Navigation Links
Process leading to protein diversity in cells important for proper neuron firing
Date:11/18/2010

tained introns are necessary to produce a functional ion channel called BKCa in the dendrite. BKCa channels need to have these introns spliced out in the cytoplasm to work correctly. Introns were once thought of as junk DNA, but are now being shown to exert important regulatory control. Indeed, in some cases mutations in introns are responsible for causing disease, while in previous work Eberwine and colleagues were able to show that a retained intron is responsible for proper cellular localization of the final translated protein.

One particular intron, i17a, is found next to a portion of the BKCa protein, called the STREX domain. When STREX is in the channel protein BKCa, physiological properties such as burst firing and action potential change. These are important bio-electrical actions governing how nerve cells communicate with each other.

For the STREX domain to be part of the larger BKCa protein, i17a has to be removed in the cytoplasm. If i17a isn't spliced out in the cytoplasm very little STREX-containing BKCa protein is made. This leads to a poorly functioning neuron.

Diseases such as epilepsy that are based on electrical misfiring in the brain could be targets of manipulating cytoplasmic splicing to control how much STREX-containing BKCa protein is made and ultimately available in a neuron cell membrane. The diversity in splicing allows for different types of protein to be made, including the STREX-containing protein. In turn, other proteins are then able to bind to the channel, which in turn leads to other molecular events necessary for correct nerve firing.

The generality of this phenomena is being investigated with the goal being to understand this form of cellular regulation such that it can be experimentally manipulated in a directed and meaningful manner.


'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert  

Page: 1 2

Related biology news :

1. ID Solutions Achieves Full-Production Delivery and Payment for Fingerprint Processing Software for TWIC
2. So-called sandfish could help materials handling and process technology specialists
3. Nanoscopic screening process to speed drug discovery
4. Major source of radon exposure overlooked at former Ohio uranium-processing plant
5. Repairing DNA damage: Researchers discover critical process in cancer treatment
6. LSUHSC research identifies key contributor to Alzheimers disease process
7. Ants may help researchers unlock mysteries of human aging process
8. New papers offer insights into process of malarial drug resistance
9. Rivers are carbon processors, not inert pipelines
10. Unique transatlantic tie-up to understand the aging process
11. Evolutionary process more detailed than previously believed, study shows
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Process leading to protein diversity in cells important for proper neuron firing
(Date:9/18/2014)... research has found clownfish larvae can swim up to 400 ... able to cope with environmental change. , Clownfish spend their ... but as babies they must wander the open ocean, says ... Excellence for Coral Reef Studies (Coral CoE) at James Cook ... go, but now we,ve been given a rare glimpse into ...
(Date:9/17/2014)... scientists were instrumental in the creation of the Santa ... classify the fire threat potential of the powerful, hot, ... into an inferno. The index was introduced Sept. 17 ... and San Diego Gas and Electric. , The index ... that will be used to help fire agencies and ...
(Date:9/17/2014)... an EC-FP5 four-year project, delivering its first release in ... participations in several EC projects, as a part of ... (EU BON), to increase the general awareness of the ... general dissemination of the Fauna Europaea results, the ... novel e-Publishing tools to prepare data papers for all ...
Breaking Biology News(10 mins):Nemo's epic journey to find a new home 2UCLA scientists play key role in developing new Santa Ana Wildfire Threat Index 2Contributions on Fauna Europaea: Data papers as innovative model on expert involvement 2
... medical project aimed at improving the prevention, diagnosis and ... serious conditions is launched this week after several years ... living in the south Manchester area are being given ... nationwide later this year. , They are being sent ...
... Scientists have developed a successful strategy for interfering with ... primates exposed to the lethal disease. This is the ... nonhuman primates. The findings could serve as the basis ... for known, emerging, and genetically engineered pathogens. , ...
... significant advance for regenerative medicine, researchers at Rice University have ... bone marrow such that the cells themselves produce a growth ... The research, which appears online this week in the Proceedings ... because of the science ?researchers found they could coax bone ...
Cached Biology News:Multi-million pound UK Biobank underway 2Multi-million pound UK Biobank underway 3Gene-specific Ebola therapies protect non-human primates from lethal disease 2Findings advance use of adult stem cells for replacement bone 2
(Date:9/18/2014)... Leatherwood Plastics has selected Vycom’s ... stay competitive in the semiconductor, clean room and ... impact product quality and productivity, according to Dwight ... in 1980 in Lewisville, TX, Leatherwood Plastics ... left the business. Much of Leatherwood’s equipment building ...
(Date:9/18/2014)... 2014 /PRNewswire/ - Oncothyreon Inc. (NASDAQ: ONTY ... but separate underwritten offerings of 10,000,000 shares of its ... $2.00 per share, for expected gross proceeds of $20 ... Preferred Stock at a price to the public of ... million. Each share of Series A Convertible Preferred Stock ...
(Date:9/18/2014)... (PRWEB) September 18, 2014 SeqLL ... Sequencing (tSMS™) technology, announced today the closing of ... investment, led by Genomic Diagnostic Technologies, will increase ... diagnostic applications. , Founded in March 2013 by ... Bioinformatics Analyst at Helicos BioSciences, SeqLL has continued ...
(Date:9/18/2014)... at USC have developed a new microscopy technology ... living animals at higher-than-ever resolution. , Dubbed "Complementation ... imaging resolutions that are an order of magnitude ... into the behavior of biomolecules at the nanometer ... 18 by Nature Communications , the researchers ...
Breaking Biology Technology:Leatherwood Plastics Selects Vycom’s Flametec PVC-C Material to Stay Competitive in Semiconductor and Lab Equipment Industries 2Oncothyreon Prices $40 Million Concurrent Public Offerings of Common Stock and Preferred Stock 2Oncothyreon Prices $40 Million Concurrent Public Offerings of Common Stock and Preferred Stock 3SeqLL Closes Series-A Funding Round for Expansion of Single Molecule Sequencing 2Scientists pioneer microscopy technique that yields fresh data on muscular dystrophy 2
... ,Jia Hu of China - Source: Getty Images The ... every four years. They're held every year. Though this is ... year as the pervasive growth of the industry becomes part ... run every four years and last two weeks, the biotech ...
... and rock-star futurist, spoke at the Young Professionals of ... by his insights and had to borrow a pen ... some R-squared commentary: , ,Watts: When Jesus Christ died, ... laid down, there were 200,000 Christians. Guess Paul was ...
... who switch from traditional paper phone bills to SBC ... , ,Through the "Save a StampHelp Save a Life" campaign, ... SBC Services Inc. will contribute $1 dollar for every SBC ... to Nov. 15, 2004. , ,In 2004, an estimated 216,000 ...
Cached Biology Technology:The Olympics: A Biotech Perspective 2The Olympics: A Biotech Perspective 3Watts Up 2
... (phospho Y1007) ( Abpromise for ... Antigen: Synthesized phosphopeptide derived from ... of tyrosine 1007 (K-E-Y P -Y-K). ... 3717 Swiss ...
... Perm Buffer III is ... fixation of PBMCs (or ... staining for intracellular kinases ... simultaneously. Applications: Intracellular ...
Cytofix/Cytoperm Kit 250 Tests...
The BD PhosFlow Fix Buffer I can be used for the simultaneous fixation and permeabilization of cells prior to intracellular staining. Applications: Intracellular Staining (Flow) Storage Temperature:...
Biology Products: