Navigation Links
Promising new drug being evaluated as possible treatment option for fragile X syndrome
Date:1/7/2009

(Chicago) A pilot trial of an oral drug therapy called fenobam has shown promising initial results and could be a potential new treatment option for adult patients with Fragile X syndrome (FXS). Findings of the open label, single-dose study by researchers at Rush University Medical Center and the University of California, Davis, Medical Center are to be published in the upcoming January issue of the Journal of Medical Genetics.

Results of an initial evaluation of the safety of fenobam, which is an mGluR5 antagonist, in adult males and females with Fragile X syndrome showed there were no adverse side effects from the medication.

"This is the first study assessing the safety and pharmokinetic metabolism of an mGluR5 antagonist in humans with Fragile X syndrome," said Dr. Elizabeth Berry-Kravis, pediatric neurologist at Rush and principal investigator of the study. "Also, some patients showed calmed behavior and rapid reduction in hyperactivity and anxiety, similar to effects of the drug in mouse models."

Fragile X syndrome is the most common inherited cause of mental impairment and the most common known cause of autism. Fragile X affects 1 in 4000 males and 1 in 6000 females of all races and ethnic groups (source Centers for Disease Control). About 1 in 259 women carry fragile X and could pass it to their children. About 1 in 800 men carry fragile X; their daughters will also be carriers. Symptoms of Fragile X syndrome include mental impairment such as learning disabilities, attention deficit, hyperactivity, autistic-like behaviors, and anxiety and unstable mood.

Fragile X syndrome is caused by lack of activity of the FMR1 gene, which is responsible for a protein called FMRP. Without FMRP, activation of cell pathways by a brain receptor protein called mGluR5 goes unchecked, and it has been theorized that this plays an important part in Fragile X syndrome.

To test this theory, past researchers have used
'/>"/>

Contact: Deborah Song
deb_song@rush.edu
312-942-0588
Rush University Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. UIC researchers find promising new targets for antibiotics
2. New book defines promising young field of adult neurogenesis
3. Sirtris unveils promising, novel SIRT1 activators for treating diseases of aging
4. Cancer and arthritis therapy may be promising treatment for diabetes
5. Unique whey protein is promising supplement for strict PKU diet
6. Promising new drug targets identified for Huntingtons disease
7. Promising new nanotechnology for spinal cord injury
8. Biodesigns Rittmann offers promising perspectives on societys energy challenge
9. UIC researchers make promising finding in severe lung disease
10. New treatment approach promising for lymphoma patients in the developing world
11. Immunotherapy in high-risk pediatric sarcomas shows promising response

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/30/2009)...irst comprehensive review of the state of Antarcti...imate system is published this week (Tuesday 1 Dec...search (SCAR). The review - Antarctic Climate Cha...rch from the icy continent, identifies areas for f...t questions that policy makers have about Antarcti...
(Date:11/30/2009)...BURGHA University of Pittsburgh team overcame a ma...ls such as those that could lead to more efficient... exhaust less toxic. The researchers reported Nov....of high-temperature stability in metallic nanopart...red by a vulnerability to extreme heat. , Gtz Ve...
(Date:11/30/2009)...ditors of The Journal of Experimental Biology ar...entre National de la Recherche Scientifique (CNRS)...winner of this year,s JEB Outstanding Paper Priz...tanding achievement and is intended to encourage y...ditor-in-Chief, and adds that ,we truly appreciate...
Breaking Biology News(10 mins):First comprehensive review of the state of Antarctica's climate 2First metallic nanoparticles resistant to extreme heat 2French scientist wins the Journal of Experimental Biology Outstanding Paper Prize 2009 2French scientist wins the Journal of Experimental Biology Outstanding Paper Prize 2009 3French scientist wins the Journal of Experimental Biology Outstanding Paper Prize 2009 4FoodBizDaily com Announces New Free Report International Trade Opportunity 3A The Brazilian Acai Berry 54107 1FoodBizDaily com Announces New Free Report International Trade Opportunity 3A The Brazilian Acai Berry 54107 2Bionovo Announces Second Quarter 2009 Highlights and Financial Results 4842 1Bionovo Announces Second Quarter 2009 Highlights and Financial Results 4842 2Bionovo Announces Second Quarter 2009 Highlights and Financial Results 4842 3Bionovo Announces Second Quarter 2009 Highlights and Financial Results 4842 4Bionovo Announces Second Quarter 2009 Highlights and Financial Results 4842 5Bionovo Announces Second Quarter 2009 Highlights and Financial Results 4842 6Bionovo Announces Second Quarter 2009 Highlights and Financial Results 4842 7Bionovo Announces Second Quarter 2009 Highlights and Financial Results 4842 8More Evidence Healthy Living Brings Long Life 54102 1More Evidence Healthy Living Brings Long Life 54102 2More Evidence Healthy Living Brings Long Life 54102 3
...issions from using coal are set to double by 2030,...of mitigating global climate change. In view of t... it is vital to minimise emissions where coal is u...nded the launch of the Near Zero Emissions Coal (N...m of this study is to look at the feasibility of b...
... amounts of lead in children,s blood -- amounts we...iated with reduced IQ scores, finds a new six-year...lead exposure on cognitive function in children wh...s for Disease Control and Prevention (CDC) standar... 100 parts per billion. The researchers compared c...
...diseases such as malaria and dengue cause sufferin...s at least one million deaths annually, and is par... five. In addition to the human toll, these disea...mmunities that can least afford it. Various appro...icides, vaccine development, and preventive medici...
Other Biology News:UK scientists lead China closer to carbon capture and storage 2Even minute levels of lead cause brain damage in children 2Selfish DNA and the Genetic Control of Vector-Borne Diseases 2Selfish DNA and the Genetic Control of Vector-Borne Diseases 3
(Date:11/30/2009)...COLUMBUS, Ohio, Nov. 30 The Ohio C...of the nation,s first minority business early-stag...land December 3, is called "Transforming the Lands...arly-Stage Capital Summit." It will feature severa...business leaders and local minority entrepreneurs....
(Date:11/30/2009)...NEW YORK, Nov. 30 The M...(MJFF) today announced $1.5 million in total award...ally disease-modifying therapies for Parkinson,s d...pproaches to Drug Discovery for Parkinson,s Diseas...poration, plc (NYSE: ELN ), a neuroscience-based...
(Date:11/30/2009)...ICAGO, Nov. 30 Dr. Jessica Torrent...ington University Medical Center in Washington, D....-Specific Gamma Imaging (BSGI) in clinical practic... of breast cancer today at the annual meeting of t..., "The purpose of the exhibit was to demonstrat...
(Date:11/30/2009)... PDS, a leader in providing smart and ...nnounces Pajama Pathology®, evolutionizing wor...lsquo;gold standard’ software used by 8 of t...ut on a ‘cost per slide’ basis. , ...ovember 30, 2009 -- PDS has announced another evol...
Breaking Biology Technology:Ohio Capital Fund Announces Sponsorship of Minority Business Conference 2The Michael J. Fox Foundation Announces $1.5 Million in Funding to Advance Development of Drug Targets for Disease-Modifying Parkinson's Disease Treatments 2The Michael J. Fox Foundation Announces $1.5 Million in Funding to Advance Development of Drug Targets for Disease-Modifying Parkinson's Disease Treatments 3Breast-Specific Gamma Imaging In Clinical Practice as an Adjunct Imaging Modality for Diagnosis of Breast Cancer 2Pajama Pathology -- the New Wave of Preclinical Pathology Embraced by PDS 2Pajama Pathology -- the New Wave of Preclinical Pathology Embraced by PDS 3
... resonance image of a hand. Source: Kemie Guaida. ...ralian-based Intelligent Image Management will lic...re imaging systems. , ,TeraMedica,s Intelligent Im...lian company based its name, is TeraMedica,s archi...tly from imaging devices or to work with picture a...
...w there are at least five different types of paten...include: (1) a search for competitors patents, (2)...4) a right-to-use search and (5) a patent validity...egy and a different goal. , 1. A search for compet...s typically performed on a periodic basis and look...
...omething new is happening in American business. , ...of things are still wretchedly out of whack about ...it, but in little ways, people are starting to act...mes when you least expect it). , ,Right here in th...examples of the HF in action. , ,A friend goes on ...
Other Biology Technology:Australian company will sell TeraMedica's medical imaging software 2Five ways your company can benefit from patent searches 2Five ways your company can benefit from patent searches 3'Don't work here' job interviews set new Midwest technology trend 2'Don't work here' job interviews set new Midwest technology trend 3'Don't work here' job interviews set new Midwest technology trend 4'Don't work here' job interviews set new Midwest technology trend 5
...'s family of light scattering instruments. The HTm...ph and enables you to get multi-angle light scatte... easily installed in the oven of any Waters 150C, ...get three angles of light scattering data taken si...
CD25 MicroBeads, non-human primate from Miltenyi Biotec
...es, for 10 chips, provides the reagents and suppli...ysis (picogram levels) with 10 chips on the Experi...1,250 microliters RNA gel, 20 microliters RNA High...ters RNA HighSens loading buffer, 100 microliters ...
Mouse Anti-Verotoxin II (Shiga-like) A subunit (SLT-2a) Monoclonal Antibody, Unconjugated, Clone 557 from Meridian Life Science, Inc.
Biology Products: