Navigation Links
Protein anchors help keep embryonic development 'just right'
Date:6/12/2014

The "Goldilocks effect" in fruit fly embryos may be more intricate than previously thought. It's been known that specific proteins, called histones, must exist within a certain rangeif there are too few, a fruit fly's DNA is damaged; if there are too many, the cell dies. Now research out of the University of Rochester shows that different types of histone proteins also need to exist in specific proportions. The work further shows that cellular storage facilities keep over-produced histones in reserve until they are needed.

Associate Professor of Biology Michael Welte has discovered that the histone balance is regulated by those storage facilities, called lipid dropletswhich are best known as fat depots.

The findings were published today in the journal Current Biology.

Welte had previously discovered that another proteincalled Jabbaanchored histones onto lipid droplets. In his latest research, he found that excess histones migrate outside the nucleus to the droplets, where they are temporarily held until needed to create new chromosomes.

"People have observed histone proteins on lipid droplets in multiple organisms, including mammals," said Welte. "The results of this research project may very well help us understand the role of histones and lipid droplets in humans."

Welte found that by deleting the Jabba anchors from the cell, one particular type of histone increased in proportion in the nucleus, since they had no way to be held in reserve away from the cell nuclei. That made the embryo more sensitive to environmental stresses like higher temperature, leading to defects during cell division and reduced viability.

Just as it is in humans, the embryonic stage is a crucial time for the fruit fly (Drosophila melanogaster). Starting from a single cell, it has to rapidly multiply in cell number and develop into a larva while coping with stresses from the environment. The embryo does all of t
'/>"/>

Contact: Peter Iglinski
peter.iglinski@rochester.edu
585-273-4726
University of Rochester
Source:Eurekalert  

Page: 1 2

Related biology news :

1. IU biologists offer clearer picture of how protein machine systems tweak gene expression
2. Making memories: How 1 protein does it
3. Embryonic development protein active in cancer growth
4. More effective method of imaging proteins
5. The loss of a protein makes jump the tumor to the lymph node
6. Gold nanoantennas detect proteins
7. The Japanese traditional therapy, honokiol, blocks key protein in inflammatory brain damage
8. New hope for treating Alzheimers Disease: A role for the FKBP52 protein
9. Protein jailbreak helps breast cancer cells live
10. Plant research reveals new role for gene silencing protein
11. Newly found protein helps cells build tissues
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Protein anchors help keep embryonic development 'just right'
(Date:8/28/2014)... FASEB MARC (Maximizing Access to Research Careers) ... the American College of Sports Medicine,s Conference on ... in Miami, Florida. These awards are meant ... and scientists from underrepresented groups into the mainstream ... the participation of young scientists at the American ...
(Date:8/28/2014)... . Cars, planes ... of sophisticated assembly lines. Mobile assembly carriers, on to which ... assembly lines. In the case of a car body, the ... a precise spatial and chronological sequence, resulting in a complete ... of such an assembly line at molecular level has been ...
(Date:8/28/2014)... assigned a number of 435-million-year-old fossils to a ... in shallow marine habitats and were far less ... , Before they sank to the bottom ... some 435 million years ago, these arthropods preyed ... although they were not exactly inconspicuous, possessing a ...
Breaking Biology News(10 mins):Nanoscale assembly line 2Nanoscale assembly line 3Paleontology: Oldest representative of a weird arthropod group 2
... at levels consumed by breast cancer patients and survivors in ... rats, new research found., The role of folate, a ... development and progression of breast cancer is highly controversial. ... breast cancer, recent studies have suggested that taking high amounts ...
... When the temperature rises on Baffin Island, in the ... ice for thousands of years, are exposed. Using radiocarbon ... has calculated the age of relic moss samples that ... moss samples would have been destroyed by erosion had ...
... the Montreal Neurological Institute and Hospital in Canada ... Parkinson,s disease are involved in the early-stage quality ... reported in T he EMBO Journal , removes ... mitochondria., "PINK1 and parkin, are implicated in selectively ...
Cached Biology News:Large amounts of folic acid shown to promote growth of breast cancer in rats 2Quality control of mitochondria as a defense against disease 2
(Date:8/28/2014)... “This kit has an improved extraction efficiency and provides users ... said Mark Tess, PhD, Mycotoxin Product Manager for Charm Sciences. ... USDA-GIPSA inspection agencies that have a need to detect aflatoxin ... a matter of minutes with nothing but our equipment and ... grain before accepting it, but they no longer have to ...
(Date:8/28/2014)... , Aug. 28, 2014  Next month, executives from clinical ... key industry events beginning with Patient-Centered Clinical Trials 2014 ... Boston , September 4-5. Patient recruitment experts ... Aaron Fleishman will share insights on the benefits ... variety of tactics – from media to mobile apps – ...
(Date:8/28/2014)... 2014 Scientists, researchers, and technologists will ... Laser Damage 2014 symposium. Marking its 46th year, ... will run 14-17 September. The event is sponsored by ... . , The premier conference for basic and applied ... optical materials will engage researchers and engineers from numerous ...
(Date:8/28/2014)... New York, NY (PRWEB) August 28, 2014 ... has renewed its long term partnership with PTI ... to provide clients with state of the art leak ... state of the art instruments currently available. As part ... a new High Voltage Leak Detection Instrument ...
Breaking Biology Technology:BBK Worldwide Leads Sessions at Key September Events 2Laser Damage to Draw Researchers, Engineers, Scientists to 46th Annual Conference 2Laser Damage to Draw Researchers, Engineers, Scientists to 46th Annual Conference 3Whitehouse Labs Renews Partnership with PTI Inspection Systems 2Whitehouse Labs Renews Partnership with PTI Inspection Systems 3
... Inc. (OTC Bulletin Board: GNLK, www.genelinkbio.com ) today ... private label distribution partnership serving the healthcare and wellness ... gives GeneLink reach into new areas of the rapidly ... available to us.  The HelixLife team is very experienced ...
... From the U.S. Food and Drug Administration Duchenne... -- AMSTERDAM, September 24, 2010 ... ... --> ... s = ,; var first_result; // Results are keyed by longUrl, so we need to grab the ...
... GeneLink, Inc. (OTC Bulletin Board: ... pleased to report that the Superior Court of Pennsylvania ... the Company,s former CEO and President, John DePhillipo, and ... subsidiary GeneWize Life Sciences, Inc., and several of the ...
Cached Biology Technology:GeneLink Announces HelixLife Private Label Distribution Agreement 2AMT Receives Orphan Drug Designation From the U.S. Food and Drug Administration Duchenne Muscular Dystrophy Gene Therapy 2AMT Receives Orphan Drug Designation From the U.S. Food and Drug Administration Duchenne Muscular Dystrophy Gene Therapy 3AMT Receives Orphan Drug Designation From the U.S. Food and Drug Administration Duchenne Muscular Dystrophy Gene Therapy 4AMT Receives Orphan Drug Designation From the U.S. Food and Drug Administration Duchenne Muscular Dystrophy Gene Therapy 5AMT Receives Orphan Drug Designation From the U.S. Food and Drug Administration Duchenne Muscular Dystrophy Gene Therapy 6AMT Receives Orphan Drug Designation From the U.S. Food and Drug Administration Duchenne Muscular Dystrophy Gene Therapy 7AMT Receives Orphan Drug Designation From the U.S. Food and Drug Administration Duchenne Muscular Dystrophy Gene Therapy 8
... Model 1575 immunowash microplate washer 100-240 V, ... have flat-, U-, or V-bottom wells. The ... and vertical needle positions to an accuracy ... aspiration, and overflow washing. It can store ...
... MULTI-FUN Incubator is a compact benchtop ... a microprocessor controller with a large ... and agitation speed. Air circulation inside ... incubator. Temperature can be easily calibrated ...
... is a compact benchtop and stackable ... controller with a large display screen ... speed. Air circulation inside to evenly ... can be easily calibrated from the ...
... siRNA --- a cocktail of 3 siRNAs ... interestis our most popular product. The siTrio ... knockdown of your target gene when used ... transfection and confirmation of optimal transfection with ...
Biology Products: