Navigation Links
Programmable DNA scissors found for bacterial immune system
Date:6/28/2012

Genetic engineers and genomics researchers should welcome the news from the Lawrence Berkeley National Laboratory (Berkeley Lab) where an international team of scientists has discovered a new and possibly more effective means of editing genomes. This discovery holds potentially big implications for advanced biofuels and therapeutic drugs, as genetically modified microorganisms, such as bacteria and fungi, are expected to play a key role in the green chemistry production of these and other valuable chemical products.

Jennifer Doudna, a biochemist with Berkeley Lab's Physical Biosciences Division and professor at the University of California (UC) Berkeley, helped lead the team that identified a double-RNA structure responsible for directing a bacterial protein to cleave foreign DNA at specific nucleotide sequences. Furthermore, the research team found that it is possible to program the protein with a single RNA to enable cleavage of essentially any DNA sequence.

"We've discovered the mechanism behind the RNA-guided cleavage of double-stranded DNA that is central to the bacterial acquired immunity system," says Doudna, who holds appointments with UC Berkeley's Department of Molecular and Cell Biology and Department of Chemistry, and is an investigator with the Howard Hughes Medical Institute (HHMI). "Our results could provide genetic engineers with a new and promising alternative to artificial enzymes for gene targeting and genome editing in bacteria and other cell types."

Doudna is one of two corresponding authors of a paper in the journal Science describing this work titled "A programmable dual RNA-guided DNA endonuclease in adaptive bacterial immunity." The second corresponding author is Emmanuelle Charpentier of the Laboratory for Molecular Infection Medicine at Sweden's Ume University. Other co-authors of the paper were Martin Jinek, Krzysztof Chylinski, Ines Fonfara and Michael Hauer.

Bacterial and archaeon
'/>"/>

Contact: Lynn Yarris
lcyarris@lbl.gov
510-486-5375
DOE/Lawrence Berkeley National Laboratory
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. $500,000 Gruber Foundation Genetics Prize goes to Philadelphia scientist
2. Foundational concept of ecology tested by experiment
3. Clues to nervous system evolution found in nerve-less sponge
4. UCSF pair win Gruber Foundation Neuroscience prize
5. AGU: Unique microbes found in extreme environment
6. Esther B. OKeeffe Foundation gives $2 million to the Scripps Research Institute
7. Nuisance seaweed found to produce compounds with biomedical potential
8. A whale of a discovery: New sensory organ found in rorqual whales
9. Human-like spine morphology found in aquatic eel fossil
10. National Psoriasis Foundation awards more than $2 million for research
11. New York Stem Cell Foundation scientist grows bone from human embryonic stem cells
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Programmable DNA scissors found for bacterial immune system
(Date:7/24/2014)... on different species of fish, according to a ... Exeter which tested fish anti-predator behaviour. , ... predator model when exposed to additional noise, whereas ... , Lead author Dr Irene Voellmy of Bristol,s ... many aquatic environments have increased substantially during the ...
(Date:7/24/2014)... terroir, meaning the microbial populations found on surfaces in ... the final flavor according to research published ahead of ... . This is the first time investigators have taken ... Many sake makers inoculate with both bacteria and yeast, ... of California, Davis, but he and his colleagues investigated ...
(Date:7/24/2014)... at NJIT this week for an all-day public forum ... Protection Agency (EPA) to dredge toxic sediment from an ... EPA has called the plan, which proposes removing 4.3 ... of the riverbed, one of the largest cleanups in ... and disposed off-site. , "We need to ensure the ...
Breaking Biology News(10 mins):The microbes make the sake brewery 2Experts Weigh the Pros and Cons of a $1.7 Billion EPA Cleanup Plan for the Passaic River at an NJIT 2
... scientists survey five New York flu seasons , On the ... for Genomic Research (TIGR) have captured influenza evolution in action. ... , the researchers report the first large-scale project to sequence ... the rapidly evolving flu virus in a human population--and a ...
... RNA is enough to clearly distinguish cancerous thyroid tissue ... findings provide more evidence that an emerging set of ... force in the development of cancer and other diseases. ... Proceedings of the National Academy of Sciences. , Scientists ...
... UK have one of the highest rates of resistance to ... a second wave epidemic of resistant virus, a new study ... concerned that the large reductions in deaths and improvements to ... (combination antiretroviral therapy) may be compromised because of this. , ...
Cached Biology News:First big influenza genome study reveals flu evolution 2First big influenza genome study reveals flu evolution 3First big influenza genome study reveals flu evolution 4Role of microRNA identified in thyroid cancer 2Role of microRNA identified in thyroid cancer 3HIV drug resistance increasing in UK and among highest in the world 2
(Date:7/24/2014)... (PRWEB) July 24, 2014 Your ... advances in modeling lithium-ion battery storage capacity. , ... from a theoretical model created at Lawrence ... that predicts how carbon components will perform ... storage emphasizes the urgent need for higher-performance batteries. ...
(Date:7/24/2014)... San Francisco, CA (PRWEB) July 24, 2014 ... Wednesday to be semi-finalists in Livestrong’s Big C Competition. ... Decisive Health are each headed to the semi-final round. ... in Livestrong’s exclusive three-month accelerator program, complete with mentoring ... country. , As part of the angelMD commitment ...
(Date:7/24/2014)... , July 24, 2014 WIRB-Copernicus Group ... regulatory and ethical review services for clinical research, ... Formerly a division of Richmond, VA ... leading biosafety and biosecurity consulting firm in ... addition, WCG,s biosafety division – WCG Biosafety™ – ...
(Date:7/24/2014)... 24, 2014 Draper University, a ... proud to announce that for 6 weeks this ... will converge on the Draper University campus in ... experiential program focused on entrepreneurship, building real-world skills, ... currently running its sixth cohort, continues to refresh ...
Breaking Biology Technology:Getting More Life out of Lithium-ion Batteries 23 angelMD Startups Make Livestrong Big C Semi-finals 2WIRB-Copernicus Group Announces Acquisition of Alliance Biosciences; Executives Join WCG Biosafety Division 2WIRB-Copernicus Group Announces Acquisition of Alliance Biosciences; Executives Join WCG Biosafety Division 3Summer Entrepreneurship Program Kicked Off by Draper University in Silicon Valley 2Summer Entrepreneurship Program Kicked Off by Draper University in Silicon Valley 3
... Space Place , the University of Wisconsin-Madison's astronomy ... Villager Mall, opening Sunday, Aug. 28. Opening week activities continue ... the public. , ,"We had pretty much outgrown our ... Jim Lattis. "Our programming, our attendance has increased steadily every ...
... aside, every biologist knows that men and women truly are ... where those differences come to the fore: around 80 percent ... play behaviors also differ greatly between the sexes - just ... , ,Early in human development, critical brain proteins known as ...
... Technologies, a life sciences nanotechnology company, has received a ... Medical Sciences. , ,The Small Business Innovation Research grant ... crystal based technology to enable faster screening of drugs ... by using liquid crystals to measure topography on a ...
Cached Biology Technology:Space Place opens new astronomy center 2Gender hormones may lend to social disorder therapies 2
... Lines ,High Quality, Functionally-Validated, Ion Channel Cell ... for having a critical role in nerve ... key function in pain, CNS and the ... been investigated in therapeutic areas, such as ...
Mouse monoclonal antibody raised against a partial recombinant TTC3. NCBI Entrez Gene ID = TTC3...
Mouse polyclonal antibody raised against a partial recombinant SYT4. NCBI Entrez Gene ID = 6860...
Mouse monoclonal antibody raised against a partial recombinant IL31RA. NCBI Entrez Gene ID = IL31RA...
Biology Products: