Navigation Links
Promiscuous enzymes may be recruited to aid industry, medical fields
Date:3/3/2013

COLLEGE STATION Enzymes in cells normally perform only one job, but a new study by a Texas A&M AgriLife Research scientist might figure out how to recruit enzymes for other jobs to benefit medical fields and industry.

"We know that enzymes usually have one biological function in a cell, but many are capable of doing something quite different, when given substrate molecules those at the beginning of a chemical reaction that they don't normally encounter," said Dr. Margy Glasner, AgriLife Research biochemist in College Station.

Glasner has received more than $767,000 in a five-year grant from the National Science Foundation to study how to make use of the so-called promiscuous enzymes those that have these hidden abilities in addition to their normal function.

"If mutations improve these hidden abilities, enzymes can evolve new functions that are useful to the organism," Glasner said. "In some cases, mutations cannot improve the promiscuous activity because the enzyme is an evolutionary deadend."

The key to the research will be understanding how and why certain enzymes are capable of functioning in new jobs so their ability could be applied to help people and the environment.

Her team is trying to determine why one enzyme can evolve a new function but another, related protein cannot. An enzyme is a protein that speeds up the rate of a chemical reaction.

Her work is part of the basic science which ultimately could have such applications as removing toxins from the environment, Glasner said.

"Bacteria are good at finding ways to degrade even pesticides invented in the 1950s. But we may be overtaxing natural evolutionary processes, given the quantity of such chemicals still in the environment," she said. "If we understood the mechanism of evolution better, we might be able to design enzymes that can tackle this problem. And because enzymes can work in water and are biodegradable, they could replace t
'/>"/>

Contact: Kathleen Phillips
ka-phillips@tamu.edu
979-845-2872
Texas A&M AgriLife Communications
Source:Eurekalert

Page: 1 2

Related biology news :

1. Promiscuous squid fatigued after mating
2. ORNL process improves catalytic rate of enzymes by 3,000 percent
3. Is it a rock, or is it Jell-O? Defining the architecture of rhomboid enzymes
4. Ancient enzymes function like nanopistons to unwind RNA
5. New inhibitors of elusive enzymes promise to be valuable scientific tools
6. Researchers use blood testing to predict level of enzymes that facilitate disease progression
7. Nutrient-sensing enzymes key to starvation response and survival in newborn mammals
8. Powerful enzymes create ethanol from agricultural harvest waste
9. Alnylam and UMass Medical School announce Tuschl I patent upheld in European opposition proceedings
10. Miniature pressure sensors for medical touch
11. Research!America says house funding levels for FY13 could undermine medical progress
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2014)... PROVIDENCE, R.I. [Brown University] Asteroid and comet impacts ... animals on regional or even global scales. But new ... preserve the signatures of ancient life at the time ... Brown geologist Pete Schultz has found fragments of leaves ... a several ancient impacts in Argentina. The material could ...
(Date:4/17/2014)... trials to treat tuberculosis could be the basis for ... bacteria, fungal infections and parasites, yet evade resistance, according ... collaborators. , Led by U. of I. chemistry professor ... drug SQ109 attacks the tuberculosis bacterium, how the drug ... to malaria and how targeting multiple pathways reduces ...
(Date:4/17/2014)... April 17, 2014The development of stem cell therapies to ... to characterize stem cell populations based on cell surface ... a new marker that is highly expressed in a ... blood, which they describe in an article in ... Ann Liebert, Inc., publishers. The article is available free ...
Breaking Biology News(10 mins):Impact glass stores biodata for millions of years 2Impact glass stores biodata for millions of years 3Multitarget TB drug could treat other diseases, evade resistance 2
... their native language of 1 and 0 absolutes but struggle ... While scientists are making slow, incremental progress in their quest ... body language, a more straightforward method of communication may help ... of researchers led by Charlie Kemp, director of the Center ...
... the equatorial Pacific long before Europeans arrived in the ... the way from modern-day Chile to western Mexico, according ... of Materials Science and Engineering. Details of ... years ago were reconstructed largely through the efforts of ...
... is a conspicuous and exaggerated display shaped by sexual ... attraction. At the level of the individual, song is ... Laiolo and colleagues at the Spanish Council of Research ... in north-eastern Spain and found an association between individual ...
Cached Biology News:Robot fetches objects with just a point and a click 2Robot fetches objects with just a point and a click 3Robot fetches objects with just a point and a click 4Floating a big idea: MIT demos ancient use of rafts to transport goods 2Floating a big idea: MIT demos ancient use of rafts to transport goods 3Floating a big idea: MIT demos ancient use of rafts to transport goods 4
(Date:1/15/2014)... RedBrick Health , a fast-growing leader in consumer health ... EmblemHealth , the New York -based ... RedBrick Compass health assessment, combined with the RedBrick Journeys ... EmblemHealth is among the first health plans in the ...
(Date:1/15/2014)... 15, 2014 More than 5 million ... 1 in 3 seniors will die with Alzheimer’s or ... jaw-dropping figures have shocked many Americans into looking for ... prevent these tragic age-related cognitive disorders. Jonathan Weisman, president ...
(Date:1/15/2014)... 15, 2014 DTS Language Services, Inc ... Web Portal for Life Science organizations who need document translations. ... subject matter of their documents in advance with a selection ... time-to-delivery of translations, often a critical factor in clinical and ...
(Date:1/15/2014)... AudioNotch is the internet's leading provider of Notched Sound ... Patients listen to sound therapy that is tailor-made for ... to months, their tinnitus volume decreases. , AudioNotch has previously ... Notched White Noise. Now, AudioNotch is pleased to announce to ...
Breaking Biology Technology:EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 2EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 3Biohack Pure Offers 5 Tips for Increasing Memory in 2014 2DTS Improves Efficiency for Life Science Document Translations 2
... http://www.thirdbiotech.com ), a biotechnology incubator and life ... the ThirdBiotech Research,Group including a drug discovery ... of collaborative activities between researchers,and industry for ... (Logo: http://www.newscom.com/cgi-bin/prnh/20070911/LATU119LOGO ), "Over ...
... 25 The U.S. Food and Drug,Administration ... Drugs,voted to recommend the approval of tolvaptan, ... treatment,for patients with hyponatremia., "Otsuka is ... the,potential approval of tolvaptan, an investigational selective,V2-vasopressin ...
... is,strengthening its customer-focused biomarker services portfolio to,pharmaceutical, ... Xie will lead those efforts as Battelle,s ... a suite of biomarker services, including biomarker,discovery, ... clients,better define molecular mechanisms of diseases, toxicity, ...
Cached Biology Technology:ThirdBiotech Launches Research Institute to Promote Formation and Growth of Arizona-Based Biotech Companies 2U.S. Food and Drug Administration Advisory Committee Recommends Approval of Tolvaptan, an Investigational Treatment for Hyponatremia 2Battelle Selects Xie to Develop Biomarker Services 2
... The University of New South Wales, Sydney, Australia ... Australia This is the Fourth Edition of this ... is a large format version (330 x ... 3rd edition. This product number includes the ...
For absolute protein quantification. 4 peptides in 5 vials x 2 nmol per peptide...
... The Jouan RC10 series of vacuum concentrators/centrifugal ... protection features allied to rapid and safe ... can be combined with oil-free or high ... and a wide selection of rotors (eliminating ...
Monoclonal mouse antibody for immunihistology, clone AD12, Isotype IgG 1, purified, specific for rat pyruvatekinase type L, no cross-reactivities with other pyruvate kinase isoenzymes have been obser...
Biology Products: