Navigation Links
Promising class of antibiotics discovered for treatment of drug-resistant tuberculosis
Date:1/27/2014

rt of the cell known as the ribosome, which is responsible for protein synthesis. To do that, the spectinamides bind to a particular site on ribosomes that is not shared by other TB drugs. That allows the drug to be used in combination with other medications.

For this study, researchers used an approach called structure-based design to re-engineer how spectinomycin binds to the ribosome. To guide their design efforts, scientists used a 3-D model that provided an atomic-level view of spectinomycin bound to the tuberculosis ribosome. The study reinforces the potential of structure-based design as a tool for designing other new agents to block mechanisms TB and other bacteria use to resist current antibiotics, Lee said.

The research reports on the first 20 of the more than 120 spectinomycin derivatives that have resulted from the effort. The list includes 1599 and two other analogs tested against TB in mice.

The three analogs not only bound the ribosome tightly, but they were more successful at avoiding a TB resistance mechanism called efflux. The TB bacteria use efflux pumps as a strategy to remove drugs and other threats from the cell before they can work against the bacteria. Efflux pumps, however, did not protect TB against spectinamides.

The drugs were also effective against multi-drug-resistant strains of TB growing in the laboratory. The strains had been isolated from patients with the disease.

Researchers also found no evidence that 1599 or the two other analogs tested interfered with normal functioning of human cells. Preliminary safety testing on cells grown in the laboratory showed the drugs were not toxic to mammalian cells because they only inhibit the bacterial ribosomes and not mammalian ribosomes.

Work is underway now in mice combining 1599 with new or existing TB drugs. The goal is to identify multi-drug therapy to try in a clinical trial of patients with drug-resistant TB.


'/>"/>

Contact: Summer Freeman
summer.freeman@stjude.org
901-595-3061
St. Jude Children's Research Hospital
Source:Eurekalert  

Page: 1 2

Related biology news :

1. First complete full genetic map of promising energy crop
2. Scripps Research Institute scientists find promising vaccine targets on hepatitis C virus
3. Promising developments in early diagnosis and treatment of mesothelioma
4. Ultrasensitive biosensor promising for medical diagnostics
5. UH Case Medical Center, CardioKinetix reveal promising data for treatment for heart failure
6. 22 of Americas most promising scientists selected as Pew Biomedical Scholars
7. American Health Assistance Foundation announces grants to advance promising vision research
8. Space research institute awards funding to promising medical products
9. Promising new drug target for inflammatory lung diseases
10. Berkeley Lab scientists help develop promising therapy for Huntingtons disease
11. Stem cells + nanofibers = Promising nerve research
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Promising class of antibiotics discovered for treatment of drug-resistant tuberculosis
(Date:7/31/2015)... 31 de julho de 2015 A 10 ... ) será realizada pela BGI de 22-25 de outubro de ... A conferência está celebrando seu 10 o. ... ICG se tornou uma das reuniões mais influentes do ... científicos mais dinâmicos, entusiastas e prazerosos. ...
(Date:7/31/2015)... , 31 de julio de 2015 La 10 ... se celebrará por medio de BGI del 22 al 25 de ... Este año, la conferencia celebra su décimo ... ha convertido en una de las reuniones anuales más influyentes ... de las reuniones más dinámicas, entusiastas y mejores a nivel ...
(Date:7/31/2015)... 31, 2015 NXT-ID, Inc. (NASDAQ: NXTD ) ... on the growing mobile commerce market and creator of ... provisional patent 62/198989 for ELECTRONIC CRYPTO-CURRENCY MANAGEMENT ... method to advance crypto-currencies such as Bitcoin into the ... uniform way to manage all payments.  ...
Breaking Biology News(10 mins):A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 2A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 3La 10th International Conference on Genomics (ICG-10) se llevará a cabo en octubre 2La 10th International Conference on Genomics (ICG-10) se llevará a cabo en octubre 3NXT-ID Patents Electronic Crypto-Currency Management Technology 2NXT-ID Patents Electronic Crypto-Currency Management Technology 3NXT-ID Patents Electronic Crypto-Currency Management Technology 4
... A tiny difference in the coding pattern of a single ... drops with advancing age, investigators at the Stanford University School ... System have learned. In a study to be published ... tested the skills of experienced airplane pilots and found that ...
... eaten from silverware or worn copper jewelry, you,ve been ... into the environment, say scientists at the University of ... and the public have been concerned that the potential ... way of environmental exposure. Now, with the ...
... available in Spanish . The study, ... the result of an interdisciplinary collaboration between two researchers: one ... the area of geographic history under the direction of the ... is Consejo Superior de Investigaciones Cientficas (CSIC Spanish National ...
Cached Biology News:Gene variation predicts rate of age-related decline in mental performance, Stanford study 2Gene variation predicts rate of age-related decline in mental performance, Stanford study 3Gene variation predicts rate of age-related decline in mental performance, Stanford study 4Nanoparticles and their size may not be big issues 2Forest fires are becoming larger and more frequent 2
(Date:8/28/2015)... , Aug. 28, 2015 ... the addition of the "Global & USA BioSimilar ... The highly awaited US Biosimilar market will ... awaited filigrastim biologic, Zarxio. How will the global market ... author reveals that biosimilars could save the US economy ...
(Date:8/28/2015)... ... August 28, 2015 , ... ... surgeon, Wade McKenna, DO, announced today that the use of sterile, dehydrated amniotic ... complete healing of an otherwise non-healing surgical knee wound. , The case involved ...
(Date:8/27/2015)... Aug. 27, 2015 /PRNewswire/ - Portage Biotech Inc. ... and Biohaven Pharmaceutical Holding Company Limited (Biohaven), announced ... I study of BHV-0223, a glutamate modulating agent. ... BHV-0223 and recently obtained clearance from the U.S. ... human testing. Portage holds 54% equity interest in ...
(Date:8/27/2015)... 2015 GlassesOff (OTCBB: GLSO), a visual ... the human vision system, announced today a partnership with eight-time ... Chris Paul to develop a new mobile app designed ... their real-life on-court performance. Vision is the inception ... shooting a ball or blocking a pass. The critical impact ...
Breaking Biology Technology:Global & USA BioSimilar Market Analysis Report 2015-2021 2Global & USA BioSimilar Market Analysis Report 2015-2021 3Dallas-Fort Worth Stem Cell Researchers Use Amniotic Tissue To Successfully Treat Non-Healing Surgical Wound 2Dallas-Fort Worth Stem Cell Researchers Use Amniotic Tissue To Successfully Treat Non-Healing Surgical Wound 3Dallas-Fort Worth Stem Cell Researchers Use Amniotic Tissue To Successfully Treat Non-Healing Surgical Wound 4Portage's Biohaven doses first human subject in Phase 1 trial with lead drug candidate BHV-0223 2Portage's Biohaven doses first human subject in Phase 1 trial with lead drug candidate BHV-0223 3Portage's Biohaven doses first human subject in Phase 1 trial with lead drug candidate BHV-0223 4Eight-Time All-Star Chris Paul and GlassesOff Partner to Develop Innovative Mobile App Designed to Improve On-Court Performance 2Eight-Time All-Star Chris Paul and GlassesOff Partner to Develop Innovative Mobile App Designed to Improve On-Court Performance 3
... , ,So how many boards can you break with one ... you juggle at one time? Even more important what projects ... improve your organizations position in the marketplace? If not, read on, ... is a program of continuous improvement that focuses on customer requirements. ...
... Wis. Whenever a new piece of technology comes out ... an instant success. More frequently, it is seen as an ... adopters, who are often making a risky gamble. To become ... field, tested in real-world conditions and purchased enough so early ...
... Quintessence Biosciences, Inc. has formed a scientific ... of cancer therapeutics. , ,Announced last week by ... the board will consist of distinguished scientific leaders who ... Quintessence Biosciences, Inc. They will also assist the company ...
Cached Biology Technology:Part 6 Project Performance Get on the path to continuous improvement 2Part 6 Project Performance Get on the path to continuous improvement 3Part 6 Project Performance Get on the path to continuous improvement 4Laying the foundation for RFID 2Laying the foundation for RFID 3Laying the foundation for RFID 4Quintessence Biosciences forms cancer therapeutic advisory board 2
... Chromo4 real-time PCR detector is an optical ... a DNA Engine or Dyad Disciple gradient-capable ... a compact scanning photonics shuttle that contains ... 500-535 nm, 555-585 nm, 620-650 nm) and ...
... highly sensitive laser confocal systems designed for ... scanners that meet your expectations, differentiating between ... optimizing the signal on the bottom as ... range for increased sensitivity. Results with VersArray ...
... four slides. The new ArraySlide 24-4 chamber ... x 7mm) individual printing surfaces for multiple ... studies. Unlike other systems, this device utilizes ... of contaminating adhesives. The chamber itself is ...
... x 3 nmol (individual) with sequence ... specifically targeted to your target gene of interestis ... you get more than 75% knockdown of your ... nM siRNA for transfection and confirmation of optimal ...
Biology Products: