Navigation Links
Protecting genes, one molecule at a time
Date:9/9/2012

An international team of scientists have shown at an unprecedented level of detail how cells prioritise the repair of genes containing potentially dangerous damage. The research, published in the journal Nature and involving academics from the University of Bristol, the Institut Jacques-Monod in France and Rockefeller University in the US, studied the action of individual molecules in order to understand how cellular repair pathways are triggered.

The genetic information that forms the "instruction booklet" for cells is encoded in the molecular building blocks of DNA, and can be damaged by mutagens such as ultraviolet light or tobacco smoke, as well as by normal "wear and tear" as the cells age. If left unrepaired, such damage can kill the cells or cause them to change their behaviour and perhaps cause disease.

Cells protect themselves by producing proteins that detect the damaged building blocks, cut them out and replace them with a patch of new DNA. Most cells, including bacteria and humans, contain mechanisms that ensure that the genes that are currently in use are repaired most quickly.

The team, led by Dr Terence Strick of the Institut Jacques Monod, Paris, used single molecules of DNA stretched in a magnetic field to watch individual proteins work on an active, damaged gene. They found that more steps are needed to repair the damage than previously thought, and that the length of time that the proteins reading the gene hesitate when they reach the damage is likely to be critical for a successful handover to the proteins that repair the gene.

Dr Nigel Savery from the University's School of Biochemistry, who led the Bristol-based part of the project, said: "Finding out how different parts of the genome are repaired at different rates is critical to understanding processes as diverse as generation of antibiotic resistance in bacteria and the patterns of mutations that give rise to cancer. Studying these processe
'/>"/>

Contact: Caroline Clancy
caroline.clancy@bristol.ac.uk
44-011-792-88086
University of Bristol
Source:Eurekalert

Page: 1 2

Related biology news :

1. Wild bees: Champions for food security and protecting our biodiversity
2. Protecting your brain: Use it or lose it
3. Penn biologists identify a key enzyme involved in protecting nerves from degeneration
4. Protecting living fossil trees
5. Nano-velcro clasps heavy metal molecules in its grips
6. University of Alberta medical scientists first in the world to look at structure of vital molecule
7. Scripps Florida scientists design molecule that reverses some fragile X syndrome defects
8. Weighing molecules 1 at a time
9. New model gives hands-on help for learning the secrets of molecules
10. Potential drug molecule shows enhanced anti-HIV activity
11. Iowa State, Ames Lab researchers invent new tool to study single biological molecules
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/2/2015)... April 2, 2015 In ... by far outperforms the strongest competitors, showing outstanding ... accuracy, the system is capable of a throughput ... proves up to be ten times faster than ... runner-up performance.      (Photo: http://photos.prnewswire.com/prnh/20150402/738673-a ...
(Date:4/2/2015)... Sweden , April 2, 2015 ... for Q1 2015 attributed to somewhat higher than 125 ... in the year-end report 2014 that revenues for Q1 ... that the company reported for Q4 2014. The operating ... to be negative. The complete interim report will as ...
(Date:4/1/2015)... -- NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or the ... mobile commerce market, announces the second shipment of a ... early access pre-order customers. Feedback from ... including Walmart, Target, AT&T, Dunkin, Donuts, Stop & Shop ... all outlets and very easy to use. Several users ...
Breaking Biology News(10 mins):DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 2DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 3Fingerprint Cards Revises Revenues for Q1 2015 2NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 2NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 3NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 4
... Council (MRC) have discovered for the first time that two ... helping to identify how the body,s own cells fight back ... open-access journal PLoS Biology , could lead to future ... cells, an entirely new concept for cancer research. The ...
... Jay Kolls, Professor and Chairman of Genetics at the LSU ... awarded a $2.1 million grant over five years by the ... of Health to determine the role and identify which T-helper ... (PCP), which can be a complication of HIV/AIDS. It can ...
... Spanish . , A new beetle that could be ... identified by Agricultural Research Service (ARS) scientists and cooperators. ... Thailand by entomologists Bob Pemberton (now retired), with the ARS ... Wright, with the ARS Australian Biological Control Laboratory (ABCL) in ...
Cached Biology News:Divide and conquer: Genes decide who wins in the body's battle against cancer 2LSUHSC awarded $2 million dollar grant to prevent pneumonia linked to immune deficiency 2Scientists identify new potential biocontrol for skunk vine 2
(Date:4/17/2015)... , April 17, 2015  US-Australian drug discovery ... a Memorandum of Understanding with the Feinstein Institute ... New York to collaborate with the ... The collaboration brings together the drug ... clinical expertise of the Feinstein Institute in neurosciences ...
(Date:4/17/2015)... (PRWEB) April 17, 2015 LC ... proteomics technologies, announced today that it is seeking ... an innovative multiplex PCR based targeted sequencing technology. ... sequence analysis, that enables accurate detection of rare ... and Omega-Primer™ technologies. The company will collaborate with ...
(Date:4/16/2015)... Spirax Sarco, the leader in ... newly designed, state-of-the-art website in the first quarter ... promotes the Spirax Sarco brand, company capabilities, and ... a site visitor might be looking for including ... serviced, the latest company news, careers, and much ...
(Date:4/16/2015)... 16, 2015 Cambridge Semantics ... driven by Semantic Web technology, and Informa ... and services for the academic and scientific, professional ... joint solution ‘Smart Data Lake for Clinical Trial ... the 2015 Bio-IT ‘Best of Show’ Award. ...
Breaking Biology Technology:Novogen and Feinstein Institute Join Forces to Find Effective Treatments for Brain Cancer 2Novogen and Feinstein Institute Join Forces to Find Effective Treatments for Brain Cancer 3Novogen and Feinstein Institute Join Forces to Find Effective Treatments for Brain Cancer 4Novogen and Feinstein Institute Join Forces to Find Effective Treatments for Brain Cancer 5Novogen and Feinstein Institute Join Forces to Find Effective Treatments for Brain Cancer 6LC Sciences Seeks Beta Testers of Targeted Sequencing Method Ahead of Q4 Launch 2LC Sciences Seeks Beta Testers of Targeted Sequencing Method Ahead of Q4 Launch 3Spirax Sarco website has a new look 2Cambridge Semantics and Informa Named Bio-IT Award Finalist for Smart Data Lake Solution for Clinical Trial and Competitive Intelligence 2Cambridge Semantics and Informa Named Bio-IT Award Finalist for Smart Data Lake Solution for Clinical Trial and Competitive Intelligence 3
... centralised genotyping diagnostic service to facilitate the identification ... commercial poultry flocks. The test will allow ... two isolates and thus provide statistically significant evidence ... any such virus from a source flock to ...
... at 4:30pm ET European Commission Decision ... Company to Provide Update on FDA review of Qutenza ... - CHMP issued positive opinion recommending approval ... pain in non-diabetic adults, either alone or in combination ...
... 25 Percent to $62.6 Million -- Conference Call Today ... 7 PDL BioPharma, Inc. (PDL) (Nasdaq: ... quarter ended March 31, 2009. Total revenues from continuing ... million, a 25 percent increase from $50.2 million for ...
Cached Biology Technology:Avian Adenovirus Genotyping Diagnostic Service 2NeurogesX Reports First Quarter 2009 Results 2NeurogesX Reports First Quarter 2009 Results 3NeurogesX Reports First Quarter 2009 Results 4NeurogesX Reports First Quarter 2009 Results 5NeurogesX Reports First Quarter 2009 Results 6NeurogesX Reports First Quarter 2009 Results 7NeurogesX Reports First Quarter 2009 Results 8NeurogesX Reports First Quarter 2009 Results 9NeurogesX Reports First Quarter 2009 Results 10NeurogesX Reports First Quarter 2009 Results 11PDL BioPharma Announces First Quarter 2009 Financial Results 2PDL BioPharma Announces First Quarter 2009 Financial Results 3PDL BioPharma Announces First Quarter 2009 Financial Results 4PDL BioPharma Announces First Quarter 2009 Financial Results 5PDL BioPharma Announces First Quarter 2009 Financial Results 6PDL BioPharma Announces First Quarter 2009 Financial Results 7PDL BioPharma Announces First Quarter 2009 Financial Results 8PDL BioPharma Announces First Quarter 2009 Financial Results 9