Navigation Links
Prolonged stress sparks ER to release calcium stores and induce cell death in aging-related diseases
Date:9/14/2009

Li et al. explain how prolonged stress sparks the endoplasmic reticulum (ER) to release its calcium stores, inducing cells to undergo apoptosis in several aging-related diseases.The study will appear in the September 21, 2009 issue of the Journal of Cell Biology (online September 14).

Stressful conditions cause misfolded proteins to accumulate in the ER. Cells try to recover by slowing down translation and increasing production of their protein folding machinery. But if the stress continues, prolonged expression of a transcription factor called CHOP promotes cell death instead. The apoptotic machinery is triggered by calcium released from the ER, but how CHOP induces this step wasn't known.

Li et al. zoomed in on two ER proteinsan oxidase called ERO1-alpha and the calcium channel IP3Rto connect the dots between CHOP induction and calcium release. ERO1-alpha is a transcriptional target of CHOP, and its reexpression in cells lacking CHOP restored the cell death pathway. On the other hand, knocking down ERO1-alpha or IP3R prevented calcium release and apoptosis in response to ER stress. Insulin-resistant obese miceknown to suffer increased ER stressshowed elevated IP3R-dependent calcium release, indicating that the pathway operates in vivo.

The researchers think that ERO1-alpha oxidizes the ER lumen, promoting the formation of a key disulphide bond in IP3R that makes the channel more active. Senior author Ira Tabas points out the importance of understanding this mechanism further: mice lacking CHOP are protected against cell death arising from a variety of pathologies, including advanced atherosclerosis, diabetes, and neurodegeneration.


'/>"/>

Contact: Rita Sullivan
news@rupress.org
212-327-8603
Rockefeller University Press
Source:Eurekalert

Page: 1

Related biology news :

1. Prolonged effects of a warming anomaly on grasslands
2. Breathless babies: Preemies lung function shows prolonged impairment
3. Prolonged respiratory problems for oil spill clean-up volunteers
4. New method monitors early sign of oxidative stress in cancer
5. Study of huge numbers of genetic mutations point to oxidative stress as underlying cause
6. Hormone levels contribute to stress resilience
7. Stress signals link pre-existing sickness with susceptibility to bacterial infection
8. Short stressful events may improve working memory
9. Stop and smell the flowers -- the scent really can soothe stress
10. Help for climate-stressed corals
11. Stress puts double whammy on reproductive system, fertility
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/13/2017)... , April 13, 2017 UBM,s Advanced ... will feature emerging and evolving technology through ... Innovation Summits will run alongside the expo portion of ... sessions, panels and demonstrations focused on trending topics within ... advanced design and manufacturing event will take place June ...
(Date:4/11/2017)... April 11, 2017 No two people ... at the New York University Tandon School of ... have found that partial similarities between prints are ... in mobile phones and other electronic devices can ... The vulnerability lies in the fact that fingerprint-based ...
(Date:4/5/2017)... 5, 2017 Today HYPR Corp. , ... server component of the HYPR platform is officially ... end-to-end security architecture that empowers biometric authentication across Fortune ... already secured over 15 million users across the financial ... connected home product suites and physical access represent a ...
Breaking Biology News(10 mins):
(Date:4/20/2017)... Koert van Mensvoort - founder of the Next Nature Network and ... has written a ,Letter to Humanity, in support of International Earth ... and victim to its own technology, but to employ technology to enhance our ... ... of the Next Nature Network and Fellow of ‘Next Nature’ at the University ...
(Date:4/19/2017)... ... April 18, 2017 , ... The Vibrating ... key device for generating monodisperse droplets of known diameters for research applications such ... monodisperse solid particles by drying monodisperse droplets. , The VOAG requires forcing ...
(Date:4/19/2017)... , ... April 18, 2017 , ... ... Halo Labs . The move comes after the company changed focus to making ... our new brand and our new technology,” says CEO Robert Hart. Founders Bernardo ...
(Date:4/19/2017)... ... April 19, 2017 , ... WHO: Peggy Lillis ... through education and advocacy. Founded in 2010 in memory of a single-parent mom ... foundation has become the most-consulted source for patient-focused information on C. diff infections ...
Breaking Biology Technology: