Navigation Links
Protein adaptation shows that life on early earth lived in a hot, acidic environment
Date:4/4/2011

applied a constant force to the protein, causing it to rapidly unfold and expose its disulfide bonds to the thioredoxin enzymes. The rate at which a thioredoxin enzyme snipped the disulfide bonds determined the enzyme's level of efficiency.

The study results showed that the three oldest thioredoxin enzymes -- those thought to have inhabited Earth 4.2 to 3.5 billion years ago -- were able to operate in lower pH environments than the modern thioredoxin enzymes.

"Our analysis indicates that ancient thioredoxin enzymes were well adapted to function under acidic conditions and that they maintained their high level of activity as they evolved in more alkaline environments," said Fernndez.

To measure the temperature range in which the enzymes operated, professor Jose Sanchez-Ruiz and graduate student Alvaro Ingls-Prieto from the Departamento de Qumica-Fsica at the Universidad de Granada in Spain used a technique called differential scanning calorimetry. This method measures the stability of enzymes by heating the enzymes at a constant rate and measuring the heat change associated with their unfolding.

The researchers found that the ancient proteins were stable at temperatures up to 32 degrees Celsius higher than the modern thioredoxins. The experiments showed that the enzymes exhibited higher temperature stability the older they were. The results provide evidence that ancestral thioredoxins adapted to the cooling trend of ancient oceans, as inferred from geological records.

"Our results confirm that life has the remarkable ability to adapt to a wide range of historical environmental conditions; and by extension, life will undoubtedly adapt to future environmental changes, albeit at some cost to many species," said Gaucher.

This study also showed that the experimental resurrection of ancient proteins together with the sensitivity of single-molecule techniques can be a powerful tool for understanding the origin and evolu
'/>"/>

Contact: Abby Robinson
abby@innovate.gatech.edu
404-385-3364
Georgia Institute of Technology Research News
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Researchers identify new role for cilia protein in mitosis
2. Common chaperone protein found to work in surprising way, say Scripps Research scientists
3. Intelligent design: Engineered protein fragment blocks the AIDS virus from entering cells
4. HIV protein unveils vaccine target
5. Molecular muscle: Small parts of a big protein play key roles in building tissues
6. Mutant prions help cells foil harmful protein misfolding
7. Scripps Research team discovers new details about medically important protein family
8. Novel method could improve the performance of proteins used therapeutically
9. Synthetic biology: TUM researchers develop novel kind of fluorescent protein
10. UCLA engineers demonstrate use of proteins as raw material for biofuels, biorefining
11. Rockefeller Scientists discover new compound that rids cells of Alzheimer protein debris
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Protein adaptation shows that life on early earth lived in a hot, acidic environment
(Date:9/30/2014)... professor and Howard Hughes Medical Institute investigator, and ... recipients in the 2014 round of grants from ... BRAIN (Brain Research through Advancing Innovative Neurotechnologies) Initiative ... September 30, provides more than $3 million in ... , The BRAIN Initiative, launched last year, is ...
(Date:9/30/2014)... German . FRANKFURT. ... in the world. Because they grow underground, people use trained ... of truffles is not only of interest to gourmets. A ... the Goethe University Frankfurt have discovered that the smell of ... trapped inside truffle fruiting bodies. , White truffles from the ...
(Date:9/30/2014)... hope: A new research report published in October 2014 ... explains how scientists developed a synthetic version of a ... in human and mouse eggs similar to the natural ... fertilization. , "We believe that the results of this ... of human fertilization by providing a precise answer to ...
Breaking Biology News(10 mins):Salk scientists receive $3 million for BRAIN Initiative grant 2On the trail of the truffle flavor 2Synthetic sperm protein raises the chance for successful in vitro fertilization 2
... used topically in many skin creams and cosmetics because ... Now, new research just published in the Journal of ... and how it might actually benefit skin from the ... cocoa may actually help improve the appearance of women's ...
... is the only culprit in the steady increase in the ... challenged by a scientist speaking at the 22nd annual conference ... Prague, Czech Republic, Wednesday 21 June 2006. Professor ... that his research had shown that improved nutrition, both maternal ...
... (LANP) have unveiled the "nanoegg," the latest addition ... of the versatile nanoshell, nanoeggs are asymmetric specks ... harnessed for molecular imaging, medical diagnostics, chemical sensing ... July 18 issue of the Proceedings of the ...
Cached Biology News:New study reveals components of cocoa may enhance the appearance of the skin 2Nutrition a major factor in rise in twin pregnancies 2Nutrition a major factor in rise in twin pregnancies 3Rice scientists unveil 'nanoegg' 2
(Date:9/30/2014)... Nematicide is a type of chemical ... parasitic roundworms, found in massive quantities virtually everywhere—in ... animals. Nematicides have tended to be broad-spectrum toxicants ... through the soil. A single gram of soil ... more than 10,000 species classified, they are one ...
(Date:9/30/2014)... 30, 2014 Follow us on ... each type of cholesterol carrier or lipoprotein in the ... excessive cholesterol levels in the body, especially along the ... heart attack and other cardiovascular disorders. Cardiovascular Diseases (CVD) ... for cholesterol levels on a regular basis, to assess ...
(Date:9/30/2014)... Fast, semi-automatic creation of ... documents ChemAxon , a leader ... for life science research, launches ChemCurator, an application ... from documents. Markush structures are essential ... and understanding Markush structures is a difficult and ...
(Date:9/30/2014)... Sept. 30, 2014  KemPharm, Inc., a clinical-stage ... development of proprietary new molecular entity (NME) prodrugs, ... Trademark Office (USPTO) issued U.S. Patent No. 8,816,083 ... Acid, Benzoic Acid Derivatives and Heteroaryl Carboxylic Acid ... Use Thereof." The patent, which extends ...
Breaking Biology Technology:Nematicides Market by Types (Fumigants, Organophosphates, Carbamate and Bio-Nematicides), Applications (Agrochemicals, Industrial, and Others), and Geography (North America, Europe, Asia-Pacific & ROW) - Global Trends & Forecasts to 2019 2Surging Diabetic, Obese and Hypertensive Population Drives the Global Cholesterol Testing Market, According to New Report by Global Industry Analysts, Inc. 2Surging Diabetic, Obese and Hypertensive Population Drives the Global Cholesterol Testing Market, According to New Report by Global Industry Analysts, Inc. 3Surging Diabetic, Obese and Hypertensive Population Drives the Global Cholesterol Testing Market, According to New Report by Global Industry Analysts, Inc. 4ChemAxon Introduces ChemCurator for Chemical Information Extraction and Markush Structure Creation 2KemPharm, Inc. Receives Patent from the USPTO for Novel Prodrug of Hydromorphone, KP511 2
... CLINTON, N.J. and JERUSALEM, July 6 Ikaria Holdings, ... Ikaria has entered into an agreement to obtain a ... treatment for preventing pathological cardiac remodeling following acute myocardial ... phase I/II clinical trial, is administered via the coronary ...
... /PRNewswire-FirstCall/ - avVaa World Health Care Products Inc. (Pink ... of nationally branded therapeutic, natural skin and health care ... an agreement with 3PL Worldwide, Inc., for all Order ... CEO explains that "3PL Worldwide offers true multichannel support ...
... July 6 /PRNewswire-FirstCall/ -- Verenium Corporation (Nasdaq: ... the $29.5 million of outstanding 8% Senior Convertible Notes due ... July 1, 2009 is effective as of 8:00 a.m. today. ... with holders of 87% of the Notes, which is above ...
Cached Biology Technology:IKARIA(R) to In-License BioLineRx's BL-1040 2IKARIA(R) to In-License BioLineRx's BL-1040 3avVaa World Health Care Products, Inc. Signs Agreement with 3PL Worldwide, Inc., for Order Management & Fulfillment for avVaa's Product 2Verenium Completes Amendment to 8% Senior Convertible Notes 2Verenium Completes Amendment to 8% Senior Convertible Notes 3Verenium Completes Amendment to 8% Senior Convertible Notes 4