Navigation Links
Prostate cancer vaccines more effective with hormone therapy
Date:7/9/2008

PHILADELPHIA Among patients with castration-resistant prostate cancer, the addition of hormone therapy following vaccine treatment improved overall survival compared with either treatment alone or when the vaccine followed hormone treatment, according to recent data published in the July 15 Clinical Cancer Research, a journal of the American Association for Cancer Research.

Philip M. Arlen, M.D., director of the Clinical Research Group for the Laboratory of Tumor Immunology and Biology, Center for Cancer Research, at the National Cancer Institute, said the findings have important implications for guiding treatment decisions for prostate cancer patients.

"Vaccines, if and when they are approved, can be safely and effectively combined with other therapies, including hormones," said Arlen. "There appears to be an advantage in overall survival."

Arlen and colleagues enrolled 42 patients who had castration-resistant prostate cancer. These patients were randomly assigned to receive either a poxvirus-based prostate-specific antigen vaccine or hormone therapy with nilutamide. At progression, patients received the other therapy and continued to receive their original therapy.

For all the patients enrolled in the study, the three-year survival probability was 71 percent and the median overall survival was 4.4 years. Patients randomized to the vaccine had a three-year survival probability of 81 percent and an overall survival of 5.1 years, while patients taking nilutamide had a three-year survival probability of 62 percent and an overall survival of 3.4 years.

Of the 42 patients in the study, 12 patients who were originally assigned to vaccine switched to nilutamide plus vaccine and eight patients who were originally assigned to nilutamide switched to vaccine plus hormone, due to rising levels of prostate-specific antigen with no evidence of metastasis. For patients who received vaccine and then nilutamide, the three-ye
'/>"/>

Contact: Jeremy Moore
Jeremy.moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

Page: 1 2

Related biology news :

1. Counting tumor cells in blood predicts treatment benefit in prostate cancer
2. Urologists identify 7 biomarkers that may help pinpoint prostate cancer recurrence
3. Certain form of tomatoes could be key to prostate cancer prevention
4. Estrogen helps drive distinct, aggressive form of prostate cancer
5. Genes may play role in risk assessment for prostate cancer among Hispanics and caucasians
6. Biomarker predicts malignancy potential of HG-PIN lesions in the prostate
7. Potential association of type 2 diabetes genes with prostate cancer
8. New, noninvasive prostate cancer test beats PSA in detecting prostate cancer
9. Prostate cancer: Watchful wait or vaccinate?
10. Nanomedicine research for prostate cancer supported by $5 million gift
11. Safeway Inc. and PCF to fund landmark prostate cancer research collaboration
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/20/2015)... The announcement comes as demand for fire ... Ireland,s foremost records management company, has ... an impressive track record of clients within the first 12 ... management sector in Dubai . As a ... employ a further eight staff members at its Irish headquarters. ...
(Date:4/14/2015)... April 14, 2015  HYPR Corp. today announced ... ® ) Alliance tm , an industry consortium ... commit to share technology and collaborate to deliver ... interoperable, more secure and private, and easier to ... verification that protects sensitive user information and eliminates ...
(Date:4/13/2015)... 2015 According to a ... Market Forecast & Opportunities, 2020", the global biometrics market ... 14% till 2020. The biometrics market is garnering ... and review of biometric management systems. The constant ... with greater efficiency, are resulting in increasing installation ...
Breaking Biology News(10 mins):Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 2Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 3HYPR Corp. Joins the FIDO Alliance 2HYPR Corp. Joins the FIDO Alliance 3Global Biometrics Market to Cross US$ 21 Billion by 2020: TechSci Research 2
... In the war against infectious disease, identifying the ... Wang and his colleagues from the Biodesign Institute at ... individual virus particles. Their research opens the door to ... may further the study of a broad range of ...
... University researchers have demonstrated a way to dramatically simplify ... New testing instrumentation developed by Antonia Garcia ... costly and produce results in less time. Current ... of working with blood, saliva, urine and other biological ...
... Ind. - A biosensor utilizing black platinum and carbon ... a better understanding of how the plant hormone auxin ... an associate professor of agricultural and biological engineering and ... movement of auxin along a plant,s root surface in ...
Cached Biology News:Visualizing viruses: new research pinpoints tiny invaders 2Visualizing viruses: new research pinpoints tiny invaders 3Health diagnosis made simpler 2Health diagnosis made simpler 3Health diagnosis made simpler 4Sensor important to understanding root, seedling development 2
(Date:4/17/2015)... 17, 2015 Reed Technology and ... regulatory data management, preparation, and submission to the U.S. ... of a new Lot Distribution Report (LDR) service for ... remain compliant with the FDA’s new rule on electronic ... to monitor the volume and timing of particular biologics ...
(Date:4/17/2015)... April 17, 2015 Global Stem ... GTCbio Stem Cell Summit 2015 April 27 - 29, ... latest developments in all areas of stem cell research ... stem cells and regenerative medicine. , The conference ... as well as translational research in stem cell therapies, ...
(Date:4/16/2015)... CAMBRIDGE, Mass. (PRWEB) April 16, 2015 ... of smart data solutions driven by Semantic Web ... provider of specialist information and services for the ... today announced that its joint solution ‘Smart Data ... named a finalist for the 2015 Bio-IT ‘Best ...
(Date:4/16/2015)... Regis Technologies looks forward to being ... Research (AACR) annual meeting. Regis will exhibit at this ... April 18, in Philadelphia and running through April 22, ... the oldest and largest organization focused on cancer research. ... partners with survivors to promote awareness and research funding. ...
Breaking Biology Technology:Reed Tech Announces FDA Lot Distribution Report (LDR) Service for Manufacturers of Biologic Products 2Reed Tech Announces FDA Lot Distribution Report (LDR) Service for Manufacturers of Biologic Products 3Global Stem Cells Group To Join GTCbio Stem Cell and Regenerative Medicine Summit in Boston, April 27-29, 2015 2Global Stem Cells Group To Join GTCbio Stem Cell and Regenerative Medicine Summit in Boston, April 27-29, 2015 3Cambridge Semantics and Informa Named Bio-IT Award Finalist for Smart Data Lake Solution for Clinical Trial and Competitive Intelligence 2Cambridge Semantics and Informa Named Bio-IT Award Finalist for Smart Data Lake Solution for Clinical Trial and Competitive Intelligence 3Regis Technologies Joins American Association for Cancer Research Annual Meeting 2
... Physicians and scientists from Reproductive Medicine Associates of ... their groundbreaking research study entitled Cleavage Stage ... Blastocyst Biopsy Does Not: A Novel Paired Analysis ... The study, led by Richard T. Scott, M.D. ...
... NEW YORK, Oct. 19, 2011 Progenitor Cell Therapy ... NBS ) ("NeoStem" or the "Company"), today ... the demands associated with its contract development and manufacturing ... add to the PCT client list.  NeoStem is an ...
...  Science Applications International Corporation (SAIC) (NYSE: SAI ... the National Institute of Allergy and Infectious Diseases (NIAID), ... provide preclinical services for the development of biopharmaceutical products ... at the end of fiscal year 2011.  The total ...
Cached Biology Technology:Revolutionary IVF Study May Change the Way Embryos are Biopsied for Genetic Disease 2Revolutionary IVF Study May Change the Way Embryos are Biopsied for Genetic Disease 3Progenitor Cell Therapy, a Wholly-Owned Subsidiary of NeoStem, Inc., Announces Additions to Management 2Progenitor Cell Therapy, a Wholly-Owned Subsidiary of NeoStem, Inc., Announces Additions to Management 3SAIC Awarded Contract by National Institute of Allergy and Infectious Diseases 2
... Topo I, Wild Type ... Tris-HCl, 1 mM DTT, 200 µM EDTA, 20% ... topoisomerase I (Topo I) is a monomeric protein ... gene. It catalyzes the relaxation of both positive ...
RNase-Free DNase 50 l...
Request Info...
... is a DNA-dependent RNA polymerase which is ... It efficiently synthesizes in vitro transcripts from ... from a T7 promoter. Transcripts can ... in vitro translation, substrates in RNA processing ...
Biology Products: