Navigation Links
Protein abundant in cancerous cells causes DNA 'supercoiling'
Date:3/11/2013

s its way along the inner tube wall. Inside of the tube is a wide spiral path that has a strong positive electrical charge.

"Such a striking feature is unusual," said Chen. Who is also a member of the USC Norris Cancer Center. "When you see that, you know it must have a special function." Indeed, it turns out that the positively charged spiral path attracts and binds to the DNA strand, which has a negatively charged phosphate backbone.

Holding the DNA tightly to the spiral path inside the helical filament tube causes the DNA double-helix to change structure, creating supercoils. Future research by the team will explore how the DNA topology changes caused by MCM impacts cancer cell formation as well as its utility in cancer therapy.


'/>"/>
Contact: Robert Perkins
perkinsr@usc.edu
213-740-9226
University of Southern California
Source:Eurekalert

Page: 1 2

Related biology news :

1. Selectively manipulating protein modifications
2. Specialised germanium surface as universal protein adapter
3. A cancer-promoting protein is found to also suppress cell growth
4. Age-related dementia may begin with neurons inability to dispose of unwanted proteins
5. Stressed proteins can cause blood clots for hours
6. Adding to the list of disease-causing proteins in brain disorders
7. Analytical trick accelerates protein studies
8. Antibacterial proteins molecular workings revealed
9. Nano-machines for bionic proteins
10. Bridges experimental and bioinformatics perspectives to delineate protein-DNA interactions
11. Discovering cell surface proteins behavior
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2014)... the September issue of The FASEB Journal ... to diagnose the leading cause of blindness in ... occurred. This advance involves quantifying the early molecular ... retinal vessels. Using new probes developed by scientists, ... development of diabetic retinopathy. , "My goal is ...
(Date:9/2/2014)... Washington D.C., September 2, 2014 A study ... Journal of the American Academy of Child ... adolescents diagnosed with a psychiatric diagnosis had an ... exposed to antipsychotics. , Using data from the ... by Dr. Ren Ernst Nielsen, Psychiatry, Aalborg University ...
(Date:9/2/2014)... Konservat-Lagersttte of lithographic limestone is well known as ... from that area (for example, Archaeopteryx). Now, for ... in the French equivalent of these outcrops - ... oldest known water treader. , Despite the abundance ... fossils have been obtained from the Late Kimmeridgian ...
Breaking Biology News(10 mins):Molecular probes permit doctors to detect diabetic retinopathy before vision fails 2Risk of diabetes in children and adolescents exposed to antipsychotics 2Exceptionally well preserved insect fossils from the Rhône Valley 2
... provide the next generation of human therapeutic drugs. , ... by Queensland University of Technology PhD researcher Liam St ... and major trauma. , The genetic code for the ... researcher Liam St Pierre from QUT's School of Life ...
... of the brain when small stones are scattered on the ... researchers at UC Davis. The brains of those young fish ... and the fish also showed behavior closer to wild than ... hatchery and the wild fish," said graduate student Rebecca Kihslinger, ...
... the bilateral body axes in animals as diverse as flies ... in patterning an animal with a different body plan--a simple ... jellyfish, are members of the phylum Cnidaria, and they possess ... bilateral body plan exhibited by vertebrates and many other animals. ...
Cached Biology News:Taipan venom no snake oil 2How to grow a bigger brain 2Anemone genes reveal versatile building blocks for body plans 2
(Date:9/2/2014)... EUGENE, Ore. -- Scientists, including University of Oregon ... to create scaffolds of self-assembling, synthetic proteins called ... processes. , The accomplishment -- detailed this week ... by the Proceedings of the National Academy ... an alternative design of the two-dimensional peptoid nanosheets ...
(Date:9/2/2014)... (PRWEB) September 02, 2014 Myriant ... the signage of a distribution agreement with Azelis ... now distributing Myriant’s bio-succinic acid in the Nordics, ... Ireland, targeting customers in the industrial and base ... powerhouse, Azelis offers a far-reaching chemical portfolio with ...
(Date:9/2/2014)... ROCKVILLE, Md. , Sept. 2, 2014 /PRNewswire/ ... of novel anti-infective biologic and drug candidates targeting ... announced today positive results from its final preclinical ... Drug Administration (FDA) guidance, this bridging study was ... product candidate designed to prevent the devastating effects ...
(Date:9/2/2014)... The inventors of tinAway, a novel treatment ... seeking support for development costs through a crowdfunding campaign. ... ), was launched on September 1, 2014. , tinAway ... is based on ten years of neuroscience research. ... software engineers, Dr. Ian Dixon and Mr. Tony Burgess, ...
Breaking Biology Technology:UO-Berkeley Lab unveil new nano-sized synthetic scaffolding technique 2Myriant and Azelis Sign European Distribution Agreement for Bio-Succinic Acid 2Synthetic Biologics to Initiate Clinical Trials of SYN-004 in 4Q 2014 to Prevent Potentially Deadly C. difficile Infections 2Synthetic Biologics to Initiate Clinical Trials of SYN-004 in 4Q 2014 to Prevent Potentially Deadly C. difficile Infections 3Synthetic Biologics to Initiate Clinical Trials of SYN-004 in 4Q 2014 to Prevent Potentially Deadly C. difficile Infections 4Synthetic Biologics to Initiate Clinical Trials of SYN-004 in 4Q 2014 to Prevent Potentially Deadly C. difficile Infections 5tinAway Pty. Ltd. launch a crowdfunding campaign to fund a clinical trial of tinAway, a new potential cure for chronic tinnitus 2tinAway Pty. Ltd. launch a crowdfunding campaign to fund a clinical trial of tinAway, a new potential cure for chronic tinnitus 3tinAway Pty. Ltd. launch a crowdfunding campaign to fund a clinical trial of tinAway, a new potential cure for chronic tinnitus 4tinAway Pty. Ltd. launch a crowdfunding campaign to fund a clinical trial of tinAway, a new potential cure for chronic tinnitus 5
... 29 NOMAD Bioscience GmbH,Munich, Germany ... developing,plant-made biomaterials and biopharmaceuticals that address ... series of high-value products such as,nanopatterned ... and,enzymes for important markets including biofuels, ...
... Cooperation with Kentucky Bioprocessing for future-oriented technology, ... 29 Bayer,Innovation GmbH and Kentucky Bioprocessing, ... at KBP,s Owensboro plant in the US ... biopharmaceuticals. Based on Bayer,s proprietary,magnICON(R) technology, plant ...
... Sept. 29 Covance Inc. (NYSE:,CVD) announced today ... joint venture,with WuXi Pharmatech to provide preclinical contract ... become an attractive region for outsourced drug,development services ... pursue our original strategy to build our own ...
Cached Biology Technology:Nomad Bioscience: New Plant Biotechnology Company Founded to Focus on Biomaterials and Biopharmaceuticals 2Bayer Broadens Its Manufacturing Basis for Biopharmaceuticals in Tobacco Plants 2Bayer Broadens Its Manufacturing Basis for Biopharmaceuticals in Tobacco Plants 3Bayer Broadens Its Manufacturing Basis for Biopharmaceuticals in Tobacco Plants 4Covance Decides to Pursue Its Original Preclinical Strategy in China 2
... The Fujifilm Life Science FLA-8000 Fluorescent Image ... in a single laser imaging system. This ... samples labeled with fluorescent dyes or radioisotopes ... most demanding laboratories. Speed, image quality and ...
...
...
... PC, is used to perform runs ... from the Experion automated electrophoresis system. ... and simulated gel views and summarizes ... a Results table. This software is ...
Biology Products: