Navigation Links
Project aims to fuse top-down, bottom-up approaches in systems biology
Date:5/4/2011

The National Institutes of Health has awarded Virginia Tech researchers a $2.13 million grant to develop new systems biology approaches to study cells, one of the most basic units of life. Systems biology aims to study complex cellular systems by systematically stimulating them, monitoring cellular responses, formulating mathematical and computational models to understand the data, and proposing new experiments to refine these models.

T.M. Murali, associate professor of computer science at Virginia Tech https://bioinformatics.cs.vt.edu/~murali/; John Tyson, university distinguished professor of biology, http://www.biol.vt.edu/faculty/tyson/; and Jean Peccoud of the Virginia Bioinformatics Institute http://www.vbi.vt.edu/faculty/personal/Jean_Peccoud, proposed to the National Institutes of Health a novel approach to link the two dominant paradigms in systems biology.

NIH is awarding the interdisciplinary team for their proposal titled "Integrating Top-Down and Bottom-Up Models in Systems Biology with Application to Cell Cycle Control in Budding Yeast."

Murali, principal investigator, described the project: "Two distinct approaches are being used to study complex cellular systems. The first, top-down approach automatically analyzes large-scale datasets for correlations between genes and proteins. However, it is often difficult to design experiments from these results.

"The second, bottom-up approach painstakingly crafts detailed models that can be simulated computationally. Although such simulations can suggest wet lab experiments, developing the models is a manual process that can take many years. These approaches have largely been developed separately until now. Our project will meld the strengths of these two approaches into a single framework
'/>"/>

Contact: Lynn Nystrom
tansy@vt.edu
540-231-4371
Virginia Tech
Source:Eurekalert  

Page: 1 2

Related biology news :

1. €12 million ($16.9 million) project to develop new tools for malaria control
2. Uncertain future for Joshua trees projected with climate change
3. BGI to Play Pivotal Sampling, Next-Generation Sequencing and Bioinformatics Role in Earth Microbiome Project
4. Drier conditions projected to accelerate dust storms in the southwest
5. Climate projections show human health impacts possible within 30 years
6. Former ASPB president leading sustainable bioenergy education project
7. $4 million project to protect Irish and Scottish waterways
8. LCD projector used to control brain and muscles of tiny organisms such as worms
9. Water, water everywhere focus of new sustainability project
10. Grants fund projects that will tackle Grand Challenges
11. Patriot Data Solutions Group Selected to Assist Louisiana District Attorney Association with Pilot Project
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Project aims to fuse top-down, bottom-up approaches in systems biology 
(Date:12/19/2014)... Research and Markets ( http://www.researchandmarkets.com/research/86ncd6/micro_market ) has announced ... Perimeter Security Systems Market" report to their offering. ... American perimeter security market is estimated to grow at a ... market holds a larger share in this market, ...
(Date:12/17/2014)... and Markets ( http://www.researchandmarkets.com/research/s6qzt5/samsung_galaxy_s5 ) has announced ... Home Button Synaptics Fingerprint Sensor Technology Analysis" report ... Based on a totally different sensing ... first time a fingerprint sensor in its product. ...
(Date:12/17/2014)... Dec. 16, 2014 Valencell, a leader in performance ... technology to industry leaders such as Intel, Jabra, Atlas, ... biometric wearable products. These products will be showcased at ... Las Vegas . "Our partners ...
Breaking Biology News(10 mins):Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 3Samsung Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology Analysis 2Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2
... -- Vision researchers at Barrow Neurological Institute have ... sources to human vision. By tuning lighting devices to ... believe billions of dollars in energy costs could be ... by Stephen Macknik, PhD, of Barrow,s Laboratory of Behavioral ...
... fossil fuel burning and forest fires reaches all the ... long before it travels that far. Now, lab research ... than ride on the surface of airborne particles, pollutants ... The results will help scientists improve atmospheric air-quality and ...
... Wash.Washington State University researchers have found an unlikely recipe for ... urine infused with metabolized antibiotic. The urine will kill off ... antibiotic-resistant E. coli will survive in the soil ... bedding. , "I was surprised at how well this works, ...
Cached Biology News:Barrow scientists discover ways to optimize light sources for vision 2Airborne particles smuggle pollutants to far reaches of globe 2Airborne particles smuggle pollutants to far reaches of globe 3WSU scientists find new way for antibiotic resistance to spread 2
(Date:1/22/2015)... January 22, 2015 Shimadzu Scientific ... UV-1280 multipurpose UV-visible spectrophotometer. Offering wavelength scanning from ... is ideal for applications in a variety of ... , The user-friendly UV-1280 enables intuitive operation, while ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 GEA Niro ... table top laboratory homogenizer, the PandaPLUS 2000, which is ... nanoemulsions , and cell disruption . This compact ... products, fruit juices, liquid food, food additives and ingredients ...
(Date:1/22/2015)... (PRWEB) January 21, 2015 Cambridge Semantics, the ... technology, today announced that 2014 was a record-breaking year across ... capabilities of the Anzo Smart Data Platform and our Smart ... utilize insights from diverse data which led to record growth ...
(Date:1/22/2015)... Protocol Networks brings independent technology consulting to ... independent consultants, Protocol Networks has recently announced its expansion ... years, his company has attracted several clients in The ... well as others. With the success of these engagements, ...
Breaking Biology Technology:Shimadzu’s New Monitored Single-Beam UV-Vis Spectrophotometer Offers Comprehensive Measurement Options in a Compact Body 2GEA Niro Soavi Announces the PandaPLUS 2000 Homogenizer for Processing New Applications for Nanoemulsions and Cell Disruption 2Cambridge Semantics Announces Record Results for 2014 2Protocol Networks Brings Independent Technology Consulting to the Constitution State 2
... and Successful Mobile Imaging ... Services Network, ... a leading provider of medical diagnostic imaging systems,and services to physicians, ... Frost & Sullivan,s 2007 North American,Nuclear Medicine Equipment Product Line Strategy ...
... P. Supports Program to Recognize Exemplary Work, ... commitment of oncology nurses, Ortho Biotech Products, L. ... Extraordinary Healer,Award for Oncology Nursing, which honors one ... daily their unwavering,dedication, compassion and helpfulness. Last year, ...
... Presentation to be Webcast -, MONTVALE, N.J., Feb. ... today that Noah Berkowitz, M.D., Ph.D.,President and Chief Executive ... BIO CEO & Investor Conference on Monday, February 11,2008 ... held from February 11 -,13, 2008 at the Waldorf-Astoria ...
Cached Biology Technology:Digirad Corporation to Receive Frost & Sullivan 2007 North American Award for Product Strategy 2Digirad Corporation to Receive Frost & Sullivan 2007 North American Award for Product Strategy 3Call for Entries - 2008 CURE Extraordinary Healer Award for Oncology Nursing 2Synvista Therapeutics to Present at the 10th Annual BIO CEO & Investor Conference 2Synvista Therapeutics to Present at the 10th Annual BIO CEO & Investor Conference 3
... from Magnetofection technology, SilenceMag is the ... Simple, rapid and easy to use, ... toxic. Specifically designed for siRNA delivery, ... very low doses of siRNA.,SilenceMag formulation ...
... Labeling Kit provides a unique signal amplification ... targets, including cell-surface receptors and subcellular structures. ... the patented ELF 97 phosphatase substrate, which ... the site of enzymatic activity a ...
... from Magnetofection technology, SilenceMag is the ... Simple, rapid and easy to use, ... toxic. Specifically designed for siRNA delivery, ... very low doses of siRNA.,SilenceMag formulation ...
... Radiochemical Purity is >95%NEN Radiolabeled Ligands\n\nReceptor-related ... continual availability of new radiolabeled ligands selected ... offers a wide range of products and ... including over 400 state-of-the-art radioligands. If you ...
Biology Products: