Navigation Links
Promising new treatment for Alzheimer's suggested based on Hebrew University research
Date:7/20/2009

Research carried out at the Hebrew University of Jerusalem has resulted in a promising approach to help treat Alzheimer's disease in a significant proportion of the population that suffers from a particularly rapid development of this disease.

In the research at the Silberman Institute of Life Sciences of the Hebrew University, scientists solved a mystery as to why people who carried a mutated gene known as BChE-K were prone to more rapid development of Alzheimer's than those who had a normal version of the gene. This mutation appears in about 20 percent of the American and Israeli populations.

In theory, the carriers of the mutated gene should actually be more protected from the devastating effects of the disease, since the mutated protein (the enzyme that is the product of the gene) breaks down the neurotransmitter acetylcholine at a slower rate than in those who have the normal gene. The result is that the carriers maintain higher levels of this neurotransmitter, so they should in principle be protected from Alzheimer's disease, in which acetylcholine levels decrease.

Indeed, these carriers tend to develop the disease later than others, but when that happens, it progresses more rapidly and does not respond to medication. Therefore, the bottom line is that carriers of the mutated gene have a greater risk than others for disease progression. The reason for this anomalous situation has been a puzzle for a long time, but the studies by the Hebrew University scientists solved it by finding the explanation for this increased risk, thereby offering as well a possible new therapeutic solution.

At the Wolfson Center for Structural Biology at the Hebrew University, the researchers found that the mutation in the BChE-K gene damages the very end, or tail, of the resultant mutant enzyme protein. This tail is the part of BChE which is important for protection from the Alzheimer's disease plaques. It does this by interacting with the
'/>"/>

Contact: Rebecca Zeffert
rebeccaz@savion.huji.ac.il
972-258-81641
The Hebrew University of Jerusalem
Source:Eurekalert

Page: 1 2

Related biology news :

1. UIC researchers find promising new targets for antibiotics
2. New book defines promising young field of adult neurogenesis
3. Sirtris unveils promising, novel SIRT1 activators for treating diseases of aging
4. Cancer and arthritis therapy may be promising treatment for diabetes
5. Unique whey protein is promising supplement for strict PKU diet
6. Promising new drug targets identified for Huntingtons disease
7. Promising new nanotechnology for spinal cord injury
8. Biodesigns Rittmann offers promising perspectives on societys energy challenge
9. UIC researchers make promising finding in severe lung disease
10. New treatment approach promising for lymphoma patients in the developing world
11. Immunotherapy in high-risk pediatric sarcomas shows promising response
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2014)... DIEGO , July 24, 2014 Pfenex Inc. ... public offering of 8,333,333 shares of its common stock at ... addition, Pfenex has granted the underwriters a 30-day option to ... the initial public offering price. The shares are expected to ... under the symbol "PFNX". William Blair ...
(Date:7/23/2014)... Children who have been abused or neglected early ... emotional and physical health problems. In a new ... way genes are activated, which has implications for ... a particular child,s individual characteristics and genetics interacted ... understand how health problems emerge. In the new ...
(Date:7/23/2014)... In Aesop,s fable about the crow and the pitcher, a ... he tries to drink from it, he finds the water ... over the pitcher, the bird drops pebbles into it ... enough for him to drink his fill. , Highlighting the ... often be more effective than brute force. It also characterizes ...
Breaking Biology News(10 mins):Pfenex Inc. Announces Pricing Of Initial Public Offering 2Stress tied to change in children's gene expression related to emotion regulation, physical health 2Stress tied to change in children's gene expression related to emotion regulation, physical health 3Smarter than a first-grader? 2Smarter than a first-grader? 3Smarter than a first-grader? 4
... EAST LANSING, Mich. A repellant for sea lampreys could ... destructive invasive species in the Great Lakes, says a Michigan ... cues have on lampreys. When scents from dead sea lampreys ... efforts to escape are dramatic. In the past, these reactions ...
... used to the fact that most new-born foals suffer from ... including supplementing the mothers, diets with -carotene, which is known ... However, Juliane Kuhl in the group of Christine Aurich at ... this food supplement has no real effect on the incidence ...
... led by Professor Malcolm McConville from the Bio21 Institute, University ... used for many infectious parasites and bacteria. The technique has ... down to the particular atoms it uses as a food ... field because the more we know about these dangerous pathogens ...
Cached Biology News:Sea lampreys fear the smell of death 2No treatment is the best treatment -- diarrhea in young foals 2
(Date:7/24/2014)... York, NY - July 24, 2014 -- Keryx Biopharmaceuticals, ... from the long-term, randomized, active control Phase 3 study ... iron-based phosphate binder, for the treatment of hyperphosphatemia in ... PERFECTED study (PhosphatE binding and iRon delivery with FErric ... Journal of the American Society of Nephrology ...
(Date:7/24/2014)... PARK, Calif. , July 24, 2014 /PRNewswire/ ... company in the emerging field of regenerative medicine, ... webcast of a presentation to investors on Tuesday, ... p.m. PDT.  The presentation will include an overview ... To access the webcast, visit http://www.ustream.tv/channel/asterias-biotherapeutics ...
(Date:7/24/2014)... Yet, scientists are making progress in devising suitable ... approach relies on quantum dotsa kind of artificial ... A new study demonstrates that changing the coupling ... electrical impulses can help better control them. This ... as quantum information units, which would produce faster ...
(Date:7/24/2014)... DUBLIN , July 24, 2014 ... the "Global Genomics and Proteomics Analytical Instruments Market ... http://photos.prnewswire.com/prnh/20130307/600769 Genomics is the ... is the study of the structure and functions of ... and bioinformatics tools and technology. Genomics involves the mapping ...
Breaking Biology Technology:Zerenex (ferric citrate) long-term Phase 3 study results published in JASN 2Zerenex (ferric citrate) long-term Phase 3 study results published in JASN 3Zerenex (ferric citrate) long-term Phase 3 study results published in JASN 4Asterias Biotherapeutics Announces Live Investor Webcast 2Asterias Biotherapeutics Announces Live Investor Webcast 3Asterias Biotherapeutics Announces Live Investor Webcast 4Global Genomics and Proteomics Analytical Instruments Market 2014-2018: Key Vendors are Agilent, Bio-Rad , F. Hoffmann, La Roche, Illumina, PerkinElmer and Thermo Fisher Scientific 2
... 1, 2011 Tengion, Inc. (Nasdaq: TNGN ), ... entered into definitive agreements with certain investors in connection with ... Securities Act of 1933, as amended.  Medtronic (NYSE: ... the financing and, as part of its investment, secured a ...
... Wash., March 1, 2011 Iverson Genetic Diagnostics, Inc. announced ... dverse Event R eduction f or A ... itiation) was initiated at WellStar Health System in Marietta and ... genetic testing to determine a personalized warfarin dose for individual ...
... gold particles are currently intensively investigated for possible ... and molecular electronics. The particles are prepared in ... gold cores can be stabilised with various organic ... using organothiolate ligands that have a strong chemical ...
Cached Biology Technology:Tengion Announces Pricing of $31.4 Million Private Placement 2Tengion Announces Pricing of $31.4 Million Private Placement 3WARFARIN Study Launched at WellStar Health System to Assess Impact of Genetic Testing in Reducing Hospitalizations and Deaths Caused by Warfarin 2WARFARIN Study Launched at WellStar Health System to Assess Impact of Genetic Testing in Reducing Hospitalizations and Deaths Caused by Warfarin 3WARFARIN Study Launched at WellStar Health System to Assess Impact of Genetic Testing in Reducing Hospitalizations and Deaths Caused by Warfarin 4Fingerprints of a gold cluster revealed 2
... The Polymerase gene from Thermus aquaticus ... in E. coli, then highly purified ... is used in the amplification and ... The quality of the Taq DNA ...
... iTaq DNA polymerase is ... suitable for both conventional and ... is supplied at a concentration ... and includes 5,000 units polymerase, ...
Rabbit polyclonal to hnRNP-U...
... is an antibody-mediated hot-start DNA ... and real-time PCR applications. The ... concentration of 5 units per ... polymerase, 1.25 ml 10x PCR ...
Biology Products: