Navigation Links
Promising new compound for treating stroke
Date:2/21/2012

Researchers at the University of Copenhagen have designed, produced and patented a new chemical compound for the possible treatment of brain damage caused by stroke. The compound binds 1,000 times more effectively to the target protein in the brain than the potential drug currently being tested on stroke victims. The results of biological tests have just been published in the renowned journal PNAS.

More than 140,000 people die each year from stroke in the United States. Stroke causes the brain to release large amounts of glutamate, an activating signal compound, all at once. This overactivates the receptors in the surrounding healthy tissue, causing the level of calcium in the cells to rise dramatically. This then kick-starts a toxic chain reaction causing cell death. Scientists believe that this process is the cause of the brain damage that occurs in the wake of a stroke. Therefore they are looking for compounds that can limit cell death:

"Research on animal models shows that the new compound we have designed and produced reduces the dead area in the brain after a stroke by 40 per cent. In addition, we can show that our compound is far more biologically effective than the potential drug currently being tested in clinical trials," explains Anders Bach, medicinal chemist and postdoc at the Faculty of Health and Medical Sciences.

Improving motor function in animals

A research project based at the Faculty of Health and Medical Sciences is the catalyst for the development of drugs to treat brain damage resulting from stroke. A new chemical compound has shown to be extremely potent, binding 1,000 times better than the potential drug currently under clinical development. Biological tests also indicate that the new compound shows high biological activity in animal models and is able to pass through the nearly impermeable blood-brain barrier, which is otherwise a fundamental challenge in clinical drug development. The result
'/>"/>

Contact: Anders Bach
anba@farma.ku.dk
(45) 40-32-08-06
University of Copenhagen
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Promising early results with therapeutic cancer vaccines
2. Massage is promising for muscle recovery
3. State of the Union speech: Promising outlook for research and innovation
4. Deep brain stimulation shows promising results for unipolar and bipolar depression
5. WISeKey General Assembly Votes Unanimously to Propel the Company into a Promising and Disruptive Future
6. Improved rainwater harvesting system promising
7. Fate Therapeutics Announces Promising Data From Phase 1b Study of ProHema at the 2011 American Society of Hematology Annual Conference
8. Promising results in mice on needle-free candidate universal vaccine against various flu viruses
9. More promising natural gas storage?
10. Progeria: Promising results from new gene therapy on animals
11. New method of growing high-quality graphene promising for next-gen technology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/6/2014)... groundbreaking paper from a team of Florida State University ... plants could adapt to and survive environmental swings such ... the latest issue of the journal The Plant ... of DNA and proteins) is organized in a cell ... genes are turned on and others are turned off. ...
(Date:11/6/2014)... November 6, 2014 - Insilico Medicine, Inc, a ... and age related diseases announced a research collaboration ... cancer, Champions Oncology, Inc (OTC: CSBR). , "There ... personalized medicine, but Champions Oncology,s TumorGraft technology is ... the chemotherapy regimen experimentally generating vast amounts of ...
(Date:11/5/2014)... great diversity in their ability to identify scents and ... in their perceptual evaluation of odors, with women outperforming ... , Sex differences in olfactory detection may play a ... to one,s perception of smell, which is naturally linked ... has been suggested to be cognitive or emotional, rather ...
Breaking Biology News(10 mins):Maize analysis yields whole new world of genetic science 2Insilico Medicine, Inc announces research collaboration with Champions Oncology, Inc 2The female nose always knows: Do women have more olfactory neurons? 2
... people usually don,t die from a heart attack. But the ... succumb to congestive heart failure, the most common cause of ... hope for achieving what the body can,t do: mending broken ... built a scaffold that supports the growth and integration of ...
... -- A microscopic gene may play a gigantic role when ... to one Kansas State University research team. The team ... Disintegrin and Metalloprotease family, or ADAM family, and its role ... is a good guy or a bad guy in breast ...
... against cancerous tumors, radiation therapy often harms healthy tissue as ... of Tel Aviv University,s Department of Biomedical Engineering is developing ... and minimal damage to surrounding tissue. His innovative ... uses heat to kill the tumor cells but leaves ...
Cached Biology News:A strategy to fix a broken heart 2A strategy to fix a broken heart 3K-State research team investigates mutated gene's role in breast cancer 2A 'magnetic' solution to identify and kill tumors 2
(Date:11/22/2014)... MA (PRWEB) November 21, 2014 ... key investors will gather on December 3rd at ... Biotech Conferences series. GeneticRx will take place at ... Medical School and will discuss the present and ... therapy, exon skipping, and gene editing—as well as ...
(Date:11/22/2014)... November 21, 2014 On November 17th ... the 2014 Emerging Medical Technologies Summit in San Francisco ... Widely regarded among Silicon Valley investors and technology ... innovation, the win also positions Briteseed to move ... competition in 2015 and compete with other elite innovation ...
(Date:11/22/2014)... 21, 2014  The element of surprise has been ... they strike without warning. Until now, epidemiologists had nothing ... viral outbreak, resulting in suboptimal responses to both the ... Photo - http://photos.prnewswire.com/prnh/20141121/160242 ... removed because virus gene structural changes have been found ...
(Date:11/21/2014)... Nov. 21, 2014   TRU-D SmartUVC LLC and ... superbug-killing UVC automated disinfection robot, TRU-D SmartUVC, at FIS 2014 ... Nov. 23 to 26 at Stand 23. The ... United Kingdom,s largest infection-related event of its ... to one of the leading events of its type throughout ...
Breaking Biology Technology:Pioneering Academics and Key Industry Leaders to Discuss Rare Diseases and the Emergence of New Genetic Medicines at Genetic Rx on December 3rd 2Insight Product Development Accelerator Member Wins MedTech Innovator Award Competition 2Insight Product Development Accelerator Member Wins MedTech Innovator Award Competition 3Viruses' Advantage of Surprise is Lost 2TRU-D SmartUVC to Showcase Superbug-Killing Robot at FIS 2014 2TRU-D SmartUVC to Showcase Superbug-Killing Robot at FIS 2014 3
... screens with siRNA libraries, Ambion scientists identified , ... screen results. , ... Reduce siRNA concentration Use , ... Correct for cell number Note cell type , ...
... RNA later protects cellular RNA , ... Whether you are in the lab, in the OR, ... can use this aqueous, non-toxic Tissue Collection:RNA , ... -20C. , Characterization ...
... Kit , , ... protocols optimized to minimize endogenous RNase activity , ... histological and fluorescent stains , Designed for use , ... , Compatible with Arcturus LCM Systems , ...
Cached Biology Technology:Recommendations for Successful siRNA Library Screens 2Recommendations for Successful siRNA Library Screens 3Recommendations for Successful siRNA Library Screens 4Recommendations for Successful siRNA Library Screens 5Recommendations for Successful siRNA Library Screens 6Recommendations for Successful siRNA Library Screens 7Recommendations for Successful siRNA Library Screens 8Preserve Samples for RNA Expression Microarrays RNAlater Around the World 2Preserve Samples for RNA Expression Microarrays RNAlater Around the World 3Preserve Samples for RNA Expression Microarrays RNAlater Around the World 4Preserve Samples for RNA Expression Microarrays RNAlater Around the World 5Protect RNA and Improve Target Cell Identification 2Protect RNA and Improve Target Cell Identification 3Protect RNA and Improve Target Cell Identification 4Protect RNA and Improve Target Cell Identification 5Protect RNA and Improve Target Cell Identification 6
Goat Anti-Horse IgG(T) Antibody, Unconjugated...
Identify and characterize Phosphoinositide (PI(3,4,5)P3) binding...
Mouse polyclonal antibody to MCFD2 - multiple coagulation factor deficiency 2...
Rabbit polyclonal to ErbB 2 (phospho Y1248) ( Abpromise for all tested applications). entrezGeneID: 2064 SwissProtID: P04626...
Biology Products: