Navigation Links
Probiotic bacterium lessens severity of Salmonella infections by hoarding iron
Date:7/17/2013

Irvine, Calif., July 17, 2013 UC Irvine microbiologists have learned how a probiotic bacterium used to treat irritable bowel syndrome can soothe gut bacterial infections caused by Salmonella, paving the way for potential relief from foodborne illnesses that affect millions of people annually.

Manuela Raffatellu, assistant professor of microbiology & molecular genetics, and colleagues at UC Irvine and the University of Washington identified how a probiotic strain of E. coli reduces Salmonella colonization by competing with this pathogen for iron, an essential nutrient that Salmonella acquires in the gut in order to replicate at high levels.

In fact, the researchers discovered that the E. coli strain called Nissle 1917 acquires iron more efficiently than does Salmonella. As a result, Salmonella counts in the gut decrease when Nissle is administered during infection. Study results appear in today's issue of Cell Host & Microbe.

"Although we focused on Salmonella, our findings suggest that this approach can be effective against other gut bacterial pathogens that need iron to grow," said Raffatellu, who's also a member of UC Irvine's Institute for Immunology. "By understanding how these 'bad bugs' get nutrients, we can further study methods to eradicate them."

Most people infected with Salmonella develop diarrhea, fever and abdominal cramps 24 to 72 hours after infection. The illness usually lasts four to seven days, and the majority of affected individuals recover without treatment. According to the Centers for Disease Control & Prevention, about 42,000 cases of salmonellosis are reported annually in the U.S. Because many milder cases are not diagnosed or reported, the actual number of infections is estimated to be between 1 million and 4 million per year.

For nearly a century, the E. coli Nissle 1917 strain has been administered to patients with a variety of bowel disorders, but little has been known about how this probiotic bacterium works. Nissle 1917 is a key ingredient in a German probiotic product currently unavailable in the U.S. market.


'/>"/>

Contact: Tom Vasich
tmvasich@uci.edu
949-824-6455
University of California - Irvine
Source:Eurekalert

Related biology news :

1. Study shows probiotic Lactobacillus reuteri NCIMB 30242 significantly increased vitamin D levels
2. Study finds taking probiotics has benefits for patients in hospitals
3. Probiotics found to reduce hepatic encephalopathy
4. Study: Probiotics reduce stress-induced intestinal flare-ups
5. New study shows probiotics help fish grow up faster and healthier
6. Behind closed doors: Researchers show how probiotics boost plant immunity
7. By adding VSL#3 probiotic to traditional therapies UC patients can improve remission rates
8. Invisible helpers: How probiotic bacteria protect against inflammatory bowel diseases
9. Scientists discover ethnic differences in immune response to TB bacterium
10. Bacterium counteracts coffee ring effect
11. Scientists confirm that the Justinianic Plague was caused by the bacterium Yersinia pestis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/6/2017)... Forecasts by Product Type (EAC), Biometrics, Card-Based ... & Logistics, Government & Public Sector, Utilities / Energy ... Nuclear Power), Industrial, Retail, Business Organisation (BFSI), Hospitality & ... for a definitive report on the $27.9bn Access Control ... ...
(Date:4/5/2017)... 5, 2017 Today HYPR Corp. , ... server component of the HYPR platform is officially ... end-to-end security architecture that empowers biometric authentication across Fortune ... already secured over 15 million users across the financial ... connected home product suites and physical access represent a ...
(Date:4/4/2017)... , April 4, 2017   EyeLock LLC , ... that the United States Patent and Trademark Office (USPTO) ... covers the linking of an iris image with a ... and represents the company,s 45 th issued patent. ... is very timely given the multi-modal biometric capabilities that ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... ... October 10, 2017 , ... ... conjugate (ADC) therapeutics, today confirmed licensing rights that give it exclusive global ... technology developed in collaboration with Children’s Hospital Los Angeles (CHLA). Additionally, ...
(Date:10/10/2017)... ... October 10, 2017 , ... ... business process optimization firm for the life sciences and healthcare industries, announces a ... in San Francisco. , The presentation, “Automating GxP Validation for Agile Cloud Platforms,” ...
(Date:10/9/2017)... ... October 09, 2017 , ... The Giving Tree Wellness ... targeting the needs of consumers who are incorporating medical marijuana into their wellness ... Arizona. , As operators of two successful Valley dispensaries, The Giving Tree’s two ...
(Date:10/6/2017)... ... October 06, 2017 , ... The HealthTech Venture Network (HTVN) ... their fourth annual Conference where founders, investors, innovative practitioners and collaborators are invited ... competition showcasing early stage digital health and med tech companies. , This day-long ...
Breaking Biology Technology: