Navigation Links
Process leading to protein diversity in cells important for proper neuron firing
Date:11/18/2010

tained introns are necessary to produce a functional ion channel called BKCa in the dendrite. BKCa channels need to have these introns spliced out in the cytoplasm to work correctly. Introns were once thought of as junk DNA, but are now being shown to exert important regulatory control. Indeed, in some cases mutations in introns are responsible for causing disease, while in previous work Eberwine and colleagues were able to show that a retained intron is responsible for proper cellular localization of the final translated protein.

One particular intron, i17a, is found next to a portion of the BKCa protein, called the STREX domain. When STREX is in the channel protein BKCa, physiological properties such as burst firing and action potential change. These are important bio-electrical actions governing how nerve cells communicate with each other.

For the STREX domain to be part of the larger BKCa protein, i17a has to be removed in the cytoplasm. If i17a isn't spliced out in the cytoplasm very little STREX-containing BKCa protein is made. This leads to a poorly functioning neuron.

Diseases such as epilepsy that are based on electrical misfiring in the brain could be targets of manipulating cytoplasmic splicing to control how much STREX-containing BKCa protein is made and ultimately available in a neuron cell membrane. The diversity in splicing allows for different types of protein to be made, including the STREX-containing protein. In turn, other proteins are then able to bind to the channel, which in turn leads to other molecular events necessary for correct nerve firing.

The generality of this phenomena is being investigated with the goal being to understand this form of cellular regulation such that it can be experimentally manipulated in a directed and meaningful manner.


'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert  

0

GOOD

Page: 1 2

Related biology news :

1. ID Solutions Achieves Full-Production Delivery and Payment for Fingerprint Processing Software for TWIC
2. So-called sandfish could help materials handling and process technology specialists
3. Nanoscopic screening process to speed drug discovery
4. Major source of radon exposure overlooked at former Ohio uranium-processing plant
5. Repairing DNA damage: Researchers discover critical process in cancer treatment
6. LSUHSC research identifies key contributor to Alzheimers disease process
7. Ants may help researchers unlock mysteries of human aging process
8. New papers offer insights into process of malarial drug resistance
9. Rivers are carbon processors, not inert pipelines
10. Unique transatlantic tie-up to understand the aging process
11. Evolutionary process more detailed than previously believed, study shows
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Process leading to protein diversity in cells important for proper neuron firing
(Date:5/16/2013)... MD (May 17, 2013) Illustrating a commitment ... American Gastroenterological Association (AGA) Research Foundation has ... Student Research Fellowship Award recipients. Supported by the ... Diseases (NIDDK), this new award helps underrepresented minority ... disease and nutrition research. , "By establishing this ...
(Date:5/16/2013)... in neurodegenerative disease also plays a critical role in ... In a study of the common fruit fly, the ... responsible for sleeping and waking on a 24-hour rhythm. ... sleep-wake cycle is disturbed, making waking up on a ... discovery is particularly interesting because mutations in the human ...
(Date:5/16/2013)... S.C. , May 16, 2013 ... in combination with a custom thin film transistor ... highest forensic quality roll image in the smallest ... today. Sherlock, an Appendix F Mobile ID FAP ... a 95% reduction in size and weight when ...
Breaking Biology News(10 mins):Underrepresented minority students receive fellowships in digestive disease and nutrition research 2Gene involved in neurodegeneration keeps clock running 2
... the course of a lifetime, the heart pumps some 250 ... to do this, the muscle fibers of the heart have ... Wolfgang Rottbauer, vice chair of the Department of Medicine III ... has discovered a protein that is responsible for the stability ...
... just as vital to your health as what you eat, ... experiments in mice revealed that the daily waxing and waning ... mostly controlled by food intake and not by the body,s ... feeding time determines the activity of a large number of ...
... named 12 new grant recipients for 2009. The awards, ... spectrum of lupus research. All were selected for their ... ultimately prevent, treat, and cure the complex disease of ... new and established lupus researchers across the nation and ...
Cached Biology News:New genetic cause of cardiac failure discovered 2Feeding the clock 2Feeding the clock 3Lupus Research Institute announces 2009 novel research grants 2Lupus Research Institute announces 2009 novel research grants 3
(Date:5/17/2013)... Men’s skin is biologically different than women’s skin,( says skin ... known to react more aggressively when hormones change, and acne ... other acne causing factors like P.acnes bacteria and excess dirt ... unsightly acne scars. Adult acne treatment, Probiotic Action shares new ... to reduce and prevent acne scarring. , In order to ...
(Date:5/17/2013)... Tooth decay is an epidemic in American children with ... The World Health Organization says that worldwide, 60–90% ... What are the long-term effects of this transmissible infection? ... the oral bacterial imbalance and serious systemic issues like heart ... is also 100% preventable? Answer: there has been no way ...
(Date:5/16/2013)... 2013 A new selection of ... Cole-Parmer is designed to meet the dynamic needs ... The new Cole-Parmer® MS-3400 Centrifuges are ... lab. They ensure a powerful and complete separation ... Their standard four-place swinging buckets hold 50-mL tubes. ...
(Date:5/16/2013)... HAYWARD, Calif. , May 16, 2013 ... University, Beijing , and the ... www.magceutics.com ) have demonstrated a novel therapy for reversing ... brain magnesium levels, they find significant cognitive improvement in ... to demonstrate a mechanism for reversing cognitive decline for ...
Breaking Biology Technology:Adult Acne Treatment, Probiotic Action Shares New Insight on Why Men’s Skin Scars from Acne and How to Prevent It 2Seeing the Future: How a Revolutionary New Bacterial Screening Device Can Predict a Patient’s Future for Tooth Decay 2Seeing the Future: How a Revolutionary New Bacterial Screening Device Can Predict a Patient’s Future for Tooth Decay 3Cole-Parmer Offers Enhanced Selection of Centrifuges 2Elevation of Brain Magnesium Reverses Memory Deficits in Alzheimer Mice 2Elevation of Brain Magnesium Reverses Memory Deficits in Alzheimer Mice 3
... simple and convenient technique that combines nanoscale structural ... goal. With current analytical instruments, spatial resolution is ... too complex or sample size too large to ... University of Illinois have demonstrated a method for ...
... March 27 Genta,Incorporated (Nasdaq: GNTA ) ... the Company,s request for an extension of,time to ... Pursuant to the Panel,s decision, the listing of ... NASDAQ Global Market to,The NASDAQ Capital Market, effective ...
... Ind., March 27 As hospital leaders prepare,for ... mandated by Center for,Medicare & Medicaid Services ( ... P. Malone is offering insights about how to ... from the H-CAHPS,( http://www.cahps.ahrq.gov ) survey will ...
Cached Biology Technology:Femtogram-level chemical measurements now possible, U. of I. team reports 2Genta Granted Extension to Achieve Compliance with NASDAQ Listing Requirements 2Genta Granted Extension to Achieve Compliance with NASDAQ Listing Requirements 3Patient Experience Expert to Present 'The Power of Wow!' in Health Care Service Delivery 2
... Microdissection , CapSure HS and CapSure Macro ... extraction of populations of pure cells from ... Capture Microdissection., Ensure the Integrity of ... All CapSure LCM Caps have a patented ...
... system is used for single-color real-time detection ... or JOE fluorophores and features a real-time ... data from 96 wells, a gene expression ... analysis. The system includes the optical module ...
... Microdissection , CapSure HS and CapSure Macro ... extraction of populations of pure cells from ... Capture Microdissection., Ensure the Integrity of ... All CapSure LCM Caps have a patented ...
Opticon continuous fluorescence detector; includes optical base, analysis software, computer and monitor (this is an accessory for the DNA Engine thermal cyclers which must be ordered seperately)...
Biology Products: