Navigation Links
Promising class of antibiotics discovered for treatment of drug-resistant tuberculosis
Date:1/27/2014

St. Jude Children's Research Hospital scientists have discovered a promising new class of antibiotics that could aid efforts to overcome drug-resistance in tuberculosis (TB), a global killer. The drugs increased survival of mice infected with TB and were effective against drug-resistant strains of TB. St. Jude led the international research effort, results of which appear in the current issue of the journal Nature Medicine.

The antibiotics, called spectinamides, were created by changing the chemical structure of an existing antibiotic, spectinomycin, which does not work against TB.

In multiple trials of mice with both active and chronic TB infections, researchers report that one version of the new drugan analog known as 1599was as good as or better than current TB drugs at reducing levels of the bacteria in the lungs of mice. In addition, 1599 caused no serious side effects.

"This study demonstrates how classic antibiotics derived from natural products can be redesigned to create semi-synthetic compounds to overcome drug resistance," said corresponding author Richard Lee, Ph.D., a member of the St. Jude Department of Chemical Biology and Therapeutics. "I hope the result will be drugs that are more effective against tuberculosis and offer a faster route to a cure with fewer side effects."

TB remains a leading cause of global illness and death. The latest data from the World Health Organization estimates that TB kills 1.3 million persons annually and sickens 8.6 million worldwide. Current treatment requires months of multi-drug therapy to eradicate the slow-growing bacterium, which can lie dormant for years without causing symptoms and results in hard to treat chronic or latent infections. The rise of multi-drug resistant TB, including strains reportedly resistant to all available medications, has further complicated treatment.

This new class of antibiotics works against TB by disrupting the function of a pa
'/>"/>

Contact: Summer Freeman
summer.freeman@stjude.org
901-595-3061
St. Jude Children's Research Hospital
Source:Eurekalert  

Page: 1 2

Related biology news :

1. First complete full genetic map of promising energy crop
2. Scripps Research Institute scientists find promising vaccine targets on hepatitis C virus
3. Promising developments in early diagnosis and treatment of mesothelioma
4. Ultrasensitive biosensor promising for medical diagnostics
5. UH Case Medical Center, CardioKinetix reveal promising data for treatment for heart failure
6. 22 of Americas most promising scientists selected as Pew Biomedical Scholars
7. American Health Assistance Foundation announces grants to advance promising vision research
8. Space research institute awards funding to promising medical products
9. Promising new drug target for inflammatory lung diseases
10. Berkeley Lab scientists help develop promising therapy for Huntingtons disease
11. Stem cells + nanofibers = Promising nerve research
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Promising class of antibiotics discovered for treatment of drug-resistant tuberculosis
(Date:7/11/2014)... risk of kidney injury related to the use of ... of HES molecules, according to a report in ... Anesthesia Research Society (IARS). , The "total mass of ... cultured human renal proximal tubule cells (PTCs), concludes the ... University Hospital Wrzburg, Austria. Other factorssuch as differences ...
(Date:7/11/2014)... the hippocampus, the marginal division of the striatum ... is the impact degree of substance P in ... function? Yan Yu and his team, College of ... immunofluorescence staining, that substance P receptor, neurokinin 1 ... marginal division of normal rats. Unilateral or bilateral ...
(Date:7/11/2014)... receptor type 1 can inhibit voltage-gated calcium ... neurotransmitter release. However, some scholars demonstrated that ... Ca2+ influx and increase neurotransmitter release. Dr. ... Affiliated to Tongji Medical College, Huazhong University ... cell voltage-clamp and calcium imaging in cultured ...
Breaking Biology News(10 mins):In lab studies, hydroxyethyl starch has direct harmful effects on kidney cells 2
... Ohio Researchers, health care engineers and medical ... National Conference on Value-driven Engineering to Improve Medical ... Austen BioInnovation Institute in Akron (ABIA) and sponsored ... some of the nation,s leading biomedical device engineering ...
... many aspects of who we are from the colour ... but how are the genes, and consequently the proteins they ... new group of molecules which control some of the fundamental ... developing new therapies for treating neurodegenerative diseases. The research, ...
... in German . Leipzig/Dresden/Freiburg. In recent ... around the world. As a team of researchers from the ... Dresden and the University of Freiburg headed by the UFZ ... global pollination benefit" in the open-access journal PLoS ONE ...
Cached Biology News:Medical device, health professionals attend first national conference on value-driven engineering 2Medical device, health professionals attend first national conference on value-driven engineering 3Doubling the information from the double helix 2Global prices of pollination-dependent products such as coffee could rise in the long term 2Global prices of pollination-dependent products such as coffee could rise in the long term 3
(Date:7/10/2014)... Los Angeles, CA (PRWEB) July 10, 2014 ... Analytical and Bioanalytical techniques during 18-20 August, 2014 at ... to critically review the recent developments in Analytical & ... across the globe. , Speaking on this occasion, Dr. ... that Analytica Acta conference is a remarkable one ...
(Date:7/10/2014)... July 10, 2014  Kainos Capital, a firm specializing ... announced that it has acquired the Slim-Fast brand from ... business. Terms of the transaction were not disclosed. ... replacement business that markets ready-to-drink shakes, powders, bars and ... and in the United Kingdom ...
(Date:7/10/2014)... the fight against terrorism with the creation of a ... the use of light and special glass fibres. , ... Chemical , the researchers describe a novel optical fibre ... as 6.3 ppm (parts per million). It requires an ... explosives detection has involved looking for metals that encase ...
(Date:7/10/2014)... The lithium-ion batteries that power our laptops and electric ... a single charge with the help of a sponge-like ... to replace the graphite traditionally used in one of ... times the energy storage capacity of graphite. A paper ... was published today in Nature Communications . , ...
Breaking Biology Technology:A Critical Review of Analytical Techniques for Improved Living Standards 2A Critical Review of Analytical Techniques for Improved Living Standards 3A Critical Review of Analytical Techniques for Improved Living Standards 4Kainos Capital Acquires Slim-Fast From Unilever 2Detecting trace amounts of explosives with light 2Silicon sponge improves lithium-ion battery performance 2Silicon sponge improves lithium-ion battery performance 3
... , BOTHELL, Wash., Aug. 7 SCOLR Pharma, ... for the three and six months ended June 30, 2009. ... President and CEO, said, "We continue to advance discussions with a ... potential partners have been committing resources to due diligence and preliminary ...
... HUNTSVILLE, Ala., Aug. 7 EGEN, Inc. (EGEN), a biopharmaceutical ... that Jason Fewell, Ph.D., has been promoted from Director of ... , , Dr. Fewell possesses more than ... industry and has served at EGEN since 2003 as Director ...
... BRISBANE, Calif., Aug. 7 InterMune, Inc. (Nasdaq: ... Officer and President of InterMune, will present at the Canaccord Adams ... at 10:30 a.m. EDT. , , To access ... parties may log on to the investor relations page of InterMune,s ...
Cached Biology Technology:SCOLR Pharma, Inc. Reports Second Quarter 2009 Financial Results 2SCOLR Pharma, Inc. Reports Second Quarter 2009 Financial Results 3SCOLR Pharma, Inc. Reports Second Quarter 2009 Financial Results 4SCOLR Pharma, Inc. Reports Second Quarter 2009 Financial Results 5SCOLR Pharma, Inc. Reports Second Quarter 2009 Financial Results 6SCOLR Pharma, Inc. Reports Second Quarter 2009 Financial Results 7SCOLR Pharma, Inc. Reports Second Quarter 2009 Financial Results 8EGEN, Inc. Announces the Promotion of Jason Fewell, Ph.D., to Vice-President of Preclinical Research and Development 2
ma. plate stack height 70mm...
... 45° Fixed Angle rotor ... Centra CL2, Centra CL3/CL3R, HN-SII ... body style rotor accepts 15 ... and disposable conical tubes as ...
... The MBS Satellite Thermal Cycler ... flexible solution for medium to ... MBS combines the latest in ... software and PC control, resulting ...
...
Biology Products: