Navigation Links
Protein 'chatter' linked to cancer activation
Date:8/13/2007

Hamilton, ON. August 13, 2007 Scientists have found the existence of cross-talk between human chromosome ends and the protein complexes central to the stability of the entire human genome, a chat that contributes to cancer development.

The research, published today in Nature Structural & Molecular Biology, sheds new light on the pathology of three related but non-curable cancer-predisposed human disorders: ataxia telangiectasia, ataxia telangiectasia-like disorder, and Nijmegen breakage syndrome.

The proteins whose deficiency is responsible for these three human disorders have the job of ensuring that chromosome ends are maintained and protected, says Xu-Dong Zhu, assistant professor of biology and the lead author on the study. As we age, our chromosome ends become shorter. Individuals whose ends deteriorate faster are at a higher risk of developing cancer because short chromosome ends are a serious threat to the stability of our genome. When the genome becomes unstable, it puts our bodies at greater risk of cancer.

Zhu adds that patients with ataxia telangiectasia, ataxia telangiectasia-like disorder, and Nijmegen breakage syndrome experience an accelerated rate of loss of DNA from chromosome ends. We didnt know why this happens; now we have found that the communication link between these proteins and a protein crucial for maintenance of chromosome ends is either missing or nonfunctional in these patients.

Zhu further explains that lack of this cross talk in normal cells promotes short chromosome ends and as a result promotes cancer formation. A key difference between cancer cells and normal cells is that the former maintain their chromosome ends and have the unlimited potential to grow. Disruption of this communication in cancer cells induces shortening of chromosome ends and may restrict their potential to grow.

Zhu says that the discovery will help researchers understand the onset and progression of thes
'/>"/>

Contact: Jane Christmas
chrisja@mcmaster.ca
905-525-9140 x27988
McMaster University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Quantum Dots Research Leads to New Knowledge about Protein Binding in Plants
2. Protein discovery could unlock the secret to better TB treatment
3. New, automated tool successfully classifies and relates proteins in unprecedented way
4. New binding target for oncogenic viral protein
5. Controversial drug shown to act on brain protein to cut alcohol use
6. Timing is everything: First step in protein building revealed
7. UWs Rosetta software to unlock secrets of many human proteins
8. Researchers find how protein allows insects to detect and respond to pheromones
9. Researchers Uncover Key Step In Manufacture of Memory Protein
10. Signaling protein builds bigger, better bones in mice
11. Ancient olfaction protein is shared by many bugs, offering new pest control target
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2015)... 17, 2015 Increasing ... technological advancement to drive biometric systems market in ...   According to a recently released ... &  Opportunities, 2020 ", biometric systems market in ... growth at CAGR of over 22% through 2020. ...
(Date:4/13/2015)... , April 13, 2015 ... TechSci Research, "Global Biometrics Market Forecast & Opportunities, 2020", ... a CAGR of around 14% till 2020. The ... for large scale implementation and review of biometric ... launch of new products with greater efficiency, are ...
(Date:4/9/2015)... JOSE, Calif. , April 9, 2015 ... human interface solutions, announced today that it will report ... on Thursday, April 23, 2015, after the close of ... for analysts and investors at 2:00 p.m. PT (5:00 ...   To participate on the live call, ...
Breaking Biology News(10 mins):Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 2Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 3Global Biometrics Market to Cross US$ 21 Billion by 2020: TechSci Research 2Synaptics to Report Third Quarter Results on April 23 2
... the Panama Canal currently underway has created a rare opportunity ... sensitive Central American rain forest habitats. Dr. Amy Berkov, ... (CCNY), is leading a research effort that could shed new ... "If you want to study biodiversity and conservation, you need ...
... grasslands and the spread of forests may have been the ... woolly mammoth, woolly rhino and cave lion, according to Durham ... the theory that human beings were the primary cause of ... increased pressure on habitats. The research is part of ...
... Alzheimer,s disease destroys brain cells and their connections ... that disrupt work, hobbies and daily life. Symptoms can ... in the United States as Namenda), which is currently ... part, developed by Stuart A. Lipton, M.D., Ph.D., Director ...
Cached Biology News:CCNY biologists study rainforest host-plant associations 2CCNY biologists study rainforest host-plant associations 3Dwindling green pastures, not hunting, may have killed off the mammoth 2Dwindling green pastures, not hunting, may have killed off the mammoth 3Study explains why Alzheimer's drug is both safe and effective 2
(Date:5/1/2015)... -- Investor-Edge has initiated coverage on ... GENE ), Agilent Technologies Inc. (NYSE: A ... ), Sequenom Inc. (NASDAQ: SQNM ), and ... report on Genetic Technologies can be accessed at ... the NASDAQ Composite ended at 4,941.42, down 1.64%, ...
(Date:4/30/2015)... May 01, 2015 Spirax Sarco, the ... extremely proud to announce that for the first time ... a winner of a Queen’s Award for Innovation – ... design and manufacture of a unique flowmeter. , The ... alternative to traditional steam flow measurement. The device ...
(Date:4/30/2015)... , April 30, 2015 /PRNewswire/ - BioAmber Inc. ... sustainable chemicals, today announced that it has commenced an underwritten ... expects to grant the underwriters a 30-day option to ... shares of common stock offered in the public offering. ... can be no assurance as to whether or when ...
(Date:4/30/2015)... Hungary (PRWEB) April 30, 2015 ... lab notebook with integrated protocols and specimen management ... software solutions and consulting services for life science ... development of Labguru’s newest feature: chemical structure and ... domain features for biologists, bio-chemists, and more, the ...
Breaking Biology Technology:Life Sciences Tools and Services Stocks on our Radar -- Genetic Technologies, Agilent Technologies, Thermo Fisher Scientific, Sequenom, and PerkinElmer 2Life Sciences Tools and Services Stocks on our Radar -- Genetic Technologies, Agilent Technologies, Thermo Fisher Scientific, Sequenom, and PerkinElmer 3Life Sciences Tools and Services Stocks on our Radar -- Genetic Technologies, Agilent Technologies, Thermo Fisher Scientific, Sequenom, and PerkinElmer 4Life Sciences Tools and Services Stocks on our Radar -- Genetic Technologies, Agilent Technologies, Thermo Fisher Scientific, Sequenom, and PerkinElmer 5Spirax Sarco Receives a Queen’s Award for Innovation 2Spirax Sarco Receives a Queen’s Award for Innovation 3BioAmber Inc. Announces Public Offering Of Common Stock 2BioAmber Inc. Announces Public Offering Of Common Stock 3Labguru Integrates ChemAxon's Marvin JS, to Enhance Functionality for Chemists 2
... is financing a materials science project being conducted jointly ... with the Jlich Research Center. The support is to ... will total 550,000. The project managers, Professor Dr. Angelika ... Physical Chemistry at Johannes Gutenberg University Mainz (JGU), were ...
... Elsevier,s Computers & Graphics announces the upcoming publication ... incorporate the Collage Authoring Environment, a workflow and publication platform ... Paper Grand Challenge. The call for submissions for the special ... the 3DOR Workshop. Collage Authoring Environment allows authors ...
... The Houston Technology Center (HTC), Texas, ... gala, "A Celebration of Entrepreneurs . "  The ... impact on the region,s economy; and developed lifesaving and ... Beth Williams, CEO of TechTrans International, Inc., as this ...
Cached Biology Technology:En route to a quantum computer 2Leading Technology Incubator Honors Extraordinary Entrepreneurs 2Leading Technology Incubator Honors Extraordinary Entrepreneurs 3
Buckets for tube holder inserts...
...
... Block MBS Start up kit. Includes configured ... choice of 2 MultiBlock satellite thermal ... blocks. User friendly software. Store/track ... height heated lid. Outstanding uniformity. ...
Glycerokinase; from Bacillus stearothermophilus...
Biology Products: