Navigation Links
Probiotic bacterium lessens severity of Salmonella infections by hoarding iron
Date:7/17/2013

Irvine, Calif., July 17, 2013 UC Irvine microbiologists have learned how a probiotic bacterium used to treat irritable bowel syndrome can soothe gut bacterial infections caused by Salmonella, paving the way for potential relief from foodborne illnesses that affect millions of people annually.

Manuela Raffatellu, assistant professor of microbiology & molecular genetics, and colleagues at UC Irvine and the University of Washington identified how a probiotic strain of E. coli reduces Salmonella colonization by competing with this pathogen for iron, an essential nutrient that Salmonella acquires in the gut in order to replicate at high levels.

In fact, the researchers discovered that the E. coli strain called Nissle 1917 acquires iron more efficiently than does Salmonella. As a result, Salmonella counts in the gut decrease when Nissle is administered during infection. Study results appear in today's issue of Cell Host & Microbe.

"Although we focused on Salmonella, our findings suggest that this approach can be effective against other gut bacterial pathogens that need iron to grow," said Raffatellu, who's also a member of UC Irvine's Institute for Immunology. "By understanding how these 'bad bugs' get nutrients, we can further study methods to eradicate them."

Most people infected with Salmonella develop diarrhea, fever and abdominal cramps 24 to 72 hours after infection. The illness usually lasts four to seven days, and the majority of affected individuals recover without treatment. According to the Centers for Disease Control & Prevention, about 42,000 cases of salmonellosis are reported annually in the U.S. Because many milder cases are not diagnosed or reported, the actual number of infections is estimated to be between 1 million and 4 million per year.

For nearly a century, the E. coli Nissle 1917 strain has been administered to patients wi
'/>"/>

Contact: Tom Vasich
tmvasich@uci.edu
949-824-6455
University of California - Irvine
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study shows probiotic Lactobacillus reuteri NCIMB 30242 significantly increased vitamin D levels
2. Study finds taking probiotics has benefits for patients in hospitals
3. Probiotics found to reduce hepatic encephalopathy
4. Study: Probiotics reduce stress-induced intestinal flare-ups
5. New study shows probiotics help fish grow up faster and healthier
6. Behind closed doors: Researchers show how probiotics boost plant immunity
7. By adding VSL#3 probiotic to traditional therapies UC patients can improve remission rates
8. Invisible helpers: How probiotic bacteria protect against inflammatory bowel diseases
9. Scientists discover ethnic differences in immune response to TB bacterium
10. Bacterium counteracts coffee ring effect
11. Scientists confirm that the Justinianic Plague was caused by the bacterium Yersinia pestis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/10/2015)... , April 10, 2015 ... addition of the "Security Competitive Profiles - NEC" ... http://photos.prnewswire.com/prnh/20130307/600769) , NEC will continue to supply ... to the market, with a company focus on the ... anticipated. Winning opportunities in the ...
(Date:4/2/2015)... April 2, 2015 At its 2015 ACMG ... City , the American College of Medical Genetics ... directors to its Board.  Members of the ACMG Board ... for forming and advancing its policies and programs. ACMG ... "It,s an eventful time in medical genetics ...
(Date:3/31/2015)... , March 31, 2015  Elephant Talk Communications ... a global provider of Software Defined Network Architecture (ET ... announced total revenue of approximately $20.4 million for the ... restated $19.5 million for the year ended December 31, ... 2014, the Company had completed its multi-year transition away ...
Breaking Biology News(10 mins):NEC Security Competitive Profile 2015 2American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 2American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 3American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 4American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 5American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 6American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 7American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 8Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 2Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 3Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 4Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 5Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 6
... tiger snakes stranded for thousands of years on tiny islands ... twice the size of their mainland cousins. Now, new research ... of these elapids was driven by the need to have ... at 35 inches (89 cm) long, patrol swampy areas in ...
... CHAMPAIGN, Ill. Miscanthus grasses are used in ... fuels. They also belong to a prominent grass family that ... maps of Miscanthus sinensis (an ornamental that ... biofuels crop) are a first step toward sequencing the ...
... 15, 2012) This fall, Drexel Environmental Science students will ... locally and across the globe as a result of ... Natural Sciences. Out of the affiliation comes the Department ... will work and learn among some of the world,s ...
Cached Biology News:Big-mouthed babies drove the evolution of giant island snakes 2Big-mouthed babies drove the evolution of giant island snakes 3Maps of Miscanthus genome offer insight into grass evolution 2Maps of Miscanthus genome offer insight into grass evolution 3New museum-university partnership ushers in new era of environmental science education 2
(Date:5/6/2015)... -- Oxis Biotech, Inc. (OXIS), a wholly owned subsidiary of ... Cassian Yee , M.D., Professor, Department of Melanoma ... of Texas MD Anderson Cancer Center joined its scientific ... Immunology, Division of Cancer Medicine, and Director, Solid Tumor ... University of Texas MD Anderson Cancer Center.  ...
(Date:5/6/2015)... GA (PRWEB) May 06, 2015 ... based on the products of cells grown under ... its 105F immunomodulatory treatment candidate for melanoma during ... Meeting, taking place May 6-9, 2015 in Atlanta, ... multipotent cells produce a soluble material with anti-oncologic ...
(Date:5/5/2015)... RURO, Inc., a leading LIMS, RFID and sample ... major content upgrade to its bestselling, Commercial Off-The-Shelf (COTS) ... a significant advancement of FreezerPro® system , ... also simplifying , New FreezerPro® VM ... Download available immediately for free to “Gold” support subscribers ...
(Date:5/5/2015)... 5, 2015 Roka Bioscience, Inc. (NASDAQ: ROKA ... solutions for the detection of foodborne pathogens,  today announced that ... of America Merrill Lynch 2015 Health Care Conference on May ... Encore at the Wynn, Las Vegas NV. ... will be available through the investor relations section of Roka ...
Breaking Biology Technology:Oxis Biotech Appoints Cassian Yee, M.D. To Its Scientific Advisory Board 2Oxis Biotech Appoints Cassian Yee, M.D. To Its Scientific Advisory Board 3Novel Immunomodulatory Treatment Induces Apoptosis in Melanoma 2RURO Releases version 7 of FreezerPro® software 2
... Oriental,Bioengineering (NYSE: AOB ) announced today that ... decision to cancel its,convertible preferred stock offering at ... resulting in terms that were not acceptable to,the ... made in this press release are forward-looking and ...
... 5 Cardiac Science,Corporation (Nasdaq: CSCX ... diagnosis,resuscitation, rehabilitation, and informatics products, announced today,that ... Needham & Company Biotechnology,and Medical Technology Conference ... senior vice president and chief financial officer, ...
... Anesiva,Inc. (Nasdaq: ANSV ) today announced ... NF-kappa B Decoy (NF-kB Decoy) program, which includes ... (TFT). NF-kB Transcription Factor Decoy inhibits NF-kappa B, ... such as inflammatory,bowel disease (IBD), eczema, rheumatoid arthritis, ...
Cached Biology Technology:Cardiac Science to Present at Needham Biotechnology & Medical Technology Conference 2Anesiva and Transcription Factor Therapeutics, Inc. Announce Licensing Agreement for Development and Commercialization of NF-kappa B Clinical Program 2Anesiva and Transcription Factor Therapeutics, Inc. Announce Licensing Agreement for Development and Commercialization of NF-kappa B Clinical Program 3
... revolutionizes imaging software for the microscopy ... microscopes, cameras, components and peripherals with ... tools. Its intuitive interface simplifies workflow ... while providing powerful features such as ...
...
BD BioCoat Poly-D-Lysine 60 mm Culture Dishes, tissue-culture treated polystyrene with a uniform application of poly-D-lysine....
... incorporates the critical design features demanded by ... research. The Series 4000 delivers improved performance, ... discoveries to biomarker assays all on the ... to fit into the research plans of ...
Biology Products: