Navigation Links
Progesterone changes may cause cognitive impairment of Alzheimer's disease patients
Date:12/6/2013

Steroid hormones and their metabolites within the central nervous system are commonly defined as neuroactive steroids or neurosteroids. Although neuroactive steroids have been shown to improve learning and memory ability and protect against amyloid beta (Aβ) peptide-induced neurotoxicity, changes in their level during Alzheimer's disease and their role in Aβ-mediated cognitive impairment remain elusive given the limitation in sample sizes and analysis methods. To gain a better understanding on the role of neuroactive steroids in the pathology of Alzheimer's disease, Dr. Sha Liu and colleagues from Hebei Medical University, China investigated the effect of progesterone administration against Aβ2535-induced impairment in vivo. In their study, intracerebral injection of aggregated Aβ2535 into the bilateral hippocampal CA1 region impaired learning and memory abilities of rats, accompanied by reduced levels of progesterone. Treatment of these Alzheimer's disease rats with exogenous progesterone could reverse cognitive impairment. Therefore, this study, published in the Neural Regeneration Research (Vol. 8, No. 30, 2013), provides a possible therapeutic strategy for Alzheimer's disease via neuroactive steroids, particularly progesterone.


'/>"/>

Contact: Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research
Source:Eurekalert

Page: 1

Related biology news :

1. Progesterone may be why pregnant women are more vulnerable to certain infections
2. State of Michigan adopts NIHs PRB progesterone therapy to combat infant mortality
3. Measuring progesterone receptor expression to improve hormone-receptor-positive cancer management
4. Rapid climate changes, but with a 120 year time lag
5. Your first hug: How the early embryo changes shape
6. Men with prostate cancer who ate a low-fat fish oil diet showed changes in their cancer tissue
7. Changes to fisheries legislation have removed habitat protection for most fish species in Canada
8. Small changes in ag practices could reduce produce-borne illness
9. Despite menu changes, calorie and sodium levels in chain restaurant entrees remain the same overall
10. Epigenetic changes observed in blood may point to early stages in Parkinson disease
11. Little changes -- large effects
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/16/2016)... FRANCISCO , June 16, 2016 ... size is expected to reach USD 1.83 ... by Grand View Research, Inc. Technological proliferation and ... banking applications are expected to drive the market ... ) , The development of advanced ...
(Date:6/7/2016)... , June 7, 2016  Syngrafii Inc. ... a business relationship that includes integrating Syngrafii,s patented ... branch project. This collaboration will result in greater ... the credit union, while maintaining existing document workflow ... http://photos.prnewswire.com/prnh/20160606/375871LOGO ...
(Date:6/2/2016)... , June 2, 2016 Perimeter ... Platforms, Unmanned Systems, Physical Infrastructure, Support & Other Service  ... visiongain offers comprehensive analysis of the global ... market will generate revenues of $17.98 billion in 2016. ... DVTEL Inc, a leader in software and hardware technologies ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... , ... June 23, 2016 , ... ... pleased to announce the launch of their brand, UP4™ Probiotics, into Target stores ... 35 years, is proud to add Target to its list of well-respected retailers. ...
(Date:6/23/2016)... - FACIT has announced the creation of a ... Propellon Therapeutics Inc. ("Propellon" or "the Company"), to ... of first-in-class WDR5 inhibitors for the treatment of ... an exciting class of therapies, possessing the potential ... patients. Substantial advances have been achieved with the ...
(Date:6/23/2016)... , June 23, 2016 Houston Methodist ... the Cy-Fair Sports Association to serve as their ... agreement, Houston Methodist Willowbrook will provide sponsorship support, ... connectivity with association coaches, volunteers, athletes and families. ... the Cy-Fair Sports Association and to bring Houston ...
(Date:6/23/2016)... Prostate Cancer Foundation (PCF) is pleased to announce 24 new Young ... cancer. Members of the Class of 2016 were selected from a pool of ... More About the Class of 2016 PCF Young Investigators ... ... ...
Breaking Biology Technology: