Navigation Links
Progesterone changes may cause cognitive impairment of Alzheimer's disease patients
Date:12/6/2013

Steroid hormones and their metabolites within the central nervous system are commonly defined as neuroactive steroids or neurosteroids. Although neuroactive steroids have been shown to improve learning and memory ability and protect against amyloid beta (Aβ) peptide-induced neurotoxicity, changes in their level during Alzheimer's disease and their role in Aβ-mediated cognitive impairment remain elusive given the limitation in sample sizes and analysis methods. To gain a better understanding on the role of neuroactive steroids in the pathology of Alzheimer's disease, Dr. Sha Liu and colleagues from Hebei Medical University, China investigated the effect of progesterone administration against Aβ2535-induced impairment in vivo. In their study, intracerebral injection of aggregated Aβ2535 into the bilateral hippocampal CA1 region impaired learning and memory abilities of rats, accompanied by reduced levels of progesterone. Treatment of these Alzheimer's disease rats with exogenous progesterone could reverse cognitive impairment. Therefore, this study, published in the Neural Regeneration Research (Vol. 8, No. 30, 2013), provides a possible therapeutic strategy for Alzheimer's disease via neuroactive steroids, particularly progesterone.


'/>"/>

Contact: Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research
Source:Eurekalert

Page: 1

Related biology news :

1. Progesterone may be why pregnant women are more vulnerable to certain infections
2. State of Michigan adopts NIHs PRB progesterone therapy to combat infant mortality
3. Measuring progesterone receptor expression to improve hormone-receptor-positive cancer management
4. Rapid climate changes, but with a 120 year time lag
5. Your first hug: How the early embryo changes shape
6. Men with prostate cancer who ate a low-fat fish oil diet showed changes in their cancer tissue
7. Changes to fisheries legislation have removed habitat protection for most fish species in Canada
8. Small changes in ag practices could reduce produce-borne illness
9. Despite menu changes, calorie and sodium levels in chain restaurant entrees remain the same overall
10. Epigenetic changes observed in blood may point to early stages in Parkinson disease
11. Little changes -- large effects
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/12/2017)... PUNE, India , January 12, 2017 A new ... - 2022," projects that the global biometric technology market is expected to generate revenue ... 2022. Continue Reading ... ...      (Logo: http://photos.prnewswire.com/prnh/20140911/647229) ...
(Date:1/6/2017)... , Jan. 5, 2017  SomaLogic announced today ... Life Alliance" established by iCarbonX, the ... build a "Global Digital Health Ecosystem that can ... combination of individual,s biological, behavioral and psychological data, ... between the companies, SomaLogic will provide proteomics data ...
(Date:1/3/2017)... LAS VEGAS , Jan. 3, 2017 ... announced the introduction of Onitor Track, an innovative biometric ... and men, showcasing this month at the 2017 Consumer ... . In the U.S., the World ... affect more than two-thirds of adults who are overweight ...
Breaking Biology News(10 mins):
(Date:1/16/2017)... , ... January 16, 2017 , ... ... laws precedential publication its decision on the appeal filed by India-based Dishman Pharmaceutical ... breach of contract against DPCL and one of its Dishman Group’s 100% wholly ...
(Date:1/14/2017)... , Jan. 13, 2017  The Alliance for ... in response to FDA final guidance on ... its continued leadership in emphasizing the importance of distinct ... keenly aware of the benefits biosimilars will bring to ... Yet the portion of the Guidance dealing ...
(Date:1/13/2017)... ... January 13, 2017 , ... FireflySci, in response to ... three new solutions for measurements where traditional cuvette applications are not convenient. For ... an oddly-shaped sample that would not fit into a typical cuvette inside a ...
(Date:1/12/2017)... ... January 12, 2017 , ... After her brain cancer ... gave her only a few months to live. Now a paper publishing January ... Rosendahl’s disease and increased both the quantity and quality of her life: Adding ...
Breaking Biology Technology: