She also noted that the information on PSA genetics may improve utility in screening. Rafnar also pointed out that although "...much work remains. finding causative variants at known loci define functions."
The lecture by Prof. Freddie Hamdy (Oxford, UK), 'What is the best practice in bio-banking?' focussed on the dilemmas in prostate cancer (how to identify the population at risk, how to prevent overtreatment and treatment failure). "We can treat, we can cure, but who should we treat and cure?", he said. Collection and cohorts of prostate cancer samples are important in order to look for new biomarkers. But the search for prognostic markers needs a multi-targeted approach. "The focus should be on the benefit to the patient; it should result in e.g. a reduction in mortality or of side effects", says Hamdy.
Dr Schenk-Braat (Rotterdam, NL) says: "The incidence of prostate cancer will increase and PSA is not a sensitive enough tool to identify men at risk". The P-Mark project evaluates promising biomarkers and has selected 3: osteoprotegerin (a bone turnover protein discovered by the group of Prof Hamdy), PCA3 (Jacques Schalkens (Nijmegen, NL) group) and multikallikreins (project of Profs Lilja (New York, US) and Petterson). An across marker validation study is ongoing. "We can name the European prostate biobank, increased support of the validation of biomakers and the prostate risk indicator as a few results from the P-Mark project", says Schenk-Braat.
In another update lecture, Dr. O. Kallioniemi (Helsinki, Finland) discussed the integration of high-throughput technologies to identify drug targets and new therapeutic options for prostate cancer. Amongst his conclusions are:
|Contact: Lindy Brouwer|
European Association of Urology