Navigation Links
Proliferation cues 'natural killer' cells for job change
Date:6/12/2014

PROVIDENCE, R.I. [Brown University] The immune system maintains a rich abundance of "natural killer" cells to confront microbial invaders, but as the body gains the upper hand in various infections it sometimes starts to produce even more of the cells. For three decades, scientists haven't understood what purpose that serves. In a new paper, Brown University researchers show one: proliferation helps change the NK cells' function from stimulating the immune response to calming it down, lest it get out of hand.

In a series of experiments now published online in the Journal of Immunology, the researchers show that the process of proliferation unlocks expression of the gene in NK cells for producing Interleukin-10(IL-10), a protein that moderates other immune system cells.

"It's really important for regulating potentially dangerous CD8 T cell responses," said Margarite Tarrio, co-lead author of the paper and a graduate student in the lab of Brown immunology Professor Christine Biron. "If you get CD8 T cells that are hyperactivated they can cause a tremendous amount of damage."

Ever since Biron and colleagues published the first observations of NK cell proliferation in 1982, she has sought to figure out why it happens. Knowing the answer is important both as a matter of basic immunology and because NK cells, as crucial members of the body's first line of infection defense, are often the subjects of efforts to harness the immune system in protection against infections and cancer.

"The work provides another important role for lymphocyte proliferation, to set up the conditions needed for changing function," Biron said. "It is likely to be part of the mechanism for changing the functions of other immune cells, and the insight may help in designing vaccines."

Shown down to the gene

An association between NK cells and IL-10 production doesn't necessarily emerge in all infections,
'/>"/>

Contact: David Orenstein
david_orenstein@brown.edu
401-863-1862
Brown University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Deer proliferation disrupts a forests natural growth
2. Stem cell proliferation and differentiation observed within hydrogel
3. Scientists discover a natural molecule to treat type 2 diabetes
4. Hijacking bacterias natural defences to trap and reveal pathogens
5. Stanford researchers rethink natural habitat for wildlife
6. Significant baseline levels of arsenic found in Ohio soils are due to natural processes
7. Problem wells source of greenhouse gas at unexpected stage of natural gas production
8. Academy of Natural Sciences receives major grant for program to protect drinking water
9. Natural history dying of neglect
10. Natural plant compounds may assist chemotherapy
11. Decline of natural history troubling for science, society
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Proliferation cues 'natural killer' cells for job change
(Date:4/14/2015)... April 14, 2015  HYPR Corp. today announced ... ® ) Alliance tm , an industry consortium ... commit to share technology and collaborate to deliver ... interoperable, more secure and private, and easier to ... verification that protects sensitive user information and eliminates ...
(Date:4/13/2015)...  higi, a leading cloud-based consumer engagement platform that ... with their communities around health and wellness, announced today ... API.  ... and convenient vehicle to receive validated health information from ... The API will allow higi,s trusted partners, on a ...
(Date:4/8/2015)... , April 8, 2015  Infinisource, a leading ... services, and Morpho, a leading supplier of biometric ... produce the market,s most advanced biometrically-enabled time clock, ... NXG time clock is setting a bold, new ... data for the small and mid-size employer. When ...
Breaking Biology News(10 mins):HYPR Corp. Joins the FIDO Alliance 2HYPR Corp. Joins the FIDO Alliance 3higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 2higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 3iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 3
... of microbes is essential for promoting human and environmental ... of America,s (ESA) 96th Annual Meeting from August 7-12, ... the human body and other research on microbial and ... in Austin, Texas. Bellybutton microbiomes ...
... release is available in Spanish . Rising ... predicted higher temperatures on semi-arid rangelands, according to a study ... a team of U.S. Department of Agriculture (USDA) and university ... the atmosphere, leading to drier soils. In contrast, higher CO2 ...
... the levels of a natural body chemical may allow doctors ... health outcomes of critically ill patients. "Infection is a ... to find ways to improve the outcomes of sick, elderly ... says Daren Heyland, a professor of Medicine at Queen,s, director ...
Cached Biology News:USDA scientists study effects of rising carbon dioxide on rangelands 2Finding could reduce antibiotic use in critically ill patients 2
(Date:4/30/2015)... Nitto Avecia, a leading biotechnology manufacturer and oligonucleotide ... capability to serve biotechnology pharmaceutical clients. A commitment ... to drive Nitto Avecia to enhance synthesis scale ... , In Fall 2014, Nitto Avecia first demonstrated ... Milford, MA facility, which is recognized as a ...
(Date:4/30/2015)... 2015  The Paul G. Allen Family Foundation announced ... to six groups of researchers with projects at the ... neuroscience: growing mature human brain cells in the laboratory. ... million over three years.  "This new ... especially significant because the field of neuronal maturation is ...
(Date:4/30/2015)... SHANGHAI , April 30, 2015 WuXi ... WX ), a leading global contract R&D services provider, ... a preliminary non-binding proposal letter, dated April 29, 2015, ... Ge Li (the "Chairman"), founder, chairman and chief ... Capital Partners ("ABG") that proposes a transaction (the "Transaction") ...
(Date:4/30/2015)... California (PRWEB) April 30, 2015 ... 2015 PharmaSUG Annual Conference held in Orlando, ... of Staffing Solutions along with Leslie Kolman, Manager of ... the latest Clinovo news at Booth #17. , ... Annual Conference again this year”, Says Trisha Heredia, Senior ...
Breaking Biology Technology:Biotechnology Manufacturer Nitto Avecia Expands Capacity to Meet Client Demand 2The Paul G. Allen Family Foundation Awards $7.5 Million To Study Brain Cell Growth And Development 2The Paul G. Allen Family Foundation Awards $7.5 Million To Study Brain Cell Growth And Development 3The Paul G. Allen Family Foundation Awards $7.5 Million To Study Brain Cell Growth And Development 4The Paul G. Allen Family Foundation Awards $7.5 Million To Study Brain Cell Growth And Development 5WuXi PharmaTech Announces Receipt of Proposal 2WuXi PharmaTech Announces Receipt of Proposal 3WuXi PharmaTech Announces Receipt of Proposal 4WuXi PharmaTech Announces Receipt of Proposal 5WuXi PharmaTech Announces Receipt of Proposal 6Clinovo Exhibits at the 2015 PharmaSUG Annual Conference on May 17-20th in Orlando, FL 2Clinovo Exhibits at the 2015 PharmaSUG Annual Conference on May 17-20th in Orlando, FL 3
... Emerging Growth Equities,Ltd. initiates coverage of CombiMatrix Corporation ... an $18.00 price target. CombiMatrix is a life ... genetic,diagnostics that leverage its core CustomArray technology., ... and investment,banking firm that provides high quality distribution, ...
... Product Line Extension Builds on Existing Brand Strength and Pediatric ... ... Focus, PLYMOUTH MEETING, Pa., Aug. 18 /Xinhua-PRNewswire-FirstCall/ ... that the Sunstone (Tangshan) Pharmaceutical Co., Ltd.,("Sunstone"), its wholly-owned subsidiary, ...
... of Trade Alerts on stocks making news today., Investors ... by visiting:, http://www.BeaconEquity.com/m , Today,s Trade Alerts include: Elan ... ), Amgen Inc. (Nasdaq: AMGN ), Genentech Inc. (NYSE: ... Gilead Sciences Inc. (Nasdaq: GILD )., Join the ...
Cached Biology Technology:Emerging Growth Equities, Ltd. Initiates Coverage of CombiMatrix Corporation with a BUY Rating and an $18.00 Price Target 2BMP Sunstone Receives Production License from the SFDA to Manufacture and Market Pediatric Multivitamin Granules in the PRC 2BMP Sunstone Receives Production License from the SFDA to Manufacture and Market Pediatric Multivitamin Granules in the PRC 3BMP Sunstone Receives Production License from the SFDA to Manufacture and Market Pediatric Multivitamin Granules in the PRC 4BeaconEquity.com Issues Trade Alerts on Biotechnology Stocks: ELN, PFE, AMGN, DNA, BIIB, GILD 2BeaconEquity.com Issues Trade Alerts on Biotechnology Stocks: ELN, PFE, AMGN, DNA, BIIB, GILD 3
This device is designed to run four simultaneous separations with the following StemSep ; column sizes: 0.3in., 0.5in., and 0.6in.. Depending on the column size, a range of 2x10 7 - 1.5 x 10 9 cell...
... sensitive silver stain. Reproducible ... baths or reversers needed. ... polysaccharides. Linear protein-to-stain color ... multiple gels per tray. ...
... to rapidly and reliably amplify unknown ... APA Technology. APAgene provides hassle-free, ready-to ... price. All necessary ingredients are provided ... can be used for identifying transgene/genomic ...
... This CLS number is a ... easily match Cornings product number. ... please order under the old ... customer service for assistance. ID ...
Biology Products: