Navigation Links
Promising candidates for malaria vaccine revealed
Date:1/18/2010

Walter and Eliza Hall Institute researchers have uncovered a group of proteins that could form the basis of an effective vaccine against malaria.

Presently there is no malaria vaccine available, and these new findings support the development of a vaccine against the blood-stage of malaria.

Malaria is an infection of blood cells and is transmitted by mosquitoes. The most common form of malaria is caused by the parasite Plasmodium falciparum. Malaria parasites burrow into red blood cells by producing specific proteins. Once inside red blood cells, the parasites rapidly multiply, leading to massive numbers of parasites in the blood stream that can cause severe disease and death.

Dr James Beeson, Dr Freya Fowkes and Dr Jack Richards from the institute's Infection and Immunity division, along with Dr Julie Simpson from the University of Melbourne, have identified proteins produced by malaria parasites during the blood-stage that are effective at promoting immune responses that protect people from malaria illness.

Their findings are published today in the international journal PLoS Medicine.

Drs Fowkes and Beeson identified these proteins by reviewing and synthesising data from numerous scientific studies that had looked at the relationship between antibodies produced by the human immune system in response to malaria infection and the ability of these antibodies to protect against malaria.

Dr Beeson said malaria caused by Plasmodium falciparum was a leading cause of death and disease globally, particularly among young children. "As well as presenting an enormous health burden, malaria also has a major impact on social and economic development in countries where the disease is endemic," Dr Beeson said. "Vaccines are urgently needed to reduce the burden of malaria and perhaps eventually eradicate the disease.

"A malaria vaccine that stimulates an efficient immune response against the proteins that malaria parasites use to burrow into red blood cells would stop the parasite from replicating and prevent severe illness."

Dr Fowkes said the review of existing studies had illustrated how little was known about blood-stage malaria proteins and their suitability for use in vaccine development.

"Only about six blood-stage malaria proteins have been well studied out of a potential 100 proteins," she said. "There is an urgent need for malaria researchers to better coordinate their research efforts on these proteins. This will take us one step closer to developing an effective vaccine."


'/>"/>

Contact: Penny Fannin
fannin@wehi.edu.au
61-393-452-345
Walter and Eliza Hall Institute
Source:Eurekalert  

Related biology news :

1. UIC researchers find promising new targets for antibiotics
2. New book defines promising young field of adult neurogenesis
3. Sirtris unveils promising, novel SIRT1 activators for treating diseases of aging
4. Cancer and arthritis therapy may be promising treatment for diabetes
5. Unique whey protein is promising supplement for strict PKU diet
6. Promising new drug targets identified for Huntingtons disease
7. Promising new nanotechnology for spinal cord injury
8. Biodesigns Rittmann offers promising perspectives on societys energy challenge
9. UIC researchers make promising finding in severe lung disease
10. New treatment approach promising for lymphoma patients in the developing world
11. Immunotherapy in high-risk pediatric sarcomas shows promising response
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Promising candidates for malaria vaccine revealed
(Date:6/16/2016)... SAN FRANCISCO , June 16, 2016 /PRNewswire/ ... Market size is expected to reach USD ... report by Grand View Research, Inc. Technological proliferation ... and banking applications are expected to drive the ... ) , The development of ...
(Date:6/3/2016)... 2016 Das DOTM ... Nepal hat ein 44 Millionen ... Kennzeichen, einschließlich Personalisierung, Registrierung und IT-Infrastruktur, an ... und Implementierung von Identitätsmanagementlösungen. Zahlreiche renommierte internationale ... teilgenommen, aber Decatur wurde als konformste und ...
(Date:5/24/2016)... Ampronix facilitates superior patient care by providing unparalleled technology to leaders of the medical ... premium product recently added to the range of products distributed by Ampronix. ... ... ... Ampronix News ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... (PRWEB) , ... June 23, 2016 , ... ... is pleased to announce the launch of their brand, UP4™ Probiotics, into Target ... over 35 years, is proud to add Target to its list of well-respected ...
(Date:6/23/2016)... (PRWEB) , ... June 23, 2016 , ... ... Plate® YM (Yeast and Mold) microbial test has received AOAC Research Institute approval ... of microbial tests introduced last year,” stated Bob Salter, Vice President of Regulatory ...
(Date:6/23/2016)... ... June 23, 2016 , ... STACS DNA Inc., the ... at the Arkansas State Crime Laboratory, has joined STACS DNA as a Field Application ... team,” said Jocelyn Tremblay, President and COO of STACS DNA. “In further expanding our ...
(Date:6/23/2016)... NEW YORK , June 23, 2016 ... the trading session at 4,833.32, down 0.22%; the Dow Jones ... the S&P 500 closed at 2,085.45, down 0.17%. Stock-Callers.com has ... INFI ), Nektar Therapeutics (NASDAQ: NKTR ... BIND Therapeutics Inc. (NASDAQ: BIND ). Learn more ...
Breaking Biology Technology: