Navigation Links
Protein can help cells or cause cancer, Purdue researcher finds
Date:7/7/2009

WEST LAFAYETTE, Ind. - A Purdue University scientist has discovered a key process in cell growth that can lead to the formation of tumors.

Xiaoqi Liu, an assistant professor of biochemistry, found that an overabundance of the polo-like kinase 1, or Plk1, molecule during cell growth, as well as a shortage of the p53 molecule, will lead to tumor formation. Studies in Liu's laboratory showed that the Plk1 molecule indirectly attacks p53 in a process called ubiquitination.

"This provides the mechanism for how p53 loses its function in cancer cells," said Liu, whose work was published in the early online publication of the Journal of Biological Chemistry. "If we understand how the cancer forms, then we can create a more useful therapeutic approach to treating that cancer."

During cell growth, Plk1 uses its protein kinase activity called phosphorylation, which consists of adding a phosphate group to a protein called Topors. Topors binds itself to p53 molecules during the ubiquitination process. Phosphorylation is basically an instruction from Plk1 to increase its ubiquitination activity, which kills p53 molecules.

Liu said p53 could be thought of as a protective force. When Topors kills off that force, Plk1 becomes stronger, allowing the cells to become cancerous.

"We're trying to understand how p53 is regulated. We want to keep p53 as normal as possible," Liu said. "In about 50 percent of cancers, p53 had lost its function, and there was too much Plk1. Since Plk1 is overexpressed in cancers, it is a cancer therapy target."

Topors can also carry out a function called sumoylation, in which Topors binds to p53 molecules and creates more p53. Liu was able to force cells in his lab to go through the ubiquitination or sumoylation process to show how p53 molecules were affected.

Liu said it is unknown why the Plk1 molecule chooses to initiate ubiquitination over sumoylation.

Researchers from Sic
'/>"/>

Contact: Brian Wallheimer
bwallhei@purdue.edu
765-496-2050
Purdue University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Plant protein doorkeepers block invading microbes, study finds
2. Structural biology scores with protein snapshot
3. Proteins in gel
4. Targeting helpers of heat shock proteins could help treat cancer, cardiovascular disease
5. Researchers observe single protein dimers wavering between two symmetrically opposed structures
6. Cancer-causing protein can also help fight the tumors it causes
7. TRAPping proteins that work together inside living cells
8. Protein regulates movement of mitochondria in brain cells
9. Protein linked to change in tissue that surround and support breast tumors
10. Dual role in breast tissue for a protein involved in leukemia
11. Protein that triggers plant cell division revealed by researchers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/17/2014)... from the University of Copenhagen have shown for the ... lungs of Cystic fibrosis patients, giving them the opportunity ... in chronic infections. , The study also discovered the ... (CF) patients was halted or slowed down by the ... all the oxygen and helped "suffocate" the bacteria, forcing ...
(Date:10/16/2014)... Oregon and Washington land managers have a new synthesis ... eastside moist mixed-conifer (MMC) forests in the two states. ... Forests in Eastern Oregon and Washington: A Synthesis of ... Management, a general technical report published by the U.S. ... response to a request from managers for a synthesis ...
(Date:10/16/2014)... 2014) – Post-menopausal women experienced improvements in vaginal ... or genital bleeding, after 12 weeks of daily ... soy germ-based nutritional supplement previously shown to help ... peer-reviewed pilot study reported in a poster at ... meeting. , "These data documented improved vaginal ...
Breaking Biology News(10 mins):Scientists opens black box on bacterial growth in cystic fibrosis lung infection 2New report synthesizes best available science on management of moist mixed-conifer forests 2S-equol supplements associated with improved measures of reproductive health in postmenopausal women 2
... the Department of Agriculture and Food Western Australia (DAFWA) ... Australia,s worst agricultural weeds. , "We are initiating a ... to control one and two-leaf Cape tulips (Moraea flaccida ... as a biological control agent," CSIRO Entomology,s Dr John ...
... on the miracle of life. The joining of egg and ... if the chromosome information from each parent has been translated ... is that when extra copies of chromosomes or fewer than ... birth defects can occur. Now, scientists at the University of ...
... may study grasses by profession, but Texas AgriLife Research forage agronomist Dr. Dariusz Malinowski ... And it is that ... Malinowski ... with his master,s degree in horticulture. , ...
Cached Biology News:Cape tulips -- pretty but pests in pastures 2UGA researchers propose model for disorders caused by improper transmission of chromosomes 2UGA researchers propose model for disorders caused by improper transmission of chromosomes 3Unique winter-hardy hibiscus has roots with AgriLife Research scientist in Vernon 2Unique winter-hardy hibiscus has roots with AgriLife Research scientist in Vernon 3
(Date:10/22/2014)... and BOSTON , Oct. ... ), a leading global specialty pharmaceutical company, and Rhythm, ... granted an exclusive option to acquire Rhythm,s wholly owned ... a peptide ghrelin agonist, for the treatment of diabetic ... Rhythm has completed a successful Phase 2 trial of ...
(Date:10/22/2014)... 22, 2014 Involution Studios , ... of a new infographic, Understanding Ebola . ... beautifully designed, easy to follow informative tool for anyone ... outbreak, symptoms and prevention. , "As the news has ... 2014 Ebola outbreak represents not only a healthcare crisis ...
(Date:10/22/2014)... Rock Hill, SC (PRWEB) October 22, 2014 ... the expansion of its cardiovascular pharmacogenetics menu, which ... improved patient outcomes. With PCLS’s evidence-based results, ... individual needs and optimize their therapy, while minimizing ... , In the U.S., according to the FDA ...
(Date:10/22/2014)... NEW YORK , Oct. 22, 2014 ... Diabetes Federation, approximately 400 million people worldwide are living ... 552 million people by 2030.  The global market for ... In 2012 approximately 330,000 people worldwide died from pancreatic ... of death due to cancer in the ...
Breaking Biology Technology:Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 2Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 3Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 4Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 5Involution Studios' Ebola Infographic Provides Key Disease Information and Statistics at a Glance 2PCLS Announces Expansion of Cardiovascular Pharmacogenetic Testing Menu 2PCLS Announces Expansion of Cardiovascular Pharmacogenetic Testing Menu 3Nuvilex Brief Analyst Report: Thinking Outside the Box by BrokerBank Securities, Inc. 2
... 2011 Interleukin Genetics, Inc. (OTCQB: ILIU) announced ... Wedbush Securities Life Sciences Management Access Conference at the Le ... City. The presentation is scheduled for Wednesday, Aug. 17 at ... second floor.   Interleukin,s management team will be ...
... Mass., Aug. 10, 2011 Boston Scientific Corporation (NYSE: ... Institute™ (NLI), a clinical education program and online resource ... awareness of spinal cord stimulation (SCS) technology, procedures and ... meeting of the International Spine Intervention Society (ISIS) occurring ...
... DIEGO, Aug. 9, 2011 Verenium Corporation (Nasdaq: ... development and commercialization of high-performance enzymes, today reported a summary ... quarter and six months ended June 30, 2011. ... terms of product revenues and partnership negotiations in the first ...
Cached Biology Technology:Interleukin Genetics, Inc. to Present at the 2011 Wedbush Securities Life Sciences Management Access Conference 2Boston Scientific Launches Neuromodulation Learning Institute To Enhance Clinical Education For Spinal Cord Stimulation 2Boston Scientific Launches Neuromodulation Learning Institute To Enhance Clinical Education For Spinal Cord Stimulation 3Boston Scientific Launches Neuromodulation Learning Institute To Enhance Clinical Education For Spinal Cord Stimulation 4Verenium Reports Financial Results for the Second Quarter and Six Months Ended June 30, 2011 2Verenium Reports Financial Results for the Second Quarter and Six Months Ended June 30, 2011 3Verenium Reports Financial Results for the Second Quarter and Six Months Ended June 30, 2011 4Verenium Reports Financial Results for the Second Quarter and Six Months Ended June 30, 2011 5Verenium Reports Financial Results for the Second Quarter and Six Months Ended June 30, 2011 6Verenium Reports Financial Results for the Second Quarter and Six Months Ended June 30, 2011 7Verenium Reports Financial Results for the Second Quarter and Six Months Ended June 30, 2011 8Verenium Reports Financial Results for the Second Quarter and Six Months Ended June 30, 2011 9
... preparations are prepared from customers high-copy ... to multi-gram scales. Each preparation is ... glycerol stocks are maintained to facilitate ... (Clonal selection includes screening colonies for ...
... channels for automated gigaseal patch clamping. ... voltage-gated ion channels, such as hERG and ... The four pipette heads afford more efficient ... drug discovery. The glass-coated tunnels of ...
... be able to handle larger sample volumes, automate ... as interface with telemetry systems. The AccuSampler ... dogs, pigs, and primates. The system may ... the computer can be located outside the animal ...
... The GST•Tag™ Antibody Plate is ... GST•Tag Monoclonal Antibody. This antibody (mouse ... S. japonicum glutathione-S-transferase (GST), ... virtually any GST•Tag fusion protein in ...
Biology Products: