Navigation Links
Promising new drug targets identified for Huntington's disease
Date:3/23/2008

Research funded by the Wellcome Trust has provided a number of promising new drug targets for Huntington's disease, a neurodegenerative disease. Scientists at the University of Cambridge have identified a number of candidate drugs to investigate further which encourage cells to "eat" the malformed proteins that lead to the disease.

Huntington's disease is one of a number of degenerative diseases marked by build up of a malformed proteins in brain cells, mainly in the basal ganglia and the cerebral cortex. Normally, cells dispose of or recycle their waste material, including unwanted or misfolded proteins, through a process known as autophagy, or 'self-eating'.

The group of Professor David Rubinsztein, a Wellcome Trust Senior Clinical Fellow at the University of Cambridge, has previously shown that stimulating autophagy in the cells can be an effective way of preventing the malformed proteins from building up. However, there are currently no treatments available that slow the neurodegeneration in people with Huntington's disease. Rapamycin, an immunosuppressant used to lower the body's natural immunity in patients who receive kidney transplants, is the most promising candidate drug currently available but can have significant side effects.

Now, in research published today online in the journal Nature Chemical Biology, Professor Rubinsztein and colleagues have shown that a number of FDA-approved drugs for treatments such as migraine and hypertension are able to stimulate autophagy in fruit flies and zebrafish through unexpected pathways.

"By screening a number of drugs that have already been shown to be safe in humans, we have been able to identify some unexpected and very promising pathways involved in Huntington's," says Professor Rubinsztein. "In collaboration with Cahir OKanes group in Cambridge and Summit Plc, we have shown that these drugs can alleviate the toxicity of the Huntingtons disease mutation in cell-based, fly a
'/>"/>

Contact: Craig Brierley
c.brierley@wellcome.ac.uk
44-207-611-7329
Wellcome Trust
Source:Eurekalert

Page: 1 2

Related biology news :

1. UIC researchers find promising new targets for antibiotics
2. New book defines promising young field of adult neurogenesis
3. Sirtris unveils promising, novel SIRT1 activators for treating diseases of aging
4. Cancer and arthritis therapy may be promising treatment for diabetes
5. Unique whey protein is promising supplement for strict PKU diet
6. Nicotinic receptors may be important targets for treatment of multiple addictions
7. Central targets may hinder wider waste management objectives
8. New X-ray technique targets terrorists and tumors
9. New drug targets may fight tuberculosis and other bacterial infections in novel way
10. Study of successful drug targets could hasten development of new medications
11. A screening strategy using zebrafish targets genes that protect against hearing loss
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/20/2015)... 19, 2015 Research and Markets ( http://www.researchandmarkets.com/research/rswjb4/hand_geometry ... - Global Strategic Business Report" report to their offering. ... Geometry in US$ Thousands. The report provides separate comprehensive analytics ... Japan , Europe , ... Rest of World. Annual estimates and forecasts are ...
(Date:3/19/2015)... , March 19, 2015  NXT-ID, Inc. (NASDAQ: ... focused on the growing mobile commerce market, announces its biometric ... news clip that aired this week on Washington ... In a segment "The Next Great Thing", host ... new way to pay, and ,a really big breakthrough in ...
(Date:3/17/2015)... 17, 2015 Emotient, the leader in ... announced general availability of Emotient Analytics , ... analysis of facial expressions. The system analyzes videos ... products and services. It delivers audience response metrics ... - as derived from facial evidence of emotional ...
Breaking Biology News(10 mins):Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 2Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 3Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 4NXT-ID's Wocket Smart Wallet Featured on Fox News Segment, "The Next Great Thing" 2NXT-ID's Wocket Smart Wallet Featured on Fox News Segment, "The Next Great Thing" 3New Emotient Web Service Measures Audience Response Using On-Demand Facial Expression Analysis 2New Emotient Web Service Measures Audience Response Using On-Demand Facial Expression Analysis 3New Emotient Web Service Measures Audience Response Using On-Demand Facial Expression Analysis 4
... For winter sports athletes, including Olympians competing in Vancouver ... have a significant impact on performance, requiring athletes in ... snowboarding, to retool highly technical moves to accommodate more ... and benefits of training and performing at sea level ...
... greatly benefit the U.S., say scientists in an Energy ... America (ESA), the nation,s largest organization of ecological scientists. ... economic benefits of biofuel production, U.S. policies need to ... In the report, scientists Virginia Dale, Keith Kline, ...
... JOLLA, Calif., February 12, 2010 An international team ... Burnham Institute for Medical Research), Nijmegen Centre for Molecular ... a protein implicated in cancer metastasis, also plays a ... fatal disorder. The research was published on February 12 ...
Cached Biology News:Winter Olympics: Altitude affects skill sports, not just endurance events 2Winter Olympics: Altitude affects skill sports, not just endurance events 3Beyond the corn field: Balancing fuel, food and biodiversity 2Researchers identify mechanism for Frank-Ter Haar syndrome 2
(Date:3/25/2015)... Mass. and REYKJAVIK, Iceland , ... capabilities for using the genome to create better medicine, today ... the largest studies of whole-genome data yet undertaken. ... Nature Genetics – are built around the most ... a team of deCODE scientists led by Kari Stefansson ...
(Date:3/25/2015)... 25, 2015 Having added two International ... part of 2014, ITRA Global proudly announced recently the ... Tenant Representative Alliance, based in the United States, is ... and occupiers of commercial real estate. , Saltwood ... in Poland that exclusively advises occupiers of office space, ...
(Date:3/25/2015)... , March 25, 2015 /CNW/ - The Gairdner ... the 2015 Canada Gairdner Awards, recognizing some of the ... Among the world,s most esteemed ... in science and provide a $100,000 (CDN) prize to each ... stronger culture of research and innovation across the ...
(Date:3/25/2015)... , March 25, 2015  CASI Pharmaceuticals, Inc. (Nasdaq: ... acquisition, development and commercialization of innovative therapeutics addressing cancer ... with a commercial focus on China ... trial of its target therapy drug candidate ENMD-2076 in ... Chinese Academy of Medical Sciences in Beijing ...
Breaking Biology Technology:Landmark deCODE Studies Demonstrate the Power of Truly Big Genomics for Improving Medicine Worldwide 2International Organization Expands its Global Reach to Warsaw, Poland 22015 Canada Gairdner Awards Honour Top Medical Discoveries Around The World 22015 Canada Gairdner Awards Honour Top Medical Discoveries Around The World 32015 Canada Gairdner Awards Honour Top Medical Discoveries Around The World 42015 Canada Gairdner Awards Honour Top Medical Discoveries Around The World 52015 Canada Gairdner Awards Honour Top Medical Discoveries Around The World 62015 Canada Gairdner Awards Honour Top Medical Discoveries Around The World 72015 Canada Gairdner Awards Honour Top Medical Discoveries Around The World 8CASI Pharmaceuticals Announces Initiation Of A Phase 2 Trial With ENMD-2076 In Triple-Negative Breast Cancer In China 2CASI Pharmaceuticals Announces Initiation Of A Phase 2 Trial With ENMD-2076 In Triple-Negative Breast Cancer In China 3CASI Pharmaceuticals Announces Initiation Of A Phase 2 Trial With ENMD-2076 In Triple-Negative Breast Cancer In China 4CASI Pharmaceuticals Announces Initiation Of A Phase 2 Trial With ENMD-2076 In Triple-Negative Breast Cancer In China 5
... PALM BEACH, Fla., Jan. 3, 2012  The secret to the ... yard. Sponsored by Dr. Kenneth Beer, M.D. and Mrs. Kathy ... growth experts from The University of Pennsylvania School of Medicine ... January 29, 2012, residents of South Florida will have an ...
... 3, 2012  SuperNova Diagnostics®, Inc., a privately-held global diagnostics ... Neil J. Campbell, President and CEO, will present a ... San Francisco, CA.  Mr. Campbell,s presentation is scheduled for ... Room at the Parc 55 Wyndham Union Square Hotel. ...
... Jan. 3, 2012 Neogen Corporation has developed a new test ... lateral flow test with the fully quantitative precision of a more ... certain grains is a major concern to producers of animal feed ... for DON delivers precise results ranging from 0.3 to 6 parts ...
Cached Biology Technology:Palm Beach Residents to Learn How the Future of Regenerative Medicine Will Combat Aging 2SuperNova Diagnostics® to Present at Biotech Showcase™ 2012 During JP Morgan Healthcare Conference January 9 - 12 2Neogen Launches Fully Quantitative Lateral Flow Test for DON 2
... purification system, 100-120 V, is used for ... focusing (IEF). The system includes both the ... focusing chambers, chassis, harvesting apparatus, cooling finger, ... 3-10), 60 ml syringe, colored protein sample, ...
...
... SIGNETs BCIP/NBT Chromogen system ... Tetrazolium] chromogen in a single ... reacts in the presence of ... staining with minimal background noise. ...
... BCIP/NBT Chromogen system consists of ... in a single component,solution. The ... the presence of alkaline phosphatase ... with minimal background noise. ,The ...
Biology Products: