Navigation Links
Prostate cancer's multiple personalities revealed
Date:11/3/2010

NEW YORK (Nov. 3, 2010) -- Scientists at Weill Cornell Medical College have taken an important step toward a better understanding of prostate cancer by uncovering evidence that it is not one disease, as previously believed, but rather several factors which can be measured and, in the future, destroyed by targeted therapy.

The research team led by of Dr. Mark A. Rubin, the Homer T. Hirst Professor of Oncology in Pathology and vice chair for experimental pathology at Weill Cornell Medical College, identified secondary mutations that cause some types of prostate cancer cells to be lethal. The team believes that their discovery will lead to better tests for prostate cancer, sparing thousands of men from unnecessary biopsies, and leading to more specific and individualized therapy for prostate cancers that are likely to become deadly. The study results were published in the Oct. 29 online edition of the journal Genome Research.

The current research expands on the team's previous work with Arul M. Chinnaiyan's group at the University of Michigan that reported the first evidence that gene fusions, hybrid genes formed from two previously separate genes, play a widespread role in prostate cancer. At the time, it was known that gene fusions could drive the development of blood cancers but were only rarely detected in common solid cancers. Their finding was hailed as a landmark discovery by colleagues when it was first published in 2005 in the journal Science.

In their newly published work, Dr. Rubin and colleagues report evidence that gene fusion prostate cancers are susceptible to secondary mutations. This novel observation supports the view that aggressive cancers need to accumulate multiple mutations. Using discoveries made in this study, clinicians may be better able to diagnose and target potentially deadly tumors.

"In the future, these fusions, specific to certain types of prostate cancer, may help physicians prescribe tailor
'/>"/>

Contact: Andrew Klein
ank2017@med.cornell.edu
212-821-0560
New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College
Source:Eurekalert

Page: 1 2

Related biology news :

1. Genetic risk factors may tailor prostate cancer screening approaches
2. Prostate cancer spurs new nerves
3. Men with wives, significant others more likely to be screened for prostate cancer
4. New lab evidence suggests preventive effect of herbal supplement in prostate cancer
5. Dana-Farber oncologists present at ASCO GU -- predict prostate cancer survival using Source MDx test
6. Freezing prostate cancer does a mans body good
7. New medications show promise in treating drug-resistant prostate cancer
8. New drug shows promise in treating drug-resistant prostate cancer
9. Agent Orange exposure increases veterans risk of aggressive recurrence of prostate cancer
10. 3-D research model tackles prostate cancer spread
11. Gene activity reveals dynamic stroma microenvironment in prostate cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... of our ideas about domestication derive from Charles ... by British animal-breeding practices during the 19th century, ... improvement. , It is from Darwin that ... of captive animals from wild species and total ... But animal management in this industrial setting has ...
(Date:4/16/2014)... you cannot move your eyes up, and you cannot lift your ... so that your eyes look straight when they are rolled down ... to allow people a normal position of their head. In order ... happens. , In a paper published in the April 16 print ...
(Date:4/16/2014)... Biosciences Division of Lawrence Berkeley National Laboratory (Berkeley Lab) ... authority on the evolutionary design principles of cellular networks ... biology, has been named one of six recipients of ... Secretary Ernest Moniz. The E.O. Lawrence Award, the Department ...
Breaking Biology News(10 mins):The story of animal domestication retold 2The story of animal domestication retold 3The story of animal domestication retold 4Researchers track down cause of eye mobility disorder 2Berkeley Lab's Adam Arkin wins 2013 Lawrence Award 2Berkeley Lab's Adam Arkin wins 2013 Lawrence Award 3
... MCLEAN, Va., Nov. 29, 2012  Northrop Grumman Corporation (NYSE: ... proof of concept for an automated biometric information system ... will be operated for a trial period to enable ... enabled intelligence and to help determine the requirements for ...
... William Cooke, a professor in the UTSA College of Education ... selected to serve as the speaker of the Texas Chapter ... Tour. Over the course of a week, Cooke will deliver ... of ACSM,s Texas Chapter. "This is a big honor ...
... For the first time in its history, the American Society ... opening session of the ASCB,s Annual Meeting, for "An Evening ... Francisco, on Saturday, Dec. 15. Members of the ... will receive complimentary registration to the ASCB keynote addresses ...
Cached Biology News:Northrop Grumman Delivers Australian Automated Biometric Information System Trial Proof of Concept 2UTSA physiologist William Cooke named 2013 Lecture Series Speaker by Texas Sports Medicine Chapter 2Public invited to 'An Evening of Science & Art' at ASCB Annual Meeting 2
(Date:1/15/2014)... 2014  Bill Jacobs Automotive, a group of car dealerships headquartered ... the Heartland Blood Center and offering free oil change coupons ... place Saturday, Jan. 18 at the Bill Jacobs Cadillac and ... (Photo: http://photos.prnewswire.com/prnh/20140115/MN46637 )  The Bill Jacobs ...
(Date:1/15/2014)... SAN JOSE, California , January 15, 2014 ... for cancer, today announced the appointment of Thomas C Reynolds ... over 20 years, development experience gained in the biotechnology industry, ... "I am delighted to welcome Tom at this transformative ...
(Date:1/15/2014)... Two champions of science, technology, engineering, ... an annual competition for middle and high school students ... STEM study. The competition presents students with real-world problems ... Aptitude, Mathematics, and Sciences is a program administered ...
(Date:1/15/2014)... (PRWEB) January 15, 2014 AudioNotch is ... new therapy for the treatment of tinnitus. Patients listen ... frequency, and over a period of weeks to months, their ... Therapy in two forms: Notched Music and Notched White Noise. ...
Breaking Biology Technology:Join the Bill Jacobs Auto blood drive and receive a free oil change 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 2Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 4Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 5
... road show is making its way around Wisconsin to educate ... research - embryonic stem cell research - and its presenters ... skeptical. , ,The presentations by Tom Still, president of the ... operations for the WiCell Research Institute , are being ...
... launch of wireless Internet service in downtown Madison, several would-be ... by area coffee shops. , ,Now, Mad City Broadband ... of Madison's Capitol Square and at Dane County Regional ... The broadband service will add indoor wireless access points in ...
... Some states, including Illinois, are looking at passing statewide bills ... one statewide franchise in order to put in Project Lightspeed ... ,I think that is great. Pass HB 1500 in Illinois. ... franchise, there must be a mandate that every business and ...
Cached Biology Technology:Traveling stem cell show continues state tour 2Traveling stem cell show continues state tour 3Proposed telecom bill would have Katrina impact 2Proposed telecom bill would have Katrina impact 3Proposed telecom bill would have Katrina impact 4Proposed telecom bill would have Katrina impact 5
Agarose II (Low Melt)...
...
... I can be used in intracellular staining ... cells and to serve as an antibody ... cell permeabilization is a reversible process, it ... the presence of saponin during intracellular staining. ...
... antibody raised against a partial ... Immunogen: PPP4C (NP_002711, 218 ... recombinant protein with GST tag. ... NM_002720 ...
Biology Products: