Navigation Links
Princeton scientists find way to catalog all that goes wrong in a cancer cell
Date:12/10/2009

A team of Princeton University scientists has produced a systematic listing of the ways a particular cancerous cell has "gone wrong," giving researchers a powerful tool that eventually could make possible new, more targeted therapies for patients.

"For a very long time, cancer therapies have been developed by trial and error to essentially kill a broad variety of rapidly dividing cells, good and bad -- that's why they have massive side effects," said Saeed Tavazoie, a professor in the Department of Molecular Biology and the Lewis-Sigler Institute for Integrative Genomics, who led the research. "The goal of cancer biology is to come up with therapies that are much more rational in terms of attacking the pathways that have been co-opted by cancer cells. The big challenge is to discover these pathways so that we can restore them to their normal state."

Writing in the Dec. 11 issue of Molecular Cell, Tavazoie, along with his colleagues Hani Goodarzi, a graduate student in molecular biology, and Olivier Elemento, a former postdoctoral researcher in the department, found they were able to systematically categorize and pinpoint the alterations in cancer pathways and to reveal the underlying regulatory code in DNA. Elemento is now on the faculty of Weill Cornell Medical College in New York.

"We are discovering that there are many components inside the cell that can get mutated and give rise to cancer," Tavazoie said. "Future cancer therapies have to take into account these specific pathways that have been mutated in individual cancers and treat patients specifically for that."

The researchers developed an algorithm, a problem-solving computer program that sorts through the behavior of each of 20,000 genes operating in a tumor cell. When genes are turned "on," they activate or "express" proteins that serve as signals, creating different pathways of action. Cancer cells often act in aberrant ways, and the algorithm can detect t
'/>"/>

Contact: Kitta MacPherson
kittamac@princeton.edu
609-258-5729
Princeton University
Source:Eurekalert

Page: 1 2

Related biology news :

1. NCI awards $15.2 million to create Princeton Physical Sciences -- Oncology Center
2. Princeton team learns why some drugs pack such a punch
3. Princeton teams analysis of flu virus could lead to better vaccines
4. Princeton geoscientist offers new evidence that meteorite did not wipe out dinosaurs
5. Princeton researchers discover new type of laser
6. Princeton-led team finds secret ingredient for the health of tropical rainforests
7. Gift of $100 million to transform energy and environment research at Princeton
8. Princeton engineers develop low-cost recipe for patterning microchips
9. The pitch of blue whale songs is declining around the world, scientists discover
10. Stand Up to Cancer funds high-risk/high-reward cancer research by 13 young scientists
11. Scientists discover gene module underlying atherosclerosis development
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/29/2014)... by the international Cancer Genomics of the Kidney ... between kidney cancer and exposure to aristolochic acid, ... published in Nature Communications , have important ... more than 140,000 people every year, and in ... CAGEKID, part of the International Cancer Genome Consortium ...
(Date:10/28/2014)... have published a paper in the Proceedings of ... details about key transitions in the evolution of plant ... mosses, ferns, trees and flowers growing deep in steamy ... the ornamental plants adorning our homes, all plant life ... "Our study generated DNA sequences from a vast number ...
(Date:10/28/2014)... be building a hybrid micro-grid which will integrate ... in the region, the hybrid micro-grid will test ... diesel, storage and power-to-gas technologies, and ensure these ... built under the new Renewable Energy Integration Demonstrator- ... located offshore at Semakau Landfill and is expected ...
Breaking Biology News(10 mins):Kidney cancer in Central Europe 2New study uses DNA sequences to look back in time at key events in plant evolution 2New study uses DNA sequences to look back in time at key events in plant evolution 3NTU to build region's first renewable energy integration demonstration micro-grid 2NTU to build region's first renewable energy integration demonstration micro-grid 3
... Mary Lee Dequeant, Ph.D., a Predoctoral Researcher at the ... Stowers Institute Investigator and an investigator with the Howard ... respectively, on a paper that identifies a network of ... of spine formation in the embryo. , ...
... identified the molecular signature of these epidermal neural crest ... conflicting scientific opinions by showing that these cells are ... Their work provides a valuable resource for future mouse ... the research from Dr. Maya Sieber-Blum's laboratory, co-authored by ...
... University researchers have identified a unique mechanism of action ... the treatment of multiple sclerosis. , The researchers report ... drug that was already known to affect the functioning ... white blood cells from the lymph nodes into the ...
Cached Biology News:Stem cells found in adult hair follicles may provide alternative to embryonic stem cells 2Novel mechanism of action of new drug for MS identified 2
(Date:10/27/2014)... 2014 Kalorama Information says that PCR is ... the United States and is ... researcher said the FDA,s Emergency Use Authorization (EUA) to authorize ... the detection of the Ebola virus was an indication ... assess the IVD industry and its biennial survey on ...
(Date:10/27/2014)... The report “Smart Highway Market ... Communication, Monitoring), and by Display (Variable Message Signs, ... the global market into various sub-segments with in-depth ... the drivers and restraints for this market with ... 75 market tables and 37 figures spread through ...
(Date:10/26/2014)... The report "Data Center Networking ... Equipment, WAN Optimization Appliances]: Global Advancements, Worldwide Forecasts ... center networking market into various segments with an ... also identifies the factors driving this market, various ... with the future roadmaps. , Browse 106 market ...
(Date:10/25/2014)... (PRWEB) October 23, 2014 BioProcess ... winners for the 2014 BioProcess International Awards. The ... social corporate responsibility and technology applications that will ... treatments to a global patient base. , Winners ... peers during a very entertaining and exciting awards ...
Breaking Biology Technology:Kalorama: PCR The Go-to Test in Ebola Fight 2Kalorama: PCR The Go-to Test in Ebola Fight 3Smart Highway Market by Technology, and Display Expected to Reach $27.992.0 Million by 2019- New Report by MarketsandMarkets 2Smart Highway Market by Technology, and Display Expected to Reach $27.992.0 Million by 2019- New Report by MarketsandMarkets 3Smart Highway Market by Technology, and Display Expected to Reach $27.992.0 Million by 2019- New Report by MarketsandMarkets 4Data Center Networking Market by Ethernet Switches, SAN & Routers Worth $21.85 Billion by 2018 - New Report by MarketsandMarkets 2Data Center Networking Market by Ethernet Switches, SAN & Routers Worth $21.85 Billion by 2018 - New Report by MarketsandMarkets 3Data Center Networking Market by Ethernet Switches, SAN & Routers Worth $21.85 Billion by 2018 - New Report by MarketsandMarkets 4BioProcess International Announces Winners of the 2014 BioProcess International Awards 2BioProcess International Announces Winners of the 2014 BioProcess International Awards 3BioProcess International Announces Winners of the 2014 BioProcess International Awards 4BioProcess International Announces Winners of the 2014 BioProcess International Awards 5
... BEIJING, Aug. 20 /PRNewswire-Asia-FirstCall/ -- China Medical ... leading China-based medical device,company that develops, manufactures and markets ... its unaudited financial results,for the fourth fiscal quarter ("4Q ... the first fiscal quarter ("1Q FY2009") ended June 30, ...
... , SEATTLE, Aug. 19 Cell Therapeutics, Inc. ... into an agreement to sell $30 million of shares of its Series ... in a registered offering to a single institutional investor. Each share ... holder, at any time during its existence, into approximately 628 shares of ...
... , , COLUMBIA, Md., Aug. 19 Martek Biosciences ... the results of its third quarter of fiscal 2009 on September 2, ... at 4:45 p.m. ET Martek will conduct a conference call to discuss ... call live via webcast by visiting Martek,s web site at ...
Cached Biology Technology:China Medical Technologies to Announce Unaudited Financial Results for the Fourth Fiscal Quarter and Fiscal Year ended March 31, 2009 and the First Fiscal Quarter ended June 30, 2009 on September 1, 2009 2Cell Therapeutics, Inc. Announces Institutional Investor Purchases $30 Million of Preferred Stock and Warrants 2Cell Therapeutics, Inc. Announces Institutional Investor Purchases $30 Million of Preferred Stock and Warrants 3
... (100+kb), fosmid (40kb), and large plasmid insert ... othe BAC vector. On command 20-50 fold ... recombinant DNA purification. Available with blue-white screening ... for the highest insert stability. Kits include ...
... System is used in conjunction ... PCR of problematic and/or GC-rich ... Solution with 10X PCRX Amplification ... broader magnesium concentration broader annealing ...
6-carboxy-2',4,4',5',7,7'-hexachlorofluorescein, succinimidyl ester (6-HEX, SE) *single isomer*...
Mouse Exodus 2 - 12kDa...
Biology Products: