Navigation Links
Promising T cell therapy
Date:6/17/2014

This news release is available in German.

The cells of the human immune system are created from special stem cells in the bone marrow. In diseases affecting the bone marrow, such as leukemia, the degenerate cells must be destroyed using radiation or chemotherapy. Subsequently, the hematopoietic system has to be replaced with stem cells from the blood of a healthy donor. Because of the resulting temporary weakening of the immune system, patients are more exposed to viruses that would normally be warded off.

The cytomegalovirus (CMV), which can cause serious damage to lungs or liver in persons with a weakened defense, poses a major clinical problem. In healthy human beings, a CMV infection will usually not produce any symptoms, since the virus is kept at bay by specific immune cells. In their work, the scientists were able to demonstrate that the transfer of just a few specific immune cells is sufficient to protect the recipient with the weakened immune system against infections. To do this, they used T cells that can recognize and kill specific pathogens.

Tested in an animal model

Dr. Christian Stemberger, first author of the study, and his colleagues, first isolated T cells from the blood of healthy donor mice. These immune cells were directed against molecular elements of a bacterial species which normally causes severe infections in animals. The T cells were then transferred to recipient mice that, due to a genetic modification, could no longer produce immune cells of their own similarly to patients suffering from leukemia.

Following the T cell transfer, the researchers infected the treated recipient mice with the bacteria. The results showed that the animals now have effective immune protection against the pathogens, preventing th
'/>"/>

Contact: Vera Siegler
vera.siegler@tum.de
49-892-892-2731
Technische Universitaet Muenchen
Source:Eurekalert

Page: 1 2

Related biology news :

1. Promising discovery in the fight against antibiotic-resistant bacteria
2. Penn team identifies promising new target for gum disease treatment
3. New method yields potent, renewable human stem cells with promising therapeutic properties
4. Promising news for solar fuels from Berkeley Lab researchers at JCAP
5. Dartmouth researchers find promising results with local hyperthermia of tumors
6. New biological scaffold offers promising foundation for engineered tissues
7. Caltech-developed method for delivering HIV-fighting antibodies proven even more promising
8. Promising class of antibiotics discovered for treatment of drug-resistant tuberculosis
9. Scientists develop promising drug candidates for pain, addiction
10. New gene therapy proves promising as hemophilia treatment
11. T cell immunotherapy: Promising results in children and adults with leukemia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2015)... 9, 2015  Unchained Labs just can,t get ... of Avid Nano. Avid Nano designs, develops and ... Also today, Unchained Labs UNcaged ... to use protein sizing system. The pUNk is ... hydrodynamic size, size distribution, aggregation population and molecular ...
(Date:7/8/2015)... NEW YORK , July 8, 2015 ... today announced BD & Guidepoint Mentor, ... free access to Guidepoint,s expert network services. ... developing cutting-edge technologies to improve healthcare delivery and outcomes ... manager, each start-up entrepreneur will be able to directly ...
(Date:7/7/2015)... Research and Markets ... the "Capacitive Fingerprint Sensors Patent Landscape" ... date, fingerprint sensing technology is the most reliable ... well developed. This patent landscape focuses on fingerprint ... domain of capacitive fingerprint sensors is closely linked ...
Breaking Biology News(10 mins):Unchained Labs just can't get enough, acquires Avid Nano, rocks out the new pUNk! 2BD and Guidepoint Team to Connect Healthcare Start-up Companies With Business and Scientific Experts 2BD and Guidepoint Team to Connect Healthcare Start-up Companies With Business and Scientific Experts 3Worldwide Capacitive Fingerprint Sensors Patent Landscape Market Report 2015-2020 - Main IP Holders include Seiko Epson, AuthenTec, Sony and STMicroelectronics 2
... caught male topi antelopes in the act of faking fear in ... chances of having sex. The male antelopes, observed in southwest ... when females in heat are in their territories. When the females ... for some males to fit in a quick mating opportunity. ...
... , May 24 BIO-key International, Inc. (OTC Bulletin ... that Evidian has integrated BIO-key,s biometric software into its Enterprise Single ... solution at two major pharmaceutical companies. , ... (Logo: http://www.newscom.com/cgi-bin/prnh/20050509/BIOKEYLOGO ) , ...
... Neurone Disease Association is funding its first ever stem ... this fatal, neurological condition. Pulling together world-class ... Prof Sir Ian Wilmut from the University of Edinburgh; ... Tom Maniatis of Columbia University New York; the Association,s ...
Cached Biology News:Male antelopes trick females into extra sex opportunities 2Male antelopes trick females into extra sex opportunities 3BIO-key(R) Biometric Identification Now Incorporated Into Evidian Enterprise Single Sign-On Solution 2BIO-key(R) Biometric Identification Now Incorporated Into Evidian Enterprise Single Sign-On Solution 3BIO-key(R) Biometric Identification Now Incorporated Into Evidian Enterprise Single Sign-On Solution 4Harnessing the power of stem cells to unlock the secrets of motor neuron disease 2Harnessing the power of stem cells to unlock the secrets of motor neuron disease 3Harnessing the power of stem cells to unlock the secrets of motor neuron disease 4
(Date:7/29/2015)... Research and Markets ... the "Global Biosimilars Market, 2015 - 2025" ... Global Biosimilars Market, 2015 - 2025, report provides ... market. With the blockbuster biologics losing patent protection ... are being viewed as viable substitutes to the ...
(Date:7/29/2015)... July 29, 2015  Therapath Neuropathology ( www.Therapath.com ... partnerships with VA and Military Medical centers both ... Density (ENFD) and Sweat Gland Nerve Fiber Density ... ( https://therapath.com/skin ). Demonstration of ... (ENFD) on punch skin biopsy is a highly ...
(Date:7/29/2015)... NJ (PRWEB) , ... July 29, 2015 , ... The ... approval of combination products , in particular, drug/device combinations. The current system received ... by the Initiative for Patient Centered Innovation (iPCI) of Fairleigh Dickinson University’s ...
(Date:7/29/2015)... San Francisco, CA (PRWEB) , ... July 29, 2015 , ... ... wake in the morning is quite normal. Although there are a considerable number of ... is well understood that this post-sleep material is a mixture of mucus, blood cells, ...
Breaking Biology Technology:Global Biosimilars Market to 2025: Monoclonal Antibodies (mAbs), Insulin, Interferons, G-CSF/ GM-CSF, Erythropoietins and Others 2Global Biosimilars Market to 2025: Monoclonal Antibodies (mAbs), Insulin, Interferons, G-CSF/ GM-CSF, Erythropoietins and Others 3Neuropathology services for VA and Military health systems 2Third Medical Innovation Impact Index Issued by Fairleigh Dickinson University’s Initiative for Patient-Centered Innovation (iPCI) 2Third Medical Innovation Impact Index Issued by Fairleigh Dickinson University’s Initiative for Patient-Centered Innovation (iPCI) 3What Are ‘Eye Crusties’ Made Of? uBiome Invites Citizen Scientists to Find Out 2What Are ‘Eye Crusties’ Made Of? uBiome Invites Citizen Scientists to Find Out 3What Are ‘Eye Crusties’ Made Of? uBiome Invites Citizen Scientists to Find Out 4
... NATICK, Mass., Sept. 14 Boston Scientific,Corporation ... reflecting experience from the,first 15,000 patients(1) monitored ... event data represents the industry,s largest,experience with ... LATITUDE Patient Management system can detect clinical ...
... to the nanoscale look to atomic spin as one ... setting the spin of an atom, let alone measuring ... California, Berkeley, physicists have succeeded in measuring the spin ... quantum computers and "spintronic" devices built from nanoscale transistors ...
... Md., Sept. 13 Martek Biosciences,Corporation (Nasdaq: ... at the,upcoming UBS Global Life Sciences Conference in ... 24-27, 2007 at the Grand Hyatt in New,York. ... Tuesday, September 25th at,3:00 p.m. Eastern Time. ...
Cached Biology Technology:Boston Scientific Releases Remote Monitoring Data from its Wireless LATITUDE(R) Patient Management System 2Boston Scientific Releases Remote Monitoring Data from its Wireless LATITUDE(R) Patient Management System 3Boston Scientific Releases Remote Monitoring Data from its Wireless LATITUDE(R) Patient Management System 4Physicists pin down spin of surface atoms 2Physicists pin down spin of surface atoms 3
... RS232/Serial data collection and automation that is ... instrument integration with Microsoft Excel , ... meters, titrators, density meters, force gauges, spectrophotometers, ... instruments can be added and configured by ...
Mouse monoclonal [5H9] to RAD52 ( Abpromise for all tested applications). entrezGeneID: 5893 SwissProtID: P43351...
DNA sequencing - plasmids or PCR fragments, 3-7 working days service....
Purified anti-LAT...
Biology Products: