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Probiotic found to be effective treatment for colitis in mice
Date:10/26/2009

http://www.the-aps.org">www.the-aps.org) published the research.

Study with live mice and human cells

The study occurred in two phases, one involving live mice with colitis and another that looked at human intestinal cells in a test tube. The mouse study showed that B. polyfermenticus facilitated the recovery of mice from colitis. The mice showed reduced rectal bleeding, less inflamed tissue and they gained more weight than the mice that did not receive B. polyfermenticus. The study also found that the colon tissue of the treated mice had greater angiogenesis, a process that is necessary for wounds to heal.

The test tube study allowed an in-depth look at what happens at the cellular level when human intestinal microvascular endothelial cells are exposed to B. polyfermenticus. This phase found that the probiotic treatment encouraged several steps that are part of the angiogenic process, including the migration of cells and the formation of new blood vessels.

The test tube studies also uncovered how this happens. The researchers found that B. polyfermenticus increases the production of Interleukin-8 (IL-8), a substance that enhances angiogenesis. The study also found that IL-8's receptor, CXCR2, and a cellular pathway, known as NF-κB, play a critical role in the angiogenic process.

Role of Angiogenesis

Ironically, the researchers noted that angiogenesis plays a part in causing inflammatory bowel diseases, including Crohn's disease and ulcerative colitis. Studies have shown that decreasing angiogenesis can alleviate symptoms of these diseases and promote healing during a flare up. However, this study suggests that once the flare up subsides, angiogenesis is necessary for proper healing to occur.

"Our findings suggest that the probiotic bacterium, when applied at the healing phase of experimental inflammatory bowel disease, increased angiogenesis and thus enhanced wound h
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Contact: Christine Guilfoy
cguilfoy@the-aps.org
301-634-7253
American Physiological Society
Source:Eurekalert

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