Navigation Links
Progress toward treating infections by silencing microbes' 'smart phones'
Date:10/20/2010

So disease-causing bacteria in the body finally have multiplied to the point where their numbers are large enough to cause illness. What's next? They get out their "smart phones" and whisper "Let's roll!" That's how an article in ACS' monthly Chemical Reviews describes the substances "smart phones of the microbial world" that bacteria use to transmit chemical signals that launch infections and monitor their environment. The authors describe progress toward understanding and blocking this biochemical chitchat, a development that could lead to new treatments for the growing problem of antibiotic-resistant infections.

Marvin Whiteley and Holly Huse point out that bacteria use chemical signals to communicate with each other. These signals can trigger infections when their numbers reach a certain threshold a process known as "quorum sensing." Scientists around the world are trying to find potential new drugs that garble or block those signals, and in doing so, fight infection. One prime target are the 4-quinolones, signaling molecules produced by Pseudomonas aeruginosa, a common disease-causing microbe.

Their review of more than 60 years of research on 4-quinolones found promising indications that such a conversation-stopper will be developed. Scientists, for instance, now have evidence that a certain enzyme that modifies 4-quinolones can reduce infection. "These results are encouraging for the development of new therapeutics that target 4-quinolone signaling," the article noted.


'/>"/>

Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society
Source:Eurekalert

Page: 1

Related biology news :

1. Progress toward first commercial repellent for East Coasts stinker
2. Erlotinib improves progression-free survival as first-line therapy in advanced lung cancer
3. Gene-environmental interactions and MS progression is focus of new study
4. Stem cell research: What progress has been made, what is its potential?
5. 23rd ECNP Congress: Pioneering CNS research -- translating neuroscience into clinical progress
6. At opening of XVIII International AIDS Conference, scientific, community and political leaders applaud recent progress toward universal access and urge continued momentum to finish what weve started
7. Progress made in addressing food marketing to children, but challenges remain
8. Families with rare forms of diabetes gather to celebrate progress
9. The forests of the Basque Country are progressing -- slowly, according to research group
10. 5th Annual Szent-Györgyi Prize for Progress in Cancer Research awarded
11. Study identifies key cause of chronic leukemia progression
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/22/2014)... Genomes Project, aims to accelerate breeding for desired traits ... health and welfare. Results of the project,s first phase ... individual bulls whose direct descendants number in the tens ... Nature Genetics . , According to the researchers, breeding ... hereditary diseases and to improve the efficency of milk ...
(Date:7/22/2014)... the National Institute of Standards and Technology (NIST), ... dramatically improved technique for analyzing biological cells and ... new NIST technique is an advanced form of ... that delivers signals that are 10,000 times stronger ... times stronger than obtained from comparable "coherent Raman" ...
(Date:7/22/2014)... contrast to their negative reputation as disease causing ... evolutionary functions that help to shape the world ... report by the American Academy of Microbiology. , ... all life forms on the planet, from contributing ... driving major speciation events," states Marilyn Roossinck of ...
Breaking Biology News(10 mins):Whole-genome sequencing of bulls in key beef and dairy breeds 2Enhanced NIST instrument enables high-speed chemical imaging of tissues 2Enhanced NIST instrument enables high-speed chemical imaging of tissues 3Report on viruses looks beyond disease 2
... and scents to attract pollinators has long fascinated ... researchers have gained intriguing insights into the intimate ... The study, published in the British Ecological Society,s ... to measure how much energy hummingbirds use while ...
... the online issue of Advanced Materials on Nov. ... an infrared laser, light up to reveal their location. ... gold nanoparticles covered with molecules called Raman reporters, in turn ... a dodecahedron. The Raman reporters are molecules whose jiggling ...
... HEIDELBERG, 20 November 2012 Scientists have engineered bacteria ... of the bacterial population. These altruistically inclined bacteria, which ... Biology , can be used to demonstrate the conditions ... the survival of the bacterial population. "We have ...
Cached Biology News:High-speed video and artificial flowers shed light on mysteries of hummingbird-pollinated flowers 2Tiny probes shine brightly to reveal the location of targeted tissues 2Tiny probes shine brightly to reveal the location of targeted tissues 3Engineered bacteria can make the ultimate sacrifice 2
(Date:7/22/2014)... CTD Holdings, Inc. (OTCQB:CTDH), a manufacturer and distributor ... other markets, announced today that it has closed on ... investors led by Novit L.P., an investment arm of ... the signing of a Securities Purchase Agreement under which ... a price per share of $1.00, resulting in a ...
(Date:7/22/2014)... Parsippany, NJ (PRWEB) July 22, 2014 ... analytical, precision, portable, and mechanical balances and scales, ... precision balances has won Laboratory Equipment magazine’s 2014 ... is the second consecutive year the Explorer was ... readers. The annual Readers’ Choice Awards celebrates “excellence ...
(Date:7/22/2014)... and SHENZHEN, China , July ... LTD, (BGI Tech), a subsidiary of BGI, the ... launch of a new human whole exome sequencing ... newly offered service includes in-depth bioinformatics analysis and ... until December 31, 2014. Complete ...
(Date:7/22/2014)... Quorum Review IRB, the industry leader in central IRB ... Quick Step™ . The offering went live on July ... need for seamless study start-up with a large volume of ... 50 or more North American investigator sites, as well as ... of 80 or more. Qualifying studies may also enroll international ...
Breaking Biology Technology:CTD Holdings Closes $1.725 Million Private Placement 2CTD Holdings Closes $1.725 Million Private Placement 3OHAUS Explorer Voted “Best Balance” in Laboratory Equipment’s 2014 Readers’ Choice Awards 2BGI Tech Launches Human Whole Exome Sequencing Service on Complete Genomics' Advanced Platform 2BGI Tech Launches Human Whole Exome Sequencing Service on Complete Genomics' Advanced Platform 3Quorum Review IRB Launches New Quick Step™ Service for Large Clinical Trials 2Quorum Review IRB Launches New Quick Step™ Service for Large Clinical Trials 3
... now, trademark owners have been battling search engines and ... (trademarks) that trigger online advertising. Two recent and conflicting ... and law to the new keyword technology can be ... in a recent court ruling on advertising triggered by ...
... easy to overlook last week's flurry of announcements from hard disk ... hard drives for more than 20 years - and disk storage ... greatest excitement comes from news that someone has packed another gigabyte ... won't blame you if you didn't pay much attention to - ...
... judged Milwaukee by the economic indicators alone, you might ... dusty, bypassed town in the hit animated movie Cars. ... ending, maybe theres a more prosperous, real-life road ahead ... because without a healthy Milwaukee, most of Wisconsin will ...
Cached Biology Technology:Keyword advertisers win some, lose some 2Keyword advertisers win some, lose some 3Keyword advertisers win some, lose some 4Keyword advertisers win some, lose some 5Digital Media Superstar: Seagate? 2Digital Media Superstar: Seagate? 3It's an economic fact: As Milwaukee goes, so goes Wisconsin 2It's an economic fact: As Milwaukee goes, so goes Wisconsin 3
Recommend to use at 1000X dilutions for cell culture (e.g. Add 1 ul to 1 ml of culture medium.)...
...
PHOTOMAN DIRECT COPY CAMERA, 1 EA. Category: Nucleid Acid Detection Systems....
...
Biology Products: