Navigation Links
Protecting cells
Date:8/24/2011

Scientists at Northwestern University report a surprising discovery that offers a possible new route for the treatment of neurodegenerative diseases. In a study of the transparent roundworm C. elegans, they found that a genetic switch in master neurons inhibits the proper functioning of protective cell stress responses, leading to the accumulation of misfolded and damaged proteins.

Neurodegenerative diseases, ranging from Huntington's and Parkinson's to amyotrophic lateral sclerosis and Alzheimer's, are believed to stem from early events that lead to an accumulation of damaged proteins in cells. Yet all animals, including humans, have an ancient and very powerful mechanism for detecting and responding to such damage, known as the heat shock response.

"Why are these diseases so widespread if our cells have ways to detect and prevent damaged proteins from accumulating?" said Richard I. Morimoto, who led the research together with postdoctoral colleague Veena Prahlad. "Can our body fix the problem? That is the conundrum."

"In our study, much to our surprise, we discovered that the nervous system sends negative signals to other tissues in the animal that inhibit the ability of cells to activate a protective heat shock response," Morimoto said. "The machinery to repair the damaged proteins is intact, but the nervous system is sending a signal that prevents it from doing its job."

When the signal from the nervous system was reduced, the cells' heat shock response returned, leading to elevated levels of special protective proteins, called molecular chaperones, that kept the damaged proteins in check.

Morimoto is the Bill and Gayle Cook Professor of Biology in the department of molecular biosciences and the Rice Institute for Biomedical Research in Northwestern's Weinberg College of Arts and Sciences.

The findings are published by the Proceedings of the National Academy of Sciences (PNAS).


'/>"/>

Contact: Megan Fellman
fellman@northwestern.edu
847-491-3115
Northwestern University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Research identifies type of vaccine that holds promise in protecting against TB
2. Protecting neurons could halt Alzheimers, Parkinsons diseases
3. NC State takes research lead in protecting Puerto Ricos unique freshwater fisheries
4. Protecting fresh-cut produce
5. Protecting the food crops of the future
6. Protecting cells from their neighbors
7. Strategy outlined for growing bioenergy while protecting wildlife
8. Protecting humans and animals from diseases in wildlife
9. Vidient SmartCatch Protecting Exit Lanes at Major UK Airport
10. Protecting the future: How plant stem cells guard against genetic damage
11. Researchers: EPA should recognize environmental impact of protecting foreign oil
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... 2014  Automation is fundamentally transforming the travel ... at international borders. Over the past decade, ePassports, ... veteran travelers to self process through border control ... at an increasing number of airports, seaports, and ... According to Maxine Most , Principal at ...
(Date:12/11/2014)... 09, 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/9ql3kr/biometrics_market ) has announced the addition ... report to their offering. ... the adoption of multimodal biometric systems. Multimodal biometric ... individual for verification and identification purposes. This helps ...
(Date:12/10/2014)... NEW YORK , Dec. 8, 2014 You,ve ... online banking account but can,t remember your password, site key ... birthday? Who was your first grade teacher? ... launches the app that will finally put an ... PINs – 1U TM . 1U leverages a ...
Breaking Biology News(10 mins):Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 3
... ground by alternately squeezing and stretching muscles along the ... of contractions. Snails and sea cucumbers also use this ... gastrointestinal tracts operate by a similar action, squeezing muscles ... Now researchers at MIT, Harvard University and Seoul ...
... of the Pediatric Infectious Diseases Society ( JPIDS ... to date of the impact on reducing the days ... prospective-audit-with-feedback antibiotic stewardship program (ASP). The study utilized ... the Child Health Corporation of America. A companion ...
... , Fresno, Calif. Consuming grapes may help protect ... new research published in the Journal of Nutrition ... risk factors for heart disease in men with metabolic ... inflammation. Natural components found in grapes, known as ...
Cached Biology News:Soft autonomous robot inches along like an earthworm 2Soft autonomous robot inches along like an earthworm 3First antibiotic stewardship probed in the Journal of the Pediatric Infectious Diseases Society 2Eating grapes may help protect heart health in men with metabolic syndrome, new study suggests 2
(Date:12/17/2014)... 2014 Xeno Diagnostics has again ... most recent COLA inspection. Xeno has met all ... healthcare accreditation organization. Accreditation is earned only by ... day-to-day operations, demonstrate continued accuracy in the performance ... laboratory survey. , While the Laboratory ...
(Date:12/17/2014)... CA (PRWEB) December 17, 2014 Audacity, ... activation agency and member of the Huntsworth Health Group, ... to its executive team. In her role, Gonzales will ... , “We are incredibly honored to welcome a talent ... Chief and CEO, Gaëtan Fraikin. “She is a proven ...
(Date:12/17/2014)... 2014  United Therapeutics Corporation (NASDAQ: UTHR ... as changes to Martine Rothblatt , Ph.D,s compensation ... United Therapeutics announced the promotion of Roger ... and David Zaccardelli , Pharm.D. to Executive Vice ... promotions, Dr. Rothblatt,s title will change from Chairman and ...
(Date:12/17/2014)... SAN FRANCISCO, Calif. , Dec. 17, 2014 ... results of a Phase 2 study evaluating the ... the treatment of patients with severe, chronic itch ... current standard of care, including topical steroids and ... was percent change in Visual Analog Scale (VAS) ...
Breaking Biology Technology:Xeno Diagnostics Receives 3rd Award for Laboratory Excellence 2Audacity Welcomes Healthcare Communications Expert Jamie Gonzales as Senior Vice President of Client Services 2United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 2United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 3United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 4Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 3Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 4
... Every year as the DEMO conference comes together , there's ... great in their own right, but for one reason or ... our invitation to launch at DEMO. , ,One such company ... summer. Founded by ex-Microsofter Soraya Bittencort, Mountain View, Calif.-based Nutrihand ...
... - University of Wisconsin assistant professor Helen Blackwell is being ... her work with bacteria and infections. , , Technology Review ... of Technology , recognized Blackwell as one of its top ... assistant professor of chemistry at UW-Madison, was honored for her ...
... each will receive $15,000 in funding for technology ... Gov. Jim Doyle announced Wednesday. , , Pointone ... Assistance Grant to hire professional grant research and ... company, in Wauwatosa, was established in 2001 to ...
Cached Biology Technology:The one that got away 2The one that got away 3UW researcher named top innovator 2
... Since the Flp-In System creates isogenic ... equivalent levels of the protein of ... in Figure 3. In this experiment ... (CAT) was subcloned into pcDNA5/FRT and ...
... you need to make your strain of cells ... services for preparing competent cells are comprehensive and ... cell service offers: High transformation ... Quality control performance testing ...
FRACTALKINE [Human] (Recombinant)...
rat Leptin...
Biology Products: