Navigation Links
Promising new drug targets identified for Huntington's disease
Date:3/23/2008

nd zebrafish models. The big question for us is whether they will do the same in humans."

One of the drugs tested, verapamil, which is currently used to treat high blood pressure and heart arrhythmias (among other indications), inhibits the influx of calcium into cells which, in turn, appears to regulate autophagy. Similarly, clonidine, currently used to treat hypertension or migraine, appears to work on autophagy by decreasing levels of cAMP, a molecule that is important in many biological processes.

If the drugs can stimulate autophagy effectively over long-term periods in human brains, then they may have the potential to help delay the onset of Huntington's disease. The candidate drugs are relatively safe and well tolerated when used to treat the diseases they were designed for. A minimal side-effect profile would be highly desirable for a drug treatment aiming to delay the onset or slow the progress of Huntington's. Such drugs may need to be taken for decades, and even moderate side effects may discourage people from taking them over a long period.

"We know the genetics of Huntington's disease and can predict the majority of people at risk," says Professor Rubinsztein. "If we can find a safe, well tolerated drug, then a person at risk could be placed on a drug regime to help prevent onset. It is much easier to stop something happening than having to treat it once it has started."

Professor Rubinsztein and colleagues will shortly begin testing the drugs in other animal models to evaluate their safety and efficacy.


'/>"/>

Contact: Craig Brierley
c.brierley@wellcome.ac.uk
44-207-611-7329
Wellcome Trust
Source:Eurekalert

Page: 1 2

Related biology news :

1. UIC researchers find promising new targets for antibiotics
2. New book defines promising young field of adult neurogenesis
3. Sirtris unveils promising, novel SIRT1 activators for treating diseases of aging
4. Cancer and arthritis therapy may be promising treatment for diabetes
5. Unique whey protein is promising supplement for strict PKU diet
6. Nicotinic receptors may be important targets for treatment of multiple addictions
7. Central targets may hinder wider waste management objectives
8. New X-ray technique targets terrorists and tumors
9. New drug targets may fight tuberculosis and other bacterial infections in novel way
10. Study of successful drug targets could hasten development of new medications
11. A screening strategy using zebrafish targets genes that protect against hearing loss
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... 2014) Women who are poor experience higher cortisol ... elevated levels of the stress hormone, putting them ... according to a new research from the University of ... the American Journal of Human Biology , is ... it directly to the socioeconomic status of their mothers ...
(Date:8/20/2014)... absorbs light and its energy is finally utilized ... Photovoltaic devices, mostly build from silicon based semiconductors, ... approach for the development of cheaper and renewable ... isolated membrane protein complexes of photosynthesis. Prof. Dr. ... from thermophilic cyanobacteria that live in a hot ...
(Date:8/19/2014)... improve students, chances of completing introductory biology courses ... (UH) implemented a comprehensive student success program, employing ... , Through a grant from the Texas ... Biology and Biochemistry embarked on a pilot program ... non-majors and "Introductory Biology" for science majors. These ...
Breaking Biology News(10 mins):CU Denver researcher shows economic disparities impact infant health 2A semi-artificial leaf faster than 'natural' photosynthesis 2University of Houson program earns kudos for improving grades, retaining students 2University of Houson program earns kudos for improving grades, retaining students 3
... and going to work is hard enough every day. But ... of your job down the smallest detail and the ... of credentials might mean starting from scratch. These are the ... make U.S. homes more energy efficient. A recent collaboration ...
... called ADAP (adhesion and degranulation-promoting adaptor protein) is able ... new University of Cambridge research reveals. The researchers, who ... discovery will lead to new ways of combatting HIV. ... who led the research, said: "One exciting aspect about ...
... Oct. 1, 2013  Pfenex Inc. today announced that the ... Biomedical Advanced Research and Development Authority (BARDA), has modified ... with the existing Pfenex contractual relationship begun in July, ... funding to support the development of a next generation ...
Cached Biology News:Weatherization work guidelines launched 2Weatherization work guidelines launched 3Weatherization work guidelines launched 4Weatherization work guidelines launched 5Weatherization work guidelines launched 6New target to fight HIV infection identified 2Biomedical Advanced Research and Development Authority (BARDA) Exercises Option with Pfenex Inc. To Extend Contract and Increase Funding for the Development of a Recombinant Protective Antigen (rPA) Based Anthrax Vaccine 2
(Date:8/20/2014)... lessons often have it that American Indians largely were ... pox, influenza and tuberculosis brought to the New World ... about 20 million people lived in the Americas shortly ... were killed by European diseases., But new research led ... and Johannes Krause of the University of Tubingen in ...
(Date:8/20/2014)... High performance computing (HPC) will be ... climate and Earth system model to address the ... Eight national laboratories, including Lawrence Livermore , ... Atmospheric Research, four academic institutions and one private-sector ... laboratories include Argonne, Brookhaven, Lawrence Berkeley, Los Alamos, ...
(Date:8/20/2014)... (PRWEB) August 20, 2014 The ... is being held on October 29-30 in San Francisco, ... industry, academic and government researchers and clinicians focused on ... space. , In the twelve years since the ... therapies have been introduced with pharmacogenetic information in the ...
(Date:8/20/2014)... improve the health of your heart, researchers have discovered. ... a standard TENS machine like those designed to relieve ... the small raised flap at the front of the ... The stimulation changed the influence of the nervous system ... can drive failing hearts too hard. , Professor Jim ...
Breaking Biology Technology:Unusual discovery leads to fascinating tuberculosis theory 2Unusual discovery leads to fascinating tuberculosis theory 3New Project Is the ACME of Addressing Climate Change 2New Project Is the ACME of Addressing Climate Change 36th Annual Personalized and Precision Medicine Conference Bringing Together Thought Leaders to Discuss Clinical Implementation, Dx Reimbursement, Big Data, and Sequencing 2'Tickling' your ear could be good for your heart 2
... season on CEOs lately but when luminaries like management god ... something real and serious is taking place. Heres what Herr ... January 12, 2004 issue of Fortune Magazine, the compensation inflation ... of the management team. In an executive program I have ...
... Wis. The recent onslaught of e-mail viruses, overabundant ... for computer user protection. In light of this, ... Wisconsin companies, recently began offering new computer security technologies ... spam cost U.S. corporations $8.9 billion dollars in 2002 ...
... DEMO 2004 reaches its final week, I promised I'd share ... not just at DEMO, but in the week ahead. , ... it feels a lot like the enterprise market some 20 ... departments in the early 80s) is acutely focused on the ...
Cached Biology Technology:The CEO Crisis 2Wisconsin Telcos Offer New Internet Security Solutions 2The Enterprise and the Individual 2The Enterprise and the Individual 3
Goat polyclonal to STMN2 ( Abpromise for all tested applications). Antigen: Synthetic peptide: AKTAMAYKEK, corresponding to C terminal amino acids 2-11 of STMN2. Entrez Gene ID: 11075 Swi...
Mouse monoclonal antibody to PAEP - progestagen-associated endometrial protein (placental protein 14, pregnancy-associated endometrial alpha-2-globulin, alpha uterine protein)...
Mouse polyclonal antibody to MCFD2 - multiple coagulation factor deficiency 2...
Volume adapter mounts on top of the 96 well FiltrEX filter plate and allows larger volumes (1mL) to be applied to each well in a filter plate. Adapters are nonsterile....
Biology Products: