Navigation Links
Probiotic bacterium lessens severity of Salmonella infections by hoarding iron
Date:7/17/2013

Irvine, Calif., July 17, 2013 UC Irvine microbiologists have learned how a probiotic bacterium used to treat irritable bowel syndrome can soothe gut bacterial infections caused by Salmonella, paving the way for potential relief from foodborne illnesses that affect millions of people annually.

Manuela Raffatellu, assistant professor of microbiology & molecular genetics, and colleagues at UC Irvine and the University of Washington identified how a probiotic strain of E. coli reduces Salmonella colonization by competing with this pathogen for iron, an essential nutrient that Salmonella acquires in the gut in order to replicate at high levels.

In fact, the researchers discovered that the E. coli strain called Nissle 1917 acquires iron more efficiently than does Salmonella. As a result, Salmonella counts in the gut decrease when Nissle is administered during infection. Study results appear in today's issue of Cell Host & Microbe.

"Although we focused on Salmonella, our findings suggest that this approach can be effective against other gut bacterial pathogens that need iron to grow," said Raffatellu, who's also a member of UC Irvine's Institute for Immunology. "By understanding how these 'bad bugs' get nutrients, we can further study methods to eradicate them."

Most people infected with Salmonella develop diarrhea, fever and abdominal cramps 24 to 72 hours after infection. The illness usually lasts four to seven days, and the majority of affected individuals recover without treatment. According to the Centers for Disease Control & Prevention, about 42,000 cases of salmonellosis are reported annually in the U.S. Because many milder cases are not diagnosed or reported, the actual number of infections is estimated to be between 1 million and 4 million per year.

For nearly a century, the E. coli Nissle 1917 strain has been administered to patients with a variety of bowel disorders, but little has been known about how this probiotic bacterium works. Nissle 1917 is a key ingredient in a German probiotic product currently unavailable in the U.S. market.


'/>"/>

Contact: Tom Vasich
tmvasich@uci.edu
949-824-6455
University of California - Irvine
Source:Eurekalert

Related biology news :

1. Study shows probiotic Lactobacillus reuteri NCIMB 30242 significantly increased vitamin D levels
2. Study finds taking probiotics has benefits for patients in hospitals
3. Probiotics found to reduce hepatic encephalopathy
4. Study: Probiotics reduce stress-induced intestinal flare-ups
5. New study shows probiotics help fish grow up faster and healthier
6. Behind closed doors: Researchers show how probiotics boost plant immunity
7. By adding VSL#3 probiotic to traditional therapies UC patients can improve remission rates
8. Invisible helpers: How probiotic bacteria protect against inflammatory bowel diseases
9. Scientists discover ethnic differences in immune response to TB bacterium
10. Bacterium counteracts coffee ring effect
11. Scientists confirm that the Justinianic Plague was caused by the bacterium Yersinia pestis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/15/2016)... -- A new partnership announced today will help life ... a fraction of the time it takes today, ... insurance policies to consumers without requiring inconvenient and ... rapid testing (A1C, Cotinine and HIV) and higi,s ... pulse, BMI, and activity data) available at local ...
(Date:4/13/2016)... April 13, 2016  IMPOWER physicians supporting Medicaid patients ... a new clinical standard in telehealth thanks to a ... the higi platform, IMPOWER patients can routinely track key ... body mass index, and, when they opt in, share ... visit to a local retail location at no cost. ...
(Date:3/29/2016)... LegacyXChange, Inc. (OTC: LEGX ... Protect are pleased to announce our successful effort to ... of writing instruments, ensuring athletes signatures against counterfeiting and ... athletes on LegacyXChange will be assured of ongoing proof ... Bill Bollander , CEO states, "By inserting ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... June 23, 2016 , ... ... announce the launch of their brand, UP4™ Probiotics, into Target stores nationwide. The ... is proud to add Target to its list of well-respected retailers. This list ...
(Date:6/23/2016)... Md. , June 23, 2016 A person ... from the crime scene to track the criminal down. ... the U.S. Food and Drug Administration (FDA) uses DNA evidence ... Sound far-fetched? It,s not. The FDA ... sequencing to support investigations of foodborne illnesses. Put as simply ...
(Date:6/23/2016)... -- The Prostate Cancer Foundation (PCF) is pleased to announce 24 new ... prostate cancer. Members of the Class of 2016 were selected from a pool ... Read More About the Class of 2016 PCF Young Investigators ... ... ...
(Date:6/23/2016)... ... June 23, 2016 , ... ... the launch of the Supplyframe Design Lab . Located in Pasadena, Calif., ... the future of how hardware projects are designed, built and brought to market. ...
Breaking Biology Technology: