... courses held on March 22nd. Five of these courses are on the topics of air ... ...
... , , , WASHINGTON ... director of the National Institutes of Health and recipient of the ... a February 26 Speaker Luncheon.  Topic of his talk ... The luncheon was originally scheduled for December, but postponed because of ...
... first time the European research initiative EUREKA will be ... which forms part of HANNOVER MESSE 2010 (19-23 April). ... Market for Research and Development in Hall 2. ... makes as a central European platform with respect to ...
Cached Biology Technology:Air Filtration and Gas/Solid Separation Training by the American Filtration and Separations Society 2Air Filtration and Gas/Solid Separation Training by the American Filtration and Separations Society 3Air Filtration and Gas/Solid Separation Training by the American Filtration and Separations Society 4NIH Director Francis Collins to Speak at National Press Club February 26 on 'A New Era of Quantum Leaps in Biomedical Research' 2NIH Director Francis Collins to Speak at National Press Club February 26 on 'A New Era of Quantum Leaps in Biomedical Research' 3European research initiative EUREKA presented at Research & Technology for the first time 2
... The ApopTag Red In Situ Apoptosis ... by the indirect TUNEL method, utilizing ... fluorochrome. The kit provides indirect immunofluorescence ... analyzed using either fluorescence microscopy or ...
The sample holders for gels are used to hold gels in place in the multi-sample tray I, which is used with Molecular Imager FX imaging systems....
... gel cell is a stand-alone apparatus that ... applications. The upper buffer chamber can accommodate ... long for isoelectric focusing (IEF) applications. The ... cooling core, lower buffer chamber, lid with ...
... The ApopTag Fluorescein In Situ ... in situ by the indirect TUNEL ... is conjugated to a Fluorescein reporter ... for 40 samples. Results are analyzed ...
Biology Products: