Navigation Links
Probing matters of the heart
Date:9/14/2012

CAMBRIDGE, Mass. The fate of an embryonic stem cell, which has the potential to become any type of body cell, is determined by a complex interaction of genes, proteins that bind DNA, and molecules that modify those genes and proteins.

In a new paper, biologists from MIT and the University of California at San Francisco have outlined how those interactions direct the development of stem cells into mature heart cells. The study, the first to follow heart-cell differentiation over time in such detail, could help scientists better understand how particular mutations can lead to congenital heart defects. It could also assist efforts to engineer artificial heart tissue.

"We're hoping that some of the information we've been able to glean from our study will help us to approach a new understanding of heart development, and also lead to the possibility of using cells that are generated in a dish to replace heart cells that are lost as a consequence of aging and disease," says Laurie Boyer, an associate professor of biology at MIT and a senior author of the paper, which appears in the Sept. 13 online edition of Cell.

Research in Boyer's lab focuses on how DNA is organized and controlled in different cell types to create the wide variety of cells that make up the human body.

Inside a cell, DNA is wrapped around proteins called histones, which help control which genes are accessible at any given time. Histones may be tagged with different chemical modifications, which influence whether a particular stretch of DNA is exposed or hidden.

"These modifications cause structural changes that can act as docking sites for other factors to bind," says Joe Wamstad, a postdoc in Boyer's lab and one of the lead authors of the Cell paper. "It may make the DNA more or less accessible to manipulation by other factors, helping to ensure that you don't express a gene at the wrong time."

In this paper, the researchers found that h
'/>"/>

Contact: Sarah McDonnell
s_mcd@mit.edu
617-253-8923
Massachusetts Institute of Technology
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Probing the roots of depression by tracking serotonin regulation at a new level
2. Size matters: Large Marine Protected Areas work for dolphins
3. For the rooster, size matters
4. Heart-powered pacemaker could one day eliminate battery-replacement surgery
5. Geological Society of America Cordilleran section meets in the heart of Mexico
6. Cell therapy using patients own bone marrow may present option for heart disease
7. New analysis of premature infants heartbeats, breathing could be cues for leaving NICU
8. Minneapolis Heart Institute selected to participate in Cardiovascular Cell Therapy Research Network
9. Second-generation drug used for hypertension aids heart function independent of blood pressure
10. Scientists develop new technique that could improve heart attack prediction
11. Heart study suggests city center pollution doubles risk of calcium build-up in arteries
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... 27, 2014 University of Utah biologist agan Sekercioglu, ... has won that nation,s highest science prize, which is ... Sekercioglu is among five researchers picked for 2014 the ... Council of Turkey. Three researchers won the Science Award ... Award, which is equivalent to the Science Award but ...
(Date:8/27/2014)... greatest risk to Europe based upon a proxy for ... using a ,big data, approach to scientific research. , ... Global Health ranked the top 100 pathogens affecting humans ... system which, they believe, will help governments across the ... infectious diseases, including as a result of climate change, ...
(Date:8/27/2014)... 2014 /PRNewswire-iReach/ -- The IEEE Engineering in Medicine and ... Annual International Conference (EMBC,14), this year being held at ... Chicago, Illinois , from Tuesday, August 26 through ... and industry professionals in science, medicine, and engineering are ... This year,s conference theme is ...
Breaking Biology News(10 mins):University of Utah biologist wins Turkey's top science prize 2Big data approach identifies Europe's most dangerous human and domestic animal pathogens 2Global Leaders In Science, Medicine, And Engineering Gather For The 36th Annual International Conference Of The IEEE Engineering In Medicine And Biology Society, August 26-30 In Chicago 2Global Leaders In Science, Medicine, And Engineering Gather For The 36th Annual International Conference Of The IEEE Engineering In Medicine And Biology Society, August 26-30 In Chicago 3
... remarkable eyes of a marine crustacean could inspire the next ... study from the University of Bristol published today in ... are found on the Great Barrier Reef in Australia and ... They can see in twelve colours (humans see in only ...
... 23 GenVault Corporation, the leader in ambient temperature ... announced that David Wellis, Ph.D., GenVault,s President and CEO, ... place on October 26th and 27th in La Jolla, ... an overview of the company together with recent customer, ...
... A bioethicist who specializes in moral dilemmas families face ... the first-ever March of Dimes Distinguished Lectureship in Perinatal Bioethics. ... John D. Lantos, MD, a nationally-recognized pediatrician and ethicist, delivered ... at the American Society of Bioethics and Humanities, 11th annual ...
Cached Biology News:Mantis shrimps could show us the way to a better DVD 2GenVault Corporation to Present at the 2009 BIOCOM Investor Conference 2March of Dimes establishes 2 new perinatal bioethics awards 2
(Date:8/27/2014)... 2014 Research and Markets  has ... Acid  (Biodegradable Polymer, Food & Beverage, Personal Care ... 2019" report to their offering. ... an asymmetrical carbon atom. The main applications of ... and beverage, personal care product, and pharmaceutical industries. ...
(Date:8/27/2014)... , Aug. 27, 2014 Guggenheim Securities, ... Partners, today announced the hiring of veteran equity analyst ... equity analyst. Mr. Butler will focus on the biotech/biopharma ... team a wealth of experience and a broad network ... , Senior Managing Director and Head of Equities at ...
(Date:8/27/2014)... , Aug. 27, 2014 Research and ... Stable Isotope Ratio Mass Spectrometer Industry Report 2014" ... Stable Isotope Ratio Mass Spectrometer Industry Report 2014 is ... of the global isotope ratio mass spectrometer industry. ... industry including definitions, classifications, applications and industry chain structure. ...
(Date:8/27/2014)... BIOEQUA, an innovative line of skin care ... handheld spray, has made its EQUA ESSENTIAL line available ... brand began with an unexpected discovery in an emergency ... that the application of nanospray technology allowed for liquid ... to skin's basal layer. This resulted in immediate absorption ...
Breaking Biology Technology:Global Lactic Acid (Biodegradable Polymer, Food & Beverage, Personal Care & Pharmaceutical) Market - Trends & Forecasts to 2019 2Guggenheim Securities Hires Analyst Charles "Tony" Butler to Expand Healthcare Coverage 2Global Stable Isotope Ratio Mass Spectrometer Industry Report 2014 2BIOEQUA'S EQUA ESSENTIAL Product Line Redefines Skin Care & Now Available in America 2
... to Support Development of Renewable Replacement for Light ... ... 27 Solazyme, a,bioscience company pioneering biofuels and health/wellness products from,microalgae, ... Institute of Standards and Technology to develop a,biopetroleum derived from marine ...
... E. coli bacteria, Duke University chemists and engineers have ... imprinted to create microdevices such as labs-on-a-chip. , Their ... to 1 nanometer, or billionths of a meter, the ... of the Journal of Organic Chemistry. , "This ...
... LOUIS, Sept. 27 Sigma-Aldrich (Nasdaq:,SIAL) is pleased ... named the,Vice President of R&D for the Research ... role, he will help expand Sigma-Aldrich,s,leadership position through ... science researchers. Sullivan has been involved with Sigma-Aldrich,since ...
Cached Biology Technology:Solazyme Selected for National Institute of Standards and Technology Award 2Using catalysts to stamp nanopatterns without ink 2Using catalysts to stamp nanopatterns without ink 3Sigma-Aldrich Names Patrick Sullivan New VP of Research and Development for Research Biotech 2
Liquid. 50 μg/ml in PBS, pH 7.4. PROTECT FROM LIGHT. A convenient form of propidium iodide useful for flow cytometry studies. RTECS SF7949600, CAS 25535-16-4, M.W. 668.4. ...
... is used for conventional PCR and thermal ... personal thermal cycler, which features a 96-well ... tubes or plates, programmable time, temperature, and ... modes of temperature control. The system also ...
... been developed for affinity capture of ... of ProteinChip chemical surfaces allow differential ... unique biochemical properties. Each chip has ... comparison, and the chips are color-coded ...
The Freeze 'N Squeeze DNA gel extraction kit uses a quick freeze-and-thaw cycle and centrifugation to draw 50-23,000 bp DNA out of agarose gel slices. The kit includes materials for 100 preps....
Biology Products: