Navigation Links
Probing and controlling 'molecular rattling' may mean better preservatives
Date:2/25/2009

For centuries, people have preserved fruit by mixing it with sugar, making thick jams that last for months without spoiling. Now scientists at the National Institute of Standards and Technology (NIST) have discovered* a fundamental property of mixture behavior that might help extend the life of many things including vaccines, food and library booksand save money while doing it.

In addition to jams, sugars are often used to preserve pharmaceuticals and similar biological materials. There are a number of mechanisms involved, but recently the local stiffening of the preservative was identified as a factor that can increase shelf life. Basically, stiffening the preservative decreases the rattling of the fluids molecules and stabilizes the product, presumably because these rattling motions are intimately involved in spoilingfor instance, in the protein degradation processes that lead to the loss of biological function. Several years ago, the NIST team discovered the practical importance of high-frequency molecular rattling for protein preservation.**

But while sugars and other preservatives such as salts have been used since ancient times, the prediction of how well a preservative works for a specific material has remained more an art than a science. Now, however, the NIST team has developed a relatively accessible measurement method for precisely quantifying the slowing down (or enhancement) of the local rattling motions in preservative formulations and have introduced a general mathematical framework for describing these changes. This should remove much of the guesswork in determining the best way to protect a particular commodity, says Jack Douglas of Polymers Division of NIST.

In the new paper, the team reveals a general pattern of behavior in the change in the rattling motions in mixtures that appears to apply to a variety of materials; these findings promise to be very helpful in the future development of preservatives. The paper also focuses on understanding the fundamental origin of high-frequency rattlings effects, and it addresses enhancements in measurement and analysis that should allow researchers to optimize the preservation process.

Theres a real regularity with which these changes occur, and we found a simple mathematical model that encapsulates these changes, Douglas says. The value here is that this mathematical framework allows you to consider this problem for many different materials.

Douglas speculates that the discovery could help to extend the shelf life of vaccines significantly and also could be applied to preserving other biological materials such as seeds and prepared foods. The insight gained could even help to preserve library books. These measurements can help determine the rate at which the changes occur, and that would help you predict how using more or less preservative might affect things, or how one substance stacks up against another, Douglas says. It could hasten discovery of the optimal additive for achieving a given end.


'/>"/>

Contact: Chad Boutin
boutin@nist.gov
301-975-4261
National Institute of Standards and Technology (NIST)
Source:Eurekalert

Related biology news :

1. New book presents successful strategies for probing genetic variation
2. Controlling cucumber beetles organically
3. Brain enzyme may play key role in controlling appetite and weight gain
4. bioMETRX, Inc. Signs Deal To Acquire Controlling Interest in Biometric Solutions, LLC
5. Hidden infections crucial to understanding, controlling disease outbreaks
6. Biologists identify genes controlling rhythmic plant growth
7. People with heart disease still have trouble controlling blood lipid levels
8. Controlling embryonic fate by association
9. Controlling a sea of information
10. Controlling schistosomiasis: buffalo or snails?
11. Bioclocks work by controlling chromosome coiling
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/27/2021)... ... March 25, 2021 , ... Phlexglobal announced ... Planet Group, has selected Phlexglobal and its innovative regulatory SaaS software, PhlexSubmission, as ... a comprehensive review of five regulatory software companies, with the review team including ...
(Date:3/27/2021)... ... 25, 2021 , ... The 2021 Virtual Conference on Clinical Trial Supply-Europe ... More and more, clinical trial supply conferences are featuring speakers and forums that ... Asymmetrex’s founder and CEO, James L. Sherley, M.D., Ph.D., presented a talk ...
(Date:3/23/2021)... ... March 23, 2021 , ... G-CON Manufacturing (G-CON), the ... by Matica Biotechnology (Matica Bio), a contract development and manufacturing organization (CDMO) specializing ... the cleanroom build out for its new GMP production facility in College Station, ...
Breaking Biology News(10 mins):
(Date:3/27/2021)... ... March 24, 2021 , ... ... Life Sciences and Healthcare firms of all sizes, adds depth to its team ... specialist. Pardillo, who earned his doctorate in computational chemistry from Florida International University ...
(Date:3/27/2021)... ... March 24, 2021 , ... ABI Wellness, ... and reporting approach designed under CEO Mark Watson, today announced a webinar dedicated ... featuring guest speakers Dr. Cameron Clark, Neuropsychologist and Founder of Sharp Thinking, and ...
(Date:3/27/2021)... ... ... The Xtalks editorial team is pleased to announce the launch of the ... joined by editorial team members Ayesha Rashid, Sydney Perelmutter and Mira Nabulsi to discuss ... including insights from industry experts. , The Xtalks Life Science podcast will feature ...
(Date:3/23/2021)... Conn. (PRWEB) , ... March 23, 2021 , ... ... develops solutions for characterizing microbiome populations down to the strain level, recently unveiled ... applications. , Not all microbes are created equal: some are easy to ...
Breaking Biology Technology: