Navigation Links
Promising class of antibiotics discovered for treatment of drug-resistant tuberculosis
Date:1/27/2014

St. Jude Children's Research Hospital scientists have discovered a promising new class of antibiotics that could aid efforts to overcome drug-resistance in tuberculosis (TB), a global killer. The drugs increased survival of mice infected with TB and were effective against drug-resistant strains of TB. St. Jude led the international research effort, results of which appear in the current issue of the journal Nature Medicine.

The antibiotics, called spectinamides, were created by changing the chemical structure of an existing antibiotic, spectinomycin, which does not work against TB.

In multiple trials of mice with both active and chronic TB infections, researchers report that one version of the new drugan analog known as 1599was as good as or better than current TB drugs at reducing levels of the bacteria in the lungs of mice. In addition, 1599 caused no serious side effects.

"This study demonstrates how classic antibiotics derived from natural products can be redesigned to create semi-synthetic compounds to overcome drug resistance," said corresponding author Richard Lee, Ph.D., a member of the St. Jude Department of Chemical Biology and Therapeutics. "I hope the result will be drugs that are more effective against tuberculosis and offer a faster route to a cure with fewer side effects."

TB remains a leading cause of global illness and death. The latest data from the World Health Organization estimates that TB kills 1.3 million persons annually and sickens 8.6 million worldwide. Current treatment requires months of multi-drug therapy to eradicate the slow-growing bacterium, which can lie dormant for years without causing symptoms and results in hard to treat chronic or latent infections. The rise of multi-drug resistant TB, including strains reportedly resistant to all available medications, has further complicated treatment.

This new class of antibiotics works against TB by disrupting the function of a pa
'/>"/>

Contact: Summer Freeman
summer.freeman@stjude.org
901-595-3061
St. Jude Children's Research Hospital
Source:Eurekalert  

Page: 1 2

Related biology news :

1. First complete full genetic map of promising energy crop
2. Scripps Research Institute scientists find promising vaccine targets on hepatitis C virus
3. Promising developments in early diagnosis and treatment of mesothelioma
4. Ultrasensitive biosensor promising for medical diagnostics
5. UH Case Medical Center, CardioKinetix reveal promising data for treatment for heart failure
6. 22 of Americas most promising scientists selected as Pew Biomedical Scholars
7. American Health Assistance Foundation announces grants to advance promising vision research
8. Space research institute awards funding to promising medical products
9. Promising new drug target for inflammatory lung diseases
10. Berkeley Lab scientists help develop promising therapy for Huntingtons disease
11. Stem cells + nanofibers = Promising nerve research
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Promising class of antibiotics discovered for treatment of drug-resistant tuberculosis
(Date:11/4/2014)... 2014) – A majority of Madagascar,s 101 species of ... serious consequences for the rainforests they call home. A ... impacts lemurs can have on rainforest tree populations, which ... have on the region,s rich biodiversity. , A large ... by lemurs. Lemurs in turn disperse the seeds ...
(Date:11/3/2014)... Nov. 3, 2014 Research and Markets ... Therapy - Technologies, Markets and Companies" to their offering. ... technologies and methods, which have already started to play an ... transplantation is replacing the old fashioned bone marrow transplants. Role ... is bound to become a part of medical practice. ...
(Date:11/3/2014)... Nov. 3, 2014  NeuroSigma ® , Inc. ... sciences company focused on commercialization of its non-invasive ... the treatment of neurological and neuropsychiatric disorders, announced ... has issued a Notice of Allowance for Mexican ... co-owned by NeuroSigma and the Regents of the ...
Breaking Biology News(10 mins):Gardeners of Madagascar rainforest at risk 2Gardeners of Madagascar rainforest at risk 3Global Cell Therapy - Technologies, Markets and Companies: 2014 Report 2Global Cell Therapy - Technologies, Markets and Companies: 2014 Report 3NeuroSigma Receives Notice of Allowance from the Mexican Institute of Industrial Property Covering Subcutaneous Trigeminal Nerve Stimulation (sTNS) 2NeuroSigma Receives Notice of Allowance from the Mexican Institute of Industrial Property Covering Subcutaneous Trigeminal Nerve Stimulation (sTNS) 3
... the impact of student research on life at American University,s ... Following a 2009 study at American University,s main dining ... dishes used when trays were removed, trays have mostly gone ... the first time, a new paper coauthored by AU professor ...
... Houston faculty members have been named Charter Fellows of ... contributions to scientific and technological innovation. UH faculty ... Paul Chu, a physics professor and chief scientist of ... Dan Luss, a professor in chemical and biomedical engineering, ...
... (H2S) may play a wide-ranging role in staving off ... print in the journal Molecular and Cellular Biology ... explores the compound,s plethora of potential anti-aging pathways. ... important endogenous signaling molecule because of its significant effects ...
Cached Biology News:Going trayless study shows student impact 2Going trayless study shows student impact 3National Academy of Inventors honors 3 University of Houston professors 2National Academy of Inventors honors 3 University of Houston professors 3Hydrogen sulfide: The next anti-aging agent? 2
(Date:11/22/2014)... (PRWEB) November 21, 2014 Prominent ... investors will gather on December 3rd at Genetic ... Conferences series. GeneticRx will take place at the ... School and will discuss the present and future ... exon skipping, and gene editing—as well as the ...
(Date:11/22/2014)... 22, 2014 Respiratory therapy students ... proper management of life-like respiratory ailments using the ... . Grand Rapids-based, Michigan Instruments Inc. developers of ... of the respiratory simulation units to the pro-gram, ... Valley and Muskegon Community College are collaborating to ...
(Date:11/21/2014)... USA (PRWEB) November 19, 2014 The ... our lives was shared with more than 200 primary ... postgraduate students from the University of Otago Physics Department ... . The Otago students, members of the university’s OSA/SPIE ... Zealand in early September, giving children from small, rural ...
(Date:11/21/2014)... The November 2014 issue of BioTechniques ... access journal featuring the following articles:, , ... photoresponsiveness in the retina , DNA from ... using chromogenic substrates in zebrafish , Re-use ... electrophoresis , Nuclear LC3-positive puncta in stressed ...
Breaking Biology Technology:Pioneering Academics and Key Industry Leaders to Discuss Rare Diseases and the Emergence of New Genetic Medicines at Genetic Rx on December 3rd 2Michigan Instruments Donates Two Respiratory Simulation Training and Test Lung (TTL) Devices to Grand Valley State University 2Michigan Instruments Donates Two Respiratory Simulation Training and Test Lung (TTL) Devices to Grand Valley State University 3Optics and photonics outreach programs share science, spark fascination with light 2Optics and photonics outreach programs share science, spark fascination with light 3BioTechniques: The International Journal of Life Science Methods Announces the Publication of the November 2014 Issue—Available in Print and Online 2BioTechniques: The International Journal of Life Science Methods Announces the Publication of the November 2014 Issue—Available in Print and Online 3
... ST. LOUIS, Jan. 20, 2012   On Tuesday, January ... will vote on a shareholder proposal to create a ... with its chemical products and genetically modified organisms (GMOs). ... strongest signals to date that the biotech food conglomerate ...
... PORTLAND, Ore., Jan. 20, 2012 Boulder Diagnostics Inc. ... into a license and collaboration agreement to develop rapid ... a highly specific dye technology developed at PSU. Under ... Department of Chemistry, and PSU will be entitled to ...
... Berkeley, CA A team of scientists from Bio ... the feedstocks for advanced biofuels and renewable chemicals production ... to extract the all the major sugars in seaweed ... making seaweed a cost-effective, renewable source of biomass. ...
Cached Biology Technology:Monsanto Attempts to Lockout Socially Responsible Shareholder at Annual Meeting 2Boulder Diagnostics Licenses Novel Rapid Detection Technology for Homocysteine and Related Compounds from Portland State University 2Bio architecture lab technology converts seaweed to renewable fuels and chemicals 2