Navigation Links
Princeton team learns why some drugs pack such a punch
Date:8/20/2009

constructed proteins stuck to the ribosome, jamming the translocator in the bacteria.

"This is very similar to plugging the translocator with a folded protein and, sure enough, this also causes translocator destruction," Silhavy said. "It's like putting an anchor on the spaghetti instead of a knot. They are stuck and dead forever."

Researchers had been confused as to why these antibiotics seemed to be so adept at killing some kinds of bacteria more quickly than others. These experiments provide an explanation. Translocators are essential for life and, if some bacteria have fewer translocators from the start, then they are more vulnerable to such an attack.

"While it has been known for many years that these antibiotics work by inhibiting bacterial protein synthesis, it was not clear why some bacteria in a population appeared more susceptible than others," van Stelten said. "Our work has identified a new reason why these antibiotics are lethal to bacteria that may help explain these earlier findings."

The researchers made their discovery not because of a new piece of equipment or a new technique. "Like the vast majority of advancements in science and medicine, we happened upon this remarkable answer through basic research," van Stelten said.

The finding could have important implications for medicine.

"If we are to have any hope of outpacing the antibiotic resistance obtained by bacteria, it is paramount that we fully understand the mechanism of action of the antibiotics we currently use," van Stelten said. "Unfortunately, this is often very difficult as evidenced by the fact that, 50 years on, we are still learning new things about them."

Their work also produced another important result. When the translocators in bacteria became jammed by errant proteins, the researchers observed that the translocators emitted a molecular signal -- a stress response -- that called in a destructive enzyme known as the F
'/>"/>

Contact: Kitta MacPherson
kittamac@princeton.edu
609-258-5729
Princeton University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Princeton teams analysis of flu virus could lead to better vaccines
2. Princeton geoscientist offers new evidence that meteorite did not wipe out dinosaurs
3. Princeton researchers discover new type of laser
4. Princeton-led team finds secret ingredient for the health of tropical rainforests
5. Gift of $100 million to transform energy and environment research at Princeton
6. Princeton engineers develop low-cost recipe for patterning microchips
7. Computer learns dogspeak
8. Novel polymer could improve protein-based drugs
9. Anti-psychotic drugs could help fight cancer
10. NTU professor discovers method to efficiently produce less toxic drugs using organic molecules
11. When it comes to brain damage, blankets take the place of drugs
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Princeton team learns why some drugs pack such a punch
(Date:10/17/2014)... from the University of Copenhagen have shown for the ... lungs of Cystic fibrosis patients, giving them the opportunity ... in chronic infections. , The study also discovered the ... (CF) patients was halted or slowed down by the ... all the oxygen and helped "suffocate" the bacteria, forcing ...
(Date:10/16/2014)... Oregon and Washington land managers have a new synthesis ... eastside moist mixed-conifer (MMC) forests in the two states. ... Forests in Eastern Oregon and Washington: A Synthesis of ... Management, a general technical report published by the U.S. ... response to a request from managers for a synthesis ...
(Date:10/16/2014)... 2014) – Post-menopausal women experienced improvements in vaginal ... or genital bleeding, after 12 weeks of daily ... soy germ-based nutritional supplement previously shown to help ... peer-reviewed pilot study reported in a poster at ... meeting. , "These data documented improved vaginal ...
Breaking Biology News(10 mins):Scientists opens black box on bacterial growth in cystic fibrosis lung infection 2New report synthesizes best available science on management of moist mixed-conifer forests 2S-equol supplements associated with improved measures of reproductive health in postmenopausal women 2
... the Department of Agriculture and Food Western Australia (DAFWA) ... Australia,s worst agricultural weeds. , "We are initiating a ... to control one and two-leaf Cape tulips (Moraea flaccida ... as a biological control agent," CSIRO Entomology,s Dr John ...
... on the miracle of life. The joining of egg and ... if the chromosome information from each parent has been translated ... is that when extra copies of chromosomes or fewer than ... birth defects can occur. Now, scientists at the University of ...
... may study grasses by profession, but Texas AgriLife Research forage agronomist Dr. Dariusz Malinowski ... And it is that ... Malinowski ... with his master,s degree in horticulture. , ...
Cached Biology News:Cape tulips -- pretty but pests in pastures 2UGA researchers propose model for disorders caused by improper transmission of chromosomes 2UGA researchers propose model for disorders caused by improper transmission of chromosomes 3Unique winter-hardy hibiscus has roots with AgriLife Research scientist in Vernon 2Unique winter-hardy hibiscus has roots with AgriLife Research scientist in Vernon 3
(Date:10/22/2014)... and BOSTON , Oct. ... ), a leading global specialty pharmaceutical company, and Rhythm, ... granted an exclusive option to acquire Rhythm,s wholly owned ... a peptide ghrelin agonist, for the treatment of diabetic ... Rhythm has completed a successful Phase 2 trial of ...
(Date:10/22/2014)... 22, 2014 Involution Studios , ... of a new infographic, Understanding Ebola . ... beautifully designed, easy to follow informative tool for anyone ... outbreak, symptoms and prevention. , "As the news has ... 2014 Ebola outbreak represents not only a healthcare crisis ...
(Date:10/22/2014)... Rock Hill, SC (PRWEB) October 22, 2014 ... the expansion of its cardiovascular pharmacogenetics menu, which ... improved patient outcomes. With PCLS’s evidence-based results, ... individual needs and optimize their therapy, while minimizing ... , In the U.S., according to the FDA ...
(Date:10/22/2014)... NEW YORK , Oct. 22, 2014 ... Diabetes Federation, approximately 400 million people worldwide are living ... 552 million people by 2030.  The global market for ... In 2012 approximately 330,000 people worldwide died from pancreatic ... of death due to cancer in the ...
Breaking Biology Technology:Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 2Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 3Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 4Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 5Involution Studios' Ebola Infographic Provides Key Disease Information and Statistics at a Glance 2PCLS Announces Expansion of Cardiovascular Pharmacogenetic Testing Menu 2PCLS Announces Expansion of Cardiovascular Pharmacogenetic Testing Menu 3Nuvilex Brief Analyst Report: Thinking Outside the Box by BrokerBank Securities, Inc. 2
... 2011 Interleukin Genetics, Inc. (OTCQB: ILIU) announced ... Wedbush Securities Life Sciences Management Access Conference at the Le ... City. The presentation is scheduled for Wednesday, Aug. 17 at ... second floor.   Interleukin,s management team will be ...
... Mass., Aug. 10, 2011 Boston Scientific Corporation (NYSE: ... Institute™ (NLI), a clinical education program and online resource ... awareness of spinal cord stimulation (SCS) technology, procedures and ... meeting of the International Spine Intervention Society (ISIS) occurring ...
... DIEGO, Aug. 9, 2011 Verenium Corporation (Nasdaq: ... development and commercialization of high-performance enzymes, today reported a summary ... quarter and six months ended June 30, 2011. ... terms of product revenues and partnership negotiations in the first ...
Cached Biology Technology:Interleukin Genetics, Inc. to Present at the 2011 Wedbush Securities Life Sciences Management Access Conference 2Boston Scientific Launches Neuromodulation Learning Institute To Enhance Clinical Education For Spinal Cord Stimulation 2Boston Scientific Launches Neuromodulation Learning Institute To Enhance Clinical Education For Spinal Cord Stimulation 3Boston Scientific Launches Neuromodulation Learning Institute To Enhance Clinical Education For Spinal Cord Stimulation 4Verenium Reports Financial Results for the Second Quarter and Six Months Ended June 30, 2011 2Verenium Reports Financial Results for the Second Quarter and Six Months Ended June 30, 2011 3Verenium Reports Financial Results for the Second Quarter and Six Months Ended June 30, 2011 4Verenium Reports Financial Results for the Second Quarter and Six Months Ended June 30, 2011 5Verenium Reports Financial Results for the Second Quarter and Six Months Ended June 30, 2011 6Verenium Reports Financial Results for the Second Quarter and Six Months Ended June 30, 2011 7Verenium Reports Financial Results for the Second Quarter and Six Months Ended June 30, 2011 8Verenium Reports Financial Results for the Second Quarter and Six Months Ended June 30, 2011 9
... preparations are prepared from customers high-copy ... to multi-gram scales. Each preparation is ... glycerol stocks are maintained to facilitate ... (Clonal selection includes screening colonies for ...
... channels for automated gigaseal patch clamping. ... voltage-gated ion channels, such as hERG and ... The four pipette heads afford more efficient ... drug discovery. The glass-coated tunnels of ...
... be able to handle larger sample volumes, automate ... as interface with telemetry systems. The AccuSampler ... dogs, pigs, and primates. The system may ... the computer can be located outside the animal ...
... The GST•Tag™ Antibody Plate is ... GST•Tag Monoclonal Antibody. This antibody (mouse ... S. japonicum glutathione-S-transferase (GST), ... virtually any GST•Tag fusion protein in ...
Biology Products: