Navigation Links
Promising discovery in the fight against antibiotic-resistant bacteria
Date:5/22/2014

Researchers at the University of British Columbia have identified a small molecule that prevents bacteria from forming into biofilms, a frequent cause of infections. The anti-biofilm peptide works on a range of bacteria including many that cannot be treated by antibiotics.

"Currently there is a severe problem with antibiotic-resistant organisms," says Bob Hancock, a professor in UBC's Dept. of Microbiology and Immunology and lead author of the study published today in PLOS Pathogens. "Our entire arsenal of antibiotics is gradually losing effectiveness."

Many bacteria that grow on skin, lung, heart and other human tissue surfaces form biofilms, highly structured communities of bacteria that are responsible for two-thirds of all human infections. There are currently no approved treatments for biofilm infections and bacteria in biofilms are considerably more resistant to standard antibiotics.

Hancock and his colleagues found that the peptide known as 1018-- consisting of just 12 amino acids, the building blocks of protein--destroyed biofilms and prevented them from forming.

Bacteria are generally separated into two classes, Gram-positives and Gram-negatives, and the differences in their cell wall structures make them susceptible to different antibiotics. 1018 worked on both classes of bacteria as well as several major antibiotic-resistant pathogens, including Pseudomonas aeruginosa, E. coli and MRSA.

"Antibiotics are the most successful medicine on the planet. The lack of effective antibiotics would lead to profound difficulties with major surgeries, some chemotherapy treatments, transplants, and even minor injuries," says Hancock. "Our strategy represents a significant advance in the search for new agents that specifically target bacterial biofilms."
'/>"/>

Contact: Heather Amos
heather.amos@ubc.ca
604-822-3213
University of British Columbia
Source:Eurekalert

Page: 1

Related biology news :

1. Penn team identifies promising new target for gum disease treatment
2. New method yields potent, renewable human stem cells with promising therapeutic properties
3. Promising news for solar fuels from Berkeley Lab researchers at JCAP
4. Dartmouth researchers find promising results with local hyperthermia of tumors
5. New biological scaffold offers promising foundation for engineered tissues
6. Caltech-developed method for delivering HIV-fighting antibodies proven even more promising
7. Promising class of antibiotics discovered for treatment of drug-resistant tuberculosis
8. Scientists develop promising drug candidates for pain, addiction
9. New gene therapy proves promising as hemophilia treatment
10. T cell immunotherapy: Promising results in children and adults with leukemia
11. International gene therapy trial for bubble boy disease shows promising early results
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/9/2016)... , UAE, May 9, 2016 ... when it comes to expanding freedom for high net ... Even in today,s globally connected world, there is ... conferencing system could ever duplicate sealing your deal with ... obtaining second passports by taking advantage of citizenship via ...
(Date:4/26/2016)... LONDON , April 26, 2016 ... EdgeVerve Systems, a product subsidiary of Infosys (NYSE: ... a partnership to integrate the Onegini mobile security ... (Logo: http://photos.prnewswire.com/prnh/20151104/283829LOGO ) The ... enhanced security to access and transact across channels. ...
(Date:4/15/2016)... 2016 Research and Markets has ... Market 2016-2020,"  report to their offering.  , ... ,The global gait biometrics market is expected to ... period 2016-2020. Gait analysis generates multiple ... used to compute factors that are not or ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... June 23, 2016 , ... ... to announce the launch of their brand, UP4™ Probiotics, into Target stores nationwide. ... years, is proud to add Target to its list of well-respected retailers. This ...
(Date:6/23/2016)... 23, 2016 Houston Methodist Willowbrook Hospital ... Sports Association to serve as their official health ... Methodist Willowbrook will provide sponsorship support, athletic training ... association coaches, volunteers, athletes and families. ... Sports Association and to bring Houston Methodist quality ...
(Date:6/23/2016)... 23, 2016   EpiBiome , a precision microbiome ... in debt financing from Silicon Valley Bank (SVB). The ... to advance its drug development efforts, as well as ... "SVB has been an incredible strategic partner to ... traditional bank would provide," said Dr. Aeron Tynes ...
(Date:6/23/2016)... LOUISVILLE, Ky. , June 23, 2016 /PRNewswire/ ... from two Phase 1 clinical trials of its ... double-blind, placebo-controlled, single and multiple ascending dose studies ... and pharmacodynamics (PD) of subcutaneous injection in healthy ... APL-2 subcutaneously (SC) either as a single dose ...
Breaking Biology Technology: