Navigation Links
Prize-winning research on solubility by Hebrew University doctoral student yields promise
Date:12/15/2011

Jerusalem --A method for increasing solubility (the ability of one substance to dissolve into another), developed by a graduate student at the Hebrew University of Jerusalem Casali Institute of Applied Chemistry, has yielded promising commercial benefits for industry, particularly in pharmaceuticals, cosmetics and agriculture.

The method, developed by Katy Margulis-Goshen, a Ph.D. student of Prof. Shlomo Magdassi, produces a rapid conversion of oil-in-water microemulsions, containing an insoluble substance, into a dry powder composed of nanoparticles which can easily be dissolved in water or other biological fluids.

For her work, Marguis-Goshen, who immigrated to Israel from the Ukraine in 1990, was chosen as one of the winners of this year's Kaye Innovation Awards at the university.

The process she developed is of unique industrial importance, since it leads to a significant increase in solubility and dissolution properties of almost any active ingredient, without a high energy investment.

Enhancing such solubility is especially important in the field of pharmaceutics, where nearly 50% of the newly discovered drugs cannot be administered or are very poorly absorbed due to their low solubility. Increasing solubility is also important in the field of agriculture, since the majority of insecticides are highly hydrophobic (resistant to mixing with water), and their regular application therefore requires the use of organic solvents, which are harmful to the farmer and the environment.

In cosmetics, active cosmetic ingredients for dermal delivery are usually also water resistant, so that incorporating them into non-greasy, water-based formulations is of great importance. The new process invented by Margulis-Goshen can be also applied in many other fields, such as nutrition and the manufacture of printing ink and paint.

If the active ingredient, for example, is a water-resistant drug, the powder developed in her method may be injected or incorporated into capsules, tablets and other fast-dissolving drug formulations. Such dosage forms have shown a tremendous increase in dissolution rate in water and biological fluids. They are expected to improve bioavailability of the drug, minimize its side effects by reducing the total dose needed, and allow drug targeting. A very significant improvement in drug dissolution has been shown in this way in tests with three drugs.

Similar beneficial results have been shown in applying the invention to the conversion of hydrophobic pesticides into a powder, allowing a reduction of at least six times in the effective concentration of the pesticide with utilization of water instead of organic solvents as the dispersing medium. In cosmetics, the powder containing active cosmetic ingredient may be incorporated into new, stable, water-based formulations.


'/>"/>
Contact: Jerry Barach
jerryb@savion.huji.ac.il
972-258-82904
The Hebrew University of Jerusalem
Source:Eurekalert  

Related biology news :

1. Researchers explain what makes granular material become solid
2. London researchers lead innovative new cancer treatment study
3. Antioxidant has potential in the Alzheimers fight, UGA researchers find
4. Important international collaboration with University of Guam researcher
5. Stand Up to Cancer and Melanoma Research Alliance announce dream team
6. Rose torture: severe heat in Texas yields better varieties for research
7. Intestine crucial to function of immune cells, research shows
8. UC Davis researcher develops model to foster new drug development to treat pain and epilepsy
9. Lawson research team working to personalize cancer care
10. Control by the matrix: RUB researchers decipher the role of proteins in the cell environment
11. UH Seidman Cancer Center researchers present at American Society of Hematology Annual Meeting
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Prize-winning research on solubility by Hebrew University doctoral student yields promise
(Date:3/24/2017)... Mar 24, 2017 Research and Markets has ... Market Analysis & Trends - Industry Forecast to 2025" report ... ... at a CAGR of around 15.1% over the next decade to ... report analyzes the market estimates and forecasts for all the given ...
(Date:3/22/2017)... 2017 Vigilant Solutions , a vehicle ... agencies, announced today the appointment of retired FBI special ... safety business development. Mr. Sheridan brings more ... a focus on the aviation transportation sector, to his ... Mr. Sheridan served as the Aviation Liaison Agent Coordinator ...
(Date:3/9/2017)... Australia , March 9, 2017 4Dx ... prestigious World Lung Imaging Workshop at the University of ... was invited to deliver the latest data to world ... recognised event brings together leaders at the forefront of ... in lung imaging. "The quality of ...
Breaking Biology News(10 mins):
(Date:4/20/2017)... SANTA BARBARA, CALIFORNIA (PRWEB) , ... April 20, 2017 , ... ... process optimization firm for the life sciences and healthcare industries, is pleased to announce ... of the new established USDM subsidiary “USDM Europe GmbH” based in Germany. , ...
(Date:4/20/2017)... CA (PRWEB) , ... April 20, 2017 , ... ... of clinical trials worldwide, announced today that they were named one of the ... which covers the latest developments in the pharmaceutical industry. , “We take pride in ...
(Date:4/19/2017)... ... 2017 , ... The Vibrating Orifice Aerosol Generator (VOAG) was ... droplets of known diameters for research applications such as for calibrating droplet measuring ... monodisperse droplets. , The VOAG requires forcing liquid out of an orifice ...
(Date:4/19/2017)... Waltham, MA (PRWEB) , ... April 19, 2017 ... ... of a $1.5M Series A-1 financing round. This event adds to several other ... establishment of its’ Executive and Scientific Teams. , ThermaGenix will use ...
Breaking Biology Technology: