Navigation Links
Protecting genes, one molecule at a time
Date:9/9/2012

An international team of scientists have shown at an unprecedented level of detail how cells prioritise the repair of genes containing potentially dangerous damage. The research, published in the journal Nature and involving academics from the University of Bristol, the Institut Jacques-Monod in France and Rockefeller University in the US, studied the action of individual molecules in order to understand how cellular repair pathways are triggered.

The genetic information that forms the "instruction booklet" for cells is encoded in the molecular building blocks of DNA, and can be damaged by mutagens such as ultraviolet light or tobacco smoke, as well as by normal "wear and tear" as the cells age. If left unrepaired, such damage can kill the cells or cause them to change their behaviour and perhaps cause disease.

Cells protect themselves by producing proteins that detect the damaged building blocks, cut them out and replace them with a patch of new DNA. Most cells, including bacteria and humans, contain mechanisms that ensure that the genes that are currently in use are repaired most quickly.

The team, led by Dr Terence Strick of the Institut Jacques Monod, Paris, used single molecules of DNA stretched in a magnetic field to watch individual proteins work on an active, damaged gene. They found that more steps are needed to repair the damage than previously thought, and that the length of time that the proteins reading the gene hesitate when they reach the damage is likely to be critical for a successful handover to the proteins that repair the gene.

Dr Nigel Savery from the University's School of Biochemistry, who led the Bristol-based part of the project, said: "Finding out how different parts of the genome are repaired at different rates is critical to understanding processes as diverse as generation of antibiotic resistance in bacteria and the patterns of mutations that give rise to cancer. Studying these processe
'/>"/>

Contact: Caroline Clancy
caroline.clancy@bristol.ac.uk
44-011-792-88086
University of Bristol
Source:Eurekalert

Page: 1 2

Related biology news :

1. Wild bees: Champions for food security and protecting our biodiversity
2. Protecting your brain: Use it or lose it
3. Penn biologists identify a key enzyme involved in protecting nerves from degeneration
4. Protecting living fossil trees
5. Nano-velcro clasps heavy metal molecules in its grips
6. University of Alberta medical scientists first in the world to look at structure of vital molecule
7. Scripps Florida scientists design molecule that reverses some fragile X syndrome defects
8. Weighing molecules 1 at a time
9. New model gives hands-on help for learning the secrets of molecules
10. Potential drug molecule shows enhanced anti-HIV activity
11. Iowa State, Ames Lab researchers invent new tool to study single biological molecules
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/27/2015)... SAN JOSE, Calif. , July 27, 2015 ... leading developer of human interface solutions, today announced ... ClearPad ® touchscreen solution for its stylish ... controller for its proven reliability, low power and ... with a wet finger. Huawei designers also required ...
(Date:7/23/2015)... July 23, 2015 Aware, Inc. (NASDAQ: AWRE ... reported financial results for its second quarter ended June 30, ... 2015 was $4.5 million, a decrease of 33% compared to ... in the second quarter of 2015 was $0.3 million, or ... $0.04 per diluted share, in the same period a year ...
(Date:7/21/2015)... Today, ZTE announced its Android smartphone Axon, featuring FPC,s touch ... 2015 that relate to sales of FPC1025 for this smartphone model ... for 2015. Jörgen Lantto, CEO of FPC, comments: " ... China and we are proud that ZTE ... Axon , its first smartphone ...
Breaking Biology News(10 mins):Synaptics Touchscreen Solution Powers New Huawei Watch 2Synaptics Touchscreen Solution Powers New Huawei Watch 3Aware, Inc. Reports Second Quarter 2015 Financial Results 2Aware, Inc. Reports Second Quarter 2015 Financial Results 3Aware, Inc. Reports Second Quarter 2015 Financial Results 4Aware, Inc. Reports Second Quarter 2015 Financial Results 5Aware, Inc. Reports Second Quarter 2015 Financial Results 6FPC's Touch Fingerprint Sensor FPC1025 in ZTE's Smartphone Axon 2
... by the University of Warwick, The Sainsbury Laboratory, and ... sequenced the genome of a plant disease causing organism ... plant pathogens". The research has uncovered the tactics used ... discovery also provides tools for researchers to identify the ...
... 30-year warming trend, the last three years in the Bering ... Alaska Fairbanks scientist says that the cold temperatures have helped ... the way Walleye pollock feed. Alexei Pinchuk, research professional ... three years gathering zooplankton samples in the Bering Sea. He ...
... make teeth stronger and aid in the treatment of osteoporosis. ... killer a carcinogen that causes bone, lung and bladder ... American communities, drinking water and an ingredient in the vast ... of fluoride, be it in water, consumer products or the ...
Cached Biology News:Plant disease 'stealth bomber' tactics subverted to tackle hundreds of plant pathogens 2Plant disease 'stealth bomber' tactics subverted to tackle hundreds of plant pathogens 3Researcher develops accurate method for detecting dangerous fluoride 2Researcher develops accurate method for detecting dangerous fluoride 3Researcher develops accurate method for detecting dangerous fluoride 4
(Date:7/31/2015)... ... 2015 , ... R-Biopharm is proud to announce the RIDASCREEN® ... foods, has been accepted by AOAC International as Official First Action method. The ... Products by R5 Competitive ELISA,” based on a specific monoclonal antibody to potentially ...
(Date:7/30/2015)... Mass. , July 30, 2015   ... solutions for the interpretation and analysis of genomic ... Matthew Fischer has joined the company as ... Photo - http://photos.prnewswire.com/prnh/20150730/250931 ... capabilities to integrate, interpret, analyze and explore complex ...
(Date:7/30/2015)... 2015 According to a new ... Modeling, PB/PK, PKPD, Trial Design, Toxicity Prediction, In-house, Contract ... Trial), by End Users - Global Forecast to 2020", ... reach USD 2,107.99 million by 2020 from USD 1,034.93 ... Browse more than 75 ...
(Date:7/30/2015)...   Senomyx , Inc. (NASDAQ: SNMX ), ... discover, develop, and commercialize novel flavor ingredients for the ... results for the second quarter 2015. ... on track to achieve our commercial and financial goals," ... the Company. "Since our last quarterly earnings report, our ...
Breaking Biology Technology:RIDASCREEN® Competitve Gliadin Receives AOAC Official First Action Status 2GenoSpace Introduces Matthew Fischer as Vice President of Sales and Marketing 2Biosimulation Market Worth 2,107.99 Million USD by 2020 2Biosimulation Market Worth 2,107.99 Million USD by 2020 3Biosimulation Market Worth 2,107.99 Million USD by 2020 4SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 2SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 3SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 4SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 5SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 6SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 7SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 8SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 9
... , MONROVIA, Calif. and HANGZHOU, China, Nov. ... or the "Company") (OTC Bulletin Board: NIUS), a leading U.S.-based ... children, today announced that the Company,s popular Gummy Bear products ... The Company has entered into a one year distribution contract ...
... CAMBRIDGE, Mass., Nov. 18 Knome, Inc., a ... announced the launch of KnomeDISCOVERY, the first fully ... for researchers. The new offering meets rapidly emerging ... that bundles affordable, research-tailored access to a broad ...
... , BOTHELL, Wash., Nov. 18 ... manufacturer, and marketer of proprietary cGMP hypothermic storage and cryopreservation ... it has been granted a Japanese patent for an application ... death caused by cold temperatures used in biopreservation. The patent ...
Cached Biology Technology:Niusule Expands Geographic Footprint in China 2Niusule Expands Geographic Footprint in China 3Knome Launches First Platform-Agnostic Human Genome Sequencing and Analysis Service for Researchers 2Knome Launches First Platform-Agnostic Human Genome Sequencing and Analysis Service for Researchers 3BioLife Solutions Granted Japanese Biopreservation Patent 2BioLife Solutions Granted Japanese Biopreservation Patent 3
PKC (pSer345), phospho-specific...
MAB3246 recognizes the neuro-endocrine specific protein (NSP) C....
Anti-ADAMTS-4, disintegrin-like domain Immunogen: Synthetic peptide - KLH conjugated Available Date: 38569...
Rat integrin a6b1, mainly associated with epithelial cells. Does not react with rat fibroblasts....
Biology Products: