To compare the normal protein to the K mutant, the researchers used synthetic tails of the normal and the K proteins, as well as engineered human BChE produced in the milk of transgenic goats at a U.S. company, Pharmathene. The goat- produced protein is prepared at Pharmathene for the U.S. military as protection from nerve gas poisoning (a result of earlier research at the Hebrew University). It was much more stable and efficient than the mutant protein, which suggests that the BChE-K carriers' susceptibility to Alzheimer's could be substantially improved by treating them with the engineered normal protein that is produced in the milk of the transgenic goats.
|Contact: Rebecca Zeffert|
The Hebrew University of Jerusalem