Navigation Links
Promising new compound for treating stroke
Date:2/21/2012

Researchers at the University of Copenhagen have designed, produced and patented a new chemical compound for the possible treatment of brain damage caused by stroke. The compound binds 1,000 times more effectively to the target protein in the brain than the potential drug currently being tested on stroke victims. The results of biological tests have just been published in the renowned journal PNAS.

More than 140,000 people die each year from stroke in the United States. Stroke causes the brain to release large amounts of glutamate, an activating signal compound, all at once. This overactivates the receptors in the surrounding healthy tissue, causing the level of calcium in the cells to rise dramatically. This then kick-starts a toxic chain reaction causing cell death. Scientists believe that this process is the cause of the brain damage that occurs in the wake of a stroke. Therefore they are looking for compounds that can limit cell death:

"Research on animal models shows that the new compound we have designed and produced reduces the dead area in the brain after a stroke by 40 per cent. In addition, we can show that our compound is far more biologically effective than the potential drug currently being tested in clinical trials," explains Anders Bach, medicinal chemist and postdoc at the Faculty of Health and Medical Sciences.

Improving motor function in animals

A research project based at the Faculty of Health and Medical Sciences is the catalyst for the development of drugs to treat brain damage resulting from stroke. A new chemical compound has shown to be extremely potent, binding 1,000 times better than the potential drug currently under clinical development. Biological tests also indicate that the new compound shows high biological activity in animal models and is able to pass through the nearly impermeable blood-brain barrier, which is otherwise a fundamental challenge in clinical drug development. The result
'/>"/>

Contact: Anders Bach
anba@farma.ku.dk
(45) 40-32-08-06
University of Copenhagen
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Promising early results with therapeutic cancer vaccines
2. Massage is promising for muscle recovery
3. State of the Union speech: Promising outlook for research and innovation
4. Deep brain stimulation shows promising results for unipolar and bipolar depression
5. WISeKey General Assembly Votes Unanimously to Propel the Company into a Promising and Disruptive Future
6. Improved rainwater harvesting system promising
7. Fate Therapeutics Announces Promising Data From Phase 1b Study of ProHema at the 2011 American Society of Hematology Annual Conference
8. Promising results in mice on needle-free candidate universal vaccine against various flu viruses
9. More promising natural gas storage?
10. Progeria: Promising results from new gene therapy on animals
11. New method of growing high-quality graphene promising for next-gen technology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... MARC (Maximizing Access to Research Careers) Program has ... Society of America,s 27th Annual Mouse Molecular Genetics ... in Pacific Grove, California. These awards are ... doctorates and scientists from underrepresented groups into the ... encourage the participation of young scientists at the ...
(Date:8/28/2014)... delivering compounds that could positively impact the ... be possible, thanks to researchers in Penn ... vaginal suppository made from the seaweed-derived food ... drug Tenofovir provides a woman-initiated, drug-delivery vehicle ... sexually transmitted infections during unprotected heterosexual intercourse, ...
(Date:8/28/2014)... Dyslexia, the most commonly diagnosed learning disability in ... that occurs when the regions of the brain ... The use of non-invasive functional neuroimaging tools has ... dyslexia. However, most prior work has focused on ... a gap in our understanding of how multiple ...
Breaking Biology News(10 mins):Sensory-tested drug-delivery vehicle could limit spread of HIV, AIDS 2Sensory-tested drug-delivery vehicle could limit spread of HIV, AIDS 3Dyslexic readers have disrupted network connections in the brain 2
... , NEW YORK, Sept. 8 Reportlinker.com announces ... catalogue. , , Carbon Dioxide ... , , This report analyzes the ... by the following segments: End-tidal Carbon Dioxide (EtCO2) Monitors, and ...
... , , REDWOOD CITY, Calif., ... authentication solutions, today announced that NCR Corporation is now ... on NCR,s next-generation integrated point-of-sale (POS) workstation, the NCR RealPOS ... which is embedded in the top of the NCR RealPOS 70 ...
... MADISON, WI, SEPTEMBER 21, 2009 -- In looking ... carefully examining the role of nitrogen fixation in delivering ... long, nitrogen fixation of the soil has involved a ... thus tying the agricultural industry to the availability and ...
Cached Biology News:Reportlinker Adds Carbon Dioxide Monitors Report 2Reportlinker Adds Carbon Dioxide Monitors Report 3Reportlinker Adds Carbon Dioxide Monitors Report 4Reportlinker Adds Carbon Dioxide Monitors Report 5Reportlinker Adds Carbon Dioxide Monitors Report 6Reportlinker Adds Carbon Dioxide Monitors Report 7Reportlinker Adds Carbon Dioxide Monitors Report 8Reportlinker Adds Carbon Dioxide Monitors Report 9NCR Embeds DigitalPersona U.are.U(R) 4500HD Fingerprint Sensor in New NCR RealPOS(TM) 70XRT Point-of-Sale Workstations 2Is nitrogen the new carbon? 2
(Date:8/28/2014)... (PRWEB) August 28, 2014 Best Sanitizers, ... for the food processing industry, is asking industry professionals ... side comparison of the E2 soap they’re currently using ... Foam Soap . Hand hygiene is critical to ... food processing environment. Six key criteria are identified to ...
(Date:8/28/2014)... devices in spintronics, an electronic which is not ... also on their spin and the spin-related magnetism. ... magnetic signals and vice versa. Recently, the research ... of Physics at Johannes Gutenberg University Mainz in ... Japan, has for the first time realised a ...
(Date:8/28/2014)... ATLANTA , Aug. 28, 2014   SunTrust ... of three industry veterans to its equity research ... "Our ongoing expansion in equity research demonstrates ... with unique insights to enhance their investment decision ... Equities at STRH.  "We continue to make significant ...
(Date:8/28/2014)... Washington, USA (PRWEB) August 27, 2014 ... next month for SPIE Laser Damage 2014 ... optical materials for high-power lasers will run 14-17 September. ... society for optics and photonics . , The premier ... for understanding laser damage to optical materials will engage ...
Breaking Biology Technology:Best Sanitizers, Inc. Asks Food Industry Professionals: With Fall Harvest On the Way, Is Your E2 Hand Soap Up to the Task? 2A new, tunable device for spintronics 2A new, tunable device for spintronics 3SunTrust Robinson Humphrey Expands Equity Research in Healthcare and Energy 2SunTrust Robinson Humphrey Expands Equity Research in Healthcare and Energy 3Laser Damage to Draw Researchers, Engineers, Scientists to 46th Annual Conference 2Laser Damage to Draw Researchers, Engineers, Scientists to 46th Annual Conference 3
... Stock Exchange Symbol: MS, EDMONTON, June 12 /PRNewswire-FirstCall/ - BioMS ... sclerosis (MS), today,announced that Mr. Kevin Giese, President and CEO, will ... San Diego,California., WHEN: ... WHERE: ...
... Raptor Pharmaceuticals Corp.,(OTC Bulletin Board: RPTP), today announced ... development subsidiary, will,present at the 2008 BIO International Convention ... Convention Center in San Diego, CA., Mr. Daley,s ... 2008 at 1:15p.m. (PT) in room 4 of the ...
... Calif., June 11 Jazz,Pharmaceuticals, Inc. (Nasdaq: ... shelf registration statement with the U.S. Securities and,Exchange ... registration,statement has been declared effective by the SEC, ... to an aggregate of $100 million of its,common ...
Cached Biology Technology:BioMS Medical to present at 2008 BIO International Convention 2Raptor Pharmaceuticals Corp. To Present at BIO 2008 International Convention 2Raptor Pharmaceuticals Corp. To Present at BIO 2008 International Convention 3Raptor Pharmaceuticals Corp. To Present at BIO 2008 International Convention 4Jazz Pharmaceuticals Files Form S-3 Registration Statements 2Jazz Pharmaceuticals Files Form S-3 Registration Statements 3
... is a new technology for sensitive ... small amounts of DNA (5). This ... to modify the DNA, followed by ... to distinguish methylated from unmethylated DNA. ...
... used for the synthesis of 5' capped ... Substitution of cap analog for a large ... vitro transcription reaction results in the incorporation ... fraction of the transcripts. Capped mRNAs are ...
... Incubator/Shaker HT is designed for ... Incubator/Shaker HT is ideal for ... and primer extension assays. The ... as a one-cabinet model, allowing ...
The iEMS Incubator/Shaker is a high performance microplate incubator and orbital shaker. Its superior temperature control and efficient orbital shaking reduce incubation times. It can incubate up to ...
Biology Products: