Navigation Links
Project aims to fuse top-down, bottom-up approaches in systems biology
Date:5/4/2011

The National Institutes of Health has awarded Virginia Tech researchers a $2.13 million grant to develop new systems biology approaches to study cells, one of the most basic units of life. Systems biology aims to study complex cellular systems by systematically stimulating them, monitoring cellular responses, formulating mathematical and computational models to understand the data, and proposing new experiments to refine these models.

T.M. Murali, associate professor of computer science at Virginia Tech https://bioinformatics.cs.vt.edu/~murali/; John Tyson, university distinguished professor of biology, http://www.biol.vt.edu/faculty/tyson/; and Jean Peccoud of the Virginia Bioinformatics Institute http://www.vbi.vt.edu/faculty/personal/Jean_Peccoud, proposed to the National Institutes of Health a novel approach to link the two dominant paradigms in systems biology.

NIH is awarding the interdisciplinary team for their proposal titled "Integrating Top-Down and Bottom-Up Models in Systems Biology with Application to Cell Cycle Control in Budding Yeast."

Murali, principal investigator, described the project: "Two distinct approaches are being used to study complex cellular systems. The first, top-down approach automatically analyzes large-scale datasets for correlations between genes and proteins. However, it is often difficult to design experiments from these results.

"The second, bottom-up approach painstakingly crafts detailed models that can be simulated computationally. Although such simulations can suggest wet lab experiments, developing the models is a manual process that can take many years. These approaches have largely been developed separately until now. Our project will meld the strengths of these two approaches into a single framework, thereby allowing efficient and automated data-driven analysis to augment models that can be simulated."

The advantage of the collaborative research is the merging of the expertise of the three researchers. Murali conducts research in network and combinatorial algorithms in the context of systems biology. Tyson's group has used differential equations to model regulatory networks for over 20 years. Peccoud is a molecular geneticist by training, and has proposed methods to map genotypes to phenotypes using differential equation models of molecular networks.

The three scientists will develop a framework for generating hypotheses from top-down models, test these hypotheses by integrating them into bottom-up models, and validating the hypotheses using experiments. They will use these developments to study cell division in budding yeast.

"With an improved understanding of cell cycle regulation in budding yeast, we should be able to suggest novel experiments that provide a better understanding of molecular control systems," Murali explained. Murali projected that the "methods developed in this project should be relevant to the study of any complex cellular system, including the development of cancer and the spread of infectious diseases. If we are successful, our project will result in significant advances in computationally driven experimental biology."


'/>"/>

Contact: Lynn Nystrom
tansy@vt.edu
540-231-4371
Virginia Tech
Source:Eurekalert  

Related biology news :

1. €12 million ($16.9 million) project to develop new tools for malaria control
2. Uncertain future for Joshua trees projected with climate change
3. BGI to Play Pivotal Sampling, Next-Generation Sequencing and Bioinformatics Role in Earth Microbiome Project
4. Drier conditions projected to accelerate dust storms in the southwest
5. Climate projections show human health impacts possible within 30 years
6. Former ASPB president leading sustainable bioenergy education project
7. $4 million project to protect Irish and Scottish waterways
8. LCD projector used to control brain and muscles of tiny organisms such as worms
9. Water, water everywhere focus of new sustainability project
10. Grants fund projects that will tackle Grand Challenges
11. Patriot Data Solutions Group Selected to Assist Louisiana District Attorney Association with Pilot Project
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Project aims to fuse top-down, bottom-up approaches in systems biology 
(Date:4/11/2017)... 11, 2017 NXT-ID, Inc. (NASDAQ:   ... announces the appointment of independent Directors Mr. Robin D. ... Board of Directors, furthering the company,s corporate governance and expertise. ... Gino Pereira , ... forward to their guidance and benefiting from their considerable expertise ...
(Date:4/5/2017)... April 5, 2017 Today HYPR Corp. ... the server component of the HYPR platform is officially ... the end-to-end security architecture that empowers biometric authentication across ... has already secured over 15 million users across the ... of connected home product suites and physical access represent ...
(Date:4/3/2017)... 2017  Data captured by IsoCode, IsoPlexis ... a statistically significant association between the potency ... and objective response of cancer patients post-treatment. ... whether cancer patients will respond to CAR-T ... as to improve both pre-infusion potency testing and ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... 12, 2017 , ... BioMedGPS announces expanded coverage of SmartTRAK ... module, US Hemostats & Sealants. , SmartTRAK’s US Market for Hemostats and Sealants ... sealants and biologic sealants used in surgical applications. BioMedGPS estimates the market will ...
(Date:10/12/2017)... , ... October 12, 2017 ... ... has launched Rosalind™, the first-ever genomics analysis platform specifically designed for life ... Named in honor of pioneering researcher Rosalind Franklin, who made a major ...
(Date:10/11/2017)... (PRWEB) , ... October 11, 2017 , ... ... any gene in its endogenous context, enabling overexpression experiments and avoiding the use ... with small RNA guides is transformative for performing systematic gain-of-function studies. , ...
(Date:10/11/2017)... USA (PRWEB) , ... October 11, 2017 , ... ComplianceOnline’s ... take place on 7th and 8th June 2018 in San Francisco, CA. The Summit ... as well as several distinguished CEOs, board directors and government officials from around the ...
Breaking Biology Technology: