Navigation Links
Promising new compound for treating stroke
Date:2/21/2012

s have just been published in the scientific journal PNAS Proceedings of the National Academy of Sciences of the United States of America.

"Our compound is able to pass through the blood-brain barrier, but also interesting is that it improves motor function in the animals that have been subject to stroke, for example, seen as increased grip strength in the paws of the mice," relates Anders Bach.

Alternative angle to drug development

Previously the development of drugs to combat brain damage resulting from stroke focused on blocking the receptors for signal compounds in the brain, such as glutamate. While this protected the receptor against the danger of overactivation, it unfortunately also influenced the normal vital functions of the receptor, causing unacceptable side effects.

Therefore in recent years there has been increased interest in an alternative strategy where the drug does not influence the receptor directly, but instead acts on the interactions between the receptor and the proteins in the cell. This is an important area of focus for the Chemical Biology research team at the University of Copenhagen:

"Our research is concentrated on disrupting the interaction between the so-called NMDA receptor and the intracellular protein PSD-95. Other scientists have shown interest in the same area one group has developed a particularly interesting compound that is currently undergoing clinical development. However, we have reconsidered the design of the compounds in this area and come up with a new one that is more effective," states Anders Bach.

Detailed understanding of the molecular mechanism

In order to find compounds that can detach the PSD-95 protein from the NMDA receptor, one must have a method for measuring the extent to which the compounds bind to PSD-95.

"We have established a method fluorescence polarisation that has been very successful in helping us develop a
'/>"/>

Contact: Anders Bach
anba@farma.ku.dk
(45) 40-32-08-06
University of Copenhagen
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Promising early results with therapeutic cancer vaccines
2. Massage is promising for muscle recovery
3. State of the Union speech: Promising outlook for research and innovation
4. Deep brain stimulation shows promising results for unipolar and bipolar depression
5. WISeKey General Assembly Votes Unanimously to Propel the Company into a Promising and Disruptive Future
6. Improved rainwater harvesting system promising
7. Fate Therapeutics Announces Promising Data From Phase 1b Study of ProHema at the 2011 American Society of Hematology Annual Conference
8. Promising results in mice on needle-free candidate universal vaccine against various flu viruses
9. More promising natural gas storage?
10. Progeria: Promising results from new gene therapy on animals
11. New method of growing high-quality graphene promising for next-gen technology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... of researchers from The Chinese University of Hong Kong, ... wild soybean linked to salt tolerance, with implication for ... This study published online in Nature Communications ... for crop improvement. , Soybean is an important crop ... cultivated soybeans have less genetic diversities than their wild ...
(Date:7/11/2014)... group members to reduce aggression and gain access to ... grooming activities shows a certain pattern across the day. ... Biology Letters . , Grooming between individuals in ... motives. To be groomed has hygienic benefits and is ... can provide access to infants, mating opportunities and high ...
(Date:7/11/2014)... explored two different ways that allow unprecedented experimental ... formation of oxygen molecules in photosynthesis. The two ... Nature Communications . , "The new knowledge ... water oxidation, which are key components for building ... solar energy in fuels like hydrogen, ethanol or ...
Breaking Biology News(10 mins):BGI reports a novel gene for salt tolerance found in wild soybean 2Baboons groom early in the day to get benefits later 2Molecular snapshots of oxygen formation in photosynthesis 2
... Scientists have identified some of the very earliest genetic changes ... them into a new strain of mouse that develops the ... The discoveries, reported in the August 1 issue of Cancer ... treatments that could be offered at the very first signs ...
... the closest living relative to the extinct Irish Elk (giant ... and skeletal features to prove that the giant deer - ... is the subject of numerous cave drawings - has its ... most widespread deer in the UK since their introduction by ...
... for understanding fungal diseases, two groups of researchers are ... dioxide (CO2) governs the morphogenic changes that allow pathogenic ... human body, and they provide new evidence for how ... control the growth and sexual reproduction of pathogenic microbes. ...
Cached Biology News:Building a better mouse model of lung cancer: FHIT counts 2Building a better mouse model of lung cancer: FHIT counts 3Study Holds Promise For New Way To Fight HIV 2CO2 sensing proves critical for fungal pathogens to adapt to life in air and human hosts 2CO2 sensing proves critical for fungal pathogens to adapt to life in air and human hosts 3
(Date:7/10/2014)... Angeles, CA (PRWEB) July 10, 2014 ... and Bioanalytical techniques during 18-20 August, 2014 at Double ... critically review the recent developments in Analytical & Bioanalytical ... the globe. , Speaking on this occasion, Dr. Srinubabu ... Analytica Acta conference is a remarkable one in ...
(Date:7/10/2014)... , July 10, 2014  Kainos Capital, a ... brands, today announced that it has acquired the Slim-Fast ... in the business. Terms of the transaction were not ... and meal replacement business that markets ready-to-drink shakes, powders, ... North America and in the ...
(Date:7/10/2014)... of Adelaide research may help in the fight against ... detect tiny quantities of explosives with the use of ... journal Sensors and Actuators B: Chemical , the ... detect explosives in concentrations as low as 6.3 ppm ... only a few minutes. , "Traditionally explosives detection has ...
(Date:7/10/2014)... The lithium-ion batteries that power our laptops and electric ... a single charge with the help of a sponge-like ... to replace the graphite traditionally used in one of ... times the energy storage capacity of graphite. A paper ... was published today in Nature Communications . , ...
Breaking Biology Technology:A Critical Review of Analytical Techniques for Improved Living Standards 2A Critical Review of Analytical Techniques for Improved Living Standards 3A Critical Review of Analytical Techniques for Improved Living Standards 4Kainos Capital Acquires Slim-Fast From Unilever 2Detecting trace amounts of explosives with light 2Silicon sponge improves lithium-ion battery performance 2Silicon sponge improves lithium-ion battery performance 3
... SAN CARLOS, Calif. and BROOMFIELD, Colo., Dec. 1 ... ARCA biopharma, Inc., a privately-held,biopharmaceutical company developing genetically-targeted ... announced that a special,meeting of Nuvelo,s stockholders will ... PT at Nuvelo,s headquarters at 201 Industrial Road, ...
... RIDGE, N.J., Dec. 1 Regado Biosciences, Inc.,announced today ... present at the 20th Annual Piper Jaffray Health Care ... at 10:10am (Eastern Standard Time).,Dr. Mazzo will discuss the ... clinical developments. , ...
... for nomination of candidates worldwide - , ... Technology Foundation of Japan today announced the two fields eligible ... prestigious awards in science and technology. The 2010 Japan Prize ... and biological production and environment. , , ...
Cached Biology Technology:Nuvelo and ARCA biopharma Advance Toward Completion of Merger 2Nuvelo and ARCA biopharma Advance Toward Completion of Merger 3Nuvelo and ARCA biopharma Advance Toward Completion of Merger 4Nuvelo and ARCA biopharma Advance Toward Completion of Merger 52010 Japan Prize to Honor Scientists and Researchers in Industrial Production/Production Technology and Biological Production/Environment Fields 22010 Japan Prize to Honor Scientists and Researchers in Industrial Production/Production Technology and Biological Production/Environment Fields 3
...
ANTI DIPHTH TOX A SU...
... shaker flask clips, purpose-designed to firmly retain ... clips are equipped with a top retainer ... a bottom retainer spring, and silicon tubing ... glassware. Clips include the required mounting ...
... An immuncapture enzyme-activity assay based on ... captured on monoclonal antibody coated microtiter plate. ... standards, samples or controls, 2nd ... The assay is intended for the determination ...
Biology Products: