Almost all organisms evolve from a single cell, a fertilised egg. In the first hours after fertilisation, the fate of its future development is determined. It is dictated by the separation of cells that will become sperm and ovules - germ cells-, from the remaining cells, which will be responsible for forming the body organs and tissues -, and that comprise the somatic cell line. Scientists at the Institute for Research in Biomedicine (IRB Barcelona), headed by Jordi Casanova, research professor at CSIC, have identified the mechanism that protects somatic cells against the behaviour of germ cells. When this mechanism fails, the embryo dies. Made in the fruit fly Drosophila melanogaster, this finding could be universal. This research is published today in the advanced online edition of EMBO Reports.
In the first hours of embryonic life, the egg cells show intense gene transcription activity to initiate development, with the exception of germ cells which are totally inert and repressed. The DNA of the "sex" cells will pass from parents to offspring, and therefore it is convenient to protect it against possible mutations in a period marked by considerable activity in the milieu. The silencing is governed by a repression mechanism previously described in earlier work -, that maintains only the germ line genome inactive, but whose signalling also reaches neighbouring somatic cells. The researchers have now discovered that the cells that abut germ cells are protected by a mechanism that blocks the silencing signal emitted by the latter. Casanova explains the context of the study, "it is crucial to unveil all the actors and molecular mechanisms that participate in the repression and activation of the genomes of distinct species because failures in these mechanisms are at the bases of many diseases, such as certain types of cancer."
FROM FLY TO HUMANS
The mechanism of transcription protection in somatic cells has been dis
|Contact: Snia Armengou|
Institute for Research in Biomedicine (IRB Barcelona)