Navigation Links
Probiotic bacteria could help treat Crohn's disease
Date:3/31/2011

New research suggests that infection with a probiotic strain of E. coli bacteria could help treat an reduce the negative effects of another E. coli infection that may be associated with Crohn's disease. Researchrs from the University of Auckland, New Zealand publish their results in the April 2011 issue of the journal Applied and Environmental Microbiology.

Crohn's disease is a common chronic disorder that affects the gastrointestinal tract and is believed to develop as a result of an aberrant immune response to intestinal microbes in a genetically susceptible host. Over the last decade, high levels of adherent invasive E. coli (AIEC) have been reported. One study isolated the bacteria in 36% of Crohn's sufferers compared to just 6% of controls.

Since Crohn's disease is a clinical subtype of inflammatory bowel disease (IBD) and others have reported successful treatment of IBC with the probiotic E. coli Nissle 1917 (EcN), the researchers investigated the impact EcN might have on an already established infection with AIEC in cell cultures mimicking those found in the lining of the intestines.

They found that treatment with EcN not only helped prevent the AIEC reference strain LF82 from invading the cells and establishing infection, it also appears to modulate production of immune proteins that cause inflammation.

"This study is the first to our knowledge to show that EcN can reduce some of the negative effects associated with the strain LF82 in an already established AIEC infection and emphasizes the potential of EcN in IBD treatment. In particular the use of this probiotic could be of interest in CD patients harboring pathogenic AIEC," write the researchers.


'/>"/>

Contact: Jim Sliwa
jsliwa@asmusa.org
American Society for Microbiology
Source:Eurekalert

Page: 1

Related biology news :

1. Probiotics and Health Claims
2. Probiotic identified to treat ulcers
3. Probiotics, prebiotics and biofuel-producing bacteria
4. Probiotic found in breast milk helps alleviate symptoms of digestive disorders
5. Probiotics help extremely premature infants gain weight
6. Probiotic without effect against Salmonella
7. A sticky solution for identifying effective probiotics
8. Probiotic found to be effective treatment for colitis in mice
9. Designing probiotics that ambush gut pathogens
10. Probiotics help gastric-bypass patients lose weight more quickly, Stanford study shows
11. Review of probiotic trial research finds only Bifantis able to claim efficacy for IBS symptoms
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/2/2016)... YORK , Feb. 2, 2016 /PRNewswire/ ... facilities are primarily focused on medical screening ... measure point-of-care parameters. Wearable devices that facilitate ... user,s freedom of movement are being bolstered ... for human biomedical signal acquisition coupled with ...
(Date:2/2/2016)... --Technology Enhancements Accelerate Growth of X-ray Imaging This ... computed radiography markets in Thailand , ... (TIM). It provides an in-depth analysis of ... regional market drivers and restraints. The study offers revenue ... attractiveness, both for digital and computed radiography. Market participants ...
(Date:2/1/2016)... Canada , February 1, 2016 ... technological advancements to drive global touchfree intuitive gesture control ... --> Rising sales of consumer electronics coupled ... gesture control market size through ... consumer electronics coupled with new technological advancements to drive ...
Breaking Biology News(10 mins):
(Date:2/11/2016)... ... February 11, 2016 , ... Reichert Technologies, ... continues today to pursue the highest level of accuracy and quality with the ... Refractometer and the AR5 Refractometer. Accurate, reliable and tough enough for the ...
(Date:2/11/2016)... ... , ... Global Stem Cells Group, has announced ... new facility will provide advanced protocols and state-of-the-art techniques in cellular medicine, focusing ... The new GSCG clinic is headed by four prominent Ecuadorian physicians, including Pablo ...
(Date:2/10/2016)... 10, 2016 Early-career researchers from ... Peru , Uganda and Yemen ... health and nutrition   Indonesia , ... and Yemen are being honored for their ... are also celebrated for mentoring young women scientists who are pursuing careers ...
(Date:2/10/2016)... Feb. 10, 2016 NX Prenatal Inc., a ... NeXosome® technology for early warning of adverse pregnancy ... recent study by Dr. Thomas McElrath ... Maternal Fetal Medicine,s (SMFM) annual meeting held in ... , 2016.  The presentation reported initial positive top-line ...
Breaking Biology Technology: