Navigation Links
Protein anchors help keep embryonic development 'just right'
Date:6/12/2014

The "Goldilocks effect" in fruit fly embryos may be more intricate than previously thought. It's been known that specific proteins, called histones, must exist within a certain rangeif there are too few, a fruit fly's DNA is damaged; if there are too many, the cell dies. Now research out of the University of Rochester shows that different types of histone proteins also need to exist in specific proportions. The work further shows that cellular storage facilities keep over-produced histones in reserve until they are needed.

Associate Professor of Biology Michael Welte has discovered that the histone balance is regulated by those storage facilities, called lipid dropletswhich are best known as fat depots.

The findings were published today in the journal Current Biology.

Welte had previously discovered that another proteincalled Jabbaanchored histones onto lipid droplets. In his latest research, he found that excess histones migrate outside the nucleus to the droplets, where they are temporarily held until needed to create new chromosomes.

"People have observed histone proteins on lipid droplets in multiple organisms, including mammals," said Welte. "The results of this research project may very well help us understand the role of histones and lipid droplets in humans."

Welte found that by deleting the Jabba anchors from the cell, one particular type of histone increased in proportion in the nucleus, since they had no way to be held in reserve away from the cell nuclei. That made the embryo more sensitive to environmental stresses like higher temperature, leading to defects during cell division and reduced viability.

Just as it is in humans, the embryonic stage is a crucial time for the fruit fly (Drosophila melanogaster). Starting from a single cell, it has to rapidly multiply in cell number and develop into a larva while coping with stresses from the environment. The embryo does all of that by activating a myriad of genetic on-off switches, a process that involves unwrapping and rewrapping various regions of DNA.

Histones are important to the process because they act as spools that DNA molecules wrap around to form chromosomes, making it possible for the DNA to do its work in the first place. Welte discovered that if the different histones are not in the correct proportion, the embryo has trouble developing correctly and may even die.

Achieving the correct proportion of histones is not something that happens automatically in the fruit fly embryo, as Welte found in his research. Instead, when a certain histone type is made in excess, it is redirected to the lipid-droplet holding sites outside the nucleus where it is kept until needed.

Welte and his team will try next to identify which parts of the Jabba protein actually bind with the histone. Once that's determined, scientists may have the ability to manipulate the histone storage process.

"Since histones and lipid droplets are found in humans, I very much expect that there will be a similar storage process," said Welte. "If that is the case, our findings could one day help treat or prevent diseases linked to chromosome malfunction. What I find most fascinating is that our research uncovered this intimate link between cellular fat depots and the nucleus, a connection that just a few years ago nobody would have dreamt of. "


'/>"/>

Contact: Peter Iglinski
peter.iglinski@rochester.edu
585-273-4726
University of Rochester
Source:Eurekalert  

Related biology news :

1. IU biologists offer clearer picture of how protein machine systems tweak gene expression
2. Making memories: How 1 protein does it
3. Embryonic development protein active in cancer growth
4. More effective method of imaging proteins
5. The loss of a protein makes jump the tumor to the lymph node
6. Gold nanoantennas detect proteins
7. The Japanese traditional therapy, honokiol, blocks key protein in inflammatory brain damage
8. New hope for treating Alzheimers Disease: A role for the FKBP52 protein
9. Protein jailbreak helps breast cancer cells live
10. Plant research reveals new role for gene silencing protein
11. Newly found protein helps cells build tissues
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Protein anchors help keep embryonic development 'just right'
(Date:3/1/2017)...  Aware, Inc. (NASDAQ: AWRE), a leading supplier of ... Moberg has resigned, effective March 3, 2017, as ... and Treasurer of Aware citing a desire to retire.  ... of the Board of Directors of Aware. ... and co-President, General Counsel has been named Chief Executive ...
(Date:2/26/2017)... -- Securus Technologies, a leading provider of civil and ... corrections and monitoring, announces the appointment of a ... often, too many offenders return to jail or ... to tackle this ongoing problem and improve the ... significant steps are underway, Securus continues to invest ...
(Date:2/16/2017)... , Feb. 16, 2017  Genos, a ... announced that it has received Laboratory Accreditation from ... Accreditation is presented to laboratories that meet stringent ... demonstrate scientifically rigorous processes. "Genos is ... in laboratory practices. We,re honored to be receiving ...
Breaking Biology News(10 mins):
(Date:3/29/2017)... 29, 2017 Research and Markets has ... and Global Markets" report to their offering. ... The study ... sequencing, biochips, RNA interference, synthetic biology tools and genome editing ... These technologies and products are analyzed to determine ...
(Date:3/28/2017)... ... 2017 , ... NetDimensions announced today that Scandinavian Health Limited ... management for consistent implementation of standards and regulatory requirements across SHL companies worldwide. ... improve and streamline their training and employee development programs, which are critical to ...
(Date:3/28/2017)... ... March 28, 2017 , ... Benchworks announced that ... Philadelphia. The event was offered by the Chamber of Commerce for Greater Philadelphia ... groups and interaction with speakers who are leaders in their industries. Topics included ...
(Date:3/28/2017)... March 28, 2017 Summary This ... Enzo Biochem and its partnering interests and activities since 2010. ... provides an in-depth insight into the partnering activity of one ... demand company reports are prepared upon purchase to ensure inclusion ... The report will be delivered in PDF format ...
Breaking Biology Technology: