Navigation Links
Progesterone may be why pregnant women are more vulnerable to certain infections
Date:2/28/2013

ightly less, antibody production compared to controls. On the other hand, knockout T cells stimulated in the test tube showed a conspicuous over-production of interferon-gamma, an inflammatory molecule involved in fighting off pregnancy-associated pathogens and in shaping protective antibody responses. Adding progesterone to the test tube blocked interferon-gamma in normal T cells, but not in PR knockout T cells. This suggests that progesterone suppresses interferon gamma in T cells through their PR. To sort out which aspects of the abnormal antibody responses in PR knockout mice were due to T cells, researchers immunized two groups of normal mice, one transplanted with responder T cells from PR knockout donors, the other with responder T cells from normal donors. Just like in PR knockout mice, normal mice transplanted with PR knockout responder T cells showed much higher antibody levels than normal mice.

"Pregnancy and hormones have long been known to influence immune responses, but these processes have been poorly understood, said John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology. "This new work is significant for two reasons. First, the identification of progesterone receptors as a mechanism of immune modulation during pregnancy sheds light on the pregnancy-immune phenomenon, and second, these studies define a potentially new target to modulate autoimmunity and immune-mediated problems during pregnancy."


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Page: 1 2

Related biology news :

1. State of Michigan adopts NIHs PRB progesterone therapy to combat infant mortality
2. Measuring progesterone receptor expression to improve hormone-receptor-positive cancer management
3. Few pregnant women treated for sexually transmitted infections
4. Overweight pregnant women not getting proper weight-gain advice
5. Considerable prevalence of both malaria, STIs exist among pregnant women in sub-Saharan Africa
6. Vitamin D for pregnant women and babies -- how much is enough?
7. 2 servings of salmon a week is healthy for pregnant women and their babies
8. Genetic signs of alcoholism in women studied for the first time
9. African-American, Caucasian women should take identical vitamin D doses
10. Cancer risk for African-American women with benign breast disease factors Wayne State finds
11. Geneviève Almouzni to receive the 2013 FEBS
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/7/2014)... 6, 2014 Leading Biometric companies aim ... security revolutionizing online transactions.  Companies in focus today are: NXT-ID, ... BABA ), Google Inc. (NASDAQ: GOOG ... (NASDAQ: EBAY ) and MasterCard Inc. (NYSE: MA) ... NXTDW), a biometric authentication company focused on the growing mobile ...
(Date:11/5/2014)... in the UTSA College of Sciences, is one ... receive a two-year $300,00 National Science Foundation (NSF) ... funding supports President Obama,s BRAIN Initiative, a federal ... that will demystify complex brain processes. , ... broken into the interactions of multiple components, each ...
(Date:11/4/2014)... – Temple University School of Medicine announced today ... an initiative funded by the Bill & Melinda ... of Obstetrics, Gynecology and Reproductive Sciences; and Vice ... University School of Medicine will pursue an innovative ... Blood Biomarkers to Assess Fetal Neurodevelopment.", Grand Challenges ...
Breaking Biology News(10 mins):Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 2Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 3Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 4Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 5Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 6UTSA biology professor awarded $300,000 NSF grant for brain research 2UTSA biology professor awarded $300,000 NSF grant for brain research 3Temple University School of Medicine receives Grand Challenges Explorations grant 2
... at the University of Leicester may identify reasons underlying ... men. In her doctoral study, Cardiovascular Sciences student ... male predominance of AAA, with a particular emphasis on ... study will be showcased at the University of Leicester,s ...
... KNOXVILLE -- By examining 800,000-year-old polar ice, scientists increasingly ... ice melt and that carbon dioxide has become more abundant ... scientist Jrme Chappellaz has been examining ice cores collected from ... His studies on the interconnecting air spaces of old snow ...
... climate change, carbon dioxide, pollution and other human-related phenomena on ... isolated sources of pollution and other influences. Now, a ... published a report in the latest issue of the journal ... factors on the ocean and considers what the future might ...
Cached Biology News:Increased likelihood of male death from disease 2Scientist links increase in greenhouse gases to changes in ocean currents 2 WHOI scientist takes comprehensive look at human impacts on ocean chemistry 2 WHOI scientist takes comprehensive look at human impacts on ocean chemistry 3
(Date:11/24/2014)... , Nov. 24, 2014  Last week, Representatives ... Butterfield (D-NC) took a bold bipartisan step ... introducing the OPEN Act. Original co-sponsors of the ... The Act will incentivize drug makers and innovators ... diseases and pediatric cancers, which opens the door ...
(Date:11/24/2014)... SOUTH SAN FRANCISCO, Calif. , Nov. 24, 2014 /PRNewswire/ ... announced that Bonnie H. Anderson , president and chief ... the Piper Jaffray 26 th Annual Healthcare Conference on ... New York . The live audio ... website at http://investor.veracyte.com . Please connect to the website ...
(Date:11/24/2014)... 2014 Deep Research Report on ... professional and in-depth research report on the Adipic ... its definition, classification, application, and industry chain structure ... the international market analysis, including China’s domestic market ... Europe, Asia, China, Japan etc. regions) industry analysis ...
(Date:11/24/2014)... Senior Vice President, General Manager for Clinical ... acumen Elsevier , a world-leading provider ... congratulates Diane Bartoli , Senior Vice President and ... Solutions, for being recognized in the 13 th ... Profiles in Diversity Journal ® . ...
Breaking Biology Technology:OPEN Act Introduced to Repurpose Drugs for Rare Diseases 2Veracyte to Present at the Piper Jaffray 26th Annual Healthcare Conference 2Adipic Dihydrazide Industry 2019 Research Forecasts on Worldwide, China Regions Now Available at ReportsnReports.com 2Adipic Dihydrazide Industry 2019 Research Forecasts on Worldwide, China Regions Now Available at ReportsnReports.com 3Elsevier Clinical Solutions' Diane Bartoli Featured In Profiles in Diversity Journal's 13th Annual Women Worth Watching Issue 2Elsevier Clinical Solutions' Diane Bartoli Featured In Profiles in Diversity Journal's 13th Annual Women Worth Watching Issue 3
... Reflects Full Scope of Integrated Global Services, ... Clinical,Trials today launches under a new name, Abt ... Associates Inc. The company will continue to,provide custom ... medical device and diagnostics industries,utilizing a team approach ...
... OF PRUSSIA, Pa., April 1, 2008 HighPoint Solutions,LLC, ... it,has been selected by a global biotechnology company to ... prepare for the company,s new,product launches and support its ... science companies continue to strive to create a holistic ...
... Increases 60% to $87.1 Million ... Increases 61% to $8.6 Million, XIAN, China, April ... Board: CBEH), (CBEH or the "Company"), an,energy company engaged ... finished oil products and the development, production and,distribution of ...
Cached Biology Technology:Abt Associates Clinical Trials Announces Name Change to Abt Bio-Pharma Solutions, Inc. 2HighPoint Solutions Selected by Global Biotechnology Company to Provide Master Data Management Solution 2China Bio Energy Reports Fiscal 2007 Financial Results 2China Bio Energy Reports Fiscal 2007 Financial Results 3China Bio Energy Reports Fiscal 2007 Financial Results 4China Bio Energy Reports Fiscal 2007 Financial Results 5China Bio Energy Reports Fiscal 2007 Financial Results 6China Bio Energy Reports Fiscal 2007 Financial Results 7China Bio Energy Reports Fiscal 2007 Financial Results 8China Bio Energy Reports Fiscal 2007 Financial Results 9China Bio Energy Reports Fiscal 2007 Financial Results 10China Bio Energy Reports Fiscal 2007 Financial Results 11